EFI - Enzyme Similarity Tool

Pfam Families

These data are sourced from the UniProt and EMBL-EBI InterPro databases.

Clan ID Clan Short Name Clan Size Clan UniRef90 Size Pfam ID Pfam Short Name Pfam Size Pfam UniRef90 Size
CL0001 EGF 98,804 53,061 PF00008 EGF 28,529 16,017
PF00053 Laminin_EGF 13,523 7,578
PF00084 Sushi 19,050 10,430
PF00594 Gla 2,396 1,188
PF01414 DSL 2,049 1,141
PF04863 EGF_alliinase 320 186
PF06247 Plasmod_Pvs28 358 56
PF07645 EGF_CA 29,589 16,944
PF07974 EGF_2 6,567 3,417
PF09014 Sushi_2 277 155
PF09064 Tme5_EGF_like 144 103
PF09289 FOLN 1,209 429
PF09443 CFC 282 164
PF12661 hEGF 10,182 5,439
PF12662 cEGF 7,802 3,854
PF12946 EGF_MSP1_1 2,183 146
PF12947 EGF_3 7,054 3,068
PF14670 FXa_inhibition 12,132 5,960
PF18193 Fibrillin_U_N 570 192
PF18372 I-EGF_1 1,824 745
PF18720 EGF_Tenascin 1,282 640
CL0003 SAM 50,554 22,935 PF00536 SAM_1 26,349 12,414
PF01698 SAM_LFY 1,424 249
PF02198 SAM_PNT 4,119 1,675
PF04904 NCD1 714 288
PF07647 SAM_2 17,038 7,659
PF09235 SAM_Ste50p 61 39
PF09597 IGR 1,000 598
PF13543 SAM_KSR1 627 296
PF18016 SAM_3 2,230 969
PF18017 SAM_4 679 405
PF18255 SAM_DrpA 587 78
PF18609 SAM_Exu 250 135
CL0004 Concanavalin 262,151 147,934 PF00054 Laminin_G_1 5,102 2,883
PF00139 Lectin_legB 7,197 4,885
PF00262 Calreticulin 4,770 2,393
PF00337 Gal-bind_lectin 6,643 3,749
PF00354 Pentaxin 3,327 1,891
PF00426 VP4_haemagglut 6,112 260
PF00457 Glyco_hydro_11 3,486 1,852
PF00622 SPRY 27,609 14,688
PF00629 MAM 8,348 4,561
PF00722 Glyco_hydro_16 30,526 18,395
PF00840 Glyco_hydro_7 6,942 2,080
PF01670 Glyco_hydro_12 3,035 1,670
PF01828 Peptidase_A4 1,686 1,132
PF02210 Laminin_G_2 16,547 8,159
PF02973 Sialidase 579 165
PF03388 Lectin_leg-like 3,614 1,928
PF03935 SKN1 2,359 1,626
PF05592 Bac_rhamnosid 7,811 5,066
PF05735 TSP_C 1,696 705
PF06439 DUF1080 18,529 12,924
PF06955 XET_C 4,614 2,319
PF07081 DUF1349 5,432 2,605
PF07177 Neuralized 1,953 1,032
PF07622 DUF1583 101 66
PF07675 Cleaved_Adhesin 1,104 859
PF07953 Toxin_R_bind_N 303 50
PF08244 Glyco_hydro_32C 16,843 7,901
PF08787 Alginate_lyase2 3,396 1,624
PF08978 Reoviridae_Vp9 36 13
PF09101 Exotox-A_bind 204 41
PF09206 ArabFuran-catal 1,148 666
PF09224 DUF1961 454 286
PF09264 Sial-lect-inser 66 20
PF10287 DUF2401 709 466
PF11476 TgMIC1 18 5
PF11958 DUF3472 1,293 685
PF12248 Methyltransf_FA 1,290 857
PF13385 Laminin_G_3 40,503 28,882
PF13765 PRY 11,583 6,989
PF14099 Polysacc_lyase 2,003 1,426
PF15493 YrpD 158 44
PF16346 DUF4975 445 214
PF16451 Spike_NTD 984 49
PF17689 Arabino_trans_N 2,497 818
PF17851 GH43_C2 12,463 6,646
PF17974 GalBD_like 998 378
PF18239 HA1 6 4
PF18271 GH131_N 1,044 707
PF18483 Bact_lectin 2,471 1,622
CL0005 Kazal 15,148 8,156 PF00050 Kazal_1 5,249 3,265
PF07648 Kazal_2 10,859 5,516
PF18434 Kazal_3 249 128
CL0006 C1 42,912 21,006 PF00130 C1_1 23,681 10,244
PF00569 ZZ 13,708 6,974
PF03107 C1_2 4,167 3,093
PF07975 C1_4 1,358 699
CL0007 KH 185,157 67,885 PF00013 KH_1 70,507 28,380
PF04025 DUF370 4,943 1,893
PF07650 KH_2 55,088 16,803
PF09869 DUF2096 111 81
PF13083 KH_4 19,504 7,682
PF13184 KH_5 26,650 8,685
PF14611 SLS 641 429
PF14955 MRP-S24 477 288
PF15985 KH_6 3,366 1,799
PF16005 MOEP19 374 186
PF17214 KH_7 1,377 567
PF17903 KH_8 2,551 1,288
PF17904 KH_9 1,535 444
PF17905 KH_10 62 52
CL0009 ENTH_VHS 22,228 11,658 PF00790 VHS 9,032 4,690
PF01417 ENTH 5,858 3,318
PF07651 ANTH 7,335 3,652
CL0010 SH3 214,179 100,015 PF00018 SH3_1 50,897 23,918
PF01302 CAP_GLY 10,431 5,940
PF02736 Myosin_N 7,689 3,174
PF03831 PhnA 11,869 3,875
PF06347 SH3_4 5,342 3,422
PF06372 Gemin6 374 217
PF07563 DUF1541 1,268 617
PF07653 SH3_2 19,563 9,040
PF07866 DUF1653 5,366 2,426
PF08239 SH3_3 32,479 16,935
PF08460 SH3_5 2,095 699
PF08810 KapB 1,063 346
PF11095 Gemin7 363 243
PF11302 DUF3104 174 127
PF11607 DUF3247 267 120
PF11623 NdhS 582 251
PF12208 DUF3601 159 55
PF12913 SH3_6 1,853 815
PF13457 GW 2,005 941
PF14603 hSH3 564 323
PF14604 SH3_9 32,582 15,978
PF14627 DUF4453 74 54
PF15505 DUF4648 131 48
PF17384 DUF150_C 18,931 7,510
PF17902 SH3_10 3,064 1,084
PF18103 SH3_11 37 16
PF18129 SH3_12 1,473 860
PF18335 SH3_13 8,016 3,333
PF18343 SH3_14 130 16
PF18346 SH3_15 1,353 633
PF18348 SH3_16 5,220 3,120
PF18350 SH3_17 31 7
PF18354 SH3_18 24 18
PF18597 SH3_19 231 127
PF18697 MLVIN_C 540 252
CL0011 Ig 191,867 88,512 PF00047 ig 14,112 6,512
PF01537 Herpes_glycop_D 595 98
PF01688 Herpes_gI 355 50
PF02124 Marek_A 602 72
PF02440 Adeno_E3_CR1 324 66
PF02480 Herpes_gE 741 107
PF02960 K1 1,154 92
PF03921 ICAM_N 645 317
PF05790 C2-set 528 192
PF07654 C1-set 35,455 8,686
PF07679 I-set 67,327 31,444
PF07686 V-set 49,059 28,366
PF08204 V-set_CD47 401 141
PF08205 C2-set_2 11,873 6,185
PF09085 Adhes-Ig_like 161 73
PF09191 CD4-extracel 216 80
PF09291 DUF1968 150 95
PF10430 Ig_Tie2_1 197 47
PF11465 Receptor_2B4 222 135
PF13895 Ig_2 14,190 7,543
PF13927 Ig_3 53,612 27,778
PF15028 PTCRA 90 53
PF15910 V-set_2 359 141
PF16680 Ig_4 335 196
PF16681 Ig_5 219 135
PF16706 Izumo-Ig 136 69
PF16758 UL141 153 12
PF17736 Ig_C17orf99 503 252
PF17737 Ig_C19orf38 98 66
PF18452 Ig_6 1,396 638
PF18589 ObR_Ig 362 157
CL0012 Histone 96,399 29,138 PF00125 Histone 55,309 8,138
PF00808 CBFD_NFYB_HMF 15,402 8,201
PF02269 TFIID-18kDa 2,943 1,514
PF02291 TFIID-31kDa 1,862 994
PF02969 TAF 2,283 1,055
PF03540 TFIID_30kDa 1,640 900
PF03847 TFIID_20kDa 2,010 1,161
PF04719 TAFII28 1,754 1,075
PF05236 TAF4 2,327 1,314
PF07524 Bromo_TP 3,691 2,042
PF09123 DUF1931 494 149
PF09415 CENP-X 999 634
PF15510 CENP-W 222 119
PF15511 CENP-T_C 4,198 1,149
PF15630 CENP-S 1,108 670
PF15715 PAF 240 115
PF17027 Bromo_TP_like 39 31
CL0013 Beta-lactamase 362,796 169,091 PF00144 Beta-lactamase 115,210 65,073
PF00768 Peptidase_S11 47,941 19,736
PF00905 Transpeptidase 144,573 60,818
PF02113 Peptidase_S13 15,044 7,839
PF04960 Glutaminase 12,863 4,337
PF13354 Beta-lactamase2 27,261 11,413
CL0014 Glutaminase_I 448,982 194,499 PF00117 GATase 173,445 68,096
PF01174 SNO 9,577 4,472
PF01965 DJ-1_PfpI 96,475 40,818
PF02016 Peptidase_S66 16,845 7,898
PF03575 Peptidase_S51 13,504 7,176
PF04204 HTS 9,143 3,154
PF06283 ThuA 14,905 8,903
PF07090 GATase1_like 2,902 1,506
PF07685 GATase_3 29,827 13,307
PF07722 Peptidase_C26 18,680 9,253
PF08532 Glyco_hydro_42M 9,532 5,120
PF09822 ABC_transp_aux 8,213 5,159
PF09825 BPL_N 2,113 1,257
PF13507 GATase_5 27,555 10,856
PF13709 DUF4159 5,802 3,637
PF17124 ThiJ_like 1,488 729
PF17385 LBP_M 1,087 385
PF18011 Catalase_C 7,894 2,860
CL0015 MFS 1,253,275 565,271 PF00083 Sugar_tr 165,858 77,176
PF00854 PTR2 36,159 16,533
PF01306 LacY_symp 3,244 794
PF01733 Nucleoside_tran 4,429 2,639
PF01770 Folate_carrier 1,662 1,050
PF03092 BT1 4,682 2,660
PF03137 OATP 5,377 3,061
PF03209 PUCC 2,854 1,321
PF03219 TLC 2,282 1,407
PF03825 Nuc_H_symport 5,764 2,048
PF05631 MFS_5 1,720 986
PF05977 MFS_3 38,043 19,649
PF05978 UNC-93 3,543 2,179
PF06609 TRI12 2,682 1,704
PF06779 MFS_4 8,068 3,373
PF06813 Nodulin-like 3,534 2,100
PF06963 FPN1 1,872 1,223
PF07672 MFS_Mycoplasma 94 51
PF07690 MFS_1 920,448 406,803
PF11700 ATG22 12,632 6,683
PF12832 MFS_1_like 11,849 5,708
PF13000 Acatn 3,782 1,968
PF13347 MFS_2 32,713 14,834
CL0016 PKinase 1,068,229 597,755 PF00069 Pkinase 590,067 338,286
PF00454 PI3_PI4_kinase 22,197 12,014
PF01163 RIO1 11,412 5,788
PF01504 PIP5K 10,022 5,377
PF01633 Choline_kinase 8,933 4,955
PF01636 APH 121,791 65,442
PF02816 Alpha_kinase 3,222 2,096
PF02958 EcKinase 7,637 5,167
PF03109 ABC1 37,992 17,347
PF03770 IPK 5,761 3,321
PF03881 Fructosamin_kin 9,724 5,302
PF04183 IucA_IucC 10,674 4,338
PF04655 APH_6_hur 4,876 2,644
PF05445 Pox_ser-thr_kin 143 44
PF06090 Ins_P5_2-kin 1,812 1,164
PF06176 WaaY 942 315
PF06293 Kdo 14,244 6,189
PF06315 AceK 4,305 1,171
PF06702 Fam20C 1,363 701
PF06734 UL97 419 31
PF07387 Seadorna_VP7 31 21
PF07714 Pkinase_Tyr 154,351 91,164
PF07804 HipA_C 16,445 9,099
PF07914 DUF1679 1,142 938
PF08757 CotH 10,389 7,412
PF09192 Act-Frag_cataly 342 185
PF10009 DUF2252 6,101 2,967
PF10140 YukC 1,214 366
PF10707 YrbL-PhoP_reg 1,218 586
PF12260 PIP49_C 1,738 799
PF12330 Haspin_kinase 7,931 4,408
PF13095 FTA2 435 302
PF13575 DUF4135 2,084 1,348
PF14531 Kinase-like 607 192
PF16474 KIND 1,068 630
PF17667 Pkinase_fungal 6,578 5,813
PF18101 Pan3_PK 1,751 867
PF18762 Kinase-PolyVal 266 183
CL0018 bZIP 41,151 21,841 PF00170 bZIP_1 27,246 14,149
PF03131 bZIP_Maf 3,668 1,658
PF07716 bZIP_2 10,236 6,141
CL0020 TPR 1,050,013 601,433 PF00514 Arm 22,376 10,085
PF00515 TPR_1 53,083 29,839
PF00613 PI3Ka 6,481 3,117
PF00637 Clathrin 8,157 3,683
PF00806 PUF 8,186 4,656
PF01239 PPTA 4,394 2,641
PF01347 Vitellogenin_N 4,339 2,570
PF01394 Clathrin_propel 2,359 682
PF01535 PPR 70,842 45,925
PF01602 Adaptin_N 19,004 8,474
PF01603 B56 5,463 2,469
PF01749 IBB 4,423 1,622
PF01816 LRV 814 571
PF01851 PC_rep 4,274 1,659
PF02020 W2 6,401 2,827
PF02071 NSF 4 4
PF02184 HAT 1,686 782
PF02259 FAT 6,674 3,744
PF02847 MA3 7,620 4,014
PF02854 MIF4G 11,686 6,206
PF02985 HEAT 8,937 4,762
PF03130 HEAT_PBS 4,709 3,256
PF03224 V-ATPase_H_N 2,249 1,081
PF03377 TAL_effector 614 202
PF03378 CAS_CSE1 1,934 974
PF03704 BTAD 22,894 16,301
PF03810 IBN_N 16,948 7,645
PF04049 ANAPC8 1,507 808
PF04050 Upf2 1,670 836
PF04184 ST7 1,506 472
PF04733 Coatomer_E 2,323 1,194
PF04826 Arm_2 1,337 646
PF04910 Tcf25 1,887 1,202
PF05004 IFRD 2,074 1,006
PF05484 LRV_FeS 419 266
PF05536 Neurochondrin 1,083 600
PF05804 KAP 1,300 688
PF05843 Suf 3,414 1,866
PF05918 API5 1,094 559
PF06041 DUF924 7,508 4,077
PF06367 Drf_FH3 5,333 2,838
PF06371 Drf_GBD 5,438 2,833
PF06552 TOM20_plant 832 559
PF06920 DHR-2 6,599 2,828
PF06957 COPI_C 2,227 964
PF07219 HemY_N 7,987 3,230
PF07571 TAF6_C 2,136 1,081
PF07719 TPR_2 34,474 21,706
PF07720 TPR_3 1,830 764
PF07721 TPR_4 4,237 3,132
PF07980 SusD_RagB 51,700 29,826
PF08144 CPL 1,530 876
PF08167 RIX1 1,340 867
PF08238 Sel1 55,732 31,264
PF08321 PPP5 2,326 1,126
PF08389 Xpo1 8,351 3,995
PF08506 Cse1 3,466 1,579
PF08569 Mo25 2,654 1,181
PF08579 RPM2 118 86
PF08623 TIP120 1,927 894
PF08631 SPO22 961 689
PF08713 DNA_alkylation 15,992 8,307
PF08767 CRM1_C 2,550 971
PF08852 DUF1822 1,266 858
PF09088 MIF4G_like 1,796 924
PF09090 MIF4G_like_2 1,909 993
PF09127 Leuk-A4-hydro_C 3,740 1,981
PF09246 PHAT 129 77
PF09268 Clathrin-link 2,132 573
PF09295 ChAPs 1,937 931
PF09311 Rab5-bind 891 373
PF09450 DUF2019 249 211
PF09613 HrpB1_HrpK 516 178
PF09759 Atx10homo_assoc 1,555 935
PF09976 TPR_21 12,047 5,777
PF09986 DUF2225 1,721 974
PF10037 MRP-S27 742 416
PF10255 Paf67 2,081 710
PF10274 ParcG 1,275 707
PF10300 DUF3808 3,131 1,724
PF10345 Cohesin_load 1,446 778
PF10366 Vps39_1 2,290 1,265
PF10373 EST1_DNA_bind 4,024 2,322
PF10374 EST1 2,785 1,501
PF10508 Proteasom_PSMB 1,137 596
PF10516 SHNi-TPR 1,664 963
PF10579 Rapsyn_N 454 187
PF10602 RPN7 3,846 1,737
PF11698 V-ATPase_H_C 2,074 950
PF11701 UNC45-central 1,552 761
PF11817 Foie-gras_1 1,840 1,048
PF11846 Wzy_C_2 2,384 1,158
PF11865 DUF3385 2,093 978
PF12031 BAF250_C 1,342 634
PF12348 CLASP_N 6,215 3,245
PF12460 MMS19_C 1,566 880
PF12569 NARP1 2,483 1,244
PF12688 TPR_5 2,801 1,409
PF12717 Cnd1 2,946 1,789
PF12719 Cnd3 1,738 1,082
PF12741 SusD-like 2,836 1,261
PF12753 Nro1 167 120
PF12755 Vac14_Fab1_bd 2,552 1,305
PF12765 Cohesin_HEAT 2,336 1,372
PF12771 SusD-like_2 8,191 5,685
PF12830 Nipped-B_C 1,928 1,143
PF12854 PPR_1 21,075 13,516
PF12862 ANAPC5 2,242 1,480
PF12895 ANAPC3 10,495 6,154
PF12968 DUF3856 28 24
PF13041 PPR_2 69,118 44,333
PF13174 TPR_6 29,820 18,758
PF13176 TPR_7 21,192 12,475
PF13181 TPR_8 133,563 82,677
PF13251 DUF4042 965 520
PF13371 TPR_9 6,524 2,687
PF13374 TPR_10 26,881 19,958
PF13414 TPR_11 45,963 30,422
PF13424 TPR_12 78,119 53,906
PF13428 TPR_14 4,995 3,381
PF13429 TPR_15 5,033 2,787
PF13431 TPR_17 6,588 4,532
PF13432 TPR_16 142,345 90,755
PF13512 TPR_18 163 124
PF13513 HEAT_EZ 7,279 3,209
PF13525 YfiO 20,615 10,128
PF13646 HEAT_2 44,884 28,031
PF13812 PPR_3 17,624 11,872
PF13838 Clathrin_H_link 3,132 882
PF14322 SusD-like_3 50,591 28,932
PF14559 TPR_19 82,451 47,371
PF14561 TPR_20 11,642 4,636
PF14852 Fis1_TPR_N 1,634 766
PF14853 Fis1_TPR_C 2,130 1,087
PF14863 Alkyl_sulf_dimr 6,447 3,026
PF14938 SNAP 4,718 2,594
PF16186 Arm_3 4,494 1,662
PF16416 GUN4_N 316 158
PF16811 TAtT 1,251 951
PF16918 PknG_TPR 2,134 1,025
PF17004 SRP_TPR_like 1,560 837
PF17177 PPR_long 5,126 3,378
PF17432 DUF3458_C 9,802 3,925
PF17874 TPR_MalT 17,141 10,282
PF18028 Zmiz1_N 280 125
PF18381 YcaO_C 3,522 659
PF18391 CHIP_TPR_N 569 264
PF18581 SYCP2_ARLD 259 176
PF18710 ComR_TPR 741 198
CL0021 OB 1,225,717 467,785 PF00164 Ribosom_S12_S23 35,876 5,567
PF00181 Ribosomal_L2 37,268 8,897
PF00313 CSD 78,180 23,227
PF00366 Ribosomal_S17 30,763 10,337
PF00436 SSB 53,066 23,645
PF00575 S1 141,166 49,978
PF00900 Ribosomal_S4e 4,308 1,663
PF01132 EFP 29,173 8,467
PF01176 eIF-1a 33,983 6,479
PF01200 Ribosomal_S28e 3,098 950
PF01287 eIF-5a 3,497 1,434
PF01330 RuvA_N 25,373 10,570
PF01336 tRNA_anti-codon 103,041 39,507
PF01588 tRNA_bind 58,366 23,732
PF01796 OB_aCoA_assoc 18,094 9,972
PF01938 TRAM 42,714 17,669
PF01957 NfeD 21,985 11,318
PF02303 Phage_DNA_bind 309 188
PF02721 DUF223 1,513 1,212
PF02760 HIN 375 169
PF02765 POT1 1,710 1,054
PF03100 CcmE 10,703 5,068
PF03120 DNA_ligase_OB 30,204 13,272
PF03319 EutN_CcmL 5,475 2,601
PF03459 TOBE 31,746 12,345
PF03870 RNA_pol_Rpb8 1,911 797
PF03919 mRNA_cap_C 2,189 1,176
PF04057 Rep-A_N 1,992 1,172
PF04076 BOF 4,244 1,206
PF04679 DNA_ligase_A_C 24,950 13,261
PF06125 DUF961 2,008 267
PF07076 DUF1344 950 422
PF07290 DUF1449 2,331 933
PF07404 TEBP_beta 22 13
PF07497 Rho_RNA_bind 22,932 7,189
PF07717 OB_NTP_bind 27,409 12,020
PF08206 OB_RNB 17,858 6,272
PF08292 RNA_pol_Rbc25 1,757 892
PF08402 TOBE_2 72,598 29,035
PF08418 Pol_alpha_B_N 1,242 705
PF08585 RMI1_N 2,513 1,623
PF08646 Rep_fac-A_C 4,512 3,026
PF08661 Rep_fac-A_3 1,673 967
PF08804 gp32 827 433
PF09103 BRCA-2_OB1 1,105 712
PF09104 BRCA-2_OB3 422 253
PF09285 Elong-fact-P_C 29,324 8,597
PF09883 DUF2110 421 205
PF10246 MRP-S35 523 319
PF10341 TPP1 406 271
PF10447 EXOSC1 1,635 912
PF10451 Stn1 641 430
PF10991 DUF2815 1,646 778
PF11325 DUF3127 2,747 1,443
PF11506 DUF3217 20 8
PF11604 CusF_Ec 8,172 3,795
PF11736 DUF3299 4,511 1,787
PF11967 RecO_N 25,134 11,598
PF12658 Ten1 400 269
PF12667 NigD_N 1,218 394
PF12857 TOBE_3 5,633 1,262
PF12869 tRNA_anti-like 1,201 888
PF13114 RecO_N_2 721 142
PF13509 S1_2 8,168 2,909
PF13742 tRNA_anti_2 23,875 10,535
PF14444 S1-like 902 445
PF14481 Fimbrial_PilY2 43 19
PF14743 DNA_ligase_OB_2 2,862 1,658
PF15072 DUF4539 927 580
PF15490 Ten1_2 508 328
PF16099 RMI1_C 595 405
PF16100 RMI2 409 263
PF16450 Prot_ATP_ID_OB 13,558 3,341
PF16669 TTC5_OB 590 332
PF16686 POT1PC 1,125 711
PF16745 RsgA_N 7,661 3,328
PF16773 Phage_SSB 214 13
PF16853 CDC13_N 50 34
PF16900 REPA_OB_2 3,239 2,002
PF16992 RNA_pol_RpbG 77 50
PF17092 PCB_OB 10,588 3,901
PF17185 NlpE_C 1,356 380
PF17191 RecG_wedge 23,042 10,023
PF17207 MCM_OB 17,931 7,227
PF17215 Rrp44_S1 1,807 812
PF17216 Rrp44_CSD1 2,478 1,173
PF17244 CDC24_OB3 342 208
PF17245 CDC24_OB2 263 168
PF17246 CDC24_OB1 250 165
PF17746 SfsA_N 8,162 3,856
PF17758 Prot_ATP_OB_N 3,088 771
PF17768 RecJ_OB 23,378 10,431
PF17845 FbpC_C_terminal 38 6
PF17847 GlcV_C_terminal 44 19
PF17849 OB_Dis3 4,137 2,152
PF17850 CysA_C_terminal 2,130 717
PF17875 RPA43_OB 928 610
PF17876 CSD2 20,263 7,476
PF17878 ssDBP 3 3
PF17879 DNA_ligase_C 171 72
PF17912 OB_MalK 33,059 11,113
PF18018 DNA_pol_D_N 1,870 1,072
PF18352 Gp138_N 1,560 714
PF18543 ID 151 121
PF18614 RNase_II_C_S1 2,097 1,264
PF18691 Cdc13_OB2 24 12
PF18693 TRAM_2 15,562 5,951
CL0022 LRR 235,606 146,787 PF00560 LRR_1 33,885 24,115
PF01030 Recep_L_domain 4,925 2,580
PF03382 DUF285 5,275 4,223
PF05725 FNIP 1,871 1,518
PF07723 LRR_2 2,226 1,773
PF07725 LRR_3 2,435 1,771
PF12468 TTSSLRR 622 151
PF12799 LRR_4 16,660 10,623
PF13306 LRR_5 21,033 14,514
PF13516 LRR_6 47,464 31,247
PF13855 LRR_8 138,116 82,852
PF14580 LRR_9 11,448 6,537
CL0023 P-loop_NTPase 6,737,828 2,896,770 PF00004 AAA 305,647 125,295
PF00005 ABC_tran 1,846,976 768,407
PF00006 ATP-synt_ab 145,379 33,766
PF00009 GTP_EFTU 296,872 76,974
PF00025 Arf 25,163 9,862
PF00063 Myosin_head 33,848 14,712
PF00071 Ras 97,498 41,160
PF00142 Fer4_NifH 46,356 4,730
PF00154 RecA 48,932 9,947
PF00158 Sigma54_activat 149,603 64,765
PF00176 SNF2_N 86,017 46,695
PF00225 Kinesin 46,883 26,439
PF00265 TK 15,685 6,212
PF00270 DEAD 334,760 152,192
PF00271 Helicase_C 485,029 224,330
PF00308 Bac_DnaA 36,159 13,608
PF00350 Dynamin_N 32,147 15,954
PF00406 ADK 42,828 18,258
PF00437 T2SSE 96,805 44,015
PF00448 SRP54 65,373 24,740
PF00485 PRK 36,075 13,506
PF00488 MutS_V 52,245 24,424
PF00493 MCM 19,013 8,002
PF00503 G-alpha 13,051 5,711
PF00519 PPV_E1_C 3,067 729
PF00580 UvrD-helicase 81,955 36,977
PF00625 Guanylate_kin 43,965 18,315
PF00685 Sulfotransfer_1 21,629 13,931
PF00693 Herpes_TK 865 100
PF00709 Adenylsucc_synt 30,990 10,417
PF00735 Septin 12,919 4,483
PF00910 RNA_helicase 15,064 2,922
PF00931 NB-ARC 71,046 50,527
PF01057 Parvo_NS1 3,405 555
PF01078 Mg_chelatase 28,247 13,813
PF01121 CoaE 28,186 14,934
PF01202 SKI 41,051 19,427
PF01268 FTHFS 18,420 7,319
PF01443 Viral_helicase1 8,672 2,093
PF01580 FtsK_SpoIIIE 47,266 22,004
PF01583 APS_kinase 20,497 9,376
PF01591 6PF2K 5,717 2,457
PF01637 ATPase_2 5,914 3,632
PF01656 CbiA 57,059 27,248
PF01695 IstB_IS21 31,531 13,053
PF01712 dNK 13,361 5,877
PF01715 IPPT 31,674 16,500
PF01745 IPT 487 287
PF01926 MMR_HSR1 229,103 92,524
PF01935 DUF87 17,098 9,568
PF02223 Thymidylate_kin 30,872 16,084
PF02224 Cytidylate_kin 24,547 11,482
PF02263 GBP 4,380 2,434
PF02283 CobU 13,943 6,973
PF02367 TsaE 26,204 13,372
PF02374 ArsA_ATPase 14,639 6,563
PF02399 Herpes_ori_bp 939 501
PF02421 FeoB_N 19,660 8,964
PF02456 Adeno_IVa2 417 121
PF02463 SMC_N 77,176 35,840
PF02492 cobW 57,272 22,893
PF02499 DNA_pack_C 725 133
PF02500 DNA_pack_N 508 95
PF02534 T4SS-DNA_transf 16,528 6,792
PF02562 PhoH 36,724 12,394
PF02572 CobA_CobO_BtuR 14,707 5,750
PF02606 LpxK 15,603 8,173
PF02689 Herpes_Helicase 3,998 2,100
PF02702 KdpD 11,138 3,947
PF02841 GBP_C 2,630 1,370
PF03028 Dynein_heavy 8,751 5,530
PF03029 ATP_bind_1 15,242 5,826
PF03192 DUF257 324 261
PF03193 RsgA_GTPase 24,327 10,458
PF03205 MobB 8,996 4,452
PF03215 Rad17 1,986 1,270
PF03237 Terminase_6 11,697 5,928
PF03266 NTPase_1 2,611 1,639
PF03308 MeaB 16,431 8,453
PF03354 Terminase_1 9,875 4,359
PF03567 Sulfotransfer_2 11,387 7,049
PF03618 Kinase-PPPase 12,401 3,823
PF03668 ATP_bind_2 18,129 6,666
PF03796 DnaB_C 38,438 15,238
PF03846 SulA 2,753 731
PF03969 AFG1_ATPase 16,368 6,590
PF03976 PPK2 21,774 10,124
PF04257 Exonuc_V_gamma 9,472 3,851
PF04310 MukB 2,056 261
PF04317 DUF463 4,038 1,307
PF04466 Terminase_3 4,297 2,254
PF04548 AIG1 7,474 4,933
PF04665 Pox_A32 1,496 356
PF04670 Gtr1_RagA 3,668 1,589
PF04851 ResIII 99,664 44,952
PF05049 IIGP 1,146 845
PF05127 Helicase_RecD 5,281 2,487
PF05179 CDC73_C 1,830 978
PF05272 VirE 5,454 2,307
PF05496 RuvB_N 31,313 11,086
PF05609 LAP1C 637 353
PF05621 TniB 3,771 2,031
PF05625 PAXNEB 1,832 1,041
PF05673 DUF815 8,086 3,286
PF05707 Zot 2,519 1,564
PF05729 NACHT 28,526 22,233
PF05783 DLIC 2,459 1,205
PF05872 DUF853 10,427 4,349
PF05876 Terminase_GpA 5,768 2,748
PF05879 RHD3 2,569 1,563
PF05894 Podovirus_Gp16 66 46
PF05970 PIF1 15,374 11,412
PF06048 DUF927 3,368 1,857
PF06068 TIP49 4,379 1,580
PF06144 DNA_pol3_delta 22,628 9,664
PF06309 Torsin 1,487 823
PF06414 Zeta_toxin 6,031 3,417
PF06418 CTP_synth_N 30,702 10,066
PF06431 Polyoma_lg_T_C 2,248 163
PF06564 CBP_BcsQ 3,613 1,540
PF06733 DEAD_2 15,397 7,160
PF06745 ATPase 11,611 6,250
PF06858 NOG1 2,840 1,321
PF06990 Gal-3-0_sulfotr 1,606 1,039
PF07015 VirC1 1,686 749
PF07034 ORC3_N 1,619 1,001
PF07088 GvpD 213 132
PF07517 SecA_DEAD 34,309 13,199
PF07529 HSA 5,288 2,858
PF07652 Flavi_DEAD 31,909 866
PF07693 KAP_NTPase 6,927 4,961
PF07724 AAA_2 114,751 36,517
PF07726 AAA_3 39,348 16,682
PF07728 AAA_5 43,462 19,948
PF07755 DUF1611 3,538 2,022
PF07931 CPT 2,088 1,355
PF07999 RHSP 2,363 1,561
PF08298 AAA_PrkA 7,611 1,663
PF08303 tRNA_lig_kinase 910 566
PF08351 DUF1726 4,490 2,099
PF08423 Rad51 11,565 5,724
PF08433 KTI12 2,173 1,427
PF08438 MMR_HSR1_C 2,393 1,146
PF08477 Roc 4,417 2,894
PF09037 Sulphotransf 1,195 648
PF09140 MipZ 2,551 1,174
PF09439 SRPRB 1,869 1,052
PF09547 Spore_IV_A 2,824 916
PF09711 Cas_Csn2 694 346
PF09807 ELP6 960 594
PF09818 ABC_ATPase 2,265 1,222
PF09820 AAA-ATPase_like 9,629 5,394
PF09848 DUF2075 4,710 2,865
PF10088 DUF2326 1,297 881
PF10236 DAP3 1,850 1,085
PF10412 TrwB_AAD_bind 8,241 4,154
PF10443 RNA12 848 504
PF10483 Elong_Iki1 1,329 828
PF10609 ParA 39,426 17,207
PF10649 DUF2478 1,236 860
PF10662 PduV-EutP 2,557 788
PF10923 DUF2791 2,316 1,177
PF10996 Beta-Casp 18,407 9,504
PF11111 CENP-M 328 183
PF11398 DUF2813 1,992 579
PF11496 HDA2-3 465 330
PF11602 NTPase_P4 11 7
PF12128 DUF3584 840 429
PF12344 UvrB 27,017 8,666
PF12399 BCA_ABC_TP_C 62,868 23,940
PF12696 TraG-D_C 10,505 4,666
PF12774 AAA_6 9,625 6,023
PF12775 AAA_7 8,658 5,560
PF12780 AAA_8 8,766 5,646
PF12781 AAA_9 8,941 5,574
PF12846 AAA_10 7,720 2,571
PF12848 ABC_tran_Xtn 82,566 24,343
PF13086 AAA_11 28,542 17,557
PF13087 AAA_12 35,338 21,140
PF13166 AAA_13 3,857 2,740
PF13173 AAA_14 24,828 15,316
PF13175 AAA_15 18,444 13,006
PF13177 DNA_pol3_delta2 57,832 28,253
PF13189 Cytidylate_kin2 8,586 4,655
PF13191 AAA_16 40,560 27,125
PF13207 AAA_17 3,151 2,132
PF13238 AAA_18 11,837 6,416
PF13245 AAA_19 27,804 15,118
PF13304 AAA_21 31,024 20,506
PF13307 Helicase_C_2 31,817 13,130
PF13337 Lon_2 1,982 1,033
PF13361 UvrD_C 92,125 41,707
PF13401 AAA_22 26,356 15,376
PF13469 Sulfotransfer_3 20,618 13,857
PF13476 AAA_23 32,767 19,393
PF13479 AAA_24 4,286 2,292
PF13481 AAA_25 33,360 13,410
PF13500 AAA_26 29,623 12,445
PF13514 AAA_27 4,457 2,392
PF13521 AAA_28 11,540 5,958
PF13538 UvrD_C_2 33,558 15,640
PF13555 AAA_29 4,299 2,033
PF13558 SbcCD_C 19,341 8,827
PF13604 AAA_30 34,407 16,313
PF13614 AAA_31 94,008 40,140
PF13654 AAA_32 8,010 3,140
PF13671 AAA_33 28,918 15,846
PF13871 Helicase_C_4 3,314 1,614
PF13872 AAA_34 3,333 1,694
PF13892 DBINO 2,274 1,082
PF14396 CFTR_R 296 109
PF14417 MEDS 3,788 2,783
PF14516 AAA_35 4,131 2,770
PF14532 Sigma54_activ_2 3,836 1,990
PF14617 CMS1 1,264 728
PF16203 ERCC3_RAD25_C 6,548 2,403
PF16575 CLP1_P 4,266 2,654
PF16796 Microtub_bd 856 669
PF16813 Cas_St_Csn2 131 62
PF16834 CSM2 53 35
PF16836 PSY3 85 60
PF17213 Hydin_ADK 203 160
PF17784 Sulfotransfer_4 4,574 3,081
PF18128 HydF_dimer 2,383 1,306
PF18133 HydF_tetramer 2,434 1,342
PF18747 Ploopntkinase2 50 14
PF18748 Ploopntkinase1 63 13
PF18751 Ploopntkinase3 164 17
PF18766 SWI2_SNF2 17,521 8,788
CL0025 His_Kinase_A 1,047,649 537,969 PF00512 HisKA 547,820 281,677
PF02518 HATPase_c 840,702 421,027
PF02895 H-kinase_dim 18,506 9,051
PF07536 HWE_HK 10,353 6,184
PF07568 HisKA_2 15,646 8,991
PF07730 HisKA_3 94,316 53,499
PF10090 HPTransfase 2,444 1,227
PF13581 HATPase_c_2 54,095 30,989
PF13589 HATPase_c_3 49,713 25,990
PF14501 HATPase_c_5 13,080 6,627
CL0026 CU_oxidase 193,857 75,271 PF00116 COX2 80,261 20,105
PF00127 Copper-bind 15,248 8,852
PF00394 Cu-oxidase 44,308 18,515
PF00812 Ephrin 2,128 1,023
PF02298 Cu_bind_like 7,169 4,634
PF06481 COX_ARM 6,049 1,614
PF06525 SoxE 443 312
PF07731 Cu-oxidase_2 43,951 21,911
PF07732 Cu-oxidase_3 48,921 24,343
PF08526 PAD_N 578 293
PF08985 DP-EP 147 91
PF12306 PixA 913 415
PF13473 Cupredoxin_1 19,165 9,193
PF14699 hGDE_N 1,328 675
PF16986 CzcE 311 189
CL0027 RdRP 571,638 118,355 PF00078 RVT_1 443,234 85,783
PF00680 RdRP_1 38,812 4,900
PF00972 Flavi_NS5 10,952 562
PF00978 RdRP_2 7,260 1,300
PF00998 RdRP_3 38,894 1,659
PF02123 RdRP_4 4,594 672
PF04197 Birna_RdRp 892 38
PF05919 Mitovir_RNA_pol 519 363
PF07727 RVT_2 26,604 23,220
PF17501 Viral_RdRp_C 19 8
CL0028 AB_hydrolase 1,217,865 661,764 PF00135 COesterase 48,789 30,999
PF00151 Lipase 7,850 4,766
PF00326 Peptidase_S9 93,589 52,189
PF00450 Peptidase_S10 24,319 15,060
PF00561 Abhydrolase_1 235,015 122,532
PF00756 Esterase 55,969 27,361
PF00975 Thioesterase 35,634 19,576
PF01083 Cutinase 9,851 4,835
PF01674 Lipase_2 3,990 2,263
PF01738 DLH 50,436 26,953
PF01764 Lipase_3 22,947 14,417
PF02089 Palm_thioest 5,745 3,414
PF02129 Peptidase_S15 28,603 14,827
PF02230 Abhydrolase_2 23,771 13,056
PF02273 Acyl_transf_2 195 82
PF02450 LCAT 6,149 3,660
PF03096 Ndr 3,681 1,326
PF03283 PAE 3,751 2,206
PF03403 PAF-AH_p_II 7,305 4,696
PF03583 LIP 10,128 4,982
PF03893 Lipase3_N 1,216 688
PF03959 FSH1 6,297 4,028
PF04083 Abhydro_lipase 4,609 3,203
PF04301 DUF452 964 388
PF05057 DUF676 7,428 4,745
PF05277 DUF726 3,521 2,059
PF05448 AXE1 7,441 4,472
PF05576 Peptidase_S37 1,187 583
PF05577 Peptidase_S28 6,491 4,430
PF05677 DUF818 244 167
PF05705 DUF829 3,024 1,890
PF05728 UPF0227 8,294 3,020
PF05990 DUF900 4,848 2,972
PF06028 DUF915 3,656 1,403
PF06057 VirJ 2,573 890
PF06259 Abhydrolase_8 4,483 2,739
PF06342 DUF1057 392 282
PF06441 EHN 10,545 6,379
PF06500 DUF1100 4,255 1,923
PF06821 Ser_hydrolase 10,028 4,728
PF06850 PHB_depo_C 5,074 2,069
PF07082 DUF1350 1,004 578
PF07167 PhaC_N 9,212 4,068
PF07176 DUF1400 1,603 979
PF07224 Chlorophyllase 884 584
PF07519 Tannase 7,627 4,555
PF07819 PGAP1 6,055 3,611
PF07859 Abhydrolase_3 90,431 51,623
PF08237 PE-PPE 3,650 1,918
PF08386 Abhydrolase_4 11,305 7,385
PF08538 DUF1749 1,567 952
PF08840 BAAT_C 3,796 2,381
PF09752 DUF2048 1,703 799
PF09994 DUF2235 9,785 6,538
PF10081 Abhydrolase_9 2,568 1,292
PF10142 PhoPQ_related 1,324 787
PF10230 LIDHydrolase 1,797 1,112
PF10340 Say1_Mug180 427 302
PF10503 Esterase_phd 11,548 7,337
PF11144 DUF2920 386 240
PF11187 DUF2974 3,520 1,589
PF11288 DUF3089 1,751 1,226
PF11339 DUF3141 1,604 865
PF12048 DUF3530 1,794 804
PF12146 Hydrolase_4 109,282 57,373
PF12695 Abhydrolase_5 2,747 1,449
PF12697 Abhydrolase_6 167,257 94,496
PF12715 Abhydrolase_7 1,307 804
PF12740 Chlorophyllase2 3,041 1,970
PF16929 Asp2 846 380
CL0029 Cupin 892,999 444,725 PF00027 cNMP_binding 146,581 75,818
PF00190 Cupin_1 15,269 7,578
PF00908 dTDP_sugar_isom 24,988 13,834
PF01050 MannoseP_isomer 17,879 8,750
PF01238 PMI_typeI 15,507 6,995
PF01987 AIM24 15,587 6,003
PF02041 Auxin_BP 348 212
PF02311 AraC_binding 71,396 31,353
PF02373 JmjC 14,921 8,157
PF02375 JmjN 6,284 3,433
PF02668 TauD 41,614 21,261
PF02678 Pirin 37,459 16,251
PF03079 ARD 6,602 2,737
PF03171 2OG-FeII_Oxy 42,403 23,338
PF03336 Pox_C4_C10 255 59
PF04074 DUF386 7,987 2,576
PF04115 Ureidogly_lyase 6,405 2,770
PF04209 HgmA 10,891 3,941
PF04622 ERG2_Sigma1R 1,379 750
PF04831 Popeye 1,299 683
PF04962 KduI 11,586 4,465
PF05118 Asp_Arg_Hydrox 8,288 3,652
PF05523 FdtA 4,286 2,940
PF05721 PhyH 40,068 24,884
PF05726 Pirin_C 22,317 10,264
PF05899 Cupin_3 12,282 4,660
PF05962 HutD 5,714 2,646
PF05995 CDO_I 7,528 3,661
PF06052 3-HAO 3,820 1,877
PF06172 Cupin_5 6,879 3,946
PF06249 EutQ 2,592 1,016
PF06339 Ectoine_synth 3,623 1,246
PF06560 GPI 1,675 963
PF06719 AraC_N 12,248 5,139
PF06865 Ppnp 5,458 1,651
PF07350 DUF1479 2,819 1,156
PF07385 Lyx_isomer 1,900 891
PF07847 PCO_ADO 1,912 1,105
PF07883 Cupin_2 138,467 68,675
PF08007 Cupin_4 9,920 4,400
PF08487 VIT 6,659 4,306
PF08943 CsiD 1,193 263
PF09313 DUF1971 2,959 836
PF09859 Oxygenase-NA 3,132 1,614
PF10014 2OG-Fe_Oxy_2 3,197 1,512
PF10637 Ofd1_CTDD 1,490 926
PF11699 CENP-C_C 1,050 696
PF12851 Tet_JBP 1,025 556
PF12852 Cupin_6 12,971 6,315
PF12933 FTO_NTD 407 138
PF12973 Cupin_7 9,019 4,995
PF13532 2OG-FeII_Oxy_2 21,050 11,665
PF13621 Cupin_8 13,589 8,261
PF13640 2OG-FeII_Oxy_3 28,801 15,370
PF13661 2OG-FeII_Oxy_4 2,421 1,536
PF13757 VIT_2 323 205
PF13759 2OG-FeII_Oxy_5 4,024 2,940
PF14226 DIOX_N 39,060 21,665
PF14499 DUF4437 962 618
PF14525 AraC_binding_2 15,366 7,629
PF16161 DUF4867 954 426
PF16802 DUF5070 30 14
PF16867 DMSP_lyase 1,190 724
PF17954 Pirin_C_2 13,346 5,048
PF18637 AUDH_Cupin 73 61
CL0030 Ion_channel 182,879 90,444 PF00060 Lig_chan 16,340 9,023
PF00520 Ion_trans 71,157 34,968
PF01007 IRK 4,399 1,520
PF02386 TrkH 32,979 14,894
PF03814 KdpA 11,312 3,612
PF07885 Ion_trans_2 42,652 24,070
PF08016 PKD_channel 4,809 3,143
CL0031 Phosphatase 353,641 171,403 PF00102 Y_phosphatase 26,603 14,200
PF00581 Rhodanese 153,074 76,523
PF00782 DSPc 33,964 18,880
PF01451 LMWPc 49,889 25,502
PF02302 PTS_IIB 45,379 12,484
PF02383 Syja_N 8,748 4,790
PF03162 Y_phosphatase2 3,763 2,253
PF04179 Init_tRNA_PT 1,022 653
PF04273 DUF442 6,983 3,522
PF04722 Ssu72 1,760 848
PF05706 CDKN3 1,136 648
PF06602 Myotub-related 8,157 3,810
PF13350 Y_phosphatase3 13,843 7,505
PF14566 PTPlike_phytase 1,608 922
PF14671 DSPn 2,171 1,094
PF16809 NleF_casp_inhib 107 30
CL0032 Dim_A_B_barrel 321,395 140,146 PF01037 AsnC_trans_reg 105,270 33,867
PF02426 MIase 3,606 1,235
PF03795 YCII 36,982 19,133
PF03927 NapD 2,744 1,242
PF03992 ABM 55,826 27,010
PF04261 Dyp_perox 14,924 5,476
PF04486 SchA_CurD 567 288
PF04673 Cyclase_polyket 1,028 499
PF05336 rhaM 8,731 4,452
PF06778 Chlor_dismutase 6,424 2,336
PF07045 DUF1330 12,328 6,789
PF07110 EthD 7,132 4,161
PF07237 DUF1428 3,533 1,782
PF07682 SOR 84 45
PF07876 Dabb 12,993 7,455
PF07978 NIPSNAP 11,380 5,869
PF08734 GYD 3,583 1,984
PF08803 ydhR 1,882 772
PF09448 MmlI 658 377
PF11639 HapK 285 183
PF11695 DUF3291 1,970 1,335
PF13816 Dehydratase_hem 1,018 493
PF13826 DUF4188 2,011 1,228
PF14026 DUF4242 3,053 1,718
PF16291 DUF4937 1,162 276
PF17805 AsnC_trans_reg2 5,001 2,888
PF18075 FtsX_ECD 17,954 7,629
PF18232 Chalcone_N 78 40
CL0033 POZ 110,556 56,538 PF00651 BTB 80,134 43,694
PF02214 BTB_2 16,856 7,227
PF03931 Skp1_POZ 6,284 3,148
PF07707 BACK 26,945 10,510
PF11822 DUF3342 477 256
PF16017 BTB_3 811 304
CL0034 Amidohydrolase 528,200 250,848 PF00449 Urease_alpha 12,628 3,170
PF00962 A_deaminase 27,618 12,001
PF01026 TatD_DNase 49,113 22,624
PF01244 Peptidase_M19 20,614 10,716
PF01876 RNase_P_p30 2,544 1,565
PF01979 Amidohydro_1 202,525 92,085
PF02126 PTE 5,504 2,640
PF02614 UxaC 7,758 3,427
PF02811 PHP 76,891 35,074
PF04909 Amidohydro_2 67,915 36,640
PF07969 Amidohydro_3 61,834 30,453
PF12228 DUF3604 2,852 2,123
PF12890 DHOase 240 162
PF13263 PHP_C 6,196 3,785
CL0035 Peptidase_MH 435,820 208,556 PF00246 Peptidase_M14 37,836 22,143
PF00274 Glycolytic 9,863 4,313
PF00883 Peptidase_M17 31,533 14,275
PF01520 Amidase_3 44,108 21,436
PF01546 Peptidase_M20 186,603 81,956
PF02127 Peptidase_M18 11,622 5,177
PF04389 Peptidase_M28 49,074 29,549
PF04952 AstE_AspA 21,880 9,784
PF05013 FGase 13,418 7,114
PF05343 Peptidase_M42 19,070 7,624
PF05450 Nicastrin 1,190 671
PF05908 Gamma_PGA_hydro 1,891 788
PF07454 SpoIIP 3,885 1,728
PF10994 DUF2817 1,694 1,002
PF16254 DUF4910 1,248 789
PF17033 Peptidase_M99 843 250
PF18266 Ncstrn_small 910 517
CL0036 TIM_barrel 1,843,841 786,887 PF00121 TIM 37,896 15,483
PF00215 OMPdecase 34,815 14,717
PF00218 IGPS 26,742 10,986
PF00290 Trp_syntA 25,485 11,031
PF00478 IMPDH 41,540 12,001
PF00490 ALAD 23,933 8,623
PF00682 HMGL-like 84,188 33,576
PF00697 PRAI 22,493 11,406
PF00701 DHDPS 69,673 29,467
PF00724 Oxidored_FMN 75,651 32,846
PF00793 DAHP_synth_1 47,614 16,747
PF00809 Pterin_bind 51,457 22,321
PF00834 Ribul_P_3_epim 32,824 13,292
PF00923 TAL_FSA 32,923 12,321
PF00977 His_biosynth 49,803 18,886
PF01070 FMN_dh 34,608 15,500
PF01081 Aldolase 24,197 10,086
PF01116 F_bP_aldolase 34,216 10,832
PF01168 Ala_racemase_N 76,158 36,356
PF01180 DHO_dh 38,984 17,150
PF01207 Dus 51,318 21,216
PF01261 AP_endonuc_2 114,104 55,282
PF01474 DAHP_synth_2 11,261 3,763
PF01487 DHquinase_I 9,432 4,405
PF01645 Glu_synthase 36,083 13,040
PF01680 SOR_SNZ 10,226 2,706
PF01729 QRPTase_C 25,242 11,480
PF01791 DeoC 34,270 13,565
PF01884 PcrB 4,182 2,127
PF01964 ThiC_Rad_SAM 17,916 5,208
PF02007 MtrH 578 305
PF02581 TMP-TENI 34,339 17,145
PF02679 ComA 2,243 1,374
PF02784 Orn_Arg_deC_N 54,456 21,021
PF03060 NMO 43,319 19,092
PF03102 NeuB 12,411 7,782
PF03437 BtpA 3,197 1,679
PF03599 CdhD 2,733 1,813
PF03740 PdxJ 14,653 6,054
PF03786 UxuA 8,947 3,835
PF03851 UvdE 3,899 1,856
PF03932 CutC 10,674 4,696
PF04055 Radical_SAM 402,416 186,901
PF04095 NAPRTase 19,906 6,889
PF04131 NanE 5,484 2,032
PF04309 G3P_antiterm 3,949 1,355
PF04476 4HFCP_synth 1,327 787
PF04481 DUF561 756 424
PF04898 Glu_syn_central 22,491 7,563
PF05114 DUF692 8,239 4,417
PF05690 ThiG 17,577 5,698
PF06134 RhaA 3,554 1,242
PF06187 DUF993 2,476 1,132
PF07071 KDGP_aldolase 2,098 373
PF08013 Tagatose_6_P_K 3,257 1,095
PF09043 Lys-AminoMut_A 1,229 601
PF09863 DUF2090 3,056 969
PF16552 OAM_alpha 343 201
PF17285 PRMT5_TIM 1,894 981
CL0037 Lysozyme 254,855 117,339 PF00062 Lys 2,483 1,261
PF00182 Glyco_hydro_19 9,468 4,544
PF00912 Transgly 77,256 33,338
PF00959 Phage_lysozyme 11,745 5,053
PF01374 Glyco_hydro_46 1,311 739
PF01464 SLT 84,914 41,115
PF01832 Glucosaminidase 23,388 10,417
PF03998 Utp11 1,792 1,047
PF05497 Destabilase 685 515
PF05838 Glyco_hydro_108 4,135 2,284
PF06737 Transglycosylas 8,022 4,154
PF06871 TraH_2 353 197
PF10464 Peptidase_U40 37 6
PF11508 DUF3218 15 4
PF13406 SLT_2 22,168 10,184
PF13647 Glyco_hydro_80 18 6
PF13702 Lysozyme_like 3,980 868
PF16754 Pesticin 393 291
PF18013 Phage_lysozyme2 2,739 1,367
CL0039 HUP 1,042,248 470,451 PF00133 tRNA-synt_1 102,530 45,009
PF00579 tRNA-synt_1b 70,147 28,863
PF00582 Usp 118,884 62,105
PF00733 Asn_synthase 42,141 23,028
PF00749 tRNA-synt_1c 64,688 28,474
PF00750 tRNA-synt_1d 33,541 14,721
PF00764 Arginosuc_synth 25,765 7,546
PF00875 DNA_photolyase 24,492 13,718
PF01012 ETF 58,202 22,489
PF01171 ATP_bind_3 44,098 22,125
PF01406 tRNA-synt_1e 36,333 16,280
PF01467 CTP_transf_like 85,343 40,216
PF01507 PAPS_reduct 40,904 15,615
PF01747 ATP-sulfurylase 8,001 3,637
PF01902 Diphthami_syn_2 6,554 3,980
PF01921 tRNA-synt_1f 5,747 2,651
PF02540 NAD_synthase 59,199 23,564
PF02568 ThiI 11,906 4,574
PF02569 Pantoate_ligase 22,204 10,714
PF03054 tRNA_Me_trans 31,806 12,811
PF03720 UDPG_MGDP_dh_C 48,863 24,093
PF04244 DPRP 6,384 3,675
PF05636 HIGH_NTase1 5,649 2,431
PF06508 QueC 18,303 7,839
PF06574 FAD_syn 25,905 11,694
PF08218 Citrate_ly_lig 2,660 895
PF09334 tRNA-synt_1g 55,372 23,169
PF10079 BshC 3,827 2,250
PF13603 tRNA-synt_1_2 29,196 11,943
PF16581 HIGH_NTase1_ass 135 89
PF16715 CDPS 652 370
CL0040 tRNA_synt_II 437,645 180,349 PF00152 tRNA-synt_2 89,691 35,146
PF00587 tRNA-synt_2b 114,151 44,966
PF01409 tRNA-synt_2d 34,081 12,664
PF01411 tRNA-synt_2c 40,274 17,614
PF02091 tRNA-synt_2e 14,823 3,661
PF03099 BPL_LplA_LipB 60,348 29,421
PF03590 AsnA 5,196 1,499
PF04017 DUF366 403 250
PF13393 tRNA-synt_His 46,994 20,609
PF16917 BPL_LplA_LipB_2 846 567
PF17759 tRNA_synthFbeta 30,899 14,035
CL0041 Death 22,638 11,415 PF00531 Death 11,327 5,652
PF00619 CARD 6,193 3,275
PF01335 DED 2,091 995
PF02758 PYRIN 2,572 1,290
PF14786 Death_2 253 138
PF16739 CARD_2 765 410
PF18461 Atypical_Card 176 102
CL0042 Flavoprotein 190,725 82,416 PF00258 Flavodoxin_1 44,845 17,637
PF02525 Flavodoxin_2 42,938 16,837
PF03358 FMN_red 79,510 37,116
PF07972 Flavodoxin_NdrI 6,598 1,875
PF12641 Flavodoxin_3 1,870 931
PF12682 Flavodoxin_4 5,683 3,255
PF12724 Flavodoxin_5 9,313 4,965
CL0043 Chelatase 177,667 80,481 PF00148 Oxidored_nitro 19,165 7,878
PF00762 Ferrochelatase 23,375 9,913
PF01297 ZnuA 36,218 16,593
PF01497 Peripla_BP_2 83,360 38,102
PF01903 CbiX 12,416 6,639
PF06180 CbiK 3,042 1,339
PF11844 DUF3364 1,369 406
CL0044 Ferritin 211,947 88,078 PF00210 Ferritin 51,770 18,443
PF00268 Ribonuc_red_sm 26,300 6,824
PF01786 AOX 3,054 1,759
PF02332 Phenol_Hydrox 4,567 1,297
PF02915 Rubrerythrin 21,969 11,146
PF03232 COQ7 7,129 3,321
PF03405 FA_desaturase_2 5,848 1,883
PF03713 DUF305 13,187 7,725
PF04305 DUF455 5,033 2,717
PF05067 Mn_catalase 8,069 2,847
PF05138 PaaA_PaaC 12,336 4,638
PF05974 DUF892 7,427 3,422
PF06175 MiaE 5,675 1,972
PF07875 Coat_F 5,170 2,250
PF09537 DUF2383 4,553 2,428
PF09968 DUF2202 894 701
PF11266 Ald_deCOase 606 253
PF11553 DUF3231 3,013 1,599
PF11583 AurF 6,175 2,155
PF12902 Ferritin-like 1,400 908
PF13628 DUF4142 7,954 4,275
PF13668 Ferritin_2 5,768 3,690
PF13794 MiaE_2 2,203 784
PF14530 DUF4439 1,894 1,072
PF18536 DUF5623 122 86
CL0045 Rubredoxin 31,037 15,047 PF00301 Rubredoxin 15,381 6,401
PF01215 COX5B 1,907 1,027
PF06397 Desulfoferrod_N 2,492 1,495
PF08421 Methyltransf_13 4,878 3,052
PF10276 zf-CHCC 6,375 3,073
CL0046 Thiolase 328,311 140,380 PF00108 Thiolase_N 114,678 39,697
PF00109 ketoacyl-synt 126,152 61,806
PF00195 Chal_sti_synt_N 11,652 4,471
PF01154 HMG_CoA_synt_N 6,775 2,944
PF02797 Chal_sti_synt_C 11,658 4,675
PF02801 Ketoacyl-synt_C 121,826 59,012
PF02803 Thiolase_C 113,032 38,725
PF07451 SpoVAD 3,743 1,385
PF08392 FAE1_CUT1_RppA 4,277 2,265
PF08540 HMG_CoA_synt_C 6,504 2,770
PF08541 ACP_syn_III_C 49,035 20,993
PF08545 ACP_syn_III 43,630 18,164
PF08990 Docking 4,030 2,849
PF13723 Ketoacyl-synt_2 3,991 1,921
PF16197 KAsynt_C_assoc 38,472 25,423
PF18605 PikAIV_N 1,261 842
CL0047 CuAO_N2_N3 6,907 3,366 PF02727 Cu_amine_oxidN2 5,591 2,627
PF02728 Cu_amine_oxidN3 5,629 2,574
PF09248 DUF1965 531 360
CL0048 LolA_LolB 67,113 34,596 PF03548 LolA 16,668 7,718
PF03550 LolB 6,604 2,597
PF03888 MucB_RseB 5,305 2,089
PF04507 DUF576 892 312
PF07044 DUF1329 6,165 2,344
PF07161 LppX_LprAFG 1,390 754
PF07608 DUF1571 870 472
PF09697 Porph_ging 4,610 3,241
PF09865 DUF2092 1,245 923
PF11306 DUF3108 10,621 6,061
PF11659 DUF3261 1,639 771
PF14125 DUF4292 2,648 1,795
PF14371 DUF4412 935 789
PF16584 LolA_2 860 443
PF17131 LolA_like 6,577 4,271
PF18234 VioE 69 36
CL0049 Tudor 157,906 85,054 PF00385 Chromo 21,192 12,759
PF00565 SNase 21,682 13,596
PF00567 TUDOR 9,142 5,427
PF00855 PWWP 12,065 6,088
PF01393 Chromo_shadow 2,734 1,472
PF02294 7kD_DNA_binding 65 10
PF02820 MBT 4,071 1,848
PF04397 LytTR 58,174 30,243
PF05641 Agenet 4,276 2,247
PF06003 SMN 1,927 1,015
PF07039 DUF1325 1,728 947
PF08169 RBB1NT 787 371
PF08605 Rad9_Rad53_bind 212 154
PF09038 53-BP1_Tudor 387 202
PF09465 LBR_tudor 383 200
PF11160 Hva1_TUDOR 3,943 2,330
PF11515 Cul7 786 385
PF11717 Tudor-knot 6,047 3,064
PF12148 TTD 544 257
PF14061 Mtf2_C 708 242
PF15057 DUF4537 431 289
PF16090 DUF4819 448 280
PF16719 SAWADEE 865 538
PF17516 ProQ_C 1,871 336
PF18104 Tudor_2 1,763 652
PF18115 Tudor_3 891 509
PF18336 Tudor_FRX1 1,277 346
PF18337 Tudor_RapA 4,381 933
PF18339 Tudor_1_RapA 4,416 986
PF18358 Tudor_4 564 310
PF18359 TUDOR_5 524 303
PF18380 GEN1_C 664 464
PF18704 Chromo_2 323 223
CL0050 HotDog 343,822 158,484 PF01575 MaoC_dehydratas 61,131 27,205
PF01643 Acyl-ACP_TE 7,948 3,938
PF02551 Acyl_CoA_thio 428 235
PF03061 4HBT 124,463 55,270
PF03756 AfsA 1,767 1,129
PF07977 FabA 35,282 13,083
PF09500 YiiD_C 3,646 1,101
PF10862 FcoT 291 150
PF13279 4HBT_2 32,615 16,229
PF13452 MaoC_dehydrat_N 20,007 9,655
PF13622 4HBT_3 25,906 11,076
PF14539 DUF4442 8,609 3,912
PF14765 PS-DH 28,815 19,600
CL0051 NTF2 229,455 119,923 PF00866 Ring_hydroxyl_B 8,492 3,115
PF02136 NTF2 8,620 4,411
PF02982 Scytalone_dh 683 363
PF03284 PHZA_PHZB 387 180
PF04280 Tim44 11,309 5,264
PF04335 VirB8 8,487 2,521
PF05223 MecA_N 5,390 2,155
PF05494 MlaC 10,987 5,176
PF07080 DUF1348 5,964 2,441
PF07107 WI12 461 322
PF07366 SnoaL 14,608 8,789
PF07858 LEH 2,003 1,058
PF07961 MBA1 337 220
PF08332 CaMKII_AD 4,468 1,609
PF10184 DUF2358 2,324 1,416
PF10429 Mtr2 178 112
PF11393 T4BSS_DotI_IcmL 1,182 597
PF11533 DUF3225 1,986 879
PF12642 TpcC 2,475 845
PF12680 SnoaL_2 58,881 32,431
PF12707 DUF3804 51 33
PF12870 DUF4878 1,419 801
PF12883 DUF3828 2,757 862
PF12893 Lumazine_bd_2 4,235 2,663
PF13026 DUF3887 1,989 1,047
PF13474 SnoaL_3 12,122 7,097
PF13577 SnoaL_4 22,196 12,912
PF14254 DUF4348 494 218
PF14534 DUF4440 20,245 13,530
PF14729 DUF4467 281 88
PF15008 DUF4518 378 234
PF16022 DUF4783 895 585
PF16111 DUF4829 228 178
PF16156 DUF4864 1,546 989
PF16247 DUF4904 10 5
PF16800 Endopep_inhib 578 181
PF17117 DUF5104 362 209
PF17118 DUF5105 710 208
PF17775 UPF0225 9,493 4,641
PF18042 ORF_12_N 565 213
CL0052 NTN 282,692 121,131 PF00227 Proteasome 54,854 19,463
PF00310 GATase_2 23,167 7,908
PF01019 G_glu_transpept 39,151 19,717
PF01112 Asparaginase_2 14,724 7,700
PF01804 Penicil_amidase 16,177 9,017
PF02275 CBAH 8,691 3,640
PF03417 AAT 6,906 4,142
PF03577 Peptidase_C69 7,689 3,067
PF04916 Phospholip_B 1,770 1,111
PF07826 IMP_cyclohyd 1,683 829
PF09147 DUF1933 43 21
PF10584 Proteasome_A_N 14,158 4,670
PF12481 DUF3700 1,098 574
PF13230 GATase_4 10,228 3,677
PF13522 GATase_6 47,788 17,250
PF13537 GATase_7 48,635 23,434
CL0053 4H_Cytokine 11,273 4,324 PF00103 Hormone_1 2,548 706
PF00143 Interferon 1,727 722
PF00489 IL6 382 169
PF00714 IFN-gamma 356 116
PF00715 IL2 217 60
PF00726 IL10 872 315
PF00727 IL4 343 125
PF00758 EPO_TPO 368 190
PF01109 GM_CSF 112 48
PF01110 CNTF 137 63
PF01291 LIF_OSM 251 125
PF01415 IL7 261 92
PF02024 Leptin 373 116
PF02025 IL5 147 78
PF02059 IL3 70 29
PF02372 IL15 466 238
PF02404 SCF 374 147
PF02947 Flt3_lig 156 83
PF03039 IL12 237 107
PF03487 IL13 122 51
PF05337 CSF-1 231 107
PF06875 PRF 415 104
PF07400 IL11 154 70
PF14565 IL22 162 90
PF15036 IL34 165 81
PF15177 IL28A 288 154
PF15216 TSLP 72 37
PF16647 GCSF 152 65
PF16649 IL23 87 41
CL0054 Knottin_1 5,310 3,158 PF00304 Gamma-thionin 1,906 1,080
PF00451 Toxin_2 219 158
PF00537 Toxin_3 793 502
PF01097 Defensin_2 820 447
PF05294 Toxin_5 37 25
PF05453 Toxin_6 35 18
PF06876 SCRL 334 243
PF07333 SLR1-BP 543 381
PF08086 Toxin_17 33 17
PF09132 BmKX 14 13
PF10868 Defensin_like 208 120
PF11415 Toxin_37 165 28
PF14865 Macin 70 67
PF14866 Toxin_38 116 57
PF18251 Defensin_5 3 4
CL0055 Nucleoplasmin 175,046 17,653 PF00073 Rhv 70,124 3,528
PF00500 Late_protein_L1 5,468 1,298
PF00688 TGFb_propeptide 8,182 3,074
PF00718 Polyoma_coat 4,777 201
PF00729 Viral_coat 1,216 291
PF00738 Polyhedrin 590 66
PF00760 Cucumo_coat 2,337 444
PF00894 Luteo_coat 2,443 187
PF00915 Calici_coat 31,434 922
PF00983 Tymo_coat 433 99
PF01318 Bromo_coat 20 8
PF01766 Birna_VP2 4,093 121
PF01787 Ilar_coat 919 80
PF01829 Peptidase_A6 16 15
PF02226 Pico_P1A 17,275 600
PF02247 Como_LCP 238 71
PF02248 Como_SCP 226 52
PF02443 Circo_capsid 3,795 186
PF02956 TT_ORF1 4,661 857
PF03014 SP2 9,753 173
PF03066 Nucleoplasmin 1,327 644
PF03115 Astro_capsid_N 3,182 408
PF03340 Pox_Rif 149 39
PF03391 Nepo_coat 690 101
PF03566 Peptidase_A21 43 18
PF03678 Adeno_hexon_C 2,562 187
PF03688 Nepo_coat_C 701 97
PF03689 Nepo_coat_N 602 90
PF03898 TNV_CP 64 63
PF08435 Calici_coat_C 7,587 200
PF08462 Carmo_coat_C 65 4
PF08762 CRPV_capsid 1,101 409
PF08935 VP4_2 1,903 122
PF11175 DUF2961 2,938 1,764
PF11492 Dicistro_VP4 357 236
PF11729 Capsid-VNN 810 70
PF12264 Waikav_capsid_1 86 33
PF12944 HAV_VP 1,300 60
PF15414 DUF4621 28 6
PF16530 IHHNV_capsid 161 3
PF16903 Capsid_N 2,290 608
PF17800 NPL 2,607 1,651
CL0056 C_Lectin 83,622 52,427 PF00059 Lectin_C 30,586 19,879
PF00193 Xlink 3,307 1,676
PF01413 C4 2,305 1,292
PF03440 APT 325 76
PF03781 FGE-sulfatase 44,738 28,457
PF05473 UL45 234 120
PF05966 Chordopox_A33R 134 39
PF06482 Endostatin 1,306 807
PF07588 DUF1554 823 387
PF07979 Intimin_C 444 59
PF08391 Ly49 380 162
PF16825 DUF5075 203 109
CL0057 Met_repress 117,268 59,276 PF01340 MetJ 1,759 151
PF01402 RHH_1 23,288 12,096
PF02697 VAPB_antitox 1,166 860
PF03693 ParD_antitoxin 7,995 4,405
PF03869 Arc 5,038 2,653
PF04221 RelB 10,497 4,366
PF05509 TraY 931 422
PF05534 HicB 6,511 3,541
PF07181 VirC2 79 35
PF07362 CcdA 3,054 1,482
PF07704 PSK_trans_fac 2,017 1,240
PF07764 Omega_Repress 225 18
PF07878 RHH_5 1,232 834
PF08681 DUF1778 5,578 2,848
PF08870 DndE 996 643
PF08972 DUF1902 638 441
PF09274 ParG 619 276
PF09386 ParD 429 234
PF09957 VapB_antitoxin 4,385 2,572
PF10723 RepB-RCR_reg 741 183
PF10784 Plasmid_stab_B 884 149
PF10802 DUF2540 30 20
PF11020 DUF2610 166 69
PF11423 Repressor_Mnt 109 31
PF11903 ParD_like 3,471 1,490
PF12441 CopG_antitoxin 2,424 1,624
PF12651 RHH_3 1,505 722
PF13467 RHH_4 5,741 2,841
PF14384 BrnA_antitoxin 6,077 3,649
PF15919 HicB_lk_antitox 13,829 7,853
PF15970 HicB-like_2 374 187
PF16762 RHH_6 381 136
PF16777 RHH_7 604 31
PF17206 SeqA_N 1,920 476
PF17414 MatP_C 1,531 237
PF17723 RHH_8 962 479
PF18064 ParB_C 244 168
CL0058 Glyco_hydro_tim 657,919 338,224 PF00128 Alpha-amylase 142,227 62,643
PF00150 Cellulase 35,201 20,470
PF00232 Glyco_hydro_1 48,502 20,677
PF00331 Glyco_hydro_10 12,967 8,147
PF00332 Glyco_hydro_17 11,468 6,507
PF00704 Glyco_hydro_18 47,069 25,083
PF00728 Glyco_hydro_20 23,091 12,719
PF00933 Glyco_hydro_3 70,176 36,979
PF01055 Glyco_hydro_31 28,179 14,786
PF01120 Alpha_L_fucos 15,685 9,218
PF01183 Glyco_hydro_25 18,571 8,598
PF01229 Glyco_hydro_39 4,121 2,804
PF01301 Glyco_hydro_35 12,967 7,232
PF01373 Glyco_hydro_14 2,478 1,241
PF01630 Glyco_hydro_56 1,905 1,151
PF02055 Glyco_hydro_30 6,718 4,056
PF02057 Glyco_hydro_59 1,288 767
PF02065 Melibiase 12,146 6,390
PF02156 Glyco_hydro_26 6,292 3,967
PF02286 Dehydratase_LU 1,302 306
PF02324 Glyco_hydro_70 786 248
PF02446 Glyco_hydro_77 16,197 7,861
PF02449 Glyco_hydro_42 12,940 7,213
PF02638 GHL10 10,017 4,982
PF02836 Glyco_hydro_2_C 38,240 19,733
PF03198 Glyco_hydro_72 3,859 2,267
PF03537 Glyco_hydro_114 4,782 3,102
PF03644 Glyco_hydro_85 2,399 1,394
PF03659 Glyco_hydro_71 2,224 1,548
PF03662 Glyco_hydro_79n 1,690 1,035
PF05089 NAGLU 2,824 1,600
PF05691 Raffinose_syn 2,665 1,595
PF07555 NAGidase 3,384 1,724
PF07745 Glyco_hydro_53 4,174 2,186
PF08924 DUF1906 3,649 1,886
PF10566 Glyco_hydro_97 6,929 3,540
PF11308 Glyco_hydro_129 1,391 483
PF11790 Glyco_hydro_cc 3,919 2,679
PF12876 Cellulase-like 252 131
PF12891 Glyco_hydro_44 628 429
PF12905 Glyco_hydro_101 1,239 497
PF13199 Glyco_hydro_66 673 383
PF13200 DUF4015 3,229 2,007
PF13204 DUF4038 2,630 1,697
PF14307 Glyco_tran_WbsX 2,743 1,818
PF14488 DUF4434 1,517 652
PF14587 Glyco_hydr_30_2 2,011 1,187
PF14701 hDGE_amylase 1,886 1,038
PF14871 GHL6 1,197 888
PF14872 GHL5 191 134
PF14883 GHL13 2,262 547
PF14885 GHL15 677 484
PF16126 DUF4838 1,794 1,443
PF16141 DUF4849 1,065 376
PF16317 Glyco_hydro_99 1,200 672
PF16402 DUF5010 115 79
PF16499 Melibiase_2 9,460 5,796
CL0059 6_Hairpin 208,108 113,681 PF00432 Prenyltrans 9,270 5,796
PF00723 Glyco_hydro_15 19,016 9,162
PF00759 Glyco_hydro_9 11,097 6,656
PF01122 Cobalamin_bind 622 395
PF01204 Trehalase 10,693 5,175
PF01270 Glyco_hydro_8 6,167 2,638
PF01532 Glyco_hydro_47 10,767 6,383
PF02011 Glyco_hydro_48 1,613 681
PF03200 Glyco_hydro_63 4,794 2,660
PF03632 Glyco_hydro_65m 10,650 5,411
PF03663 Glyco_hydro_76 8,055 4,554
PF04685 DUF608 3,029 1,794
PF05147 LANC_like 7,349 4,763
PF06202 GDE_C 8,681 4,875
PF06662 C5-epim_C 1,258 726
PF06824 Glyco_hydro_125 4,632 2,084
PF07221 GlcNAc_2-epim 12,033 5,861
PF07470 Glyco_hydro_88 16,055 8,164
PF07678 TED_complement 10,228 5,214
PF07944 Glyco_hydro_127 11,128 6,602
PF09492 Pec_lyase 1,652 1,089
PF10091 Glycoamylase 6,843 3,964
PF12899 Glyco_hydro_100 2,266 1,193
PF13243 SQHop_cyclase_C 9,777 5,174
PF13249 SQHop_cyclase_N 7,671 3,845
PF17167 Glyco_hydro_36 7,223 3,957
PF17389 Bac_rhamnosid6H 13,078 8,483
PF17652 Glyco_hydro81C 2,749 1,743
PF18566 Ldi 529 409
CL0060 DNA_clamp 41,921 16,946 PF00705 PCNA_N 4,223 1,861
PF00712 DNA_pol3_beta 28,211 9,975
PF02144 Rad1 1,730 1,000
PF02282 Herpes_UL42 272 35
PF02747 PCNA_C 3,900 1,725
PF02767 DNA_pol3_beta_2 29,345 10,715
PF02768 DNA_pol3_beta_3 28,488 10,137
PF02916 DNA_PPF 989 144
PF03325 Herpes_PAP 115 17
PF04005 Hus1 1,839 1,018
PF04139 Rad9 1,911 1,199
PF04929 Herpes_DNAp_acc 66 26
PF09116 gp45-slide_C 416 201
CL0061 PLP_aminotran 969,251 418,344 PF00155 Aminotran_1_2 336,555 140,630
PF00202 Aminotran_3 160,325 64,310
PF00266 Aminotran_5 159,470 74,122
PF00282 Pyridoxal_deC 36,069 17,068
PF00464 SHMT 39,177 13,457
PF01041 DegT_DnrJ_EryC1 60,430 37,220
PF01053 Cys_Met_Meta_PP 81,524 32,018
PF01212 Beta_elim_lyase 27,200 12,902
PF01276 OKR_DC_1 18,386 5,594
PF02347 GDC-P 27,671 11,541
PF03841 SelA 10,920 4,625
PF04864 Alliinase_C 972 557
PF05889 SepSecS 1,196 666
PF06338 ComK 2,486 957
PF06838 Met_gamma_lyase 4,809 1,907
PF12897 Aminotran_MocR 3,121 1,352
CL0062 APC 666,231 257,120 PF00209 SNF 33,163 14,744
PF00324 AA_permease 75,688 23,047
PF00474 SSF 78,689 34,312
PF00860 Xan_ur_permease 66,398 18,717
PF00916 Sulfate_transp 52,624 24,058
PF00955 HCO3_cotransp 8,167 3,733
PF01235 Na_Ala_symp 27,944 9,710
PF01490 Aa_trans 33,572 18,488
PF01566 Nramp 28,644 12,113
PF02028 BCCT 24,124 8,945
PF02133 Transp_cyt_pur 30,355 11,279
PF02554 CstA 15,754 4,684
PF02705 K_trans 16,247 6,546
PF03222 Trp_Tyr_perm 12,867 3,003
PF03594 BenE 8,276 2,703
PF03845 Spore_permease 12,996 6,104
PF05525 Branch_AA_trans 13,222 3,460
PF13520 AA_permease_2 125,384 50,601
PF13906 AA_permease_C 4,906 2,705
PF16983 MFS_MOT1 1,700 1,042
CL0063 NADP_Rossmann 6,294,699 2,997,904 PF00044 Gp_dh_N 54,567 16,065
PF00056 Ldh_1_N 47,143 13,533
PF00070 Pyr_redox 512 421
PF00106 adh_short 394,515 204,143
PF00107 ADH_zinc_N 260,773 112,221
PF00145 DNA_methylase 37,625 23,437
PF00208 ELFV_dehydrog 40,444 15,713
PF00291 PALP 193,689 76,181
PF00398 RrnaAD 36,314 16,666
PF00479 G6PD_N 27,512 9,329
PF00670 AdoHcyase_NAD 22,480 7,502
PF00732 GMC_oxred_N 68,085 34,912
PF00743 FMO-like 33,492 18,650
PF00890 FAD_binding_2 92,984 36,971
PF00891 Methyltransf_2 22,543 14,076
PF00899 ThiF 67,877 31,953
PF00996 GDI 4,857 2,301
PF01073 3Beta_HSD 9,114 5,521
PF01113 DapB_N 31,611 13,259
PF01118 Semialdhyde_dh 61,230 22,368
PF01134 GIDA 33,705 13,668
PF01135 PCMT 29,925 16,232
PF01170 UPF0020 21,799 9,599
PF01175 Urocanase 13,571 4,080
PF01189 Methyltr_RsmB-F 43,772 21,282
PF01209 Ubie_methyltran 26,222 11,330
PF01210 NAD_Gly3P_dh_N 31,389 13,025
PF01225 Mur_ligase 81,765 36,646
PF01232 Mannitol_dh 20,432 7,731
PF01234 NNMT_PNMT_TEMT 1,072 728
PF01262 AlaDh_PNT_C 35,619 13,994
PF01266 DAO 183,478 83,714
PF01269 Fibrillarin 3,641 1,758
PF01358 PARP_regulatory 256 108
PF01370 Epimerase 211,373 114,377
PF01408 GFO_IDH_MocA 166,010 87,961
PF01488 Shikimate_DH 38,204 17,028
PF01494 FAD_binding_3 139,771 74,936
PF01555 N6_N4_Mtase 44,999 26,511
PF01564 Spermine_synth 26,332 12,539
PF01593 Amino_oxidase 87,177 47,188
PF01596 Methyltransf_3 23,154 10,857
PF01728 FtsJ 46,244 16,931
PF01739 CheR 28,040 14,215
PF01795 Methyltransf_5 29,492 13,187
PF01861 DUF43 931 548
PF01946 Thi4 4,462 1,873
PF02005 TRM 4,195 2,484
PF02056 Glyco_hydro_4 13,705 4,435
PF02086 MethyltransfD12 17,989 9,343
PF02153 PDH 25,606 11,324
PF02254 TrkA_N 72,237 30,207
PF02310 B12-binding 69,099 34,880
PF02353 CMAS 30,216 13,606
PF02384 N6_Mtase 49,329 28,054
PF02390 Methyltransf_4 26,595 11,797
PF02423 OCD_Mu_crystall 21,660 11,441
PF02475 Met_10 6,571 4,060
PF02527 GidB 24,779 11,738
PF02558 ApbA 31,559 15,611
PF02571 CbiJ 8,414 4,242
PF02593 DUF166 547 355
PF02629 CoA_binding 36,397 11,136
PF02636 Methyltransf_28 12,349 6,879
PF02670 DXP_reductoisom 22,407 9,667
PF02719 Polysacc_synt_2 24,053 12,669
PF02737 3HCDH_N 67,269 28,308
PF02826 2-Hacid_dh_C 132,564 60,528
PF02882 THF_DHG_CYH_C 34,515 14,238
PF03059 NAS 1,168 643
PF03141 Methyltransf_29 5,376 2,965
PF03269 DUF268 639 530
PF03275 GLF 7,622 3,270
PF03291 Pox_MCEL 2,591 1,479
PF03341 Pox_mRNA-cap 117 30
PF03435 Sacchrp_dh_NADP 26,354 12,412
PF03446 NAD_binding_2 84,606 36,038
PF03447 NAD_binding_3 35,186 13,080
PF03486 HI0933_like 25,821 12,295
PF03492 Methyltransf_7 4,267 2,733
PF03514 GRAS 8,859 4,797
PF03602 Cons_hypoth95 27,121 13,272
PF03686 UPF0146 502 349
PF03721 UDPG_MGDP_dh_N 52,450 26,324
PF03807 F420_oxidored 47,428 22,649
PF03808 Glyco_tran_WecB 14,049 7,577
PF03848 TehB 3,414 1,448
PF03853 YjeF_N 23,650 13,148
PF03949 Malic_M 38,685 13,103
PF04016 DUF364 2,196 1,508
PF04072 LCM 19,442 9,115
PF04127 DFP 27,597 12,453
PF04321 RmlD_sub_bind 30,753 17,721
PF04378 RsmJ 8,157 2,765
PF04445 SAM_MT 7,305 2,605
PF04536 TPM_phosphatase 21,205 10,928
PF04672 Methyltransf_19 8,183 4,594
PF04723 GRDA 1,083 349
PF04816 TrmK 4,343 1,544
PF04820 Trp_halogenase 10,329 6,265
PF04989 CmcI 1,906 1,043
PF05050 Methyltransf_21 22,678 17,080
PF05059 Orbi_VP4 545 57
PF05063 MT-A70 5,995 3,602
PF05088 Bac_GDH 9,485 3,928
PF05148 Methyltransf_8 1,902 1,237
PF05175 MTS 68,289 31,773
PF05185 PRMT5 2,082 1,138
PF05206 TRM13 1,175 745
PF05219 DREV 744 394
PF05368 NmrA 33,070 19,613
PF05401 NodS 3,133 1,614
PF05430 Methyltransf_30 10,065 5,047
PF05575 V_cholerae_RfbT 39 13
PF05711 TylF 4,231 2,637
PF05724 TPMT 7,229 4,255
PF05834 Lycopene_cycl 5,084 3,244
PF05891 Methyltransf_PK 2,086 1,222
PF05958 tRNA_U5-meth_tr 37,250 15,398
PF05971 Methyltransf_10 6,015 2,696
PF06016 Reovirus_L2 190 34
PF06039 Mqo 9,995 2,705
PF06080 DUF938 4,262 2,655
PF06100 MCRA 4,353 1,591
PF06325 PrmA 30,963 14,047
PF06460 NSP16 2,073 144
PF06471 NSP11 2,648 177
PF06690 DUF1188 68 46
PF06859 Bin3 1,564 973
PF06962 rRNA_methylase 4,425 1,877
PF07021 MetW 6,282 2,558
PF07055 Eno-Rase_FAD_bd 4,140 1,290
PF07091 FmrO 422 228
PF07109 Mg-por_mtran_C 1,252 680
PF07156 Prenylcys_lyase 1,636 968
PF07279 DUF1442 667 398
PF07669 Eco57I 7,390 5,177
PF07757 AdoMet_MTase 1,309 898
PF07942 N2227 2,424 1,488
PF07991 IlvN 24,664 5,986
PF07992 Pyr_redox_2 351,611 148,348
PF07993 NAD_binding_4 24,863 14,349
PF07994 NAD_binding_5 4,581 1,960
PF08003 Methyltransf_9 5,813 1,873
PF08123 DOT1 2,975 1,947
PF08241 Methyltransf_11 159,871 92,358
PF08242 Methyltransf_12 18,397 10,949
PF08484 Methyltransf_14 5,810 3,626
PF08485 Polysacc_syn_2C 2,728 1,331
PF08491 SE 2,307 1,282
PF08643 DUF1776 679 384
PF08659 KR 34,497 23,197
PF08704 GCD14 7,115 3,305
PF08732 HIM1 762 415
PF09243 Rsm22 3,420 2,132
PF09445 Methyltransf_15 2,829 1,798
PF10017 Methyltransf_33 8,432 4,786
PF10237 N6-adenineMlase 1,841 1,143
PF10294 Methyltransf_16 14,381 9,409
PF10354 DUF2431 2,226 1,574
PF10672 Methyltrans_SAM 25,401 9,544
PF10727 Rossmann-like 5,182 2,593
PF11017 DUF2855 1,482 950
PF11312 Methyltransf_34 763 501
PF11599 AviRa 122 95
PF11890 DUF3410 4,179 1,257
PF11968 Bmt2 1,090 643
PF12147 Methyltransf_20 2,263 626
PF12241 Enoyl_reductase 4,194 1,321
PF12242 Eno-Rase_NADH_b 4,122 1,277
PF12692 Methyltransf_17 713 349
PF12831 FAD_oxidored 16,468 10,138
PF12847 Methyltransf_18 2,369 1,357
PF13241 NAD_binding_7 18,201 8,100
PF13288 DXPR_C 22,345 9,588
PF13380 CoA_binding_2 30,997 16,254
PF13383 Methyltransf_22 1,343 969
PF13434 K_oxygenase 10,757 4,599
PF13450 NAD_binding_8 59,718 32,843
PF13454 NAD_binding_9 8,903 4,558
PF13460 NAD_binding_10 76,100 42,552
PF13478 XdhC_C 21,002 10,773
PF13489 Methyltransf_23 84,671 51,651
PF13561 adh_short_C2 446,818 203,235
PF13578 Methyltransf_24 15,089 10,008
PF13602 ADH_zinc_N_2 50,797 28,047
PF13649 Methyltransf_25 130,039 76,072
PF13679 Methyltransf_32 9,247 4,205
PF13727 CoA_binding_3 28,273 15,019
PF13738 Pyr_redox_3 32,471 16,406
PF13847 Methyltransf_31 59,293 34,216
PF14314 Methyltrans_Mon 1,142 228
PF16363 GDP_Man_Dehyd 88,944 44,842
PF16803 DRE2_N 690 403
PF16912 Glu_dehyd_C 1,927 1,152
PF17125 Methyltr_RsmF_N 10,729 5,017
PF17173 DUF5129 435 242
PF17174 DUF5130 1,007 408
PF17175 MOLO1 694 473
PF17396 DUF1611_N 3,374 1,903
PF17836 PglD_N 7,115 4,980
PF17930 LpxI_N 4,273 2,589
PF18321 3HCDH_RFF 2,003 656
PF18706 ISPD_C 191 94
CL0064 CPA_AT 247,654 107,729 PF00999 Na_H_Exchanger 104,991 46,640
PF01758 SBF 32,457 14,680
PF03547 Mem_trans 35,173 16,863
PF03601 Cons_hypoth698 15,239 6,616
PF03616 Glt_symporter 6,998 2,197
PF03812 KdgT 2,956 820
PF03956 Lys_export 4,879 1,639
PF03977 OAD_beta 7,164 2,601
PF05684 DUF819 3,872 2,019
PF05982 Sbt_1 2,729 1,383
PF06826 Asp-Al_Ex 8,642 2,615
PF06965 Na_H_antiport_1 13,706 6,345
PF13593 SBF_like 8,991 3,434
CL0065 Cyclin 50,277 27,234 PF00134 Cyclin_N 30,554 16,833
PF00382 TFIIB 9,089 4,152
PF01857 RB_B 1,636 761
PF01858 RB_A 1,678 785
PF02984 Cyclin_C 14,722 8,022
PF03261 CDK5_activator 624 329
PF08613 Cyclin 6,841 4,176
PF09080 K-cyclin_vir_C 14 4
PF09241 Herp-Cyclin 2 2
PF11934 DUF3452 1,411 634
PF16899 Cyclin_C_2 2,160 1,006
PF18542 TFIIB_C_1 30 17
CL0066 Trefoil 57,242 31,155 PF00167 FGF 5,446 2,017
PF00197 Kunitz_legume 2,128 1,080
PF00340 IL1 1,529 701
PF00652 Ricin_B_lectin 19,133 11,075
PF02815 MIR 8,059 3,884
PF03260 Lipoprotein_11 98 62
PF03498 CDtoxinA 602 210
PF04601 DUF569 990 636
PF05270 AbfB 2,677 1,536
PF05588 Botulinum_HA-17 56 19
PF06229 FRG1 1,362 777
PF06268 Fascin 1,303 586
PF07468 Agglutinin 261 185
PF07951 Toxin_R_bind_C 184 30
PF08470 NTNH_C 113 16
PF08709 Ins145_P3_rec 3,141 1,394
PF09270 BTD 1,791 738
PF10467 Inhibitor_I48 66 58
PF14200 RicinB_lectin_2 10,695 7,144
PF15095 IL33 162 58
PF16850 Inhibitor_I66 327 268
PF18021 Agglutinin_C 92 79
PF18022 Lectin_C_term 18 16
CL0067 SIS 214,062 79,579 PF00318 Ribosomal_S2 37,904 11,826
PF00342 PGI 33,247 12,561
PF01380 SIS 112,673 41,904
PF10432 bact-PGI_C 3,686 2,309
PF10740 DUF2529 1,132 330
PF12163 HobA 675 143
PF13580 SIS_2 24,531 11,043
PF15698 Phosphatase 1,245 414
CL0068 RIIa 5,556 3,155 PF02197 RIIa 2,563 1,263
PF05186 Dpy-30 2,991 1,892
CL0069 GFP 1,865 990 PF01353 GFP 676 238
PF07474 G2F 1,187 752
CL0070 ACT 210,549 72,369 PF00585 Thr_dehydrat_C 13,840 4,316
PF01842 ACT 84,916 29,921
PF04359 DUF493 8,286 3,112
PF08753 NikR_C 5,103 2,184
PF09383 NIL 19,882 5,752
PF10000 ACT_3 2,598 1,377
PF10369 ALS_ss_C 21,716 6,729
PF13291 ACT_4 31,843 10,429
PF13710 ACT_5 16,514 5,068
PF13740 ACT_6 15,667 5,354
PF13840 ACT_7 30,110 10,785
CL0071 His_phosphatase 150,407 72,392 PF00300 His_Phos_1 132,973 63,280
PF00328 His_Phos_2 17,432 9,113
CL0072 Ubiquitin 436,542 201,306 PF00174 Oxidored_molyb 34,287 17,145
PF00240 ubiquitin 36,813 17,573
PF00564 PB1 13,265 7,026
PF00778 DIX 2,750 1,184
PF00788 RA 14,428 6,654
PF00789 UBX 11,409 6,310
PF00794 PI3K_rbd 2,615 1,047
PF01378 IgG_binding_B 40 25
PF02017 CIDE-N 1,422 759
PF02192 PI3K_p85B 1,100 401
PF02196 RBD 2,805 1,130
PF02246 B1 6 5
PF02309 AUX_IAA 7,635 3,841
PF02597 ThiS 45,062 22,687
PF02821 Staphylokinase 288 38
PF02824 TGS 60,366 20,220
PF02991 Atg8 4,408 1,557
PF03607 DCX 2,816 1,521
PF03658 Ub-RnfH 6,421 2,887
PF03671 Ufm1 751 332
PF03990 DUF348 4,942 2,574
PF04106 APG5 1,889 1,003
PF04110 APG12 1,504 840
PF04663 Phenol_monoox 710 318
PF06071 YchF-GTPase_C 29,171 9,495
PF06234 TmoB 236 146
PF06251 Caps_synth_GfcC 3,459 1,751
PF06458 MucBP 4,142 2,558
PF06487 SAP18 1,552 814
PF06805 Lambda_tail_I 2,634 733
PF08154 NLE 3,052 1,541
PF08783 DWNN 2,166 1,259
PF08817 YukD 5,000 2,319
PF09138 Urm1 1,589 880
PF09379 FERM_N 12,737 5,281
PF09469 Cobl 756 342
PF09479 Flg_new 8,523 5,999
PF10302 DUF2407 746 481
PF10531 SLBB 57,747 28,027
PF11434 CHIPS 21 2
PF11470 TUG-UBL1 1,181 738
PF11543 UN_NPL4 1,050 533
PF11620 GABP-alpha 415 178
PF11973 NQRA_SLBB 4,830 2,166
PF11976 Rad60-SLD 5,247 2,877
PF12053 Par3_HAL_N_term 1,603 637
PF12436 USP7_ICP0_bdg 3,117 1,391
PF12754 Blt1 452 251
PF13019 Sde2_N_Ubi 1,564 995
PF13881 Rad60-SLD_2 2,053 1,131
PF14451 Ub-Mut7C 2,299 1,266
PF14452 Multi_ubiq 999 701
PF14453 ThiS-like 403 220
PF14454 Prok_Ub 862 374
PF14478 DUF4430 5,470 2,919
PF14533 USP7_C2 3,289 1,323
PF14560 Ubiquitin_2 2,710 1,426