EFI - Enzyme Similarity Tool

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RadicalSAM.org, our resource for investigating sequence-function space in the radical SAM superfamily, has been updated with sequences from the UniProt Release 2024_01 and InterPro Release 98 databases (January 24, 2024) !!

https://radicalsam.org

Pfam Families

These data are sourced from the UniProt and EMBL-EBI InterPro databases.

Clan ID Short Name Size UniRef90 Size UniRef50 Size Pfam ID Short Name Size UniRef90 Size UniRef50 Size
CL0001 EGF 397,434 173,054 62,719 PF00008 EGF 112,580 50,786 18,718
PF00053 Laminin_EGF 51,952 23,488 6,386
PF00084 Sushi 71,605 33,520 13,179
PF00594 Gla 11,233 3,991 780
PF01414 DSL 8,687 3,348 1,117
PF04863 EGF_alliinase 833 445 118
PF06247 Plasmod_Pvs28 465 87 49
PF07645 EGF_CA 108,294 47,267 16,146
PF07699 Ephrin_rec_like 26,569 11,569 5,533
PF07974 EGF_2 30,214 12,084 4,782
PF09014 Sushi_2 1,214 478 127
PF09064 Tme5_EGF_like 695 431 121
PF09289 FOLN 5,061 1,200 197
PF09443 CFC 1,076 582 178
PF12661 hEGF 47,976 20,717 7,022
PF12662 cEGF 34,338 14,715 4,129
PF12946 EGF_MSP1_1 2,781 287 127
PF12947 EGF_3 29,060 12,644 4,652
PF14670 FXa_inhibition 50,872 19,259 5,117
PF18193 Fibrillin_U_N 2,245 1,015 96
PF18372 I-EGF_1 9,091 2,395 473
PF18720 EGF_Tenascin 6,237 2,750 648
PF20626 Sp38_C 1,123 443 81
PF21195 C8A_B_C6_EGF-like 3,323 1,168 135
PF21284 C7_FIM2_N 353 83 11
PF21286 CFAI_FIMAC_N 978 365 82
PF21364 FBN_EGF_st1 2,211 1,005 87
PF21700 DL-JAG_EGF-like 9,717 3,205 731
PF21795 JAG1-like_EGF2 540 177 63
CL0003 SAM 227,469 87,857 20,118 PF00536 SAM_1 101,142 38,232 9,868
PF01698 SAM_LFY 1,757 349 64
PF02198 SAM_PNT 14,920 4,032 1,307
PF02961 BAF 2,053 901 379
PF04904 NCD1 2,685 740 271
PF07647 SAM_2 67,175 26,871 6,593
PF09235 SAM_Ste50p 71 51 25
PF09597 IGR 2,153 1,206 363
PF13543 SAM_KSR1 936 421 130
PF13932 GIDA_C 37,142 17,543 1,490
PF18016 SAM_3 9,475 2,900 688
PF18017 SAM_4 1,630 771 325
PF18255 SAM_DrpA 630 94 10
PF18609 SAM_Exu 292 175 69
PF21872 SAM_5 2 2 1
PF21907 CEP-1_C 65 49 36
PF22931 TNK-like_SAM 3,941 1,583 481
PF22993 EPH_SAM 118 79 39
CL0004 Concanavalin 713,900 387,538 134,489 PF00054 Laminin_G_1 17,180 8,178 2,214
PF00139 Lectin_legB 18,616 10,808 3,751
PF00262 Calreticulin 12,978 5,102 1,237
PF00337 Gal-bind_lectin 19,811 9,441 3,512
PF00354 Pentaxin 13,277 6,266 2,041
PF00426 VP4_haemagglut 15,485 674 72
PF00457 Glyco_hydro_11 6,203 3,306 698
PF00622 SPRY 111,975 54,124 14,928
PF00629 MAM 35,695 15,854 6,363
PF00722 Glyco_hydro_16 55,877 32,977 10,224
PF00840 Glyco_hydro_7 9,926 3,683 659
PF01670 Glyco_hydro_12 6,361 3,422 953
PF01828 Peptidase_A4 3,926 2,583 1,057
PF02210 Laminin_G_2 66,639 27,901 6,918
PF02973 Sialidase 690 211 111
PF03080 Neprosin 9,665 5,833 2,450
PF03388 Lectin_leg-like 8,840 3,804 1,114
PF03935 SKN1_KRE6_Sbg1 5,227 3,399 925
PF05592 Bac_rhamnosid 16,439 11,125 2,867
PF05735 TSP_C 9,248 2,493 497
PF06009 Laminin_II 5,116 2,793 407
PF06439 3keto-disac_hyd 44,394 33,266 8,668
PF06955 XET_C 11,984 5,084 802
PF07081 DUF1349 9,183 4,895 1,173
PF07177 Neuralized 7,032 2,917 1,067
PF07622 DUF1583 176 151 119
PF07675 Cleaved_Adhesin 2,178 1,847 1,259
PF07953 Toxin_R_bind_N 336 62 32
PF08244 Glyco_hydro_32C 27,067 13,670 3,177
PF08787 Alginate_lyase2 5,435 2,996 813
PF08978 Reoviridae_Vp9 40 14 9
PF09101 Exotox-A_bind 200 39 16
PF09206 ArabFuran-catal 2,557 1,456 284
PF09224 DUF1961 885 606 178
PF09264 Sial-lect-inser 91 39 25
PF10008 DUF2251 500 234 76
PF10287 YJL171C_Tos1_C 1,338 798 219
PF11476 TgMIC1 19 4 4
PF11958 DUF3472 2,392 1,647 624
PF12248 Methyltransf_FA 3,697 2,188 1,096
PF13385 Laminin_G_3 93,747 69,861 41,087
PF13765 PRY 55,125 29,223 7,683
PF14099 Polysacc_lyase 3,582 2,603 1,368
PF14299 PP2 9,269 5,567 2,243
PF15493 YrpD 123 55 35
PF16346 GH32_BT1760-like_C 431 202 51
PF16451 bCoV_S1_N 3,362 365 42
PF17689 Arabino_trans_N 3,139 1,355 166
PF17851 GH43_C2 22,660 12,855 2,302
PF17995 GH101_N 544 144 61
PF18239 HA1 7 4 3
PF18271 GH131_N 2,614 1,516 358
PF18483 Bact_lectin 3,846 2,843 1,822
PF19559 DUF6081 563 329 108
PF19763 DUF6250 1,057 601 165
PF20407 DUF1583_N 189 163 130
PF20562 DUF6772 403 198 29
PF20773 InhA-like_MAM 9,851 6,047 2,194
PF20842 Rax2_2 1,656 945 211
PF20843 Rax2_3 1,661 946 211
PF21209 Bac_rhamnosid-like_N 744 364 63
PF21294 Polysacc_lyase_14 2,875 2,238 1,049
PF21340 Polysacc_lyase-like 1,044 612 121
PF21708 Glyco_hydro_59_C 2,535 1,119 307
PF21869 Dit-like_CBM2 97 48 26
PF21932 M2AP_beta_dom 18 4 4
PF22237 SO2946-like_C 70 68 63
PF22245 G7C_C 3 4 2
PF22585 Sialidase-like_CBM 745 432 125
PF22826 PL28 80 79 22
PF22875 Glu2-Pro 65 12 9
PF22925 TS_C 4,010 2,162 496
CL0005 Kazal 56,029 22,861 8,696 PF00050 Kazal_1 14,720 8,015 3,868
PF07648 Kazal_2 41,358 15,728 5,784
PF18434 Kazal_3 1,345 382 53
PF21287 CFAI_KAZAL 968 360 81
PF21288 C6_KAZAL 1,042 332 41
PF21330 C7_KAZAL 1,385 386 45
CL0007 KH 362,492 147,699 25,394 PF00013 KH_1 152,862 61,582 13,345
PF04025 RemA-like 7,804 3,687 558
PF07650 KH_2 90,979 33,945 3,430
PF09869 DUF2096 317 217 61
PF13083 KhpA-B_KH 30,660 14,837 2,449
PF13184 KH_5 44,117 17,572 1,971
PF14611 SLS 715 448 220
PF14955 MRP-S24 1,333 758 210
PF15985 KH_6 8,351 4,034 982
PF16005 MOEP19 851 422 184
PF17214 KH_7 3,343 1,510 206
PF17903 KH_8 6,176 2,479 429
PF17904 KH_9 5,528 1,675 242
PF17905 KH_10 83 52 29
PF20704 NucS_shadow 1,800 451 29
PF20777 SLS1_KH2 550 304 137
PF21482 GLD3_KH3 16 8 2
PF21718 DTX3L_KH-like 752 428 86
PF21800 KRR1-like_KH2 7,353 3,066 576
PF22467 KH-I_CeGLD3_rpt3 20 11 5
PF22675 KH_1_3 9,025 3,925 1,123
PF22801 GLD-3_KH2 37 22 11
PF22891 KH_PNO1_2nd 4,918 2,291 443
PF22952 KH_11 1,248 523 89
PF22985 BICC1_KH 2,067 691 207
CL0010 SH3 1,978,489 889,836 233,688 PF00018 SH3_1 197,961 76,878 18,530
PF00385 Chromo 70,815 39,276 16,253
PF00467 KOW 89,779 35,213 4,757
PF00552 IN_DBD_C 67,055 5,611 740
PF00565 SNase 40,437 26,665 11,774
PF00567 TUDOR 25,419 12,717 5,784
PF00855 PWWP 42,655 17,860 5,527
PF00924 MS_channel_2nd 138,317 77,645 20,266
PF01157 Ribosomal_L21e 9,645 3,634 659
PF01245 Ribosomal_L19 45,422 17,782 1,948
PF01302 CAP_GLY 32,392 15,112 4,601
PF01393 Chromo_shadow 7,055 3,307 1,366
PF01423 LSM 69,593 26,145 7,152
PF01426 BAH 32,175 14,193 3,719
PF01777 Ribosomal_L27e 5,133 1,830 513
PF01845 CcdB 3,920 2,020 512
PF01929 Ribosomal_L14e 6,010 2,254 590
PF02170 PAZ 31,347 13,683 4,108
PF02211 NHase_beta_C 4,975 2,895 506
PF02237 BPL_C 30,084 17,472 4,828
PF02294 7kD_DNA_binding 102 19 14
PF02427 PSI_PsaE 1,987 950 128
PF02452 PemK_toxin 42,061 26,399 5,924
PF02513 Spin-Ssty 2,458 611 154
PF02559 CarD_TRCF_RID 59,587 27,103 4,808
PF02736 Myosin_N 28,848 10,956 1,507
PF02820 MBT 15,959 4,786 1,445
PF02941 FeThRed_A 1,318 687 216
PF03217 SlpA 2,626 1,406 777
PF03831 YjdM 16,195 6,814 287
PF03947 Ribosomal_L2_C 70,988 18,986 1,514
PF03983 SHD1 2,959 2,073 1,008
PF04023 FeoA 48,432 28,557 6,566
PF04153 NOT2_3_5_C 11,953 4,744 1,358
PF04319 NifZ 2,296 1,228 139
PF04397 LytTR 95,021 57,699 16,978
PF05641 Agenet 13,548 6,075 2,347
PF06003 SMN_Tudor 4,080 1,624 544
PF06004 DUF903 5,650 930 156
PF06107 DUF951 6,898 3,667 322
PF06257 VEG 4,290 1,498 237
PF06347 SH3_4 8,152 5,613 1,846
PF06372 Gemin6 1,040 443 156
PF06442 DHFR_2 115 46 26
PF06613 KorB_C 354 123 43
PF06701 MIB_HERC2 7,663 3,295 956
PF07039 SGF29_Tudor 4,015 1,972 696
PF07126 ZapC_C 2,015 528 87
PF07563 DUF1541 1,491 850 127
PF07653 SH3_2 86,608 34,384 8,897
PF07866 DUF1653 7,725 4,161 888
PF08141 SspH 2,324 1,213 208
PF08169 RBB1NT 2,659 1,252 252
PF08207 EFP_N 47,147 17,033 1,356
PF08239 SH3_3 54,361 35,447 18,381
PF08460 SH3_5 2,310 762 362
PF08605 Rad9_Rad53_bind 328 219 105
PF08810 KapB 1,084 540 62
PF08838 DUF1811 1,270 551 49
PF08940 DUF1918 3,099 1,910 298
PF08948 PRD1_P5_spike_N 13 5 4
PF09038 53-BP1_Tudor 1,415 612 163
PF09465 LBR_tudor 1,234 324 92
PF09629 YorP 47 9 6
PF09671 Spore_GerQ 1,519 820 146
PF09926 DUF2158 2,360 1,038 540
PF09953 DUF2187 1,622 528 144
PF10383 Clr2 1,505 889 306
PF10842 DUF2642 901 503 198
PF11061 Tsr0524-like 814 386 52
PF11095 Gemin7 1,077 671 284
PF11160 Hva1_TUDOR 6,738 4,228 647
PF11302 DUF3104 230 165 72
PF11347 CRR42-like 1,144 638 139
PF11515 Cul7 2,825 1,286 228
PF11607 DUF3247 339 176 44
PF11623 NdhS 1,131 488 85
PF11717 Tudor-knot 10,918 4,558 1,427
PF11910 NdhO 1,155 543 64
PF12073 DUF3553 2,038 1,417 273
PF12148 TTD 2,555 883 139
PF12208 DUF3601 167 77 40
PF12212 PAZ_2 6 5 4
PF12701 LSM14 8,413 3,334 973
PF12913 SH3_6 2,908 1,361 472
PF12914 SH3_7 1,554 425 162
PF13234 MTR4_beta-barrel 8,298 3,556 709
PF13457 GW 2,583 1,247 701
PF13861 FLgD_tudor 9,286 4,800 1,260
PF13958 ToxN_toxin 857 542 329
PF13973 DUF4222 1,750 516 134
PF14001 YdfZ 834 93 19
PF14061 Mtf2_C 2,720 657 170
PF14192 DUF4314 1,781 932 309
PF14438 SM-ATX 6,622 2,784 743
PF14563 DUF4444 342 262 16
PF14603 hSH3 2,490 1,008 240
PF14604 SH3_9 99,957 38,455 9,932
PF14627 DUF4453 111 82 47
PF15057 DUF4537 1,513 802 322
PF15505 Vexin 298 90 16
PF15997 DUF4772 1,091 428 156
PF16090 DUF4819 1,521 749 259
PF16277 DUF4926 3,262 2,292 647
PF16719 SAWADEE 2,426 1,284 538
PF16906 Ribosomal_L26 8,737 3,777 802
PF17136 ribosomal_L24 42,668 17,853 1,545
PF17209 Hfq 18,072 5,569 691
PF17375 DUF5397 172 111 36
PF17384 DUF150_C 29,661 14,935 2,833
PF17516 ProQ_C 2,257 485 50
PF17902 SH3_10 13,923 4,321 854
PF18103 SH3_11 175 19 4
PF18104 Tudor_2 7,761 2,889 388
PF18115 Tudor_3 2,542 1,211 393
PF18129 SH3_12 3,959 1,941 565
PF18300 DUF5604 1,321 602 115
PF18309 PAZ_3 65 44 15
PF18332 XRN1_D1 3,906 1,942 516
PF18334 XRN1_D2_D3 4,038 2,003 562
PF18335 SH3_13 12,814 6,584 1,331
PF18336 Tudor_FRX1 4,541 1,398 204
PF18337 Tudor_RapA 5,747 1,617 251
PF18339 Tudor_1_RapA 5,820 1,681 272
PF18340 TraI_2B 1,534 388 134
PF18341 PSA_CBD 59 20 11
PF18342 LytB_SH3 286 47 13
PF18343 SH3_14 606 61 15
PF18346 SH3_15 4,557 1,780 551
PF18347 DUF5606 3,645 2,302 339
PF18348 SH3_16 9,391 6,286 1,404
PF18349 PAZ_4 4 4 2
PF18350 SH3_17 44 19 2
PF18354 SH3_18 53 27 8
PF18355 DUF5607 0 1 1
PF18356 DUF5608 0 1 1
PF18357 DtxR 1,233 371 23
PF18358 Tudor_4 1,839 977 294
PF18359 Tudor_5 1,864 1,021 372
PF18380 GEN1_C 1,434 957 302
PF18597 SH3_19 1,542 812 75
PF18697 MLVIN_C 2,334 1,536 961
PF18704 Chromo_2 1,157 628 176
PF19023 DUF5749 136 98 33
PF19087 DUF5776 1,714 997 571
PF20297 MSSS 12,088 6,260 1,335
PF20866 MdcG_N 3,106 1,592 375
PF20884 MUM1-like_PWWP 1,196 536 155
PF20887 PWP3A-B_N 801 346 89
PF21094 Nup188_SH3-like 1,869 601 72
PF21193 NMD_SH3 4,402 1,719 336
PF21196 PcrA_UvrD_tudor 29,294 13,381 1,992
PF21409 Ski2_beta-barrel 138 92 9
PF21485 IF5A-like_N 10,473 4,306 840
PF21530 Pif1_2B_dom 16,967 12,049 6,438
PF21743 PTM_DIR17_Tudor 2,478 1,481 847
PF21744 BAHCC1-like_Tudor 2,467 1,314 309
PF21838 DUF6897 451 290 107
PF21979 Hfq_1 1,087 663 160
PF21992 DUF6927 617 269 101
PF22010 OrtA 731 554 95
PF22253 DUF6948 177 154 70
PF22269 TagH_SH3-like 174 62 8
PF22283 DUF6960 174 127 49
PF22333 Ago_PAZ_arc 1 2 1
PF22520 Crb2_Tudor 3 4 2
PF22682 Ribosomal_uL24m-like 1,124 593 176
PF22732 MSL3_chromo-like 4,886 2,317 814
PF22845 DUF3097_N 4,513 1,910 61
PF22987 KDM3B_Tudor 3,451 1,281 201
PF22988 PWWP_KDM3B 2,945 1,172 193
PF22989 DUF7030 1,978 800 165
CL0012 Histone 204,013 70,338 23,811 PF00125 Histone 108,389 26,465 9,143
PF00808 CBFD_NFYB_HMF 31,778 15,687 5,325
PF02269 TFIID-18kDa 7,117 3,039 926
PF02291 TFIID-31kDa 4,950 2,060 653
PF02969 TAF 5,553 2,290 822
PF03540 TFIID_30kDa 3,822 1,802 538
PF03847 TFIID_20kDa 4,748 2,350 886
PF04719 TAFII28 4,080 2,127 766
PF05236 TAF4 6,583 2,895 974
PF07524 Bromo_TP 9,460 4,332 1,503
PF09123 DUF1931 821 287 82
PF09415 CENP-X 2,537 1,569 590
PF15510 CENP-W 894 452 122
PF15511 CENP-T_C 9,838 3,298 1,241
PF15630 CENP-S 2,838 1,547 562
PF15715 PAF 924 512 166
PF17027 Bromo_TP_like 54 44 33
CL0013 Beta-lactamase 589,952 334,425 86,294 PF00144 Beta-lactamase 203,675 132,180 40,104
PF00768 Peptidase_S11 69,685 35,880 8,953
PF00905 Transpeptidase 226,724 119,230 24,317
PF02113 Peptidase_S13 26,786 16,530 5,284
PF04960 Glutaminase 21,312 8,503 1,271
PF13354 Beta-lactamase2 41,938 22,303 6,461
CL0014 Glutaminase_I 761,810 387,893 58,822 PF00117 GATase 291,891 134,533 14,157
PF01174 SNO 16,840 9,088 1,015
PF01965 DJ-1_PfpI 148,520 73,084 9,696
PF02016 Peptidase_S66 25,983 15,009 2,666
PF03575 Peptidase_S51 24,578 14,829 3,391
PF04204 HTS 12,653 5,435 504
PF06283 ThuA 31,354 20,274 3,986
PF07090 GATase1_like 6,534 3,805 1,434
PF07685 GATase_3 47,750 23,890 2,562
PF07722 Peptidase_C26 31,933 18,211 4,757
PF08532 Glyco_hydro_42M 16,787 10,299 2,387
PF09822 ABC_transp_aux 17,498 12,113 4,550
PF09825 BPL_N 4,269 2,644 1,012
PF13507 GATase_5 47,172 22,502 1,941
PF13709 DUF4159 12,203 8,289 1,648
PF14258 DUF4350 10,022 6,962 2,676
PF17124 ThiJ_like 2,272 1,254 203
PF17385 LBP_M 1,474 637 87
PF18011 Catalase_C 11,856 5,055 343
PF21455 PylD_N 280 190 86
CL0015 MFS 2,284,299 1,122,885 266,737 PF00083 Sugar_tr 330,400 151,120 39,562
PF00854 PTR2 73,102 34,170 7,478
PF01306 LacY_symp 3,272 881 225
PF01733 Nucleoside_tran 12,430 5,869 1,883
PF01770 Folate_carrier 5,311 2,537 859
PF02487 CLN3 4,683 2,669 954
PF03092 BT1 10,649 5,869 2,023
PF03137 OATP 17,316 7,415 2,878
PF03209 PUCC 4,215 2,693 474
PF03219 TLC 4,546 3,015 1,356
PF03825 Nuc_H_symport 9,926 4,196 704
PF04884 UVB_sens_prot 6,891 3,783 1,374
PF05631 MFS_5 4,978 2,370 908
PF05977 MFS_3 56,317 32,961 8,960
PF05978 UNC-93 12,251 5,937 1,997
PF06237 SLC52_ribofla_tr 3,598 1,713 657
PF06609 TRI12 5,254 3,320 1,142
PF06779 MFS_4 10,624 5,079 1,136
PF06813 Nodulin-like 9,160 4,584 1,247
PF06963 FPN1 5,108 2,703 1,053
PF07672 MFS_Mycoplasma 125 61 27
PF07690 MFS_1 1,614,560 800,444 183,331
PF11700 ATG22 23,605 13,722 2,406
PF12832 MFS_1_like 21,447 11,807 4,752
PF13000 Acatn 7,056 3,708 1,155
PF13347 MFS_2 56,000 27,175 7,834
PF18943 DUF5690 1,962 1,209 267
PF23021 PGAP2IP_TM_2nd 2,472 1,035 168
PF23022 PGAP2IP_TM_1nd 2,407 994 150
CL0016 PKinase 2,659,251 1,364,219 473,359 PF00069 Pkinase 1,550,557 788,485 293,129
PF00454 PI3_PI4_kinase 60,018 27,373 7,695
PF01163 RIO1 24,418 12,420 3,090
PF01504 PIP5K 30,227 12,583 3,803
PF01633 Choline_kinase 19,790 10,170 3,490
PF01636 APH 202,878 126,085 37,874
PF02816 Alpha_kinase 11,858 6,252 2,879
PF02958 EcKL 14,525 10,216 4,613
PF03109 ABC1 74,918 37,962 9,248
PF03770 IPK 14,368 6,556 2,426
PF03881 Fructosamin_kin 17,996 10,830 2,652
PF04183 IucA_IucC 14,601 7,038 1,228
PF04655 APH_6_hur 8,242 4,914 1,087
PF05445 Pox_ser-thr_kin 174 55 23
PF06090 Ins_P5_2-kin 4,469 2,399 1,117
PF06176 WaaY 1,722 306 186
PF06293 Kdo 22,080 11,379 4,192
PF06315 AceK_kinase 6,162 2,160 289
PF06702 Fam20C 5,342 1,918 560
PF06734 UL97 483 30 16
PF07387 Seadorna_VP7 58 34 18
PF07714 PK_Tyr_Ser-Thr 474,922 233,453 86,666
PF07804 HipA_C 26,284 15,883 3,751
PF07914 DUF1679 2,203 1,727 1,090
PF08757 CotH 20,214 15,916 8,565
PF09192 Act-Frag_cataly 973 439 176
PF10009 DUF2252 10,558 5,671 1,101
PF10140 YukC 1,224 469 211
PF10707 YrbL-PhoP_reg 1,839 864 391
PF12260 PIP49_C 6,844 1,906 629
PF12330 Haspin_kinase 3,560 2,302 1,078
PF13095 FTA2 1,118 778 376
PF13575 DUF4135 3,196 2,214 1,238
PF14531 Kinase-like 656 192 133
PF16474 KIND 4,460 2,227 570
PF17667 Pkinase_fungal 16,302 13,880 8,225
PF18101 Pan3_PK 4,302 1,857 525
PF18762 Kinase-PolyVal 538 379 169
PF19250 DUF5898 95 85 66
PF19974 TCAD9 655 559 380
PF20613 HipA_2 6,005 3,414 691
PF22303 OspG_kinase 315 137 70
CL0018 bZIP 116,745 49,976 17,728 PF00170 bZIP_1 76,835 32,634 11,093
PF03131 bZIP_Maf 13,451 4,404 1,327
PF07716 bZIP_2 26,474 13,278 6,051
CL0020 TPR 3,291,539 1,760,277 685,857 PF00244 14-3-3 21,344 6,388 2,010
PF00514 Arm 75,348 26,277 7,726
PF00515 TPR_1 119,755 64,543 34,742
PF00613 PI3Ka 20,136 7,738 1,767
PF00637 Clathrin 21,580 7,479 1,943
PF00790 VHS 26,751 10,600 2,306
PF00806 PUF 22,430 11,300 3,949
PF00888 Cullin 32,565 13,409 4,631
PF01239 PPTA 11,629 6,283 2,141
PF01347 Vitellogenin_N 10,891 5,506 2,374
PF01365 RYDR_ITPR 13,789 8,559 1,190
PF01417 ENTH 15,786 6,899 1,900
PF01535 PPR 200,092 113,748 43,231
PF01602 Adaptin_N 51,457 21,118 4,463
PF01603 B56 17,724 6,009 1,402
PF01749 IBB 14,028 3,728 930
PF01816 LRV 1,482 1,127 583
PF01843 DIL 19,972 9,197 1,696
PF01851 PC_rep 11,484 3,757 803
PF02020 W2 20,440 7,857 1,731
PF02071 NSF 14 14 14
PF02184 HAT 4,053 1,444 282
PF02259 FAT 17,524 9,240 2,564
PF02847 MA3 24,129 10,684 2,809
PF02854 MIF4G 35,094 16,165 5,054
PF02985 HEAT 28,693 12,809 5,689
PF03081 Exo70_C 14,727 6,593 2,030
PF03097 BRO1 15,346 6,525 1,942
PF03130 HEAT_PBS 11,846 8,647 4,996
PF03177 Nucleoporin_C 7,724 3,692 1,203
PF03224 V-ATPase_H_N 5,646 2,107 656
PF03377 TAL_effector 388 203 78
PF03378 CAS_CSE1 4,792 1,891 630
PF03635 Vps35 5,854 2,137 728
PF03704 BTAD 50,379 37,862 16,048
PF03810 IBN_N 47,350 16,773 4,070
PF03914 CBF 12,419 6,089 1,826
PF04048 Sec8_N 4,101 1,746 475
PF04049 ANAPC8 5,090 1,862 601
PF04050 Upf2 4,284 1,813 473
PF04054 Not1 6,914 3,011 755
PF04078 Rcd1 5,709 2,113 682
PF04090 Rrn11 1,148 763 316
PF04091 Sec15_C 7,089 2,427 543
PF04097 Nic96 4,815 1,951 675
PF04100 Vps53_N 5,237 2,157 627
PF04118 Dopey_N 5,233 2,492 601
PF04124 Dor1 4,169 2,139 754
PF04129 Vps52_CC 4,204 1,865 527
PF04136 COG3_N 4,397 1,905 579
PF04177 TAP42 4,218 2,286 760
PF04184 ST7 5,391 1,504 344
PF04190 GET4 4,260 1,864 556
PF04437 RINT1_TIP1 4,500 2,075 720
PF04733 Coatomer_E 5,155 2,351 854
PF04802 PP4R3 7,407 3,328 957
PF04818 CID 25,874 11,624 3,598
PF04826 Arm_2 3,761 1,412 484
PF04840 Vps16_C 5,536 2,253 786
PF04869 Uso1_p115_head 4,938 2,206 524
PF04910 Tcf25 4,682 2,496 865
PF05004 IFRD 5,907 2,185 769
PF05282 AAR2 3,729 1,874 686
PF05327 RRN3 4,918 2,346 925
PF05470 eIF-3c_N 5,070 2,304 732
PF05484 LRV_FeS 673 434 51
PF05536 Neurochondrin 2,904 1,339 534
PF05804 KAP 3,407 1,321 576
PF05843 Suf 19,462 8,303 2,672
PF05918 API5 3,054 1,201 529
PF06041 DUF924 12,289 7,664 1,469
PF06046 Sec6 8,688 3,453 1,061
PF06060 Mesothelin 2,137 1,357 428
PF06148 COG2_N 4,078 1,863 596
PF06239 ECSIT_N 1,248 695 257
PF06248 Zw10_N 1,745 517 143
PF06292 MUN 18,170 8,590 1,387
PF06367 Drf_FH3 19,472 8,901 1,694
PF06371 Drf_GBD 19,764 9,078 1,708
PF06419 COG6_N 4,074 1,699 479
PF06552 TOM20_plant 2,045 1,170 490
PF06685 DUF1186 825 680 443
PF06920 DHR-2_Lobe_A 23,007 9,982 1,440
PF06957 COPI_C 6,058 2,112 512
PF07219 HemY_N 11,989 5,748 1,450
PF07393 Sec10_HB 6,552 2,700 797
PF07539 UTP20_N 4,201 2,438 883
PF07571 TAF6_C 5,424 2,282 767
PF07575 Nucleopor_Nup85 4,441 2,153 799
PF07651 ANTH 23,988 10,020 1,986
PF07719 TPR_2 69,682 45,894 29,510
PF07720 TPR_3 1,912 867 534
PF07721 TPR_4 8,635 6,858 5,207
PF07817 GLE1 4,189 2,139 882
PF07980 SusD_RagB 89,957 54,078 10,957
PF08144 CPL 3,855 1,819 493
PF08158 SDA1_HEAT 4,658 2,037 597
PF08161 RRP12_HEAT 4,895 2,227 643
PF08163 DNAPKcs_CC3 2,025 1,178 379
PF08166 PELP1_HEAT 667 254 60
PF08167 RIX1 3,231 1,752 660
PF08216 CTNNBL 4,459 1,983 602
PF08238 Sel1 99,710 61,355 31,892
PF08311 Mad3_BUB1_I 5,897 3,262 1,095
PF08314 Sec39 3,750 1,998 569
PF08318 COG4_m 4,666 1,966 595
PF08321 PPP5 6,788 2,645 533
PF08324 PUL 5,911 2,887 803
PF08389 Xpo1 22,385 7,924 2,302
PF08453 Peptidase_M9_N 2,675 984 252
PF08454 RIH_assoc 12,423 7,849 994
PF08506 Cse1 9,754 3,364 962
PF08514 STAG 7,937 2,911 752
PF08558 TRF 2,749 1,332 409
PF08568 Kinetochor_Ybp2 3,642 1,743 623
PF08569 Mo25 6,899 2,416 692
PF08579 RPM2 166 124 71
PF08609 Fes1 4,464 2,187 594
PF08623 TIP120 5,274 1,843 531
PF08631 SPO22 2,589 1,575 613
PF08640 U3_assoc_6 4,160 2,075 647
PF08700 VPS51_Exo84_N 11,232 5,347 1,757
PF08713 DNA_alkylation 26,002 16,571 3,713
PF08767 CRM1_C 6,606 1,960 545
PF08852 DUF1822 2,792 1,834 860
PF09088 MIF4G_like 4,281 1,768 465
PF09090 MIF4G_like_2 4,378 1,825 512
PF09127 Leuk-A4-hydro_C 9,931 4,597 850
PF09246 PHAT 219 101 43
PF09268 Clathrin-link 6,165 1,627 212
PF09295 ChAPs 3,115 1,571 747
PF09450 DUF2019 455 337 115
PF09477 Type_III_YscG 188 45 13
PF09613 HrpB1_HrpK 494 204 102
PF09759 Atx10homo_assoc 3,562 1,908 762
PF09763 Sec3_CC 5,430 2,413 545
PF09770 PAT1 3,680 1,518 328
PF09790 Hyccin 4,261 1,468 458
PF09797 NatB_MDM20 4,494 2,112 851
PF09976 TPR_21 18,549 10,816 4,381
PF09986 DUF2225 2,840 1,890 718
PF10037 MRP-S27 2,221 982 318
PF10189 Ints3_N 2,542 1,157 483
PF10191 COG7 2,995 1,331 596
PF10255 Paf67 5,584 1,447 435
PF10257 RAI16-like 7,002 2,921 776
PF10274 ParcG 3,841 1,830 588
PF10300 Iml2-TPR_39 9,694 4,000 1,322
PF10304 RTP1_C2 2,107 1,154 328
PF10345 Cohesin_load 4,111 1,923 666
PF10350 DUF2428 4,872 2,808 1,155
PF10363 RTP1_C1 3,049 1,799 658
PF10366 Vps39_1 6,092 2,602 762
PF10373 EST1_DNA_bind 10,832 5,140 1,863
PF10374 EST1 7,940 3,534 1,154
PF10392 COG5_N 3,779 1,637 488
PF10474 Syndetin_C 3,149 1,170 433
PF10475 Vps54_N 5,490 2,209 761
PF10487 Nup188_N 2,457 1,027 295
PF10508 Proteasom_PSMB 2,618 1,132 503
PF10516 SHNi-TPR 3,844 1,871 617
PF10579 Rapsyn_N 1,431 338 137
PF10602 RPN7 10,047 3,394 956
PF10858 DUF2659 53 14 9
PF10952 DUF2753 287 94 25
PF11107 FANCF 986 561 200
PF11229 Focadhesin 1,356 584 152
PF11510 FA_FANCE 1,108 510 171
PF11698 V-ATPase_H_C 5,105 1,794 458
PF11701 UNC45-central 4,680 1,699 386
PF11791 Aconitase_B_N 11,524 2,919 185
PF11817 Foie-gras_1 5,284 2,256 751
PF11841 ELMO_ARM 6,236 1,904 345
PF11846 Wzy_C_2 3,077 1,808 684
PF11865 mTOR_dom 4,903 2,034 550
PF11894 Nup192 5,163 2,343 903
PF11935 SYMPK_PTA1_N 4,683 2,278 625
PF11988 Dsl1_N 66 50 28
PF11989 Dsl1_C 138 107 67
PF12022 COG2_C 3,311 1,512 589
PF12031 BAF250_C 5,855 2,401 453
PF12243 CTK3 1,578 812 229
PF12331 Rad26-like_helical_rpts 1,007 502 124
PF12348 CLASP_N 17,236 10,482 2,096
PF12372 Htt_N-HEAT 2,264 1,180 405
PF12432 INTS1_RP2B-bd 1,787 1,094 238
PF12460 MMS19_C 4,883 2,101 612
PF12530 DUF3730 2,244 1,063 392
PF12569 NatA_aux_su 6,843 2,569 759
PF12583 TPPII_C 2,012 629 185
PF12688 TPR_5 3,734 2,336 687
PF12717 Cnd1 7,481 3,868 1,374
PF12719 Cnd3 4,484 2,186 800
PF12741 SusD-like 4,197 2,083 504
PF12753 Nro1 275 203 81
PF12755 Vac14_Fab1_bd 6,002 2,484 655
PF12765 Cohesin_HEAT 5,424 2,706 1,073
PF12771 SusD-like_2 15,369 10,942 2,202
PF12783 Sec7-like_HUS 19,541 8,300 1,797
PF12830 Nipped-B_C 5,100 2,576 857
PF12854 PPR_1 52,445 29,694 11,334
PF12862 ANAPC5 5,878 3,428 2,084
PF12895 ANAPC3 25,305 13,379 7,111
PF12922 Cnd1_N 3,849 1,844 419
PF12968 DUF3856 58 46 11
PF13041 PPR_2 196,857 110,026 38,449
PF13174 TPR_6 75,693 51,318 28,793
PF13176 TPR_7 33,417 20,354 13,087
PF13181 TPR_8 302,103 185,752 103,196
PF13251 DUF4042 2,613 1,166 440
PF13281 MAP3K_TRAF_bd 4,566 2,104 380
PF13371 TPR_9 10,276 5,445 2,416
PF13374 TPR_10 82,071 56,743 34,321
PF13414 TPR_11 96,025 64,450 37,006
PF13424 TPR_12 217,682 147,110 82,813
PF13428 TPR_14 11,180 7,832 5,597
PF13429 TPR_15 5,471 3,816 2,471
PF13431 TPR_17 15,140 10,965 7,972
PF13432 TPR_16 318,141 210,767 110,358
PF13512 TPR_18 483 214 153
PF13513 HEAT_EZ 25,194 9,066 2,407
PF13525 YfiO 31,886 18,890 5,901
PF13646 HEAT_2 100,043 69,083 34,440
PF13812 PPR_3 48,992 29,705 15,184
PF13838 Clathrin_H_link 8,315 2,323 430
PF14322 SusD-like_3 86,196 51,273 10,052
PF14559 TPR_19 218,087 143,080 76,487
PF14561 TPR_20 18,655 9,005 1,461
PF14674 FANCI_S1-cap 963 273 24
PF14675 FANCI_S1 2,195 925 325
PF14676 FANCI_S2 2,282 969 345
PF14677 FANCI_S3 1,640 613 167
PF14678 FANCI_S4 2,384 1,035 406
PF14679 FANCI_HD1 1,939 786 238
PF14680 FANCI_HD2 2,381 1,041 378
PF14718 SLT_L 7,447 3,023 761
PF14763 HPS3_C 1,439 496 149
PF14764 SPG48 1,711 591 173
PF14852 Fis1_TPR_N 3,593 1,548 349
PF14853 Fis1_TPR_C 4,350 2,010 651
PF14863 Alkyl_sulf_dimr 10,044 5,492 988
PF14906 DUF4495 1,242 524 208
PF14929 TAF1_subA 1,804 821 378
PF14938 SNAP 12,269 5,665 2,460
PF15278 Sec3_C_2 4 5 3
PF15469 Sec5 5,520 2,602 816
PF15787 DUF4704 10,365 6,055 1,260
PF16186 Arm_3 14,654 3,842 919
PF16213 DCB 14,433 6,161 1,356
PF16399 Aquarius_N_1st 4,161 1,798 467
PF16415 CNOT1_CAF1_bind 6,043 3,097 826
PF16416 GUN4_N 609 320 38
PF16417 CNOT1_TTP_bind 5,662 2,845 645
PF16418 CNOT1_HEAT 5,200 2,575 525
PF16419 CNOT1_HEAT_N 139 96 26
PF16528 Exo84_C 4,750 1,997 516
PF16782 SIL1 572 339 159
PF16804 DUF5071 679 524 302
PF16811 TAtT 2,653 2,180 911
PF16854 VPS53_C 4,270 1,634 377
PF16918 PknG_TPR 3,584 1,998 378
PF16997 Wap1 53 44 29
PF17004 SRP_TPR_like 3,578 1,405 396
PF17127 DUF5106 2,161 1,464 621
PF17177 PPR_long 14,319 8,239 3,953
PF17432 DUF3458_C 15,120 7,139 984
PF17781 RPN1_RPN2_N 6,422 1,938 512
PF17826 DUF5588 783 411 140
PF17874 TPR_MalT 30,512 20,820 12,399
PF18028 Zmiz1_N 1,500 432 147
PF18055 RPN6_N 4,871 1,417 335
PF18071 HMW1C_N 492 248 50
PF18378 Nup188_C 1,277 645 187
PF18381 YcaO_C 4,721 1,128 101
PF18391 CHIP_TPR_N 1,638 624 176
PF18529 MIX 54 12 5
PF18581 SYCP2_ARLD 903 497 162
PF18710 ComR_TPR 724 214 93
PF18768 RNPP_C 1,709 658 317
PF18770 Arm_vescicular 2,568 992 171
PF18773 Importin_rep 2,018 684 164
PF18777 CRM1_repeat 5,376 1,503 257
PF18786 Importin_rep_2 1,469 311 25
PF18787 CRM1_repeat_3 5,710 1,592 296
PF18794 HSM3_C 116 85 57
PF18795 HSM3_N 332 190 83
PF18797 APC_rep 2,680 1,066 223
PF18806 Importin_rep_3 2,683 947 289
PF18808 Importin_rep_4 5,114 1,844 517
PF18816 Importin_rep_5 2,208 690 114
PF18817 HEAT_UF 41 26 2
PF18829 Importin_rep_6 4,999 1,687 433
PF18833 TPR_22 1,463 746 143
PF18944 DUF5691 2,783 1,697 585
PF19189 Mtf2 1,592 1,036 529
PF19273 Exportin-5 4,665 2,033 724
PF19282 Exportin-T 4,100 1,622 517
PF19424 UNC80 2,455 1,254 405
PF19427 Insc_C 1,482 530 218
PF19440 TTC7_N 3,556 1,210 294
PF19704 DNAPKcs_CC5 2,168 1,269 433
PF19867 DUF6340 1,342 895 417
PF19904 DUF6377 3,032 1,343 485
PF19964 EAD11 827 752 631
PF20023 WSLR 1,309 432 101
PF20052 GAP1-C 416 252 103
PF20103 DUF6493 1,687 1,124 458
PF20168 PDS5 12,153 5,336 2,155
PF20206 Tra1_ring 5,495 3,212 980
PF20210 Laa1_Sip1_HTR5 6,019 3,026 566
PF20225 DUF6584 678 406 142
PF20262 UNC80_C 2,832 1,503 499
PF20308 TPR-S 1,809 1,509 756
PF20416 UTP20_C 4,032 2,324 782
PF20421 DHR-2_Lobe_C 23,648 10,159 1,376
PF20425 Neurobeachin 6,227 3,621 485
PF20431 E_motif 76,717 41,313 10,347
PF20468 HPS6_C 786 224 61
PF20500 DNA-PKcs_N 2,083 1,227 439
PF20502 DNAPKcs_CC1-2 2,018 1,185 401
PF20518 Apc1_MidN 2,667 1,319 358
PF20649 COG5_C 3,953 1,703 524
PF20651 EXOC6_Sec15_N 6,930 2,312 476
PF20652 Sec8_C 3,254 1,351 332
PF20653 COG6_C 4,491 1,943 635
PF20654 Sec3_C-term 5,598 2,519 534
PF20655 Vps52_C 4,362 1,946 597
PF20662 COG4_C 4,521 1,849 545
PF20663 COG4_N 4,266 1,703 462
PF20665 Zw10_middle 2,716 1,084 418
PF20666 ZW10_C 2,797 1,163 500
PF20667 Sec10_N 4,380 1,479 361
PF20669 Exo70_N 10,679 4,167 894
PF20671 COG3_C 4,695 2,113 728
PF20867 UVSSA_N 1,962 1,021 350
PF20925 Htt_bridge 1,695 794 183
PF20926 Htt_N-HEAT_1 2,115 1,035 317
PF20927 Htt_C-HEAT 2,287 1,085 352
PF20998 Nol11_C 1,373 526 157
PF21033 RMD1-3 6,006 3,016 1,116
PF21035 CCDC138_C 1,247 453 153
PF21040 CEP104-like_TOG 10,634 6,580 1,182
PF21041 XMAP215_CLASP_TOG 12,541 7,713 1,214
PF21044 CIP2A_N 1,441 508 200
PF21045 INT10 2,047 554 201
PF21047 Maestro_HEAT 4,975 2,369 718
PF21049 CFA69_ARM_rpt 1,680 844 360
PF21050 ARMC9_ARM 2,175 872 309
PF21052 EFR3_ARM 6,070 1,804 342
PF21055 ZSWIM4-8_C 5,019 1,954 292
PF21058 Stereocilin 727 461 148
PF21071 LARP1_HEAT 5,126 2,275 646
PF21072 EFR3 1,651 928 270
PF21093 Nup188_N-subdom_III 3,087 1,384 397
PF21119 RYDR_Jsol 6,002 3,879 446
PF21170 FAN1_TPR 3,598 1,848 591
PF21232 Yme1-like_N 1,336 583 78
PF21245 PI4KB-PIK1_PIK 4,134 1,847 446
PF21246 Usp38-like_N 1,933 583 161
PF21259 Rgg_C 4,897 1,667 910
PF21289 EDC4_C 3,333 1,670 464
PF21325 SHPRH_helical-1st 2,050 1,032 322
PF21505 RPN2_N 4,839 1,964 441
PF21545 T7SS_EccA1_N 2,919 1,041 243
PF21547 TTI1 3,678 1,969 706
PF21581 SCD 8,637 3,109 791
PF21587 AP5B1_N 412 177 36
PF21588 AP5B1_middle 987 508 174
PF21603 Bdbt-like_TPR 115 75 20
PF21719 MIOS_a-sol 3,153 1,408 491
PF21810 DUF6880 1,805 1,257 503
PF22037 PSD13_N 4,928 1,767 484
PF22061 CSN7_HB_subdom 3,821 1,505 402
PF22063 Pdc1_Ge1 6 7 3
PF22103 ElaD_SseL-like_N 1,291 67 33
PF22120 T6SS_Tse3_N 26 16 10
PF22121 MtxA_C 123 85 37
PF22241 PSMD12-CSN4_N 9,558 2,979 760
PF22256 BDI_1685-like_C 92 50 12
PF22316 ABhydrolase-like_N 612 291 174
PF22329 Nro1_C 6 7 3
PF22330 Rib_mS39_PPR 1,548 721 277
PF22459 PrgX_C_TPR 13 7 7
PF22493 PUF_NOP9 4,922 2,818 1,163
PF22575 Vir1p 64 51 36
PF22591 eIF3a_PCI_TPR-like 4,779 2,141 557
PF22646 PPP2R1A-like_HEAT 10,487 2,996 594
PF22695 EST1-like_DNA_bind 44 34 23
PF22766 ZW10_C2 4,057 1,862 667
PF22788 COP9_hel_rpt 4,386 1,872 706
PF22860 DUF7017 597 427 260
PF22871 AimR 1,197 533 231
PF22890 TPR_EMC2 4,107 1,748 493
PF22927 INT1_R3 1,639 1,000 200
PF22928 INTS1_R4 1,574 979 186
PF22929 INTS1_INTS2-bd 1,745 1,084 240
PF22940 CNOT1_1st 1,964 949 95
PF22956 VPS15-like_hel 4,123 1,714 424
PF22958 Ltn1_1st 3,255 1,672 581
PF22964 ZER1-like_2nd 4,502 1,407 570
PF22999 LTN1_E3_ligase_6th 4,026 1,978 727
CL0021 OB 2,315,848 1,010,961 179,194 PF00164 Ribosom_S12_S23 66,850 11,502 1,389
PF00181 Ribosomal_L2 68,613 17,824 1,205
PF00252 Ribosomal_L16 71,546 17,090 1,694
PF00313 CSD 128,616 45,137 7,314
PF00366 Ribosomal_S17 52,750 20,804 2,591
PF00436 SSB 84,442 43,722 9,138
PF00575 S1 229,467 97,612 15,267
PF00900 Ribosomal_S4e 9,490 3,719 975
PF01132 EFP 46,395 16,503 1,275
PF01176 eIF-1a 61,706 13,372 1,767
PF01200 Ribosomal_S28e 6,972 2,427 564
PF01287 eIF-5a 9,272 3,411 748
PF01330 RuvA_N 41,131 20,949 2,962
PF01336 tRNA_anti-codon 201,610 93,666 12,235
PF01588 tRNA_bind 92,773 46,016 5,991
PF01796 OB_aCoA_assoc 32,782 20,613 4,173
PF01938 TRAM 78,207 39,128 6,270
PF01957 NfeD 39,668 24,477 6,596
PF02303 Phage_DNA_bind 370 240 91
PF02721 DUF223 5,626 3,996 2,551
PF02760 HIN 838 344 156
PF02765 POT1 4,110 2,304 1,061
PF03100 CcmE 19,266 10,471 1,738
PF03120 DNA_ligase_OB 49,608 26,188 2,931
PF03319 EutN_CcmL 10,826 6,259 838
PF03459 TOBE 41,035 20,153 3,135
PF03870 RNA_pol_Rpb8 4,333 1,642 487
PF03919 mRNA_cap_C 4,921 2,269 696
PF04057 Rep-A_N 5,590 2,528 838
PF04076 BOF 5,087 1,685 553
PF04679 DNA_ligase_A_C 48,850 27,368 4,000
PF04717 Phage_base_V 35,278 18,382 5,367
PF06075 DUF936 2,576 1,288 354
PF06125 DUF961 2,388 294 87
PF06714 Gp5_OB 1,012 271 148
PF07076 DUF1344 1,523 578 188
PF07290 YqiJ_OB 2,369 895 197
PF07404 TEBP_beta 24 18 11
PF07497 Rho_RNA_bind 38,221 14,405 1,323
PF07717 OB_NTP_bind 64,008 26,158 5,210
PF08206 OB_RNB 26,116 11,639 1,925
PF08292 RNA_pol_Rbc25 4,067 1,788 538
PF08402 TOBE_2 122,694 56,397 6,844
PF08585 RMI1_N_C 6,196 3,331 1,404
PF08646 Rep_fac-A_C 13,352 7,627 3,694
PF08661 Rep_fac-A_3 3,773 2,020 713
PF08804 gp32 1,609 587 224
PF09103 BRCA-2_OB1 2,719 1,635 773
PF09104 BRCA-2_OB3 1,267 748 273
PF09285 Elong-fact-P_C 47,122 17,004 1,317
PF09883 DUF2110 889 458 106
PF10246 MRP-S35 1,387 771 285
PF10341 TPP1 967 545 301
PF10447 EXOSC1 3,868 1,768 414
PF10451 Stn1 1,765 1,024 396
PF10991 Enc34_ssDNA-bd 2,944 1,221 427
PF11325 DUF3127 5,077 2,871 497
PF11506 DUF3217 18 10 6
PF11604 CusF_Ec 11,093 6,095 1,641
PF11736 DUF3299 6,472 3,219 1,059
PF11967 RecO_N 40,610 22,367 5,988
PF12658 Ten1 813 532 162
PF12667 NigD_N 1,508 562 185
PF12857 TOBE_3 7,073 2,300 158
PF12869 tRNA_anti-like 2,385 1,936 1,166
PF13114 RecO_N_2 637 242 31
PF13509 S1_2 11,035 5,039 666
PF13742 tRNA_anti_2 38,832 21,083 3,954
PF14444 S1-like 2,641 962 287
PF14481 Fimbrial_PilY2 43 24 18
PF14743 DNA_ligase_OB_2 4,850 2,948 864
PF15072 HROB 2,237 1,376 708
PF15490 Ten1_2 1,591 832 350
PF15793 SHLD2_C 793 329 85
PF16099 RMI1_C 1,767 896 358
PF16100 RMI2 1,315 711 257
PF16450 Prot_ATP_ID_OB_C 30,506 6,570 1,037
PF16669 TTC5_OB 1,634 733 271
PF16686 POT1PC 2,735 1,544 720
PF16745 RsgA_N 11,585 6,300 714
PF16773 Phage_SSB 305 19 7
PF16853 CDC13_N 54 42 27
PF16900 REPA_OB_2 8,352 4,361 1,971
PF16992 RNA_pol_RpbG 194 135 80
PF17092 PCB_OB 16,168 7,220 771
PF17185 NlpE_C 2,029 685 289
PF17191 RecG_wedge 37,663 19,714 3,252
PF17207 MCM_OB 39,124 14,129 3,398
PF17215 Rrp44_S1 4,638 1,595 289
PF17216 Rrp44_CSD1 6,698 2,576 658
PF17244 CDC24_OB3 744 416 186
PF17245 CDC24_OB2 599 317 111
PF17246 CDC24_OB1 594 333 131
PF17746 SfsA_N 12,727 7,231 1,117
PF17758 Prot_ATP_ID_OB_N 5,404 1,534 155
PF17768 RecJ_OB 37,326 20,467 4,403
PF17845 FbpC_C_terminal 34 9 2
PF17847 GlcV_C_terminal 70 29 9
PF17849 OB_Dis3 10,465 4,404 1,221
PF17850 CysA_C_terminal 3,055 1,188 146
PF17875 RPA43_OB 2,730 1,554 552
PF17876 CSD2 28,733 13,844 2,087
PF17877 Dis3l2_C_term 3,241 1,508 416
PF17878 ssDBP 66 34 15
PF17879 DNA_ligase_C 475 143 19
PF17912 OB_MalK 49,438 20,042 1,528
PF18018 DNA_pol_D_N 4,318 2,106 635
PF18233 Cdc13_OB4_dimer 50 39 25
PF18313 TLP1_add_C 3,846 2,183 362
PF18330 Lig_C 674 383 80
PF18352 Gp138_N 2,767 961 389
PF18543 ID 163 122 33
PF18614 RNase_II_C_S1 4,062 2,666 274
PF18691 Cdc13_OB2 29 18 12
PF18693 TRAM_2 27,796 12,817 1,520
PF18914 DUF5666 5,595 4,204 2,627
PF19913 WCOB 1,520 534 140
PF20093 DUF6484 942 567 190
PF21005 MCEL_GT_OB 182 35 4
PF21189 PHA02142 1,330 797 285
PF21191 CvfB_1st 3,124 1,109 118
PF21192 NMD3_OB 4,491 1,784 390
PF21236 PRS7_OB 4,345 793 180
PF21262 RRP40_S1 4,128 2,039 557
PF21265 SBB_T7 656 216 114
PF21266 RRP4_S1 5,265 2,447 562
PF21318 BRCA2DBD_OB2 1,053 598 169
PF21430 DTP-pb9_B-dom 280 24 8
PF21473 Ssb-like_OB 4,421 2,415 828
PF21474 DNApolII_N 4,159 931 85
PF21543 CvfB_2nd 3,893 1,484 145
PF21579 PabTrmU54_TRAM_dom 93 54 2
PF21634 MOV-10_beta-barrel 4,486 2,373 735
PF21669 SHLD2_OB1 1,145 508 147
PF21710 Spt6_S1 2,468 1,060 249
PF22062 DPOA2_OB 3,907 1,980 628
PF22221 NigD_N-like 144 44 26
PF22236 TEBP_OB2-like 32 27 15
PF22287 TraI-like_C 322 124 51
PF22379 MCM10_OB 3,417 1,681 619
PF22428 Dis32-like_C 3 4 1
PF22443 FbpC-like_RD 30 6 4
PF22471 Mcm2-like_OB_arc 1 1 1
PF22557 DuOB 884 734 446
PF22657 SSB_1 4,627 1,498 284
PF22707 S1CSD-TOTE-2 295 237 135
PF22708 S1CSD-TOTE-1 179 143 73
PF22779 SHLD2_OB2 754 312 71
PF22858 DUF7016 0 1 1
PF22880 DUF7019 263 206 107
PF22896 RNR_OB1_NT 621 185 34
CL0022 LRR 728,271 383,440 167,789 PF00560 LRR_1 253,375 144,099 59,979
PF01030 Recep_L_domain 16,766 7,517 2,464
PF03382 DUF285 10,063 8,212 5,830
PF05725 FNIP 3,230 2,775 1,802
PF07723 LRR_2 6,679 4,260 2,206
PF07725 LRR_3 6,176 4,073 2,014
PF11921 DUF3439 1,150 753 55
PF12468 TTSSLRR 1,222 106 62
PF12799 LRR_4 53,978 31,015 17,854
PF13306 LRR_5 40,465 27,337 19,817
PF13516 LRR_6 140,107 77,309 37,022
PF13855 LRR_8 387,580 187,984 72,242
PF14580 LRR_9 32,026 14,465 4,782
PF18779 LRR_RI_capping 559 144 32
PF18791 Transp_inhibit 3,277 1,263 199
PF18805 LRR_10 236 81 22
PF18831 LRR_11 193 68 4
PF18837 LRR_12 1,214 225 35
PF19729 FBXL18_LRR 1,144 284 127
PF20919 DHU1_N 653 285 79
CL0023 P-loop_NTPase 12,555,789 6,121,285 1,362,386 PF00004 AAA 605,574 268,491 52,784
PF00005 ABC_tran 3,063,512 1,499,621 220,821
PF00006 ATP-synt_ab 245,452 68,484 5,465
PF00009 GTP_EFTU 500,541 161,310 20,663
PF00025 Arf 73,702 25,989 8,073
PF00063 Myosin_head 107,664 45,924 10,730
PF00071 Ras 289,896 102,925 31,603
PF00142 Fer4_NifH 52,782 9,714 809
PF00154 RecA 70,865 20,427 2,417
PF00158 Sigma54_activat 253,485 136,272 27,857
PF00176 SNF2-rel_dom 193,799 104,008 31,026
PF00225 Kinesin 142,318 68,941 21,741
PF00265 TK 26,433 12,158 1,523
PF00270 DEAD 696,070 337,819 71,599
PF00271 Helicase_C 955,170 466,698 99,683
PF00308 Bac_DnaA 48,629 22,464 4,263
PF00350 Dynamin_N 78,773 36,212 11,311
PF00406 ADK 82,646 39,375 7,697
PF00437 T2SSE 169,549 90,648 14,929
PF00448 SRP54 111,245 49,890 6,900
PF00485 PRK 62,652 27,041 4,969
PF00488 MutS_V 93,384 49,406 11,222
PF00493 MCM 41,288 15,711 4,213
PF00503 G-alpha 37,877 12,987 4,015
PF00519 PPV_E1_C 3,423 877 205
PF00580 UvrD-helicase 163,984 89,413 25,574
PF00625 Guanylate_kin 107,389 46,402 7,287
PF00685 Sulfotransfer_1 65,640 34,813 15,338
PF00693 Herpes_TK 1,235 126 61
PF00709 Adenylsucc_synt 55,002 21,373 2,806
PF00735 Septin 38,214 10,653 2,669
PF00910 RNA_helicase 24,418 5,400 2,913
PF00931 NB-ARC 153,982 105,688 45,610
PF01057 Parvo_NS1 5,431 1,269 715
PF01078 Mg_chelatase 51,962 28,919 3,538
PF01121 CoaE 47,645 29,159 6,970
PF01202 SKI 60,203 33,743 8,352
PF01268 FTHFS 32,561 14,019 1,420
PF01443 Viral_helicase1 16,436 4,366 1,878
PF01580 FtsK_SpoIIIE 73,633 41,411 8,521
PF01583 APS_kinase 37,838 19,136 2,902
PF01591 6PF2K 17,668 5,657 1,176
PF01637 ATPase_2 12,590 7,984 2,826
PF01656 CbiA 103,393 55,014 11,604
PF01695 IstB_IS21 47,955 23,371 7,919
PF01712 dNK 25,422 12,424 2,327
PF01715 IPPT 54,627 33,025 6,355
PF01745 IPT 866 615 440
PF01926 MMR_HSR1 391,830 186,503 30,796
PF01935 DUF87 30,781 19,234 5,794
PF02223 Thymidylate_kin 52,730 31,475 6,508
PF02224 Cytidylate_kin 40,027 22,555 3,184
PF02263 GBP 15,004 6,807 2,810
PF02283 CobU 21,613 12,378 2,039
PF02367 TsaE 42,618 26,168 5,752
PF02374 ArsA_ATPase 28,997 14,217 2,833
PF02399 Herpes_ori_bp 1,376 778 450
PF02421 FeoB_N 33,264 18,938 2,585
PF02456 Adeno_IVa2 808 232 76
PF02463 SMC_N 138,871 73,760 17,816
PF02492 cobW 90,936 42,593 6,422
PF02499 DNA_pack_C 816 155 45
PF02500 DNA_pack_N 536 107 37
PF02534 T4SS-DNA_transf 25,166 11,039 3,953
PF02562 PhoH 59,436 24,386 2,184
PF02572 CobA_CobO_BtuR 24,211 11,158 1,340
PF02606 LpxK 25,746 15,978 4,547
PF02689 Herpes_Helicase 1,721 522 338
PF02702 KdpD 16,721 7,091 854
PF02841 GBP_C 9,337 3,543 1,090
PF03028 Dynein_heavy 27,095 15,051 3,776
PF03029 ATP_bind_1 31,483 11,765 1,879
PF03192 DUF257 594 398 159
PF03193 RsgA_GTPase 39,349 20,714 3,244
PF03205 MobB 14,667 8,660 2,105
PF03215 Rad17 4,705 2,608 1,105
PF03237 Terminase_6N 22,711 11,389 3,510
PF03266 NTPase_1 6,592 4,304 1,923
PF03308 MeaB 32,281 18,888 2,486
PF03354 TerL_ATPase 12,802 5,837 1,402
PF03567 Sulfotransfer_2 28,083 14,754 7,558
PF03618 Kinase-PPPase 18,072 7,155 921
PF03668 RapZ-like_N 25,602 11,352 1,123
PF03796 DnaB_C 63,602 28,597 7,376
PF03846 SulA 3,347 1,088 288
PF03969 AFG1_ATPase 26,673 12,276 2,212
PF03976 PPK2 37,266 20,964 1,813
PF04257 Exonuc_V_gamma 10,633 4,999 1,661
PF04275 P-mevalo_kinase 2,159 1,272 359
PF04310 MukB 2,764 388 103
PF04317 DUF463 5,944 2,148 319
PF04466 Terminase_3 7,540 4,114 1,372
PF04548 AIG1 27,240 18,453 8,562
PF04665 Pox_A32 1,993 697 371
PF04670 Gtr1_RagA 9,709 3,631 1,111
PF04851 ResIII 152,436 76,753 17,557
PF05049 IIGP 4,644 3,210 1,377
PF05127 Helicase_RecD 9,730 4,278 1,159
PF05179 CDC73_C 4,301 1,836 572
PF05272 VapE-like_dom 9,144 3,698 1,720
PF05496 RuvB_N 46,235 19,490 1,347
PF05609 LAP1_C 2,203 993 296
PF05621 TniB 5,484 3,136 1,372
PF05625 PAXNEB 4,362 2,255 728
PF05673 DUF815 12,526 6,131 726
PF05707 Zot 3,239 2,194 1,111
PF05729 NACHT 80,909 55,459 25,713
PF05763 DUF835 2,217 1,597 756
PF05783 DLIC 7,018 2,476 812
PF05872 HerA_C 16,352 8,114 951
PF05876 GpA_ATPase 7,966 3,936 1,383
PF05879 RHD3_GTPase 4,409 2,260 795
PF05894 Podovirus_Gp16 333 247 139
PF05970 PIF1 34,102 23,996 12,219
PF06048 DUF927 4,758 2,759 1,460
PF06068 TIP49 9,917 3,002 737
PF06144 DNA_pol3_delta 30,170 15,596 4,790
PF06309 Torsin 5,490 2,229 618
PF06414 Zeta_toxin 9,225 5,826 2,433
PF06418 CTP_synth_N 53,626 20,573 1,494
PF06431 Polyoma_lg_T_C 2,455 256 98
PF06564 CBP_BcsQ 4,381 2,010 790
PF06733 DEAD_2 31,726 14,957 4,433
PF06745 ATPase 25,631 15,137 4,506
PF06858 NOG1 6,191 2,420 495
PF06911 Senescence 5,315 2,455 813
PF06990 Gal-3-0_sulfotr 5,791 3,165 1,518
PF07015 VirC1 2,210 1,068 311
PF07034 ORC3_N 4,156 2,025 743
PF07088 GvpD_P-loop 494 330 178
PF07517 SecA_DEAD 55,640 27,217 4,024
PF07652 Flavi_DEAD 37,674 3,345 305
PF07693 KAP_NTPase 16,321 10,694 5,876
PF07724 AAA_2 190,974 73,260 8,555
PF07726 AAA_3 73,236 37,339 2,529
PF07728 AAA_5 73,133 37,643 10,167
PF07755 DUF1611 6,345 3,941 440
PF07931 CPT 3,332 2,353 670
PF07999 RHSP 2,454 1,573 491
PF08245 Mur_ligase_M 256,875 140,792 25,525
PF08298 AAA_PrkA 11,333 3,036 414
PF08303 tRNA_lig_kinase 1,836 1,075 260
PF08351 TmcA_N 8,498 3,667 881
PF08423 Rad51 26,549 12,287 3,825
PF08433 KTI12 5,204 3,004 1,085
PF08438 YGR210-like_G4 5,422 2,613 323
PF08477 Roc 14,173 8,097 4,262
PF08903 DUF1846 4,501 2,094 148
PF09037 Sulphotransf 1,931 1,234 633
PF09140 MipZ 4,068 2,133 480
PF09439 SRPRB 4,300 2,184 705
PF09547 SpoIVA_ATPase 4,014 1,669 125
PF09711 Cas_Csn2 787 433 270
PF09807 ELP6 2,496 1,351 461
PF09818 ABC_ATPase 3,845 2,324 466
PF09820 AAA-ATPase_like 17,283 10,163 3,558
PF09848 SLFN-g3_helicase 7,125 4,825 1,360
PF10088 DUF2326 1,966 1,388 587
PF10236 DAP3 4,591 2,260 786
PF10412 TrwB_AAD_bind 9,993 5,443 2,027
PF10443 RNA12 1,730 969 244
PF10483 Elong_Iki1 2,905 1,649 518
PF10609 ParA 72,811 37,116 7,632
PF10649 DUF2478 1,954 1,464 415
PF10662 PduV-EutP 3,435 1,178 279
PF10923 BrxC_BrxD 4,407 2,608 651
PF10996 Beta-Casp 37,783 20,082 3,136
PF11111 CENP-M 1,202 552 169
PF11398 DUF2813 2,464 759 272
PF11496 HDA2-3 967 635 301
PF11602 NTPase_P4 19 11 9
PF12128 DUF3584 1,246 654 303
PF12344 UvrB 43,776 17,337 793
PF12399 BCA_ABC_TP_C 103,424 47,689 4,392
PF12696 TraG-D_C 14,879 7,454 2,840
PF12774 AAA_6 29,135 16,774 4,902
PF12775 AAA_7 27,020 15,521 4,329
PF12780 AAA_8 28,088 15,868 4,481
PF12781 AAA_9 28,000 15,567 4,313
PF12846 AAA_10 5,200 1,567 629
PF12848 ABC_tran_Xtn 128,716 46,299 4,657
PF13086 AAA_11 66,873 38,956 15,796
PF13087 AAA_12 79,524 44,246 17,556
PF13166 AAA_13 5,480 4,020 1,747
PF13173 AAA_14 49,231 33,118 7,235
PF13175 AAA_15 28,711 21,505 10,565
PF13177 DNA_pol3_delta2 95,784 54,626 13,528
PF13189 Cytidylate_kin2 16,586 10,330 3,177
PF13191 AAA_16 90,795 63,804 28,321
PF13207 AAA_17 7,126 4,704 1,765
PF13238 AAA_18 20,220 11,796 3,854
PF13245 AAA_19 32,406 18,072 5,795
PF13304 AAA_21 52,704 38,037 16,096
PF13307 Helicase_C_2 55,496 26,470 6,842
PF13337 BrxL_ATPase 3,532 2,027 376
PF13361 UvrD_C 151,945 82,204 23,405
PF13401 AAA_22 56,264 36,945 15,572
PF13469 Sulfotransfer_3 44,112 30,867 15,304
PF13476 AAA_23 59,217 37,686 17,673
PF13479 AAA_24 7,484 4,092 1,557
PF13481 AAA_25 56,463 26,004 8,217
PF13500 AAA_26 40,311 20,166 3,850
PF13514 AAA_27 6,945 4,562 2,571
PF13521 AAA_28 18,912 11,359 2,984
PF13538 UvrD_C_2 48,428 25,933 6,803
PF13555 AAA_29 6,083 3,449 1,198
PF13558 SbcC_Walker_B 31,590 16,353 5,856
PF13604 AAA_30 33,627 18,337 5,994
PF13614 AAA_31 152,042 76,210 19,193
PF13654 AAA_32 10,683 5,258 1,154
PF13671 AAA_33 66,032 38,015 10,363
PF13871 Helicase_C_4 8,115 3,652 1,004
PF13872 AAA_34 7,877 3,788 1,043
PF14396 CFTR_R 1,527 519 29
PF14417 MEDS 7,389 5,725 2,261
PF14516 AAA_35 8,111 5,621 2,209
PF14532 Sigma54_activ_2 5,935 3,465 1,189
PF14617 CMS1 3,325 1,589 468
PF16203 ERCC3_RAD25_C 12,437 4,519 704
PF16260 DUF4914 794 537 54
PF16575 CLP1_P 10,234 5,621 2,243
PF16796 Microtub_bd 2,130 1,660 1,117
PF16813 Cas_St_Csn2 154 79 46
PF16834 CSM2 57 43 25
PF16836 PSY3 100 78 49
PF17213 Hydin_ADK 841 592 201
PF17784 Sulfotransfer_4 10,869 7,165 3,067
PF18082 NAT_N 1,611 1,206 488
PF18128 HydF_dimer 4,075 2,569 229
PF18133 HydF_tetramer 4,162 2,633 270
PF18747 HMUD2 151 27 12
PF18748 HMUDK_HMUD1 177 28 16
PF18751 Ploopntkinase3 332 46 17
PF18766 SWI2_SNF2 26,476 15,292 2,287
PF19044 P-loop_TraG 23,615 8,609 1,950
PF19263 DUF5906 15,440 8,897 4,966
PF19518 RhoGAP_pG1_pG2 2,905 749 211
PF19557 DUF6079 1,432 1,122 549
PF19568 Spore_III_AA 8,224 4,883 1,034
PF19798 Sulfotransfer_5 4,590 3,171 650
PF19842 YqeC 3,313 2,019 933
PF19975 DO-GTPase1 608 478 245
PF19993 DO-GTPase2 1,940 1,374 620
PF19995 iSTAND 443 373 263
PF20030 bpMoxR 5,554 2,417 782
PF20307 divDNAB 201 86 53
PF20454 GpA_nuclease 7,659 3,902 1,381
PF20692 cpSF2-GREB1 2,183 1,006 153
PF20693 YobI-ATPase 1,135 901 552
PF20702 nSTAND2 303 265 166
PF20703 nSTAND1 16,557 13,737 7,523
PF20720 nSTAND3 4,285 3,517 2,326
PF21090 P-loop_SecA 51,063 24,480 2,743
PF21228 RuBisCO_activase_AAA_helical 2,421 949 166
PF21264 DYNC2H1_AAA_dom 1,637 778 261
PF21445 ADDB_N 7,598 4,126 1,743
PF21448 DNMK 2,294 1,054 573
PF21449 RIF2_ASCE 17 6 1
PF22232 TraI_hel_assoc_N 1,313 282 95
PF22298 Tsr1_G-like 4,269 2,041 442
PF22527 DEXQc_Suv3 11,395 6,135 1,175
PF22590 Cas3-like_C_2 14,609 10,526 3,764
PF22679 UvrB_D3-like 26,109 14,937 2,087
PF22688 Hda_lid 9,788 4,436 1,040
PF22916 UTP25_NTPase-like 4,511 2,299 771
CL0025 His_Kinase_A 1,882,649 1,127,202 406,317 PF00512 HisKA 953,577 576,924 220,148
PF02518 HATPase_c 1,541,839 924,396 338,077
PF02895 H-kinase_dim 28,921 17,327 3,811
PF07536 HWE_HK 17,243 10,959 3,512
PF07568 HisKA_2 27,874 17,596 7,928
PF07730 HisKA_3 169,041 110,873 35,538
PF10090 HPTransfase 4,092 2,300 571
PF13581 HATPase_c_2 99,983 61,835 17,800
PF13589 HATPase_c_3 111,519 55,119 12,167
PF13749 HATPase_c_4 20,979 14,303 4,389
PF14501 HATPase_c_5 15,037 8,430 4,871
PF22561 HisKin-conflict 86 67 61
CL0026 CU_oxidase 330,651 147,375 35,390 PF00116 COX2 116,552 35,903 4,538
PF00127 Copper-bind 28,952 18,525 6,717
PF00394 Cu-oxidase 74,017 33,872 6,315
PF00812 Ephrin 8,063 3,174 875
PF02298 Cu_bind_like 19,691 11,256 4,091
PF06481 COX_ARM 7,895 2,570 246
PF06525 SoxE 967 663 327
PF07731 Cu-oxidase_2 89,867 45,320 9,166
PF07732 Cu-oxidase_3 97,384 48,834 9,197
PF08526 PAD_N 2,534 804 102
PF08985 DP-EP 198 127 53
PF12306 PixA 1,141 566 213
PF13473 Cupredoxin_1 28,108 16,399 5,429
PF14699 hGDE_N 3,607 1,492 254
PF16986 CzcE 523 342 166
CL0027 RdRP 1,003,848 465,044 223,792 PF00078 RVT_1 755,211 357,528 166,457
PF00680 RdRP_1 61,173 9,015 3,723
PF00972 Flavi_NS5 14,307 1,712 218
PF00978 RdRP_2 11,186 2,214 1,059
PF00998 RdRP_3 49,621 6,180 1,134
PF02123 RdRP_4 7,033 1,289 799
PF04197 Birna_RdRp_palm 1,153 47 28
PF05919 Mitovir_RNA_pol 1,995 1,509 1,152
PF07727 RVT_2 99,084 84,260 49,088
PF07925 RdRP_5 525 61 31
PF20049 DUF6451 2,520 2,189 1,032
PF20483 Flavi_NS5_thumb 13,004 1,477 151
PF20488 Birna_VP1_thumb 314 23 13
PF22152 Permu_RdRp_palm 138 71 54
PF22212 CPV_RdRP_pol_dom 295 119 87
CL0028 AB_hydrolase 2,303,644 1,352,642 367,063 PF00135 COesterase 105,034 63,324 22,506
PF00151 Lipase 20,980 10,592 4,415
PF00326 Peptidase_S9 179,730 107,197 27,032
PF00450 Peptidase_S10 58,213 33,175 10,276
PF00561 Abhydrolase_1 535,989 312,128 76,075
PF00756 Esterase 93,892 54,290 13,495
PF00975 Thioesterase 57,492 34,966 14,700
PF01083 Cutinase 16,314 8,586 2,354
PF01674 Lipase_2 6,733 4,256 1,265
PF01738 DLH 88,711 52,863 11,850
PF01764 Lipase_3 50,785 30,392 12,383
PF02089 Palm_thioest 10,509 5,805 2,028
PF02129 Peptidase_S15 55,223 31,831 7,332
PF02230 Abhydrolase_2 44,871 27,046 7,600
PF02273 Acyl_transf_2 285 160 86
PF02450 LCAT 13,526 7,493 3,176
PF03096 Ndr 11,963 3,511 944
PF03283 PAE 10,151 5,469 2,270
PF03403 PAF-AH_p_II 15,700 10,101 3,364
PF03583 LIP 15,060 8,670 2,342
PF03893 Lipase3_N 3,180 1,512 279
PF03959 FSH1 13,896 8,455 3,549
PF04083 Abhydro_lipase 11,662 7,256 2,772
PF04301 BioG 1,309 612 273
PF05057 DUF676 18,022 10,718 4,474
PF05277 DUF726 7,720 4,187 1,330
PF05448 AXE1 12,881 8,492 2,498
PF05576 Peptidase_S37 2,354 1,226 290
PF05577 Peptidase_S28 16,349 9,768 3,766
PF05677 DUF818 353 260 196
PF05705 DUF829 7,919 4,467 1,800
PF05728 UPF0227 11,138 4,989 1,080
PF05990 DUF900 7,973 5,017 2,125
PF06028 DUF915 4,045 1,716 635
PF06057 VirJ 3,496 1,444 461
PF06259 Abhydrolase_8 6,982 4,610 1,353
PF06342 DUF1057 648 481 294
PF06441 EHN 22,371 13,144 1,910
PF06500 FrsA-like 6,516 3,252 801
PF06821 Ser_hydrolase 14,595 7,941 1,821
PF06850 PHB_depo_C 8,137 3,824 311
PF07082 DUF1350 2,385 1,272 478
PF07167 PhaC_N 14,586 7,692 910
PF07176 DUF1400 2,926 1,798 606
PF07224 Chlorophyllase 2,239 1,619 760
PF07519 Tannase 15,008 9,082 2,617
PF07819 PGAP1 11,812 7,143 3,165
PF07859 Abhydrolase_3 124,838 72,517 20,503
PF08237 PE-PPE 3,688 2,157 715
PF08386 Abhydrolase_4 29,703 19,885 6,315
PF08538 DUF1749 3,103 1,778 583
PF08840 BAAT_C 8,497 4,362 1,498
PF09752 ABHD18 3,739 1,740 698
PF09757 Arb2-like 1,653 916 208
PF09994 T6SS_Tle1-like_cat 17,340 11,692 4,077
PF10081 Abhydrolase_9 3,863 2,302 466
PF10142 PhoPQ_related 3,855 2,159 1,012
PF10230 LIDHydrolase 4,341 2,437 1,062
PF10340 Say1_Mug180 606 440 257
PF10503 Esterase_PHB 14,599 9,603 2,792
PF10561 C2orf69 1,728 817 294
PF10605 3HBOH 1,873 1,086 180
PF11144 DUF2920 1,255 428 165
PF11187 Mbeg1-like 3,811 1,915 1,115
PF11288 DUF3089 3,337 2,582 786
PF11339 DUF3141 2,522 1,521 288
PF12048 DUF3530 2,443 1,318 523
PF12146 Hydrolase_4 148,203 88,208 29,360
PF12695 Abhydrolase_5 3,661 2,345 890
PF12697 Abhydrolase_6 231,222 147,453 43,501
PF12715 Abhydrolase_7 2,834 1,997 611
PF12740 Chlorophyllase2 3,816 2,632 1,126
PF16929 Asp2 1,019 435 191
PF19878 DUF6351 1,532 1,179 372
PF20091 Abhydrolase_10 4,306 3,022 961
PF20408 Abhydrolase_11 14,139 8,322 1,603
PF20434 BD-FAE 59,264 40,711 12,694
PF20591 DUF6792 383 276 141
PF21498 Obc1_C 38 15 5
PF22244 GCE_fung 5,901 4,567 1,212
PF22749 Arb2 4,177 2,009 745
CL0029 Cupin 1,668,334 903,512 225,191 PF00027 cNMP_binding 297,462 165,766 49,983
PF00190 Cupin_1 32,703 15,926 4,375
PF00908 dTDP_sugar_isom 40,593 25,560 2,379
PF01050 MannoseP_isomer 23,377 12,136 1,527
PF01238 PMI_typeI_C 3,367 1,382 248
PF01987 AIM24 27,933 12,125 1,805
PF02041 Auxin_BP 859 541 175
PF02311 AraC_binding 105,278 55,075 18,329
PF02373 JmjC 48,980 22,321 6,775
PF02375 JmjN 20,089 9,575 2,221
PF02668 TauD 72,646 39,970 9,826
PF02678 Pirin 61,369 31,036 2,884
PF03079 ARD 10,644 5,061 874
PF03171 2OG-FeII_Oxy 96,049 49,454 10,743
PF03336 Pox_C4_C10 283 70 43
PF04074 DUF386 10,962 4,368 1,447
PF04115 Ureidogly_lyase 10,166 5,178 942
PF04209 HgmA_C 15,415 5,657 521
PF04622 ERG2_Sigma1R 3,218 1,528 318
PF04831 Popeye 4,139 1,534 603
PF04962 KduI 18,437 8,371 759
PF05118 Asp_Arg_Hydrox 15,535 7,442 2,520
PF05523 FdtA 6,774 5,004 921
PF05721 PhyH 85,953 52,843 13,608
PF05726 Pirin_C 37,686 19,461 1,902
PF05899 Cupin_3 19,659 8,389 1,808
PF05962 HutD 7,847 4,330 1,346
PF05995 CDO_I 12,408 6,621 1,529
PF06052 3-HAO 7,485 3,745 448
PF06172 Cupin_5 12,182 7,608 1,253
PF06249 EutQ 3,994 1,690 406
PF06339 Ectoine_synth 5,561 2,125 167
PF06560 GPI 3,134 2,038 493
PF06719 AraC_N 17,114 7,992 1,346
PF06865 Ppnp 7,737 3,006 178
PF07350 Gig2-like 5,338 2,253 465
PF07385 Lyx_isomer 3,364 1,825 213
PF07847 PCO_ADO 4,938 2,553 914
PF07883 Cupin_2 241,820 138,185 29,005
PF08007 JmjC_2 16,465 8,404 2,749
PF08487 VIT 21,774 12,719 4,634
PF08943 CsiD 1,674 341 55
PF09313 DUF1971 4,125 1,375 322
PF09859 Oxygenase-NA 4,805 2,751 197
PF10014 2OG-Fe_Oxy_2 4,593 2,564 573
PF10637 Ofd1_CTDD 3,530 1,815 523
PF11004 Kdo_hydroxy 1,376 623 121
PF11699 CENP-C_C 2,709 1,561 666
PF12851 Tet_JBP 4,216 2,398 779
PF12852 Cupin_6 20,436 11,155 2,091
PF12933 FTO_NTD 1,554 444 131
PF12973 Cupin_7 18,089 11,082 2,465
PF13532 2OG-FeII_Oxy_2 41,916 23,696 5,751
PF13621 Cupin_8 32,255 18,158 6,645
PF13640 2OG-FeII_Oxy_3 59,260 32,482 10,633
PF13661 2OG-FeII_Oxy_4 4,600 2,628 855
PF13757 VIT_2 1,496 682 129
PF13759 2OG-FeII_Oxy_5 6,782 5,065 2,176
PF14033 DUF4246 5,251 3,615 1,485
PF14226 DIOX_N 85,043 44,479 9,279
PF14499 DUF4437 1,608 1,059 337
PF14525 AraC_binding_2 20,486 11,772 4,249
PF16161 DUF4867 1,334 692 139
PF16802 DUF5070 19 14 2
PF16867 DMSP_lyase 2,060 1,266 431
PF17954 Pirin_C_2 20,395 9,720 1,017
PF18637 AUDH_Cupin 360 207 88
PF19480 DUF6016 1,958 965 213
PF20510 HgmA_N 19,191 7,558 715
PF20511 PMI_typeI_cat 24,905 12,887 2,497
PF20515 2OG-FeII_Oxy_6 2,196 1,719 844
PF21621 MPI_cupin_dom 10,956 5,165 962
PF22200 ExsA_N 4,436 2,969 633
PF22404 ToxT_N 12 3 2
PF22814 WelO5 1,159 616 238
CL0030 Ion_channel 496,422 242,676 71,492 PF00060 Lig_chan 56,606 25,266 8,974
PF00520 Ion_trans 244,671 119,197 32,878
PF01007 IRK 17,484 4,305 1,161
PF02386 TrkH 52,686 28,402 5,919
PF03814 KdpA 16,680 6,384 612
PF07885 Ion_trans_2 92,995 52,096 19,148
PF08016 PKD_channel 16,307 8,251 3,806
PF20519 Polycystin_dom 9,761 5,583 2,713
CL0031 Phosphatase 761,834 391,600 93,147 PF00102 Y_phosphatase 92,691 41,139 12,465
PF00581 Rhodanese 281,547 158,687 34,303
PF00782 DSPc 74,602 34,279 11,737
PF01451 LMWPc 82,546 49,456 8,397
PF02302 PTS_IIB 53,149 17,591 2,626
PF02383 Syja_N 25,333 10,586 2,655
PF03162 Y_phosphatase2 6,448 3,684 1,351
PF04179 Init_tRNA_PT 2,280 1,338 374
PF04273 BLH_phosphatase 8,285 4,635 934
PF04343 DUF488 10,587 7,758 1,944
PF04722 Ssu72 4,222 1,760 394
PF05706 CDKN3 1,437 601 207
PF06602 Myotub-related 29,597 10,505 2,634
PF13350 Y_phosphatase3 20,784 12,795 4,435
PF14216 DUF4326 3,157 1,930 947
PF14566 PTPlike_phytase 3,860 1,712 569
PF14671 DSPn 7,122 2,804 831
PF16809 NleF_casp_inhib 83 30 18
PF22740 PapZ_C 28,521 13,239 1,691
PF22741 PTP-NADK 4,180 2,827 1,221
PF22751 DUF488-N3a 2,377 1,467 420
PF22752 DUF488-N3i 10,617 6,283 818
PF22784 PTP-SAK 8,473 5,264 2,251
PF22785 Tc-R-P 14,932 6,883 2,772
CL0032 Dim_A_B_barrel 546,270 275,594 49,907 PF01037 AsnC_trans_reg 165,549 62,711 8,380
PF02426 MIase 5,254 2,223 416
PF03795 YCII 64,134 37,410 5,491
PF03927 NapD 4,022 2,156 716
PF03992 ABM 93,805 52,694 12,050
PF04261 Dyp_perox_N 17,188 7,201 601
PF04486 SchA_CurD 944 459 49
PF04673 Cyclase_polyket 1,718 790 77
PF05336 rhaM 15,427 8,424 894
PF06778 Chlor_dismutase 11,004 5,000 483
PF07045 DUF1330 20,193 11,943 2,316
PF07110 EthD 13,628 8,629 2,619
PF07237 DUF1428 5,914 3,510 287
PF07682 SOR 133 74 20
PF07876 Dabb 24,583 14,722 3,458
PF07978 NIPSNAP 21,692 11,315 2,153
PF08734 GYD 7,748 4,627 943
PF08803 ydhR 2,700 1,321 330
PF09448 MmlI 60 29 6
PF11639 HapK 515 359 73
PF11695 DUF3291 3,607 2,634 467
PF11746 DUF3303 3,526 2,045 594
PF13816 Dehydratase_hem 1,867 935 244
PF13826 Monooxy_af470-like 3,726 2,482 523
PF14026 SCO4226-like 6,172 3,890 595
PF14114 DUF4286 4,197 2,805 786
PF16291 DUF4937 1,450 419 135
PF17074 Darcynin 754 401 102
PF17805 AsnC_trans_reg2 9,300 6,090 853
PF18075 FtsX_ECD 28,935 14,814 3,310
PF18232 Chalcone_N 108 65 14
PF20628 Dyp_perox_C 20,861 9,280 1,213
PF21105 DyP_N 2,636 1,743 437
PF21931 ABM-like 33 24 12
PF22388 DUF6974 199 116 44
PF22482 AsnC_trans_reg_3 2,105 690 106
CL0033 POZ 338,588 140,387 55,490 PF00651 BTB 243,861 107,795 44,040
PF02214 BTB_2 63,846 19,979 6,276
PF03931 Skp1_POZ 14,746 6,885 2,615