EFI - Enzyme Similarity Tool

Pfam Families

These data are sourced from the UniProt and EMBL-EBI InterPro databases.

Clan ID Clan Short Name Clan Size Clan UniRef90 Size Pfam ID Pfam Short Name Pfam Size Pfam UniRef90 Size
CL0001 EGF 136,073 69,631 PF00008 EGF 38,735 20,755
PF00053 Laminin_EGF 18,808 9,977
PF00084 Sushi 26,223 13,793
PF00594 Gla 3,878 1,836
PF01414 DSL 3,021 1,436
PF04863 EGF_alliinase 464 241
PF06247 Plasmod_Pvs28 411 60
PF07645 EGF_CA 40,727 21,627
PF07974 EGF_2 9,283 4,439
PF09014 Sushi_2 472 250
PF09064 Tme5_EGF_like 245 185
PF09289 FOLN 1,803 614
PF09443 CFC 398 227
PF12661 hEGF 13,783 6,957
PF12662 cEGF 10,533 5,230
PF12946 EGF_MSP1_1 2,288 184
PF12947 EGF_3 8,976 3,841
PF14670 FXa_inhibition 16,965 8,012
PF18193 Fibrillin_U_N 805 372
PF18372 I-EGF_1 2,851 1,079
PF18720 EGF_Tenascin 2,105 975
CL0003 SAM 70,776 30,631 PF00536 SAM_1 37,758 16,912
PF01698 SAM_LFY 1,514 268
PF02198 SAM_PNT 5,610 2,106
PF04904 NCD1 965 346
PF07647 SAM_2 24,398 10,840
PF09235 SAM_Ste50p 57 39
PF09597 IGR 1,278 710
PF13543 SAM_KSR1 905 463
PF18016 SAM_3 3,223 1,319
PF18017 SAM_4 823 445
PF18255 SAM_DrpA 736 88
PF18609 SAM_Exu 168 110
CL0004 Concanavalin 366,755 201,533 PF00054 Laminin_G_1 6,596 3,692
PF00139 Lectin_legB 10,310 5,974
PF00262 Calreticulin 6,195 2,873
PF00337 Gal-bind_lectin 8,964 4,713
PF00354 Pentaxin 5,193 2,883
PF00426 VP4_haemagglut 7,503 423
PF00457 Glyco_hydro_11 4,300 2,190
PF00622 SPRY 41,704 22,053
PF00629 MAM 12,054 6,331
PF00722 Glyco_hydro_16 42,329 23,837
PF00840 Glyco_hydro_7 7,436 2,257
PF01670 Glyco_hydro_12 4,110 2,122
PF01828 Peptidase_A4 2,396 1,508
PF02210 Laminin_G_2 22,907 11,311
PF02973 Sialidase 671 194
PF03388 Lectin_leg-like 4,593 2,262
PF03935 SKN1 3,161 2,046
PF05592 Bac_rhamnosid 11,686 7,208
PF05735 TSP_C 2,785 1,042
PF06439 DUF1080 28,577 19,547
PF06955 XET_C 6,574 2,884
PF07081 DUF1349 7,535 3,386
PF07177 Neuralized 2,704 1,298
PF07622 DUF1583 169 131
PF07675 Cleaved_Adhesin 1,507 1,184
PF07953 Toxin_R_bind_N 310 54
PF08244 Glyco_hydro_32C 22,355 9,753
PF08787 Alginate_lyase2 4,547 2,112
PF08978 Reoviridae_Vp9 39 15
PF09101 Exotox-A_bind 210 43
PF09206 ArabFuran-catal 1,657 867
PF09224 DUF1961 620 381
PF09264 Sial-lect-inser 77 26
PF10287 DUF2401 895 534
PF11476 TgMIC1 18 4
PF11958 DUF3472 1,744 979
PF12248 Methyltransf_FA 1,537 935
PF13385 Laminin_G_3 57,094 40,445
PF13765 PRY 21,506 12,327
PF14099 Polysacc_lyase 2,718 1,827
PF15493 YrpD 149 49
PF16346 DUF4975 638 279
PF16451 Spike_NTD 1,272 56
PF17689 Arabino_trans_N 2,933 1,030
PF17851 GH43_C2 17,669 8,851
PF17974 GalBD_like 1,264 456
PF18239 HA1 6 4
PF18271 GH131_N 1,414 833
PF18483 Bact_lectin 3,227 2,075
CL0005 Kazal 20,706 10,566 PF00050 Kazal_1 6,965 4,185
PF07648 Kazal_2 15,055 7,136
PF18434 Kazal_3 441 177
CL0006 C1 58,668 28,025 PF00130 C1_1 32,676 14,463
PF00569 ZZ 18,118 8,885
PF03107 C1_2 6,151 3,885
PF07975 C1_4 1,727 799
CL0007 KH 239,233 84,804 PF00013 KH_1 92,590 35,041
PF04025 DUF370 6,119 2,365
PF07650 KH_2 70,533 21,345
PF09869 DUF2096 177 135
PF13083 KH_4 24,610 9,596
PF13184 KH_5 34,491 10,967
PF14611 SLS 826 505
PF14955 MRP-S24 631 373
PF15985 KH_6 4,284 2,191
PF16005 MOEP19 464 235
PF17214 KH_7 1,867 791
PF17903 KH_8 3,224 1,555
PF17904 KH_9 2,077 648
PF17905 KH_10 66 47
CL0009 ENTH_VHS 30,546 14,190 PF00790 VHS 12,233 5,633
PF01417 ENTH 7,801 3,865
PF07651 ANTH 10,513 4,698
CL0010 SH3 293,194 131,985 PF00018 SH3_1 70,209 31,647
PF01302 CAP_GLY 13,945 7,315
PF02736 Myosin_N 11,446 5,179
PF03831 PhnA 15,300 5,013
PF06347 SH3_4 7,476 4,484
PF06372 Gemin6 473 271
PF07563 DUF1541 1,544 761
PF07653 SH3_2 28,414 12,977
PF07866 DUF1653 6,942 3,064
PF08239 SH3_3 42,887 22,252
PF08460 SH3_5 2,538 796
PF08810 KapB 1,212 443
PF11095 Gemin7 460 306
PF11302 DUF3104 186 136
PF11607 DUF3247 325 149
PF11623 NdhS 692 290
PF12208 DUF3601 176 73
PF12913 SH3_6 3,151 1,025
PF13457 GW 3,713 1,142
PF14603 hSH3 842 438
PF14604 SH3_9 46,182 21,263
PF14627 DUF4453 81 62
PF15505 DUF4648 161 63
PF17384 DUF150_C 24,553 9,698
PF17902 SH3_10 4,281 1,629
PF18103 SH3_11 142 17
PF18129 SH3_12 1,916 1,044
PF18335 SH3_13 10,502 4,183
PF18343 SH3_14 204 17
PF18346 SH3_15 1,780 746
PF18348 SH3_16 7,201 4,156
PF18350 SH3_17 46 10
PF18354 SH3_18 48 24
PF18597 SH3_19 413 249
PF18697 MLVIN_C 1,233 701
CL0011 Ig 293,394 145,299 PF00047 ig 19,313 8,903
PF01537 Herpes_glycop_D 682 125
PF01688 Herpes_gI 429 56
PF02124 Marek_A 737 78
PF02440 Adeno_E3_CR1 343 66
PF02480 Herpes_gE 926 156
PF02960 K1 1,187 95
PF03921 ICAM_N 1,003 516
PF05790 C2-set 645 209
PF07654 C1-set 49,745 14,556
PF07679 I-set 94,916 46,221
PF07686 V-set 94,823 57,359
PF08204 V-set_CD47 555 185
PF08205 C2-set_2 17,153 8,825
PF09085 Adhes-Ig_like 184 81
PF09191 CD4-extracel 255 85
PF09291 DUF1968 178 121
PF10430 Ig_Tie2_1 275 83
PF11465 Receptor_2B4 350 209
PF13895 Ig_2 20,708 11,202
PF13927 Ig_3 75,393 39,005
PF15028 PTCRA 114 71
PF15910 V-set_2 469 194
PF16680 Ig_4 488 298
PF16681 Ig_5 285 179
PF16706 Izumo-Ig 208 97
PF16758 UL141 153 12
PF17736 Ig_C17orf99 732 325
PF17737 Ig_C19orf38 142 95
PF18452 Ig_6 2,007 824
PF18589 ObR_Ig 539 210
CL0012 Histone 120,303 39,953 PF00125 Histone 66,823 14,062
PF00808 CBFD_NFYB_HMF 20,087 10,115
PF02269 TFIID-18kDa 3,752 1,801
PF02291 TFIID-31kDa 2,360 1,179
PF02969 TAF 2,901 1,250
PF03540 TFIID_30kDa 2,070 1,067
PF03847 TFIID_20kDa 2,672 1,402
PF04719 TAFII28 2,230 1,238
PF05236 TAF4 3,171 1,590
PF07524 Bromo_TP 4,791 2,421
PF09123 DUF1931 657 202
PF09415 CENP-X 1,325 789
PF15510 CENP-W 319 168
PF15511 CENP-T_C 5,458 1,821
PF15630 CENP-S 1,445 813
PF15715 PAF 354 184
PF17027 Bromo_TP_like 48 35
CL0013 Beta-lactamase 483,845 223,929 PF00144 Beta-lactamase 157,220 88,057
PF00768 Peptidase_S11 63,080 25,111
PF00905 Transpeptidase 191,614 79,528
PF02113 Peptidase_S13 20,501 10,607
PF04960 Glutaminase 16,972 5,649
PF13354 Beta-lactamase2 34,622 15,154
CL0014 Glutaminase_I 604,447 254,020 PF00117 GATase 228,651 87,395
PF01174 SNO 12,643 5,851
PF01965 DJ-1_PfpI 129,979 52,899
PF02016 Peptidase_S66 22,491 10,371
PF03575 Peptidase_S51 18,692 9,641
PF04204 HTS 11,520 3,876
PF06283 ThuA 22,483 12,828
PF07090 GATase1_like 5,116 2,261
PF07685 GATase_3 40,720 16,912
PF07722 Peptidase_C26 24,882 11,994
PF08532 Glyco_hydro_42M 13,375 6,862
PF09822 ABC_transp_aux 11,652 7,169
PF09825 BPL_N 2,761 1,581
PF13507 GATase_5 36,917 14,468
PF13709 DUF4159 8,184 4,847
PF17124 ThiJ_like 1,920 924
PF17385 LBP_M 1,382 462
PF18011 Catalase_C 11,097 3,794
CL0015 MFS 1,692,629 719,396 PF00083 Sugar_tr 219,630 93,511
PF00854 PTR2 49,565 20,740
PF01306 LacY_symp 3,961 941
PF01733 Nucleoside_tran 5,929 3,217
PF01770 Folate_carrier 2,219 1,332
PF03092 BT1 6,365 3,262
PF03137 OATP 6,880 3,640
PF03209 PUCC 3,545 1,700
PF03219 TLC 2,877 1,788
PF03825 Nuc_H_symport 8,905 2,905
PF05631 MFS_5 2,335 1,164
PF05977 MFS_3 54,790 27,869
PF05978 UNC-93 4,517 2,476
PF06609 TRI12 3,369 1,965
PF06779 MFS_4 11,191 4,379
PF06813 Nodulin-like 4,944 2,520
PF06963 FPN1 2,602 1,449
PF07672 MFS_Mycoplasma 114 58
PF07690 MFS_1 1,242,201 520,940
PF11700 ATG22 17,197 8,744
PF12832 MFS_1_like 15,513 7,307
PF13000 Acatn 4,818 2,418
PF13347 MFS_2 45,448 19,171
CL0016 PKinase 1,451,147 762,031 PF00069 Pkinase 804,456 431,639
PF00454 PI3_PI4_kinase 29,184 14,464
PF01163 RIO1 15,042 7,372
PF01504 PIP5K 14,211 6,592
PF01633 Choline_kinase 12,179 6,153
PF01636 APH 163,393 86,546
PF02816 Alpha_kinase 4,549 2,656
PF02958 EcKinase 8,694 5,881
PF03109 ABC1 49,826 21,905
PF03770 IPK 7,033 3,793
PF03881 Fructosamin_kin 12,719 6,813
PF04183 IucA_IucC 13,720 5,387
PF04655 APH_6_hur 6,965 3,687
PF05445 Pox_ser-thr_kin 164 48
PF06090 Ins_P5_2-kin 2,306 1,361
PF06176 WaaY 1,866 372
PF06293 Kdo 19,421 8,013
PF06315 AceK 5,974 1,573
PF06702 Fam20C 1,860 896
PF06734 UL97 505 29
PF07387 Seadorna_VP7 47 32
PF07714 Pkinase_Tyr 214,230 115,754
PF07804 HipA_C 22,338 11,820
PF07914 DUF1679 1,244 982
PF08757 CotH 13,696 9,696
PF09192 Act-Frag_cataly 501 219
PF10009 DUF2252 8,283 3,947
PF10140 YukC 1,501 432
PF10707 YrbL-PhoP_reg 1,877 709
PF12260 PIP49_C 2,373 1,015
PF12330 Haspin_kinase 9,905 5,212
PF13095 FTA2 601 363
PF13575 DUF4135 2,782 1,718
PF14531 Kinase-like 619 177
PF16474 KIND 1,639 899
PF17667 Pkinase_fungal 9,498 8,087
PF18101 Pan3_PK 2,161 1,025
PF18762 Kinase-PolyVal 395 247
CL0018 bZIP 56,004 27,028 PF00170 bZIP_1 37,474 17,481
PF03131 bZIP_Maf 5,240 2,230
PF07716 bZIP_2 13,289 7,473
CL0020 TPR 1,440,404 787,800 PF00514 Arm 31,709 12,626
PF00515 TPR_1 71,086 38,268
PF00613 PI3Ka 8,893 3,727
PF00637 Clathrin 10,820 4,318
PF00806 PUF 10,929 5,643
PF01239 PPTA 5,632 3,127
PF01347 Vitellogenin_N 4,430 2,669
PF01394 Clathrin_propel 3,287 932
PF01535 PPR 101,979 57,503
PF01602 Adaptin_N 25,065 10,647
PF01603 B56 7,774 3,237
PF01749 IBB 5,926 1,947
PF01816 LRV 1,073 752
PF01851 PC_rep 5,309 1,952
PF02020 W2 8,571 3,651
PF02071 NSF 3 3
PF02184 HAT 2,201 894
PF02259 FAT 8,779 4,659
PF02847 MA3 10,160 4,995
PF02854 MIF4G 14,891 7,374
PF02985 HEAT 12,068 5,859
PF03130 HEAT_PBS 6,196 4,203
PF03224 V-ATPase_H_N 2,924 1,258
PF03377 TAL_effector 626 260
PF03378 CAS_CSE1 2,475 1,094
PF03704 BTAD 35,652 24,270
PF03810 IBN_N 22,429 8,912
PF04049 ANAPC8 1,962 915
PF04050 Upf2 2,223 1,008
PF04184 ST7 2,037 654
PF04733 Coatomer_E 3,075 1,480
PF04826 Arm_2 1,699 727
PF04910 Tcf25 2,429 1,375
PF05004 IFRD 2,784 1,204
PF05484 LRV_FeS 562 344
PF05536 Neurochondrin 1,438 730
PF05804 KAP 1,674 867
PF05843 Suf 4,248 2,111
PF05918 API5 1,432 674
PF06041 DUF924 9,868 5,220
PF06367 Drf_FH3 7,596 3,744
PF06371 Drf_GBD 7,887 3,803
PF06552 TOM20_plant 1,237 716
PF06920 DHR-2 9,043 4,427
PF06957 COPI_C 2,894 1,113
PF07219 HemY_N 10,737 4,145
PF07571 TAF6_C 2,748 1,242
PF07719 TPR_2 47,482 28,646
PF07720 TPR_3 2,468 951
PF07721 TPR_4 5,986 4,320
PF07980 SusD_RagB 77,337 43,094
PF08144 CPL 1,968 1,024
PF08167 RIX1 1,790 1,002
PF08238 Sel1 76,094 39,898
PF08321 PPP5 3,137 1,356
PF08389 Xpo1 11,001 4,563
PF08506 Cse1 4,702 1,886
PF08569 Mo25 3,568 1,392
PF08579 RPM2 131 95
PF08623 TIP120 2,578 1,002
PF08631 SPO22 1,336 859
PF08713 DNA_alkylation 21,408 11,081
PF08767 CRM1_C 3,385 1,166
PF08852 DUF1822 1,401 939
PF09088 MIF4G_like 2,274 1,040
PF09090 MIF4G_like_2 2,385 1,097
PF09127 Leuk-A4-hydro_C 5,155 2,586
PF09246 PHAT 143 75
PF09268 Clathrin-link 2,873 781
PF09295 ChAPs 2,329 1,101
PF09311 Rab5-bind 1,236 441
PF09450 DUF2019 487 341
PF09613 HrpB1_HrpK 579 216
PF09759 Atx10homo_assoc 2,011 1,084
PF09976 TPR_21 16,079 7,594
PF09986 DUF2225 2,189 1,241
PF10037 MRP-S27 961 515
PF10255 Paf67 2,637 828
PF10274 ParcG 1,633 883
PF10300 DUF3808 4,249 2,180
PF10345 Cohesin_load 1,941 880
PF10366 Vps39_1 3,099 1,436
PF10373 EST1_DNA_bind 5,089 2,734
PF10374 EST1 3,587 1,811
PF10508 Proteasom_PSMB 1,403 656
PF10516 SHNi-TPR 2,194 1,165
PF10579 Rapsyn_N 570 213
PF10602 RPN7 4,892 2,040
PF11698 V-ATPase_H_C 2,692 1,095
PF11701 UNC45-central 2,047 904
PF11817 Foie-gras_1 2,426 1,237
PF11846 Wzy_C_2 2,894 1,483
PF11865 DUF3385 2,648 1,165
PF12031 BAF250_C 1,832 939
PF12348 CLASP_N 8,079 4,744
PF12460 MMS19_C 1,996 1,011
PF12569 NARP1 3,305 1,458
PF12688 TPR_5 3,736 1,958
PF12717 Cnd1 3,848 2,035
PF12719 Cnd3 2,279 1,229
PF12741 SusD-like 3,911 1,674
PF12753 Nro1 188 136
PF12755 Vac14_Fab1_bd 3,374 1,454
PF12765 Cohesin_HEAT 3,087 1,620
PF12771 SusD-like_2 12,336 8,351
PF12830 Nipped-B_C 2,530 1,343
PF12854 PPR_1 30,579 17,090
PF12862 ANAPC5 3,026 1,840
PF12895 ANAPC3 14,218 7,757
PF12968 DUF3856 41 33
PF13041 PPR_2 99,460 55,328
PF13174 TPR_6 41,072 25,330
PF13176 TPR_7 29,162 16,346
PF13181 TPR_8 179,072 107,684
PF13251 DUF4042 1,190 606
PF13371 TPR_9 8,803 3,588
PF13374 TPR_10 36,946 26,704
PF13414 TPR_11 60,948 39,343
PF13424 TPR_12 108,205 73,009
PF13428 TPR_14 7,224 4,842
PF13429 TPR_15 6,609 3,765
PF13431 TPR_17 8,701 5,820
PF13432 TPR_16 198,188 122,283
PF13512 TPR_18 229 169
PF13513 HEAT_EZ 9,338 3,682
PF13525 YfiO 27,488 13,563
PF13646 HEAT_2 61,716 38,136
PF13812 PPR_3 24,907 14,703
PF13838 Clathrin_H_link 4,100 1,143
PF14322 SusD-like_3 75,682 41,825
PF14559 TPR_19 112,759 63,458
PF14561 TPR_20 15,813 6,164
PF14852 Fis1_TPR_N 2,059 948
PF14853 Fis1_TPR_C 2,664 1,326
PF14863 Alkyl_sulf_dimr 8,442 3,832
PF14938 SNAP 6,522 3,383
PF16186 Arm_3 6,100 1,997
PF16416 GUN4_N 371 175
PF16811 TAtT 1,639 1,268
PF16918 PknG_TPR 2,847 1,330
PF17004 SRP_TPR_like 1,994 944
PF17177 PPR_long 7,106 4,064
PF17432 DUF3458_C 13,247 5,042
PF17874 TPR_MalT 25,428 15,064
PF18028 Zmiz1_N 494 200
PF18381 YcaO_C 4,857 847
PF18391 CHIP_TPR_N 759 309
PF18581 SYCP2_ARLD 352 211
PF18710 ComR_TPR 867 212
CL0021 OB 1,623,682 600,775 PF00164 Ribosom_S12_S23 46,173 7,127
PF00181 Ribosomal_L2 48,133 11,126
PF00313 CSD 102,903 30,139
PF00366 Ribosomal_S17 38,884 12,961
PF00436 SSB 70,918 30,409
PF00575 S1 185,160 64,292
PF00900 Ribosomal_S4e 5,285 2,105
PF01132 EFP 37,376 10,669
PF01176 eIF-1a 43,529 8,183
PF01200 Ribosomal_S28e 3,915 1,303
PF01287 eIF-5a 4,464 1,818
PF01330 RuvA_N 32,968 13,462
PF01336 tRNA_anti-codon 135,164 50,687
PF01588 tRNA_bind 77,082 30,546
PF01796 OB_aCoA_assoc 23,656 13,367
PF01938 TRAM 55,911 22,544
PF01957 NfeD 29,539 15,178
PF02303 Phage_DNA_bind 361 229
PF02721 DUF223 2,551 1,893
PF02760 HIN 474 185
PF02765 POT1 2,232 1,242
PF03100 CcmE 14,816 6,733
PF03120 DNA_ligase_OB 41,012 17,148
PF03319 EutN_CcmL 7,674 3,552
PF03459 TOBE 43,539 16,212
PF03870 RNA_pol_Rpb8 2,377 959
PF03919 mRNA_cap_C 2,658 1,309
PF04057 Rep-A_N 2,712 1,426
PF04076 BOF 5,499 1,448
PF04679 DNA_ligase_A_C 36,086 17,957
PF06125 DUF961 2,978 318
PF07076 DUF1344 1,624 516
PF07290 DUF1449 3,354 1,236
PF07404 TEBP_beta 22 13
PF07497 Rho_RNA_bind 29,999 9,266
PF07717 OB_NTP_bind 36,834 14,863
PF08206 OB_RNB 23,615 8,109
PF08292 RNA_pol_Rbc25 2,225 1,071
PF08402 TOBE_2 102,972 38,034
PF08418 Pol_alpha_B_N 1,608 834
PF08585 RMI1_N 3,243 1,893
PF08646 Rep_fac-A_C 6,392 3,957
PF08661 Rep_fac-A_3 2,086 1,178
PF08804 gp32 1,064 508
PF09103 BRCA-2_OB1 1,373 816
PF09104 BRCA-2_OB3 501 289
PF09285 Elong-fact-P_C 37,511 10,792
PF09883 DUF2110 605 290
PF10246 MRP-S35 623 397
PF10341 TPP1 524 331
PF10447 EXOSC1 2,056 1,061
PF10451 Stn1 845 518
PF10991 DUF2815 2,271 950
PF11325 DUF3127 3,814 1,920
PF11506 DUF3217 19 8
PF11604 CusF_Ec 10,164 4,735
PF11736 DUF3299 6,104 2,335
PF11967 RecO_N 32,622 14,803
PF12658 Ten1 500 318
PF12667 NigD_N 1,606 468
PF12857 TOBE_3 7,446 1,697
PF12869 tRNA_anti-like 1,655 1,258
PF13114 RecO_N_2 1,097 184
PF13509 S1_2 10,370 3,700
PF13742 tRNA_anti_2 31,925 13,690
PF14444 S1-like 1,194 556
PF14481 Fimbrial_PilY2 57 26
PF14743 DNA_ligase_OB_2 3,695 2,092
PF15072 DUF4539 1,183 701
PF15490 Ten1_2 734 443
PF16099 RMI1_C 776 467
PF16100 RMI2 568 336
PF16450 Prot_ATP_ID_OB 17,021 4,060
PF16669 TTC5_OB 781 392
PF16686 POT1PC 1,493 851
PF16745 RsgA_N 9,818 4,190
PF16773 Phage_SSB 239 15
PF16853 CDC13_N 47 35
PF16900 REPA_OB_2 4,234 2,405
PF16992 RNA_pol_RpbG 93 59
PF17092 PCB_OB 14,185 5,083
PF17185 NlpE_C 2,065 499
PF17191 RecG_wedge 30,542 12,831
PF17207 MCM_OB 22,268 8,376
PF17215 Rrp44_S1 2,368 940
PF17216 Rrp44_CSD1 3,236 1,385
PF17244 CDC24_OB3 482 252
PF17245 CDC24_OB2 365 191
PF17246 CDC24_OB1 344 194
PF17746 SfsA_N 10,491 4,781
PF17758 Prot_ATP_OB_N 4,108 993
PF17768 RecJ_OB 30,858 13,315
PF17845 FbpC_C_terminal 39 6
PF17847 GlcV_C_terminal 50 20
PF17849 OB_Dis3 5,307 2,464
PF17850 CysA_C_terminal 2,771 980
PF17875 RPA43_OB 1,223 732
PF17876 CSD2 27,015 9,606
PF17878 ssDBP 3 3
PF17879 DNA_ligase_C 226 84
PF17912 OB_MalK 45,912 14,267
PF18018 DNA_pol_D_N 2,332 1,225
PF18352 Gp138_N 2,405 917
PF18543 ID 160 128
PF18614 RNase_II_C_S1 3,011 1,725
PF18691 Cdc13_OB2 20 12
PF18693 TRAM_2 21,128 7,708
CL0022 LRR 330,428 184,361 PF00560 LRR_1 48,092 30,024
PF01030 Recep_L_domain 6,523 3,361
PF03382 DUF285 8,139 5,498
PF05725 FNIP 2,051 1,673
PF07723 LRR_2 3,107 2,092
PF07725 LRR_3 3,377 2,299
PF12468 TTSSLRR 2,740 189
PF12799 LRR_4 25,133 13,323
PF13306 LRR_5 27,485 17,571
PF13516 LRR_6 68,247 41,792
PF13855 LRR_8 191,100 102,034
PF14580 LRR_9 15,232 8,208
CL0023 P-loop_NTPase 8,998,478 3,758,002 PF00004 AAA 406,462 160,087
PF00005 ABC_tran 2,502,683 999,814
PF00006 ATP-synt_ab 185,392 43,914
PF00009 GTP_EFTU 379,135 101,333
PF00025 Arf 33,911 13,562
PF00063 Myosin_head 45,136 20,413
PF00071 Ras 130,555 53,900
PF00142 Fer4_NifH 49,511 8,336
PF00154 RecA 58,764 13,294
PF00158 Sigma54_activat 205,116 87,163
PF00176 SNF2_N 116,120 58,888
PF00225 Kinesin 64,255 33,184
PF00265 TK 20,500 7,935
PF00270 DEAD 446,240 191,981
PF00271 Helicase_C 645,781 282,239
PF00308 Bac_DnaA 46,972 17,357
PF00350 Dynamin_N 43,822 20,262
PF00406 ADK 54,770 23,215
PF00437 T2SSE 130,576 58,151
PF00448 SRP54 86,168 31,610
PF00485 PRK 46,808 16,944
PF00488 MutS_V 69,032 30,867
PF00493 MCM 23,736 9,289
PF00503 G-alpha 17,469 7,022
PF00519 PPV_E1_C 3,387 873
PF00580 UvrD-helicase 110,747 48,036
PF00625 Guanylate_kin 59,590 25,042
PF00685 Sulfotransfer_1 29,383 17,790
PF00693 Herpes_TK 1,163 121
PF00709 Adenylsucc_synt 41,199 13,457
PF00735 Septin 16,075 5,545
PF00910 RNA_helicase 18,644 3,581
PF00931 NB-ARC 99,689 63,842
PF01057 Parvo_NS1 4,140 710
PF01078 Mg_chelatase 38,147 18,094
PF01121 CoaE 37,065 19,264
PF01202 SKI 54,741 25,108
PF01268 FTHFS 23,229 8,867
PF01443 Viral_helicase1 10,650 2,634
PF01580 FtsK_SpoIIIE 63,854 29,119
PF01583 APS_kinase 27,241 12,239
PF01591 6PF2K 7,812 3,035
PF01637 ATPase_2 7,871 4,504
PF01656 CbiA 77,132 35,725
PF01695 IstB_IS21 42,127 16,577
PF01712 dNK 17,218 7,595
PF01715 IPPT 41,766 21,232
PF01745 IPT 591 362
PF01926 MMR_HSR1 298,048 117,232
PF01935 DUF87 24,384 12,775
PF02223 Thymidylate_kin 40,278 20,610
PF02224 Cytidylate_kin 32,296 14,962
PF02263 GBP 6,015 3,000
PF02283 CobU 18,892 8,940
PF02367 TsaE 33,964 17,224
PF02374 ArsA_ATPase 20,047 8,647
PF02399 Herpes_ori_bp 1,113 580
PF02421 FeoB_N 26,317 11,756
PF02456 Adeno_IVa2 486 139
PF02463 SMC_N 102,297 45,603
PF02492 cobW 75,555 28,546
PF02499 DNA_pack_C 799 143
PF02500 DNA_pack_N 570 101
PF02534 T4SS-DNA_transf 23,055 8,735
PF02562 PhoH 47,913 16,040
PF02572 CobA_CobO_BtuR 19,260 7,243
PF02606 LpxK 21,073 10,758
PF02689 Herpes_Helicase 5,190 2,596
PF02702 KdpD 15,600 5,356
PF02841 GBP_C 3,769 1,740
PF03028 Dynein_heavy 11,496 7,103
PF03029 ATP_bind_1 20,751 7,352
PF03192 DUF257 344 268
PF03193 RsgA_GTPase 31,983 13,568
PF03205 MobB 12,045 5,778
PF03215 Rad17 2,567 1,486
PF03237 Terminase_6 17,196 7,664
PF03266 NTPase_1 3,523 2,213
PF03308 MeaB 22,465 11,648
PF03354 Terminase_1 13,899 5,418
PF03567 Sulfotransfer_2 14,910 9,010
PF03618 Kinase-PPPase 15,921 4,917
PF03668 ATP_bind_2 23,394 8,599
PF03796 DnaB_C 50,640 19,438
PF03846 SulA 3,663 919
PF03969 AFG1_ATPase 21,955 8,389
PF03976 PPK2 29,576 13,623
PF04257 Exonuc_V_gamma 12,557 5,012
PF04310 MukB 3,109 368
PF04317 DUF463 5,712 1,665
PF04466 Terminase_3 6,197 2,953
PF04548 AIG1 11,971 8,514
PF04665 Pox_A32 1,622 456
PF04670 Gtr1_RagA 4,942 2,164
PF04851 ResIII 133,695 57,688
PF05049 IIGP 1,923 1,429
PF05127 Helicase_RecD 7,219 3,006
PF05179 CDC73_C 2,312 1,112
PF05272 VirE 8,229 2,864
PF05496 RuvB_N 40,969 14,216
PF05609 LAP1C 806 423
PF05621 TniB 4,858 2,611
PF05625 PAXNEB 2,290 1,259
PF05673 DUF815 10,691 4,167
PF05707 Zot 3,142 1,974
PF05729 NACHT 42,041 31,276
PF05783 DLIC 3,191 1,433
PF05872 DUF853 14,209 5,760
PF05876 Terminase_GpA 9,213 3,704
PF05879 RHD3 3,666 2,130
PF05894 Podovirus_Gp16 87 61
PF05970 PIF1 22,164 15,165
PF06048 DUF927 4,698 2,360
PF06068 TIP49 5,490 1,797
PF06144 DNA_pol3_delta 29,724 12,406
PF06309 Torsin 2,019 1,094
PF06414 Zeta_toxin 7,959 4,501
PF06418 CTP_synth_N 40,108 12,678
PF06431 Polyoma_lg_T_C 2,381 220
PF06564 CBP_BcsQ 5,123 2,025
PF06733 DEAD_2 20,321 8,772
PF06745 ATPase 17,086 9,142
PF06858 NOG1 3,629 1,553
PF06990 Gal-3-0_sulfotr 2,029 1,299
PF07015 VirC1 2,438 981
PF07034 ORC3_N 2,099 1,155
PF07088 GvpD 422 247
PF07517 SecA_DEAD 43,202 16,784
PF07529 HSA 7,005 3,642
PF07652 Flavi_DEAD 35,296 2,278
PF07693 KAP_NTPase 10,021 6,813
PF07724 AAA_2 152,404 46,677
PF07726 AAA_3 54,687 22,897
PF07728 AAA_5 58,499 25,855
PF07755 DUF1611 4,676 2,650
PF07931 CPT 2,904 1,867
PF07999 RHSP 2,569 1,750
PF08298 AAA_PrkA 10,239 2,180
PF08303 tRNA_lig_kinase 1,169 664
PF08351 DUF1726 6,249 2,518
PF08423 Rad51 15,123 7,338
PF08433 KTI12 2,775 1,701
PF08438 MMR_HSR1_C 3,161 1,471
PF08477 Roc 5,805 3,662
PF09037 Sulphotransf 1,674 870
PF09140 MipZ 3,357 1,515
PF09439 SRPRB 2,388 1,282
PF09547 Spore_IV_A 3,538 1,085
PF09711 Cas_Csn2 909 404
PF09807 ELP6 1,239 737
PF09818 ABC_ATPase 2,947 1,525
PF09820 AAA-ATPase_like 14,207 7,097
PF09848 DUF2075 6,162 3,738
PF10088 DUF2326 1,752 1,151
PF10236 DAP3 2,395 1,282
PF10412 TrwB_AAD_bind 10,563 5,062
PF10443 RNA12 1,074 593
PF10483 Elong_Iki1 1,721 987
PF10609 ParA 51,994 22,186
PF10649 DUF2478 1,597 1,103
PF10662 PduV-EutP 3,786 964
PF10923 DUF2791 3,157 1,586
PF10996 Beta-Casp 24,270 12,281
PF11111 CENP-M 450 238
PF11398 DUF2813 2,622 692
PF11496 HDA2-3 551 369
PF11602 NTPase_P4 14 10
PF12128 DUF3584 1,140 551
PF12344 UvrB 35,377 10,994
PF12399 BCA_ABC_TP_C 86,787 32,568
PF12696 TraG-D_C 14,343 5,902
PF12774 AAA_6 12,689 7,842
PF12775 AAA_7 11,274 7,093
PF12780 AAA_8 11,447 7,214
PF12781 AAA_9 11,725 7,157
PF12846 AAA_10 10,574 3,115
PF12848 ABC_tran_Xtn 108,963 30,988
PF13086 AAA_11 38,564 21,598
PF13087 AAA_12 47,474 26,114
PF13166 AAA_13 5,658 3,586
PF13173 AAA_14 33,036 19,551
PF13175 AAA_15 25,541 17,326
PF13177 DNA_pol3_delta2 76,375 36,132
PF13189 Cytidylate_kin2 12,021 6,052
PF13191 AAA_16 59,376 38,185
PF13207 AAA_17 4,171 2,780
PF13238 AAA_18 15,302 8,225
PF13245 AAA_19 38,196 19,688
PF13304 AAA_21 42,846 27,350
PF13307 Helicase_C_2 42,040 16,528
PF13337 Lon_2 2,724 1,365
PF13361 UvrD_C 124,527 54,103
PF13401 AAA_22 35,846 20,722
PF13469 Sulfotransfer_3 28,507 18,992
PF13476 AAA_23 44,721 25,534
PF13479 AAA_24 5,768 2,947
PF13481 AAA_25 45,217 17,323
PF13500 AAA_26 40,241 16,080
PF13514 AAA_27 6,134 3,186
PF13521 AAA_28 15,545 7,869
PF13538 UvrD_C_2 44,722 20,124
PF13555 AAA_29 6,345 2,693
PF13558 SbcCD_C 26,881 11,500
PF13604 AAA_30 46,441 21,237
PF13614 AAA_31 124,997 52,038
PF13654 AAA_32 10,631 4,135
PF13671 AAA_33 39,275 21,076
PF13871 Helicase_C_4 4,447 2,105
PF13872 AAA_34 4,479 2,219
PF13892 DBINO 2,963 1,353
PF14396 CFTR_R 508 168
PF14417 MEDS 5,362 3,889
PF14516 AAA_35 4,960 3,310
PF14532 Sigma54_activ_2 5,185 2,545
PF14617 CMS1 1,657 887
PF16203 ERCC3_RAD25_C 8,758 3,053
PF16575 CLP1_P 5,510 3,177
PF16796 Microtub_bd 1,287 941
PF16813 Cas_St_Csn2 175 79
PF16834 CSM2 48 36
PF16836 PSY3 85 63
PF17213 Hydin_ADK 278 219
PF17784 Sulfotransfer_4 6,256 3,823
PF18128 HydF_dimer 3,116 1,572
PF18133 HydF_tetramer 3,169 1,610
PF18747 Ploopntkinase2 73 18
PF18748 Ploopntkinase1 85 16
PF18751 Ploopntkinase3 247 29
PF18766 SWI2_SNF2 23,582 11,222
CL0025 His_Kinase_A 1,437,821 723,016 PF00512 HisKA 750,665 377,562
PF02518 HATPase_c 1,147,317 563,843
PF02895 H-kinase_dim 24,671 11,957
PF07536 HWE_HK 15,725 8,441
PF07568 HisKA_2 21,151 11,959
PF07730 HisKA_3 134,264 76,026
PF10090 HPTransfase 3,319 1,586
PF13581 HATPase_c_2 75,218 41,822
PF13589 HATPase_c_3 67,710 33,066
PF14501 HATPase_c_5 17,249 8,173
CL0026 CU_oxidase 246,711 96,373 PF00116 COX2 96,405 25,597
PF00127 Copper-bind 20,440 11,523
PF00394 Cu-oxidase 56,419 22,345
PF00812 Ephrin 3,204 1,514
PF02298 Cu_bind_like 10,516 5,979
PF06481 COX_ARM 8,132 2,129
PF06525 SoxE 737 447
PF07731 Cu-oxidase_2 60,220 27,503
PF07732 Cu-oxidase_3 66,319 30,530
PF08526 PAD_N 791 323
PF08985 DP-EP 178 110
PF12306 PixA 1,214 524
PF13473 Cupredoxin_1 25,089 12,417
PF14699 hGDE_N 1,718 816
PF16986 CzcE 427 265
CL0027 RdRP 700,924 320,247 PF00078 RVT_1 537,131 268,747
PF00680 RdRP_1 45,672 5,835
PF00972 Flavi_NS5 12,617 660
PF00978 RdRP_2 8,608 1,554
PF00998 RdRP_3 45,889 5,580
PF02123 RdRP_4 5,410 866
PF04197 Birna_RdRp 1,004 45
PF05919 Mitovir_RNA_pol 1,266 889
PF07727 RVT_2 43,514 36,272
PF17501 Viral_RdRp_C 19 8
CL0028 AB_hydrolase 1,648,366 863,740 PF00135 COesterase 63,448 38,276
PF00151 Lipase 8,981 5,392
PF00326 Peptidase_S9 130,053 70,555
PF00450 Peptidase_S10 33,706 18,725
PF00561 Abhydrolase_1 318,036 162,790
PF00756 Esterase 76,558 36,761
PF00975 Thioesterase 47,252 24,989
PF01083 Cutinase 12,011 5,691
PF01674 Lipase_2 5,245 2,893
PF01738 DLH 69,642 36,171
PF01764 Lipase_3 30,155 17,566
PF02089 Palm_thioest 7,602 4,339
PF02129 Peptidase_S15 39,571 19,802
PF02230 Abhydrolase_2 31,473 17,082
PF02273 Acyl_transf_2 245 121
PF02450 LCAT 8,032 4,557
PF03096 Ndr 5,236 1,823
PF03283 PAE 5,517 2,938
PF03403 PAF-AH_p_II 9,713 6,010
PF03583 LIP 12,847 6,326
PF03893 Lipase3_N 1,688 824
PF03959 FSH1 8,082 4,857
PF04083 Abhydro_lipase 5,232 3,421
PF04301 DUF452 1,363 488
PF05057 DUF676 9,865 5,824
PF05277 DUF726 4,684 2,423
PF05448 AXE1 10,707 6,235
PF05576 Peptidase_S37 1,743 806
PF05577 Peptidase_S28 8,491 5,282
PF05677 DUF818 263 181
PF05705 DUF829 4,077 2,344
PF05728 UPF0227 10,690 3,825
PF05990 DUF900 7,015 3,882
PF06028 DUF915 4,452 1,585
PF06057 VirJ 3,451 1,200
PF06259 Abhydrolase_8 5,872 3,535
PF06342 DUF1057 431 308
PF06441 EHN 15,007 8,418
PF06500 DUF1100 5,776 2,418
PF06821 Ser_hydrolase 12,981 6,030
PF06850 PHB_depo_C 6,962 2,806
PF07082 DUF1350 1,309 667
PF07167 PhaC_N 12,441 5,453
PF07176 DUF1400 1,821 1,072
PF07224 Chlorophyllase 1,207 774
PF07519 Tannase 10,589 5,792
PF07819 PGAP1 7,884 4,578
PF07859 Abhydrolase_3 122,558 66,844
PF08237 PE-PPE 3,966 2,147
PF08386 Abhydrolase_4 15,837 9,977
PF08538 DUF1749 1,978 1,122
PF08840 BAAT_C 5,649 3,343
PF09752 DUF2048 2,137 991
PF09994 DUF2235 13,131 8,251
PF10081 Abhydrolase_9 3,340 1,710
PF10142 PhoPQ_related 2,492 1,133
PF10230 LIDHydrolase 2,299 1,344
PF10340 Say1_Mug180 512 341
PF10503 Esterase_phd 15,909 9,895
PF11144 DUF2920 2,430 452
PF11187 DUF2974 4,751 1,956
PF11288 DUF3089 2,322 1,650
PF11339 DUF3141 2,132 1,143
PF12048 DUF3530 2,422 1,044
PF12146 Hydrolase_4 147,427 75,247
PF12695 Abhydrolase_5 3,636 1,908
PF12697 Abhydrolase_6 229,246 126,242
PF12715 Abhydrolase_7 1,838 1,097
PF12740 Chlorophyllase2 4,076 2,581
PF16929 Asp2 1,026 429
CL0029 Cupin 1,210,305 578,236 PF00027 cNMP_binding 199,869 101,429
PF00190 Cupin_1 20,267 9,346
PF00908 dTDP_sugar_isom 33,001 17,936
PF01050 MannoseP_isomer 24,633 11,330
PF01238 PMI_typeI 20,219 8,889
PF01987 AIM24 20,807 7,699
PF02041 Auxin_BP 469 274
PF02311 AraC_binding 97,254 41,005
PF02373 JmjC 20,749 10,421
PF02375 JmjN 8,992 4,480
PF02668 TauD 53,134 26,070
PF02678 Pirin 50,750 21,602
PF03079 ARD 8,159 3,341
PF03171 2OG-FeII_Oxy 57,566 28,449
PF03336 Pox_C4_C10 275 63
PF04074 DUF386 11,324 3,282
PF04115 Ureidogly_lyase 8,545 3,503
PF04209 HgmA 14,897 5,190
PF04622 ERG2_Sigma1R 1,745 912
PF04831 Popeye 1,578 817
PF04962 KduI 16,290 5,893
PF05118 Asp_Arg_Hydrox 11,610 4,732
PF05523 FdtA 5,845 3,970
PF05721 PhyH 53,668 32,176
PF05726 Pirin_C 30,381 13,614
PF05899 Cupin_3 18,086 5,989
PF05962 HutD 7,588 3,466
PF05995 CDO_I 9,832 4,691
PF06052 3-HAO 5,159 2,423
PF06172 Cupin_5 9,257 5,063
PF06249 EutQ 3,642 1,273
PF06339 Ectoine_synth 4,665 1,561
PF06560 GPI 2,262 1,284
PF06719 AraC_N 16,667 6,581
PF06865 Ppnp 7,098 2,153
PF07350 DUF1479 4,167 1,400
PF07385 Lyx_isomer 2,672 1,130
PF07847 PCO_ADO 2,682 1,410
PF07883 Cupin_2 190,751 91,918
PF08007 Cupin_4 13,060 5,689
PF08487 VIT 9,274 5,949
PF08943 CsiD 1,882 314
PF09313 DUF1971 4,094 1,038
PF09859 Oxygenase-NA 4,387 2,140
PF10014 2OG-Fe_Oxy_2 4,036 1,931
PF10637 Ofd1_CTDD 1,887 1,056
PF11699 CENP-C_C 1,395 807
PF12851 Tet_JBP 1,372 763
PF12852 Cupin_6 18,624 8,539
PF12933 FTO_NTD 594 192
PF12973 Cupin_7 11,886 6,486
PF13532 2OG-FeII_Oxy_2 28,834 14,964
PF13621 Cupin_8 18,276 10,305
PF13640 2OG-FeII_Oxy_3 37,589 19,316
PF13661 2OG-FeII_Oxy_4 3,115 1,837
PF13757 VIT_2 487 299
PF13759 2OG-FeII_Oxy_5 5,011 3,610
PF14226 DIOX_N 53,195 26,432
PF14499 DUF4437 1,423 859
PF14525 AraC_binding_2 20,785 10,122
PF16161 DUF4867 1,283 518
PF16802 DUF5070 24 14
PF16867 DMSP_lyase 1,783 913
PF17954 Pirin_C_2 17,996 6,769
PF18637 AUDH_Cupin 109 87
CL0030 Ion_channel 244,424 120,681 PF00060 Lig_chan 22,042 11,273
PF00520 Ion_trans 96,604 50,241
PF01007 IRK 6,553 2,220
PF02386 TrkH 42,116 18,561
PF03814 KdpA 15,616 4,725
PF07885 Ion_trans_2 56,184 30,859
PF08016 PKD_channel 6,377 3,847
CL0031 Phosphatase 469,695 221,313 PF00102 Y_phosphatase 36,241 18,793
PF00581 Rhodanese 203,735 100,074
PF00782 DSPc 45,940 23,915
PF01451 LMWPc 66,584 33,588
PF02302 PTS_IIB 57,979 15,026
PF02383 Syja_N 11,797 5,822
PF03162 Y_phosphatase2 4,822 2,750
PF04179 Init_tRNA_PT 1,379 764
PF04273 DUF442 8,962 4,529
PF04722 Ssu72 2,271 1,047
PF05706 CDKN3 1,515 860
PF06602 Myotub-related 11,253 4,809
PF13350 Y_phosphatase3 18,218 9,608
PF14566 PTPlike_phytase 2,218 1,124
PF14671 DSPn 2,939 1,385
PF16809 NleF_casp_inhib 113 32
CL0032 Dim_A_B_barrel 438,318 185,585 PF01037 AsnC_trans_reg 141,933 43,971
PF02426 MIase 4,799 1,631
PF03795 YCII 53,015 26,835
PF03927 NapD 3,697 1,600
PF03992 ABM 75,065 35,673
PF04261 Dyp_perox 19,652 7,063
PF04486 SchA_CurD 762 350
PF04673 Cyclase_polyket 1,425 628
PF05336 rhaM 12,737 6,007
PF06778 Chlor_dismutase 8,650 3,208
PF07045 DUF1330 16,759 8,709
PF07110 EthD 9,491 5,419
PF07237 DUF1428 4,908 2,400
PF07682 SOR 89 46
PF07876 Dabb 18,210 9,774
PF07978 NIPSNAP 15,945 7,796
PF08734 GYD 5,461 2,804
PF08803 ydhR 2,608 999
PF09448 MmlI 893 494
PF11639 HapK 372 249
PF11695 DUF3291 2,784 1,850
PF13816 Dehydratase_hem 1,401 615
PF13826 DUF4188 2,716 1,616
PF14026 DUF4242 4,674 2,524
PF16291 DUF4937 1,420 339
PF17805 AsnC_trans_reg2 6,517 3,701
PF18075 FtsX_ECD 23,336 9,753
PF18232 Chalcone_N 94 45
CL0033 POZ 149,036 72,063 PF00651 BTB 107,874 55,129
PF02214 BTB_2 24,235 9,732
PF03931 Skp1_POZ 8,052 3,914
PF07707 BACK 36,116 14,007
PF11822 DUF3342 654 325
PF16017 BTB_3 1,119 379
CL0034 Amidohydrolase 717,064 332,429 PF00449 Urease_alpha 16,272 3,894
PF00962 A_deaminase 37,549 15,570
PF01026 TatD_DNase 65,111 29,282
PF01244 Peptidase_M19 28,016 14,151
PF01876 RNase_P_p30 3,263 1,930
PF01979 Amidohydro_1 273,499 121,295
PF02126 PTE 8,003 3,626
PF02614 UxaC 10,931 4,599
PF02811 PHP 103,915 46,438
PF04909 Amidohydro_2 93,491 49,680
PF07969 Amidohydro_3 85,768 41,036
PF12228 DUF3604 3,896 2,879
PF12890 DHOase 361 249
PF13263 PHP_C 8,569 5,183
CL0035 Peptidase_MH 586,137 272,445 PF00246 Peptidase_M14 50,628 28,952
PF00274 Glycolytic 12,708 5,371
PF00883 Peptidase_M17 41,581 18,304
PF01520 Amidase_3 58,078 27,700
PF01546 Peptidase_M20 251,532 107,271
PF02127 Peptidase_M18 15,194 6,272
PF04389 Peptidase_M28 67,909 39,850
PF04952 AstE_AspA 29,989 12,777
PF05013 FGase 18,729 9,381
PF05343 Peptidase_M42 25,359 9,990
PF05450 Nicastrin 1,569 795
PF05908 Gamma_PGA_hydro 2,231 952
PF07454 SpoIIP 4,819 2,160
PF10994 DUF2817 2,419 1,329
PF16254 DUF4910 1,991 1,076
PF17033 Peptidase_M99 1,339 332
PF18266 Ncstrn_small 1,136 602
CL0036 TIM_barrel 2,482,753 1,026,234 PF00121 TIM 48,650 19,747
PF00215 OMPdecase 46,103 19,088
PF00218 IGPS 35,664 14,287
PF00290 Trp_syntA 33,921 14,347
PF00478 IMPDH 54,424 15,185
PF00490 ALAD 31,906 11,204
PF00682 HMGL-like 117,431 44,021
PF00697 PRAI 30,221 14,886
PF00701 DHDPS 94,616 38,661
PF00724 Oxidored_FMN 101,095 42,355
PF00793 DAHP_synth_1 62,624 21,507
PF00809 Pterin_bind 70,403 29,834
PF00834 Ribul_P_3_epim 44,166 17,055
PF00923 TAL_FSA 44,148 15,975
PF00977 His_biosynth 66,670 24,445
PF01070 FMN_dh 46,489 19,797
PF01081 Aldolase 32,588 13,271
PF01116 F_bP_aldolase 45,190 13,613
PF01168 Ala_racemase_N 102,584 47,524
PF01180 DHO_dh 52,316 22,467
PF01207 Dus 67,375 26,745
PF01261 AP_endonuc_2 163,422 75,258
PF01474 DAHP_synth_2 15,372 4,832
PF01487 DHquinase_I 12,656 5,555
PF01645 Glu_synthase 49,472 18,001
PF01680 SOR_SNZ 13,283 3,498
PF01729 QRPTase_C 33,855 15,077
PF01791 DeoC 46,024 17,670
PF01884 PcrB 5,414 2,850
PF01964 ThiC_Rad_SAM 24,119 7,005
PF02007 MtrH 850 501
PF02581 TMP-TENI 45,750 22,054
PF02679 ComA 3,171 1,858
PF02784 Orn_Arg_deC_N 72,096 27,082
PF03060 NMO 56,654 24,690
PF03102 NeuB 16,442 9,837
PF03437 BtpA 4,603 2,159
PF03599 CdhD 3,817 2,529
PF03740 PdxJ 19,722 7,950
PF03786 UxuA 12,540 5,112
PF03851 UvdE 4,864 2,400
PF03932 CutC 14,588 6,090
PF04055 Radical_SAM 539,742 243,621
PF04095 NAPRTase 25,920 8,658
PF04131 NanE 7,623 2,564
PF04309 G3P_antiterm 4,768 1,702
PF04476 4HFCP_synth 1,916 1,076
PF04481 DUF561 920 511
PF04898 Glu_syn_central 31,061 10,518
PF05114 DUF692 11,292 5,870
PF05690 ThiG 23,287 7,422
PF06134 RhaA 5,086 1,636
PF06187 DUF993 3,766 1,521
PF07071 KDGP_aldolase 3,314 494
PF08013 Tagatose_6_P_K 4,930 1,404
PF09043 Lys-AminoMut_A 1,679 781
PF09863 DUF2090 4,382 1,237
PF16552 OAM_alpha 398 241
PF17285 PRMT5_TIM 2,472 1,107
CL0037 Lysozyme 347,884 152,859 PF00062 Lys 3,032 1,546
PF00182 Glyco_hydro_19 13,905 5,839
PF00912 Transgly 104,578 44,171
PF00959 Phage_lysozyme 17,833 6,430
PF01374 Glyco_hydro_46 1,769 944
PF01464 SLT 116,808 54,134
PF01832 Glucosaminidase 31,005 12,970
PF03998 Utp11 2,274 1,261
PF05497 Destabilase 763 581
PF05838 Glyco_hydro_108 5,971 3,016
PF06737 Transglycosylas 10,473 5,321
PF06871 TraH_2 490 258
PF10464 Peptidase_U40 37 5
PF11508 DUF3218 25 4
PF13406 SLT_2 29,748 13,246
PF13647 Glyco_hydro_80 19 6
PF13702 Lysozyme_like 5,127 1,058
PF16754 Pesticin 528 385
PF18013 Phage_lysozyme2 3,552 1,743
CL0039 HUP 1,386,295 610,619 PF00133 tRNA-synt_1 136,336 58,681
PF00579 tRNA-synt_1b 91,386 36,611
PF00582 Usp 159,673 82,124
PF00733 Asn_synthase 56,693 30,220
PF00749 tRNA-synt_1c 85,611 36,787
PF00750 tRNA-synt_1d 43,999 18,814
PF00764 Arginosuc_synth 34,396 9,759
PF00875 DNA_photolyase 32,884 17,498
PF01012 ETF 78,937 29,302
PF01171 ATP_bind_3 59,077 28,516
PF01406 tRNA-synt_1e 48,269 21,233
PF01467 CTP_transf_like 112,093 51,376
PF01507 PAPS_reduct 55,241 20,245
PF01747 ATP-sulfurylase 10,311 4,683
PF01902 Diphthami_syn_2 8,604 5,254
PF01921 tRNA-synt_1f 7,727 3,480
PF02540 NAD_synthase 78,237 30,227
PF02568 ThiI 15,575 5,884
PF02569 Pantoate_ligase 30,042 14,179
PF03054 tRNA_Me_trans 42,259 16,588
PF03720 UDPG_MGDP_dh_C 65,386 31,534
PF04244 DPRP 8,257 4,684
PF05636 HIGH_NTase1 7,156 2,939
PF06508 QueC 23,959 10,221
PF06574 FAD_syn 34,594 15,371
PF08218 Citrate_ly_lig 3,985 1,089
PF09334 tRNA-synt_1g 72,874 29,878
PF10079 BshC 5,085 3,113
PF13603 tRNA-synt_1_2 38,615 15,596
PF16581 HIGH_NTase1_ass 146 96
PF16715 CDPS 823 463
CL0040 tRNA_synt_II 574,054 230,846 PF00152 tRNA-synt_2 117,424 44,921
PF00587 tRNA-synt_2b 148,953 56,882
PF01409 tRNA-synt_2d 44,005 16,061
PF01411 tRNA-synt_2c 53,641 22,850
PF02091 tRNA-synt_2e 19,311 4,775
PF03099 BPL_LplA_LipB 79,975 38,253
PF03590 AsnA 6,742 1,823
PF04017 DUF366 475 298
PF13393 tRNA-synt_His 61,289 26,268
PF16917 BPL_LplA_LipB_2 1,138 721
PF17759 tRNA_synthFbeta 41,175 18,089
CL0041 Death 32,104 15,939 PF00531 Death 15,337 7,603
PF00619 CARD 9,442 4,838
PF01335 DED 2,803 1,268
PF02758 PYRIN 4,057 2,111
PF14786 Death_2 209 138
PF16739 CARD_2 1,114 507
PF18461 Atypical_Card 252 113
CL0042 Flavoprotein 250,615 105,398 PF00258 Flavodoxin_1 57,928 21,757
PF02525 Flavodoxin_2 56,780 21,677
PF03358 FMN_red 105,436 48,216
PF07972 Flavodoxin_NdrI 8,234 2,309
PF12641 Flavodoxin_3 2,476 1,129
PF12682 Flavodoxin_4 7,279 4,043
PF12724 Flavodoxin_5 12,525 6,509
CL0043 Chelatase 231,912 102,194 PF00148 Oxidored_nitro 24,297 9,563
PF00762 Ferrochelatase 30,942 12,777
PF01297 ZnuA 47,826 21,198
PF01497 Peripla_BP_2 108,316 48,453
PF01903 CbiX 15,888 8,538
PF06180 CbiK 4,544 1,646
PF11844 DUF3364 1,838 484
CL0044 Ferritin 281,626 115,605 PF00210 Ferritin 66,858 23,723
PF00268 Ribonuc_red_sm 33,697 8,479
PF01786 AOX 3,841 2,097
PF02332 Phenol_Hydrox 5,820 1,689
PF02915 Rubrerythrin 28,208 14,086
PF03232 COQ7 9,234 4,286
PF03405 FA_desaturase_2 7,648 2,380
PF03713 DUF305 18,186 10,243
PF04305 DUF455 6,781 3,615
PF05067 Mn_catalase 10,668 3,603
PF05138 PaaA_PaaC 16,755 6,421
PF05974 DUF892 11,795 5,032
PF06175 MiaE 7,970 2,598
PF07875 Coat_F 6,164 2,780
PF09537 DUF2383 6,328 3,382
PF09968 DUF2202 1,227 953
PF11266 Ald_deCOase 725 301
PF11553 DUF3231 3,712 2,118
PF11583 AurF 8,191 2,858
PF12902 Ferritin-like 1,985 1,298
PF13628 DUF4142 12,007 6,169
PF13668 Ferritin_2 8,313 5,019
PF13794 MiaE_2 3,061 1,062
PF14530 DUF4439 2,560 1,469
PF18536 DUF5623 160 107
CL0045 Rubredoxin 40,995 19,178 PF00301 Rubredoxin 20,359 8,063
PF01215 COX5B 2,437 1,282
PF06397 Desulfoferrod_N 3,397 1,944
PF08421 Methyltransf_13 6,455 3,927
PF10276 zf-CHCC 8,343 3,963
CL0046 Thiolase 432,670 181,007 PF00108 Thiolase_N 152,802 52,318
PF00109 ketoacyl-synt 163,735 78,106
PF00195 Chal_sti_synt_N 15,323 5,983
PF01154 HMG_CoA_synt_N 8,662 3,563
PF02797 Chal_sti_synt_C 15,404 6,231
PF02801 Ketoacyl-synt_C 156,937 74,111
PF02803 Thiolase_C 150,231 50,752
PF07451 SpoVAD 4,587 1,711
PF08392 FAE1_CUT1_RppA 6,092 2,859
PF08540 HMG_CoA_synt_C 8,244 3,311
PF08541 ACP_syn_III_C 66,273 27,528
PF08545 ACP_syn_III 58,568 23,871
PF08990 Docking 5,443 3,746
PF13723 Ketoacyl-synt_2 5,290 2,523
PF16197 KAsynt_C_assoc 49,724 31,839
PF18605 PikAIV_N 1,649 1,104
CL0047 CuAO_N2_N3 9,438 4,247 PF02727 Cu_amine_oxidN2 7,615 3,322
PF02728 Cu_amine_oxidN3 7,685 3,308
PF09248 DUF1965 750 430
CL0048 LolA_LolB 90,580 46,681 PF03548 LolA 22,097 10,089
PF03550 LolB 8,534 3,394
PF03888 MucB_RseB 7,118 2,776
PF04507 DUF576 932 333
PF07044 DUF1329 8,736 3,311
PF07161 LppX_LprAFG 1,902 1,104
PF07608 DUF1571 1,316 782
PF09697 Porph_ging 6,608 4,542
PF09865 DUF2092 1,898 1,346
PF11306 DUF3108 14,473 8,190
PF11659 DUF3261 2,055 972
PF14125 DUF4292 3,758 2,466
PF14371 DUF4412 1,350 1,135
PF16584 LolA_2 1,184 578
PF17131 LolA_like 8,525 5,652
PF18234 VioE 80 44
CL0049 Tudor 213,256 110,993 PF00385 Chromo 28,814 16,745
PF00565 SNase 29,329 17,560
PF00567 TUDOR 10,713 6,170
PF00855 PWWP 16,900 8,060
PF01393 Chromo_shadow 3,446 1,827
PF02294 7kD_DNA_binding 72 13
PF02820 MBT 5,618 2,375
PF04397 LytTR 79,288 40,987
PF05641 Agenet 6,234 2,845
PF06003 SMN 2,443 1,230
PF07039 DUF1325 2,217 1,116
PF08169 RBB1NT 1,013 560
PF08605 Rad9_Rad53_bind 236 161
PF09038 53-BP1_Tudor 582 274
PF09465 LBR_tudor 551 244
PF11160 Hva1_TUDOR 5,401 3,045
PF11515 Cul7 1,080 522
PF11717 Tudor-knot 7,637 3,689
PF12148 TTD 810 325
PF14061 Mtf2_C 985 313
PF15057 DUF4537 577 352
PF16090 DUF4819 573 353
PF16719 SAWADEE 1,354 693
PF17516 ProQ_C 2,408 417
PF18104 Tudor_2 2,654 1,078
PF18115 Tudor_3 1,228 639
PF18336 Tudor_FRX1 1,722 516
PF18337 Tudor_RapA 5,829 1,199
PF18339 Tudor_1_RapA 5,885 1,261
PF18358 Tudor_4 667 376
PF18359 TUDOR_5 634 371
PF18380 GEN1_C 894 575
PF18704 Chromo_2 428 274
CL0050 HotDog 452,260 205,056 PF01575 MaoC_dehydratas 81,940 35,771
PF01643 Acyl-ACP_TE 10,345 5,007
PF02551 Acyl_CoA_thio 498 281
PF03061 4HBT 163,523 72,074
PF03756 AfsA 2,460 1,478
PF07977 FabA 45,894 17,044
PF09500 YiiD_C 4,834 1,486
PF10862 FcoT 357 190
PF13279 4HBT_2 43,278 20,976
PF13452 MaoC_dehydrat_N 25,919 12,533
PF13622 4HBT_3 33,731 14,086
PF14539 DUF4442 11,244 5,180
PF14765 PS-DH 37,254 24,161
CL0051 NTF2 311,986 160,420 PF00866 Ring_hydroxyl_B 10,720 3,956
PF02136 NTF2 11,268 5,296
PF02982 Scytalone_dh 841 407
PF03284 PHZA_PHZB 554 249
PF04280 Tim44 14,948 6,624
PF04335 VirB8 11,494 3,125
PF05223 MecA_N 7,166 2,817
PF05494 MlaC 14,260 6,761
PF07080 DUF1348 8,023 3,202
PF07107 WI12 670 408
PF07366 SnoaL 20,654 12,304
PF07858 LEH 2,400 1,314
PF07961 MBA1 448 260
PF08332 CaMKII_AD 6,461 2,995
PF10184 DUF2358 2,924 1,664
PF10429 Mtr2 204 127
PF11393 T4BSS_DotI_IcmL 1,599 698
PF11533 DUF3225 2,587 1,182
PF12642 TpcC 3,401 1,072
PF12680 SnoaL_2 81,603 44,397
PF12707 DUF3804 52 35
PF12870 DUF4878 1,783 1,029
PF12883 DUF3828 4,301 1,133
PF12893 Lumazine_bd_2 6,080 3,744
PF13026 DUF3887 2,570 1,347
PF13474 SnoaL_3 17,210 9,859
PF13577 SnoaL_4 29,174 16,758
PF14254 DUF4348 624 264
PF14534 DUF4440 28,919 18,579
PF14729 DUF4467 287 95
PF15008 DUF4518 453 280
PF16022 DUF4783 1,321 854
PF16111 DUF4829 280 220
PF16156 DUF4864 2,130 1,236
PF16247 DUF4904 10 6
PF16800 Endopep_inhib 654 238
PF17117 DUF5104 415 227
PF17118 DUF5105 779 239
PF17775 UPF0225 12,498 6,038
PF18042 ORF_12_N 646 270
CL0052 NTN 378,330 158,148 PF00227 Proteasome 70,328 24,488
PF00310 GATase_2 32,190 11,105
PF01019 G_glu_transpept 53,078 25,906
PF01112 Asparaginase_2 20,300 10,142
PF01804 Penicil_amidase 22,670 12,664
PF02275 CBAH 11,543 4,502
PF03417 AAT 9,560 5,605
PF03577 Peptidase_C69 10,568 3,877
PF04916 Phospholip_B 2,263 1,322
PF07826 IMP_cyclohyd 2,277 1,018
PF09147 DUF1933 49 27
PF10584 Proteasome_A_N 17,748 5,626
PF12481 DUF3700 1,594 748
PF13230 GATase_4 13,390 4,763
PF13522 GATase_6 63,742 22,168
PF13537 GATase_7 64,622 30,345
CL0053 4H_Cytokine 14,755 5,825 PF00103 Hormone_1 3,203 934
PF00143 Interferon 2,464 1,047
PF00489 IL6 494 218
PF00714 IFN-gamma 397 135
PF00715 IL2 230 59
PF00726 IL10 1,077 407
PF00727 IL4 363 125
PF00758 EPO_TPO 581 291
PF01109 GM_CSF 132 53
PF01110 CNTF 223 110
PF01291 LIF_OSM 343 167
PF01415 IL7 304 88
PF02024 Leptin 441 144
PF02025 IL5 166 83
PF02059 IL3 82 34
PF02372 IL15 616 328
PF02404 SCF 549 244
PF02947 Flt3_lig 183 89
PF03039 IL12 352 168
PF03487 IL13 138 54
PF05337 CSF-1 355 164
PF06875 PRF 477 135
PF07400 IL11 280 134
PF14565 IL22 227 128
PF15036 IL34 277 129
PF15177 IL28A 380 189
PF15216 TSLP 86 47
PF16647 GCSF 197 81
PF16649 IL23 112 50
CL0054 Knottin_1 6,546 3,599 PF00304 Gamma-thionin 2,497 1,298
PF00451 Toxin_2 226 163
PF00537 Toxin_3 859 524
PF01097 Defensin_2 904 499
PF05294 Toxin_5 39 26
PF05453 Toxin_6 35 18
PF06876 SCRL 435 275
PF07333 SLR1-BP 832 459
PF08086 Toxin_17 33 18
PF09132 BmKX 15 14
PF10868 Defensin_like 298 150
PF11415 Toxin_37 165 26
PF14865 Macin 72 66
PF14866 Toxin_38 118 59
PF18251 Defensin_5 4 5
CL0055 Nucleoplasmin 201,150 22,924 PF00073 Rhv 81,056 4,856
PF00500 Late_protein_L1 6,066 1,404
PF00688 TGFb_propeptide 11,192 4,080
PF00718 Polyoma_coat 5,087 241
PF00729 Viral_coat 1,332 341
PF00738 Polyhedrin 623 68
PF00760 Cucumo_coat 2,629 644
PF00894 Luteo_coat 2,779 225
PF00915 Calici_coat 34,224 1,183
PF00983 Tymo_coat 481 111
PF01318 Bromo_coat 21 8
PF01766 Birna_VP2 4,550 249
PF01787 Ilar_coat 1,012 90
PF01829 Peptidase_A6 19 18
PF02226 Pico_P1A 20,927 772
PF02247 Como_LCP 282 75
PF02248 Como_SCP 271 59
PF02443 Circo_capsid 4,336 240
PF02956 TT_ORF1 5,158 1,160
PF03014 SP2 10,826 246
PF03066 Nucleoplasmin 1,682 837
PF03115 Astro_capsid_N 3,766 500
PF03340 Pox_Rif 167 39
PF03391 Nepo_coat 730 110
PF03566 Peptidase_A21 45 19
PF03678 Adeno_hexon_C 2,897 229
PF03688 Nepo_coat_C 736 104
PF03689 Nepo_coat_N 640 99
PF03898 TNV_CP 78 75
PF08435 Calici_coat_C 8,057 216
PF08462 Carmo_coat_C 66 4
PF08762 CRPV_capsid 1,350 478
PF08935 VP4_2 2,158 242
PF11175 DUF2961 4,605 2,644
PF11492 Dicistro_VP4 407 272
PF11729 Capsid-VNN 1,091 85
PF12264 Waikav_capsid_1 91 37
PF12944 HAV_VP 1,407 62
PF15414 DUF4621 37 7
PF16530 IHHNV_capsid 162 3
PF16903 Capsid_N 2,524 711
PF17800 NPL 3,230 1,871
CL0056 C_Lectin 118,138 74,282 PF00059 Lectin_C 45,013 29,590
PF00193 Xlink 5,300 2,671
PF01413 C4 2,839 1,517
PF03440 APT 332 76
PF03781 FGE-sulfatase 61,851 39,107
PF05473 UL45 274 143
PF05966 Chordopox_A33R 150 40
PF06482 Endostatin 1,814 1,029
PF07588 DUF1554 1,102 586
PF07979 Intimin_C 514 80
PF08391 Ly49 464 197
PF16825 DUF5075 239 124
CL0057 Met_repress 159,370 77,229 PF01340 MetJ 2,247 211
PF01402 RHH_1 31,941 16,372
PF02697 VAPB_antitox 1,582 1,169
PF03693 ParD_antitoxin 11,238 5,714
PF03869 Arc 7,178 3,594
PF04221 RelB 13,490 5,250
PF05509 TraY 1,395 548
PF05534 HicB 8,712 4,731
PF07181 VirC2 99 41
PF07362 CcdA 4,315 1,928
PF07704 PSK_trans_fac 3,009 1,662
PF07764 Omega_Repress 273 20
PF07878 RHH_5 1,449 1,004
PF08681 DUF1778 8,361 3,741
PF08870 DndE 1,370 843
PF08972 DUF1902 890 583
PF09274 ParG 800 346
PF09386 ParD 519 274
PF09957 VapB_antitoxin 6,063 3,585
PF10723 RepB-RCR_reg 1,097 221
PF10784 Plasmid_stab_B 1,364 182
PF10802 DUF2540 30 20
PF11020 DUF2610 178 82
PF11423 Repressor_Mnt 218 44
PF11903 ParD_like 4,375 1,852
PF12441 CopG_antitoxin 3,057 2,077
PF12651 RHH_3 1,894 926
PF13467 RHH_4 7,994 3,590
PF14384 BrnA_antitoxin 8,395 4,754
PF15919 HicB_lk_antitox 18,442 9,970
PF15970 HicB-like_2 442 226
PF16762 RHH_6 477 171
PF16777 RHH_7 747 38
PF17206 SeqA_N 2,480 573
PF17414 MatP_C 1,933 268
PF17723 RHH_8 1,329 693
PF18064 ParB_C 305 199
CL0058 Glyco_hydro_tim 904,066 440,717 PF00128 Alpha-amylase 195,252 82,059
PF00150 Cellulase 49,177 26,702
PF00232 Glyco_hydro_1 65,507 26,499
PF00331 Glyco_hydro_10 17,808 10,574
PF00332 Glyco_hydro_17 16,355 8,174
PF00704 Glyco_hydro_18 59,845 30,479
PF00728 Glyco_hydro_20 30,776 16,450
PF00933 Glyco_hydro_3 98,501 48,400
PF01055 Glyco_hydro_31 40,763 18,895
PF01120 Alpha_L_fucos 22,120 12,767
PF01183 Glyco_hydro_25 24,874 10,906
PF01229 Glyco_hydro_39 5,970 3,917
PF01301 Glyco_hydro_35 18,132 9,187
PF01373 Glyco_hydro_14 3,512 1,581
PF01630 Glyco_hydro_56 3,111 1,713
PF02055 Glyco_hydro_30 9,273 5,295
PF02057 Glyco_hydro_59 1,855 1,011
PF02065 Melibiase 16,693 8,493
PF02156 Glyco_hydro_26 8,708 5,376
PF02286 Dehydratase_LU 1,986 379
PF02324 Glyco_hydro_70 895 261
PF02446 Glyco_hydro_77 22,058 10,267
PF02449 Glyco_hydro_42 17,984 9,626
PF02638 GHL10 13,421 6,630
PF02836 Glyco_hydro_2_C 53,638 26,779
PF03198 Glyco_hydro_72 4,860 2,608
PF03537 Glyco_hydro_114 6,400 4,026
PF03644 Glyco_hydro_85 3,151 1,697
PF03659 Glyco_hydro_71 2,941 1,838
PF03662 Glyco_hydro_79n 2,489 1,284
PF05089 NAGLU 3,865 2,038
PF05691 Raffinose_syn 3,763 1,959
PF07555 NAGidase 4,560 2,248
PF07745 Glyco_hydro_53 5,779 2,972
PF08924 DUF1906 4,674 2,500
PF10566 Glyco_hydro_97 10,319 5,011
PF11308 Glyco_hydro_129 1,626 587
PF11790 Glyco_hydro_cc 5,611 3,567
PF12876 Cellulase-like 362 205
PF12891 Glyco_hydro_44 848 587
PF12905 Glyco_hydro_101 1,596 610
PF13199 Glyco_hydro_66 938 531
PF13200 DUF4015 4,087 2,514
PF13204 DUF4038 3,986 2,518
PF14307 Glyco_tran_WbsX 3,778 2,466
PF14488 DUF4434 2,066 845
PF14587 Glyco_hydr_30_2 2,875 1,642
PF14701 hDGE_amylase 2,428 1,265
PF14871 GHL6 1,763 1,274
PF14872 GHL5 234 162
PF14883 GHL13 2,793 702
PF14885 GHL15 943 722
PF16126 DUF4838 2,633 2,072
PF16141 DUF4849 1,371 437
PF16317 Glyco_hydro_99 1,728 988
PF16402 DUF5010 171 121
PF16499 Melibiase_2 13,066 7,504
CL0059 6_Hairpin 293,102 150,712 PF00432 Prenyltrans 12,680 7,667
PF00723 Glyco_hydro_15 26,749 12,315
PF00759 Glyco_hydro_9 15,228 8,601
PF01122 Cobalamin_bind 870 548
PF01204 Trehalase 14,676 6,554
PF01270 Glyco_hydro_8 8,079 3,292
PF01532 Glyco_hydro_47 14,503 7,643
PF02011 Glyco_hydro_48 1,926 838
PF03200 Glyco_hydro_63 6,452 3,393
PF03632 Glyco_hydro_65m 14,551 6,986
PF03663 Glyco_hydro_76 11,152 5,880
PF04685 DUF608 4,315 2,388
PF05147 LANC_like 10,099 6,273
PF06202 GDE_C 12,341 6,652
PF06662 C5-epim_C 1,688 960
PF06824 Glyco_hydro_125 6,593 2,676
PF07221 GlcNAc_2-epim 17,201 7,969
PF07470 Glyco_hydro_88 22,723 10,968
PF07678 TED_complement 14,952 6,905
PF07944 Glyco_hydro_127 17,124 9,243
PF09492 Pec_lyase 2,453 1,560
PF10091 Glycoamylase 10,158 5,588
PF12899 Glyco_hydro_100 3,220 1,517
PF13243 SQHop_cyclase_C 13,432 6,864
PF13249 SQHop_cyclase_N 10,581 4,958
PF17167 Glyco_hydro_36 10,220 5,279
PF17389 Bac_rhamnosid6H 19,530 11,986
PF17652 Glyco_hydro81C 3,737 2,208
PF18566 Ldi 724 505
CL0060 DNA_clamp 54,084 21,223 PF00705 PCNA_N 5,351 2,346
PF00712 DNA_pol3_beta 36,543 12,599
PF02144 Rad1 2,176 1,157
PF02282 Herpes_UL42 309 40
PF02747 PCNA_C 4,899 2,147
PF02767 DNA_pol3_beta_2 37,984 13,556
PF02768 DNA_pol3_beta_3 36,760 12,744
PF02916 DNA_PPF 1,232 165
PF03325 Herpes_PAP 100 18
PF04005 Hus1 2,342 1,212
PF04139 Rad9 2,524 1,464
PF04929 Herpes_DNAp_acc 98 29
PF09116 gp45-slide_C 522 211
CL0061 PLP_aminotran 1,308,287 544,344 PF00155 Aminotran_1_2 451,606 181,190
PF00202 Aminotran_3 219,099 84,556
PF00266 Aminotran_5 214,921 96,824
PF00282 Pyridoxal_deC 48,585 21,894
PF00464 SHMT 51,832 17,263
PF01041 DegT_DnrJ_EryC1 81,740 48,863
PF01053 Cys_Met_Meta_PP 109,430 41,617
PF01212 Beta_elim_lyase 37,332 17,144
PF01276 OKR_DC_1 25,088 6,967
PF02347 GDC-P 37,723 15,694
PF03841 SelA 16,134 6,274
PF04864 Alliinase_C 1,414 739
PF05889 SepSecS 1,495 815
PF06338 ComK 3,050 1,209
PF06838 Met_gamma_lyase 6,067 2,331
PF12897 Aminotran_MocR 4,132 1,737
CL0062 APC 876,814 324,113 PF00209 SNF 43,349 18,271
PF00324 AA_permease 96,470 27,810
PF00474 SSF 105,713 44,767
PF00860 Xan_ur_permease 85,514 23,136
PF00916 Sulfate_transp 69,577 30,642
PF00955 HCO3_cotransp 11,595 5,055
PF01235 Na_Ala_symp 35,207 11,899
PF01490 Aa_trans 44,598 22,097
PF01566 Nramp 38,548 15,803
PF02028 BCCT 30,154 11,047
PF02133 Transp_cyt_pur 41,024 14,172
PF02554 CstA 21,077 6,052
PF02705 K_trans 23,336 8,636
PF03222 Trp_Tyr_perm 17,191 3,473
PF03594 BenE 11,463 3,487
PF03845 Spore_permease 15,397 7,692
PF05525 Branch_AA_trans 15,630 4,073
PF13520 AA_permease_2 168,105 64,905
PF13906 AA_permease_C 7,249 3,399
PF16983 MFS_MOT1 2,350 1,345
CL0063 NADP_Rossmann 8,482,683 3,906,119 PF00044 Gp_dh_N 69,622 20,284
PF00056 Ldh_1_N 58,892 17,260
PF00070 Pyr_redox 705 566
PF00106 adh_short 527,630 265,076
PF00107 ADH_zinc_N 352,813 145,101
PF00145 DNA_methylase 52,641 30,252
PF00208 ELFV_dehydrog 53,300 20,270
PF00291 PALP 261,960 99,770
PF00398 RrnaAD 47,248 21,216
PF00479 G6PD_N 36,461 12,090
PF00670 AdoHcyase_NAD 30,005 9,832
PF00732 GMC_oxred_N 92,798 44,284
PF00743 FMO-like 44,092 22,971
PF00890 FAD_binding_2 123,625 48,210
PF00891 Methyltransf_2 30,747 18,116
PF00899 ThiF 89,992 40,513
PF00996 GDI 6,467 2,806
PF01073 3Beta_HSD 12,244 7,056
PF01113 DapB_N 41,305 17,014
PF01118 Semialdhyde_dh 81,124 28,952
PF01134 GIDA 44,240 17,455
PF01135 PCMT 41,280 21,600
PF01170 UPF0020 28,591 12,329
PF01175 Urocanase 18,769 5,545
PF01189 Methyltr_RsmB-F 58,151 26,789
PF01209 Ubie_methyltran 34,930 15,016
PF01210 NAD_Gly3P_dh_N 40,742 16,566
PF01225 Mur_ligase 109,092 47,901
PF01232 Mannitol_dh 28,615 9,858
PF01234 NNMT_PNMT_TEMT 1,342 873
PF01262 AlaDh_PNT_C 47,928 18,452
PF01266 DAO 257,363 109,754
PF01269 Fibrillarin 4,567 2,235
PF01358 PARP_regulatory 294 128
PF01370 Epimerase 289,345 150,620
PF01408 GFO_IDH_MocA 237,371 119,465
PF01488 Shikimate_DH 50,424 22,130
PF01494 FAD_binding_3 192,300 97,860
PF01555 N6_N4_Mtase 63,193 35,039
PF01564 Spermine_synth 34,866 16,426
PF01593 Amino_oxidase 118,010 61,771
PF01596 Methyltransf_3 30,353 14,004
PF01728 FtsJ 59,322 21,540
PF01739 CheR 37,584 19,125
PF01795 Methyltransf_5 38,533 16,897
PF01861 DUF43 1,239 728
PF01946 Thi4 5,824 2,397
PF02005 TRM 5,513 3,038
PF02056 Glyco_hydro_4 19,027 5,863
PF02086 MethyltransfD12 25,297 11,973
PF02153 PDH 34,252 14,752
PF02254 TrkA_N 95,030 39,020
PF02310 B12-binding 94,300 47,022
PF02353 CMAS 39,614 17,425
PF02384 N6_Mtase 67,530 36,606
PF02390 Methyltransf_4 34,914 15,095
PF02423 OCD_Mu_crystall 30,377 15,168
PF02475 Met_10 8,484 5,011
PF02527 GidB 32,905 15,204
PF02558 ApbA 42,505 20,180
PF02571 CbiJ 11,621 5,317
PF02593 DUF166 777 542
PF02629 CoA_binding 48,123 14,265
PF02636 Methyltransf_28 16,595 8,817
PF02670 DXP_reductoisom 29,670 12,565
PF02719 Polysacc_synt_2 31,985 16,332
PF02737 3HCDH_N 91,193 37,226
PF02826 2-Hacid_dh_C 178,393 78,218
PF02882 THF_DHG_CYH_C 45,720 18,186
PF03059 NAS 1,620 819
PF03141 Methyltransf_29 8,242 3,728
PF03269 DUF268 806 673
PF03275 GLF 10,615 4,202
PF03291 Pox_MCEL 3,369 1,775
PF03341 Pox_mRNA-cap 132 31
PF03435 Sacchrp_dh_NADP 35,969 16,321
PF03446 NAD_binding_2 114,163 46,905
PF03447 NAD_binding_3 47,141 17,080
PF03486 HI0933_like 33,961 15,803
PF03492 Methyltransf_7 5,816 3,391
PF03514 GRAS 12,547 5,889
PF03602 Cons_hypoth95 35,934 17,279
PF03686 UPF0146 634 426
PF03721 UDPG_MGDP_dh_N 70,532 34,428
PF03807 F420_oxidored 64,302 30,060
PF03808 Glyco_tran_WecB 18,737 9,827
PF03848 TehB 4,539 1,873
PF03853 YjeF_N 32,482 17,329
PF03949 Malic_M 50,579 16,482
PF04016 DUF364 2,862 1,941
PF04072 LCM 22,882 11,026
PF04127 DFP 36,817 16,089
PF04321 RmlD_sub_bind 41,058 23,342
PF04378 RsmJ 10,738 3,532
PF04445 SAM_MT 9,417 3,302
PF04536 TPM_phosphatase 28,388 14,595
PF04672 Methyltransf_19 12,351 6,611
PF04723 GRDA 1,256 407
PF04816 TrmK 5,353 1,897
PF04820 Trp_halogenase 14,075 8,607
PF04989 CmcI 2,391 1,347
PF05050 Methyltransf_21 30,436 22,264
PF05059 Orbi_VP4 674 74
PF05063 MT-A70 8,020 4,355
PF05088 Bac_GDH 12,955 5,411
PF05148 Methyltransf_8 2,413 1,463
PF05175 MTS 91,948 41,583
PF05185 PRMT5 2,708 1,287
PF05206 TRM13 1,440 858
PF05219 DREV 923 495
PF05368 NmrA 46,519 24,777
PF05401 NodS 4,464 2,207
PF05430 Methyltransf_30 14,135 6,550
PF05575 V_cholerae_RfbT 40 17
PF05711 TylF 5,547 3,510
PF05724 TPMT 9,574 5,539
PF05834 Lycopene_cycl 6,810 4,296
PF05891 Methyltransf_PK 2,719 1,479
PF05958 tRNA_U5-meth_tr 49,858 19,441
PF05971 Methyltransf_10 8,113 3,354
PF06016 Reovirus_L2 227 39
PF06039 Mqo 12,834 3,499
PF06080 DUF938 5,473 3,407
PF06100 MCRA 5,550 1,869
PF06325 PrmA 41,477 18,108
PF06460 NSP16 2,495 195
PF06471 NSP11 3,037 210
PF06690 DUF1188 74 49
PF06859 Bin3 2,010 1,186
PF06962 rRNA_methylase 5,456 2,306
PF07021 MetW 8,231 3,282
PF07055 Eno-Rase_FAD_bd 5,237 1,617
PF07091 FmrO 555 306
PF07109 Mg-por_mtran_C 1,559 830
PF07156 Prenylcys_lyase 2,197 1,216
PF07279 DUF1442 1,009 518
PF07669 Eco57I 10,527 7,133
PF07757 AdoMet_MTase 1,653 1,033
PF07942 N2227 3,113 1,727
PF07991 IlvN 32,548 7,742
PF07992 Pyr_redox_2 472,649 194,111
PF07993 NAD_binding_4 31,970 17,449
PF07994 NAD_binding_5 6,212 2,625
PF08003 Methyltransf_9 8,081 2,455
PF08123 DOT1 3,674 2,305
PF08241 Methyltransf_11 216,352 122,939
PF08242 Methyltransf_12 24,093 13,402
PF08484 Methyltransf_14 7,894 4,712
PF08485 Polysacc_syn_2C 3,675 1,692
PF08491 SE 3,211 1,610
PF08643 DUF1776 859 450
PF08659 KR 44,434 28,813
PF08704 GCD14 9,580 4,328
PF08732 HIM1 919 488
PF09243 Rsm22 4,810 2,661
PF09445 Methyltransf_15 3,691 2,241
PF10017 Methyltransf_33 11,322 6,327
PF10237 N6-adenineMlase 2,346 1,376
PF10294 Methyltransf_16 19,025 11,712
PF10354 DUF2431 3,022 1,955
PF10672 Methyltrans_SAM 34,020 12,472
PF10727 Rossmann-like 7,019 3,507
PF11017 DUF2855 1,894 1,220
PF11312 Methyltransf_34 1,028 584
PF11599 AviRa 182 134
PF11890 DUF3410 5,635 1,595
PF11968 Bmt2 1,360 767
PF12147 Methyltransf_20 3,267 833
PF12241 Enoyl_reductase 5,318 1,667
PF12242 Eno-Rase_NADH_b 5,236 1,612
PF12692 Methyltransf_17 1,093 435
PF12831 FAD_oxidored 23,776 14,210
PF12847 Methyltransf_18 3,024 1,625
PF13241 NAD_binding_7 24,037 10,449
PF13288 DXPR_C 29,551 12,440
PF13380 CoA_binding_2 43,599 22,192
PF13383 Methyltransf_22 1,309 974
PF13434 K_oxygenase 14,180 5,721
PF13450 NAD_binding_8 80,993 42,914
PF13454 NAD_binding_9 12,421 6,027
PF13460 NAD_binding_10 103,607 56,167
PF13478 XdhC_C 28,954 14,568
PF13489 Methyltransf_23 113,914 67,226
PF13561 adh_short_C2 601,982 264,582
PF13578 Methyltransf_24 20,400 13,342
PF13602 ADH_zinc_N_2 68,677 36,800
PF13649 Methyltransf_25 178,287 102,812
PF13679 Methyltransf_32 12,108 5,274
PF13727 CoA_binding_3 39,120 20,149
PF13738 Pyr_redox_3 44,190 21,761
PF13847 Methyltransf_31 78,301 44,110
PF14314 Methyltrans_Mon 1,529 252
PF16363 GDP_Man_Dehyd 119,700 58,265
PF16803 DRE2_N 887 466
PF16912 Glu_dehyd_C 2,845 1,638
PF17125 Methyltr_RsmF_N 14,382 6,263
PF17173 DUF5129 534 291
PF17174 DUF5130 1,301 553
PF17175 MOLO1 769 509
PF17396 DUF1611_N 4,392 2,474
PF17836 PglD_N 9,501 6,565
PF17930 LpxI_N 5,746 3,329
PF18321 3HCDH_RFF 2,575 824
PF18706 ISPD_C 307 138
CL0064 CPA_AT 334,157 138,444 PF00999 Na_H_Exchanger 141,092 60,533
PF01758 SBF 41,748 18,656
PF03547 Mem_trans 46,083 21,078
PF03601 Cons_hypoth698 20,112 8,551
PF03616 Glt_symporter 9,001 2,691
PF03812 KdgT 4,444 1,055
PF03956 Lys_export 6,108 1,953
PF03977 OAD_beta 15,045 3,358
PF05684 DUF819 5,067 2,648
PF05982 Sbt_1 3,498 1,738
PF06826 Asp-Al_Ex 11,074 3,220
PF06965 Na_H_antiport_1 19,246 8,703
PF13593 SBF_like 11,829 4,420
CL0065 Cyclin 66,525 33,134 PF00134 Cyclin_N 40,193 20,323
PF00382 TFIIB 12,087 5,195
PF01857 RB_B 2,319 946
PF01858 RB_A 2,384 984
PF02984 Cyclin_C 19,614 9,734
PF03261 CDK5_activator 968 423
PF08613 Cyclin 8,969 5,034
PF09080 K-cyclin_vir_C 16 5
PF09241 Herp-Cyclin 2 2
PF11934 DUF3452 2,032 792
PF16899 Cyclin_C_2 2,760 1,182
PF18542 TFIIB_C_1 37 18
CL0066 Trefoil 80,378 42,231 PF00167 FGF 8,481 3,191
PF00197 Kunitz_legume 2,753 1,358
PF00340 IL1 2,085 938
PF00652 Ricin_B_lectin 27,631 14,637
PF02815 MIR 10,128 5,541
PF03260 Lipoprotein_11 146 78
PF03498 CDtoxinA 925 290
PF04601 DUF569 1,428 798
PF05270 AbfB 3,773 2,064
PF05588 Botulinum_HA-17 62 23
PF06229 FRG1 1,722 930
PF06268 Fascin 1,765 747
PF07468 Agglutinin 501 277
PF07951 Toxin_R_bind_C 188 32
PF08470 NTNH_C 113 16
PF08709 Ins145_P3_rec 4,265 2,741
PF09270 BTD 2,329 928
PF10467 Inhibitor_I48 91 82
PF14200 RicinB_lectin_2 15,270 9,753
PF15095 IL33 180 57
PF16850 Inhibitor_I66 414 335
PF18021 Agglutinin_C 110 93
PF18022 Lectin_C_term 26 24
CL0067 SIS 284,546 102,696 PF00318 Ribosomal_S2 49,177 15,084
PF00342 PGI 42,845 16,238
PF01380 SIS 152,222 53,989
PF10432 bact-PGI_C 4,985 3,092
PF10740 DUF2529 1,259 403
PF12163 HobA 897 170
PF13580 SIS_2 32,848 14,490
PF15698 Phosphatase 1,739 525
CL0068 RIIa 7,340 3,906 PF02197 RIIa 3,423 1,542
PF05186 Dpy-30 3,915 2,364
CL0069 GFP 2,430 1,273 PF01353 GFP 743 286
PF07474 G2F 1,685 987
CL0070 ACT 277,474 93,252 PF00585 Thr_dehydrat_C 18,111 5,486
PF01842 ACT 112,610 38,903
PF04359 DUF493 10,852 4,067
PF08753 NikR_C 6,846 2,845
PF09383 NIL 25,746 7,158
PF10000 ACT_3 3,682 1,824
PF10369 ALS_ss_C 28,334 8,472
PF13291 ACT_4 41,670 13,494
PF13710 ACT_5 21,469 6,390
PF13740 ACT_6 20,376 6,873
PF13840 ACT_7 39,845 13,888
CL0071 His_phosphatase 199,385 92,737 PF00300 His_Phos_1 176,629 81,767
PF00328 His_Phos_2 22,754 10,971
CL0072 Ubiquitin 595,420 262,618 PF00174 Oxidored_molyb 47,641 22,951
PF00240 ubiquitin 47,498 22,896
PF00564 PB1 18,697 8,606
PF00778 DIX 3,727 1,436
PF00788 RA 20,422 9,355
PF00789 UBX 14,751 7,399
PF00794 PI3K_rbd 3,951 1,287
PF01378 IgG_binding_B 57 26
PF02017 CIDE-N 1,908 976
PF02192 PI3K_p85B 1,582 515
PF02196 RBD 3,605 1,704
PF02246 B1 6 5
PF02309 AUX_IAA 11,188 4,768
PF02597 ThiS 60,493 30,252
PF02821 Staphylokinase 342 45
PF02824 TGS 78,647 25,914
PF02991 Atg8 5,999 2,276
PF03607 DCX 4,131 2,206
PF03658 Ub-RnfH 8,289 3,748
PF03671 Ufm1 978 478
PF03990 DUF348 6,516 3,384
PF04106 APG5 2,411 1,203
PF04110 APG12 1,949 1,045
PF04663 Phenol_monoox 911 428
PF06071 YchF-GTPase_C 37,731 11,864
PF06234 TmoB 319 200
PF06251 Caps_synth_GfcC 4,923 2,250
PF06458 MucBP 9,794 3,080
PF06487 SAP18 1,996 968
PF06805 Lambda_tail_I 4,529 1,020
PF08154 NLE 3,843 1,777
PF08783 DWNN 2,801 1,458
PF08817 YukD 6,279 2,960
PF09138 Urm1 2,007 1,100
PF09379 FERM_N 18,244 7,895
PF09469 Cobl 1,212 433
PF09479 Flg_new 14,498 7,885
PF10302 DUF2407 940 568
PF10531 SLBB 80,197 37,137
PF11434 CHIPS 25 2
PF11470 TUG-UBL1 1,538 874
PF11543 UN_NPL4 1,386 648
PF11620 GABP-alpha 516 202
PF11973 NQRA_SLBB 6,042 2,748
PF11976 Rad60-SLD 6,844 3,688
PF12053 Par3_HAL_N_term 2,235 1,093
PF12436 USP7_ICP0_bdg 4,426 1,764
PF12754 Blt1 589 287
PF13019 Sde2_N_Ubi 2,009 1,177
PF13881 Rad60-SLD_2 2,889 1,478
PF14451 Ub-Mut7C 3,090 1,715
PF14452 Multi_ubiq 1,425 951
PF14453 ThiS-like 647 265
PF14454 Prok_Ub 1,216 468