EFI - Enzyme Similarity Tool

Pfam Families

These data are sourced from the UniProt and EMBL-EBI InterPro databases.

Clan ID Clan Short Name Clan Size Clan UniRef90 Size Pfam ID Pfam Short Name Pfam Size Pfam UniRef90 Size
CL0001 EGF 103,986 56,037 PF00008 EGF 30,144 16,909
PF00053 Laminin_EGF 14,278 8,008
PF00084 Sushi 20,101 11,081
PF00594 Gla 2,674 1,367
PF01414 DSL 2,190 1,208
PF04863 EGF_alliinase 322 186
PF06247 Plasmod_Pvs28 356 56
PF07645 EGF_CA 30,975 17,822
PF07974 EGF_2 6,919 3,608
PF09014 Sushi_2 321 182
PF09064 Tme5_EGF_like 169 127
PF09289 FOLN 1,290 455
PF09443 CFC 295 171
PF12661 hEGF 10,691 5,759
PF12662 cEGF 8,204 4,109
PF12946 EGF_MSP1_1 2,181 146
PF12947 EGF_3 7,346 3,245
PF14670 FXa_inhibition 12,795 6,364
PF18193 Fibrillin_U_N 591 211
PF18372 I-EGF_1 1,922 800
PF18720 EGF_Tenascin 1,408 711
CL0003 SAM 53,500 24,298 PF00536 SAM_1 28,101 13,244
PF01698 SAM_LFY 1,427 251
PF02198 SAM_PNT 4,346 1,757
PF04904 NCD1 752 303
PF07647 SAM_2 18,104 8,148
PF09235 SAM_Ste50p 61 39
PF09597 IGR 1,016 604
PF13543 SAM_KSR1 676 315
PF18016 SAM_3 2,357 1,035
PF18017 SAM_4 692 416
PF18255 SAM_DrpA 605 81
PF18609 SAM_Exu 253 138
CL0004 Concanavalin 279,302 157,936 PF00054 Laminin_G_1 5,303 3,006
PF00139 Lectin_legB 7,248 4,858
PF00262 Calreticulin 4,899 2,457
PF00337 Gal-bind_lectin 6,973 3,941
PF00354 Pentaxin 3,683 2,101
PF00426 VP4_haemagglut 5,807 261
PF00457 Glyco_hydro_11 3,581 1,895
PF00622 SPRY 30,475 16,630
PF00629 MAM 9,011 4,917
PF00722 Glyco_hydro_16 31,778 19,075
PF00840 Glyco_hydro_7 6,987 2,109
PF01670 Glyco_hydro_12 3,132 1,723
PF01828 Peptidase_A4 1,750 1,179
PF02210 Laminin_G_2 17,586 8,708
PF02973 Sialidase 601 172
PF03388 Lectin_leg-like 3,733 1,970
PF03935 SKN1 2,439 1,665
PF05592 Bac_rhamnosid 8,470 5,437
PF05735 TSP_C 1,859 776
PF06439 DUF1080 20,703 14,166
PF06955 XET_C 4,649 2,306
PF07081 DUF1349 5,699 2,747
PF07177 Neuralized 2,073 1,078
PF07622 DUF1583 99 70
PF07675 Cleaved_Adhesin 1,205 950
PF07953 Toxin_R_bind_N 310 50
PF08244 Glyco_hydro_32C 17,585 8,217
PF08787 Alginate_lyase2 3,519 1,684
PF08978 Reoviridae_Vp9 36 13
PF09101 Exotox-A_bind 208 42
PF09206 ArabFuran-catal 1,200 692
PF09224 DUF1961 492 304
PF09264 Sial-lect-inser 69 23
PF10287 DUF2401 728 474
PF11476 TgMIC1 18 5
PF11958 DUF3472 1,371 736
PF12248 Methyltransf_FA 1,325 866
PF13385 Laminin_G_3 44,036 31,162
PF13765 PRY 14,172 8,767
PF14099 Polysacc_lyase 2,182 1,496
PF15493 YrpD 158 44
PF16346 DUF4975 489 231
PF16451 Spike_NTD 998 50
PF17689 Arabino_trans_N 2,562 833
PF17851 GH43_C2 13,176 6,965
PF17974 GalBD_like 1,032 395
PF18239 HA1 6 4
PF18271 GH131_N 1,066 723
PF18483 Bact_lectin 2,825 1,748
CL0005 Kazal 15,966 8,609 PF00050 Kazal_1 5,464 3,415
PF07648 Kazal_2 11,485 5,826
PF18434 Kazal_3 283 144
CL0006 C1 44,708 21,777 PF00130 C1_1 24,895 10,739
PF00569 ZZ 14,224 7,237
PF03107 C1_2 4,205 3,093
PF07975 C1_4 1,386 712
CL0007 KH 194,028 71,291 PF00013 KH_1 73,750 29,569
PF04025 DUF370 5,318 2,058
PF07650 KH_2 57,673 17,740
PF09869 DUF2096 112 83
PF13083 KH_4 20,613 8,214
PF13184 KH_5 28,058 9,203
PF14611 SLS 657 439
PF14955 MRP-S24 489 293
PF15985 KH_6 3,434 1,831
PF16005 MOEP19 374 186
PF17214 KH_7 1,400 569
PF17903 KH_8 2,592 1,309
PF17904 KH_9 1,587 465
PF17905 KH_10 62 52
CL0009 ENTH_VHS 23,108 12,020 PF00790 VHS 9,324 4,814
PF01417 ENTH 6,081 3,445
PF07651 ANTH 7,700 3,763
CL0010 SH3 226,747 105,780 PF00018 SH3_1 53,544 25,076
PF01302 CAP_GLY 10,847 6,137
PF02736 Myosin_N 8,132 3,332
PF03831 PhnA 12,280 4,049
PF06347 SH3_4 5,615 3,612
PF06372 Gemin6 388 227
PF07563 DUF1541 1,312 635
PF07653 SH3_2 21,028 9,700
PF07866 DUF1653 5,703 2,579
PF08239 SH3_3 34,657 18,224
PF08460 SH3_5 2,260 739
PF08810 KapB 1,125 369
PF11095 Gemin7 376 251
PF11302 DUF3104 176 128
PF11607 DUF3247 274 120
PF11623 NdhS 591 259
PF12208 DUF3601 160 56
PF12913 SH3_6 1,923 854
PF13457 GW 2,569 1,019
PF14603 hSH3 615 363
PF14604 SH3_9 34,482 16,959
PF14627 DUF4453 74 55
PF15505 DUF4648 131 48
PF17384 DUF150_C 19,863 7,965
PF17902 SH3_10 3,276 1,183
PF18103 SH3_11 37 16
PF18129 SH3_12 1,512 885
PF18335 SH3_13 8,674 3,590
PF18343 SH3_14 140 16
PF18346 SH3_15 1,415 644
PF18348 SH3_16 5,537 3,286
PF18350 SH3_17 32 7
PF18354 SH3_18 47 22
PF18597 SH3_19 271 150
PF18697 MLVIN_C 543 256
CL0011 Ig 208,428 99,568 PF00047 ig 14,901 6,960
PF01537 Herpes_glycop_D 600 103
PF01688 Herpes_gI 355 50
PF02124 Marek_A 604 72
PF02440 Adeno_E3_CR1 328 66
PF02480 Herpes_gE 742 107
PF02960 K1 1,184 90
PF03921 ICAM_N 692 349
PF05790 C2-set 528 192
PF07654 C1-set 37,568 9,973
PF07679 I-set 71,920 34,004
PF07686 V-set 56,720 34,155
PF08204 V-set_CD47 406 145
PF08205 C2-set_2 12,974 6,788
PF09085 Adhes-Ig_like 161 73
PF09191 CD4-extracel 216 80
PF09291 DUF1968 150 95
PF10430 Ig_Tie2_1 201 50
PF11465 Receptor_2B4 226 139
PF13895 Ig_2 15,359 8,443
PF13927 Ig_3 57,390 29,825
PF15028 PTCRA 90 53
PF15910 V-set_2 370 157
PF16680 Ig_4 361 215
PF16681 Ig_5 222 138
PF16706 Izumo-Ig 138 70
PF16758 UL141 153 12
PF17736 Ig_C17orf99 536 267
PF17737 Ig_C19orf38 98 66
PF18452 Ig_6 1,496 680
PF18589 ObR_Ig 397 168
CL0012 Histone 98,600 29,899 PF00125 Histone 56,451 8,467
PF00808 CBFD_NFYB_HMF 15,715 8,316
PF02269 TFIID-18kDa 3,014 1,542
PF02291 TFIID-31kDa 1,909 1,010
PF02969 TAF 2,343 1,081
PF03540 TFIID_30kDa 1,676 910
PF03847 TFIID_20kDa 2,058 1,186
PF04719 TAFII28 1,788 1,095
PF05236 TAF4 2,419 1,373
PF07524 Bromo_TP 3,789 2,085
PF09123 DUF1931 501 150
PF09415 CENP-X 1,032 654
PF15510 CENP-W 240 131
PF15511 CENP-T_C 4,354 1,184
PF15630 CENP-S 1,137 685
PF15715 PAF 255 121
PF17027 Bromo_TP_like 39 31
CL0013 Beta-lactamase 382,162 178,977 PF00144 Beta-lactamase 122,037 68,844
PF00768 Peptidase_S11 50,306 20,887
PF00905 Transpeptidase 152,230 64,557
PF02113 Peptidase_S13 15,952 8,304
PF04960 Glutaminase 13,386 4,539
PF13354 Beta-lactamase2 28,359 11,976
CL0014 Glutaminase_I 472,070 204,564 PF00117 GATase 181,833 71,478
PF01174 SNO 10,054 4,685
PF01965 DJ-1_PfpI 100,306 42,440
PF02016 Peptidase_S66 17,735 8,338
PF03575 Peptidase_S51 14,263 7,560
PF04204 HTS 9,658 3,370
PF06283 ThuA 16,270 9,562
PF07090 GATase1_like 3,139 1,655
PF07685 GATase_3 31,440 13,986
PF07722 Peptidase_C26 19,752 9,759
PF08532 Glyco_hydro_42M 10,142 5,423
PF09822 ABC_transp_aux 9,082 5,599
PF09825 BPL_N 2,181 1,304
PF13507 GATase_5 29,102 11,534
PF13709 DUF4159 6,218 3,831
PF17124 ThiJ_like 1,549 754
PF17385 LBP_M 1,186 417
PF18011 Catalase_C 8,168 2,960
CL0015 MFS 1,300,039 586,383 PF00083 Sugar_tr 170,601 79,193
PF00854 PTR2 37,332 16,971
PF01306 LacY_symp 3,244 799
PF01733 Nucleoside_tran 4,581 2,708
PF01770 Folate_carrier 1,747 1,104
PF03092 BT1 4,964 2,774
PF03137 OATP 5,565 3,177
PF03209 PUCC 2,967 1,387
PF03219 TLC 2,353 1,463
PF03825 Nuc_H_symport 6,051 2,202
PF05631 MFS_5 1,741 996
PF05977 MFS_3 40,360 20,751
PF05978 UNC-93 3,659 2,242
PF06609 TRI12 2,756 1,751
PF06779 MFS_4 8,320 3,520
PF06813 Nodulin-like 3,538 2,082
PF06963 FPN1 1,938 1,257
PF07672 MFS_Mycoplasma 95 51
PF07690 MFS_1 955,007 422,269
PF11700 ATG22 13,379 7,043
PF12832 MFS_1_like 12,341 6,006
PF13000 Acatn 3,916 2,021
PF13347 MFS_2 34,279 15,687
CL0016 PKinase 1,115,316 623,280 PF00069 Pkinase 613,717 350,218
PF00454 PI3_PI4_kinase 22,897 12,348
PF01163 RIO1 11,791 5,985
PF01504 PIP5K 10,449 5,558
PF01633 Choline_kinase 9,260 5,109
PF01636 APH 127,079 68,288
PF02816 Alpha_kinase 3,406 2,206
PF02958 EcKinase 7,850 5,280
PF03109 ABC1 39,552 18,047
PF03770 IPK 5,934 3,412
PF03881 Fructosamin_kin 10,135 5,559
PF04183 IucA_IucC 11,187 4,454
PF04655 APH_6_hur 5,089 2,756
PF05445 Pox_ser-thr_kin 145 44
PF06090 Ins_P5_2-kin 1,850 1,181
PF06176 WaaY 952 318
PF06293 Kdo 15,117 6,512
PF06315 AceK 4,430 1,228
PF06702 Fam20C 1,436 728
PF06734 UL97 419 31
PF07387 Seadorna_VP7 30 20
PF07714 Pkinase_Tyr 163,349 97,545
PF07804 HipA_C 17,385 9,642
PF07914 DUF1679 1,150 945
PF08757 CotH 11,724 8,303
PF09192 Act-Frag_cataly 345 187
PF10009 DUF2252 6,363 3,087
PF10140 YukC 1,303 385
PF10707 YrbL-PhoP_reg 1,254 603
PF12260 PIP49_C 1,819 831
PF12330 Haspin_kinase 8,153 4,512
PF13095 FTA2 447 312
PF13575 DUF4135 2,238 1,420
PF14531 Kinase-like 607 193
PF16474 KIND 1,186 702
PF17667 Pkinase_fungal 6,596 5,828
PF18101 Pan3_PK 1,785 878
PF18762 Kinase-PolyVal 290 196
CL0018 bZIP 42,612 22,466 PF00170 bZIP_1 28,131 14,517
PF03131 bZIP_Maf 3,880 1,725
PF07716 bZIP_2 10,600 6,336
CL0020 TPR 1,104,725 631,733 PF00514 Arm 23,274 10,431
PF00515 TPR_1 55,744 31,521
PF00613 PI3Ka 6,749 3,235
PF00637 Clathrin 8,391 3,765
PF00806 PUF 8,327 4,721
PF01239 PPTA 4,500 2,698
PF01347 Vitellogenin_N 4,522 2,687
PF01394 Clathrin_propel 2,466 703
PF01535 PPR 71,705 46,187
PF01602 Adaptin_N 19,519 8,671
PF01603 B56 5,700 2,533
PF01749 IBB 4,586 1,658
PF01816 LRV 842 598
PF01851 PC_rep 4,362 1,675
PF02020 W2 6,653 2,926
PF02071 NSF 4 4
PF02184 HAT 1,727 798
PF02259 FAT 6,851 3,848
PF02847 MA3 7,865 4,124
PF02854 MIF4G 12,010 6,347
PF02985 HEAT 9,211 4,903
PF03130 HEAT_PBS 4,929 3,386
PF03224 V-ATPase_H_N 2,306 1,094
PF03377 TAL_effector 571 198
PF03378 CAS_CSE1 1,982 989
PF03704 BTAD 24,383 17,272
PF03810 IBN_N 17,476 7,825
PF04049 ANAPC8 1,545 818
PF04050 Upf2 1,716 853
PF04184 ST7 1,568 493
PF04733 Coatomer_E 2,388 1,226
PF04826 Arm_2 1,364 657
PF04910 Tcf25 1,921 1,219
PF05004 IFRD 2,134 1,029
PF05484 LRV_FeS 439 277
PF05536 Neurochondrin 1,119 619
PF05804 KAP 1,344 709
PF05843 Suf 3,484 1,894
PF05918 API5 1,120 569
PF06041 DUF924 7,807 4,244
PF06367 Drf_FH3 5,620 2,945
PF06371 Drf_GBD 5,732 2,951
PF06552 TOM20_plant 852 572
PF06920 DHR-2 6,806 2,918
PF06957 COPI_C 2,275 978
PF07219 HemY_N 8,276 3,385
PF07571 TAF6_C 2,190 1,102
PF07719 TPR_2 36,475 23,091
PF07720 TPR_3 1,874 799
PF07721 TPR_4 4,483 3,296
PF07980 SusD_RagB 57,259 31,814
PF08144 CPL 1,562 888
PF08167 RIX1 1,384 890
PF08238 Sel1 59,486 34,195
PF08321 PPP5 2,423 1,163
PF08389 Xpo1 8,614 4,083
PF08506 Cse1 3,585 1,627
PF08569 Mo25 2,728 1,200
PF08579 RPM2 119 87
PF08623 TIP120 1,987 913
PF08631 SPO22 992 717
PF08713 DNA_alkylation 16,957 8,835
PF08767 CRM1_C 2,643 995
PF08852 DUF1822 1,249 880
PF09088 MIF4G_like 1,837 937
PF09090 MIF4G_like_2 1,947 1,004
PF09127 Leuk-A4-hydro_C 3,910 2,062
PF09246 PHAT 130 78
PF09268 Clathrin-link 2,224 591
PF09295 ChAPs 1,981 958
PF09311 Rab5-bind 949 394
PF09450 DUF2019 439 287
PF09613 HrpB1_HrpK 519 181
PF09759 Atx10homo_assoc 1,590 951
PF09976 TPR_21 12,612 6,080
PF09986 DUF2225 1,836 1,049
PF10037 MRP-S27 770 437
PF10255 Paf67 2,119 716
PF10274 ParcG 1,319 732
PF10300 DUF3808 3,272 1,795
PF10345 Cohesin_load 1,496 793
PF10366 Vps39_1 2,368 1,299
PF10373 EST1_DNA_bind 4,140 2,378
PF10374 EST1 2,880 1,546
PF10508 Proteasom_PSMB 1,162 612
PF10516 SHNi-TPR 1,732 1,001
PF10579 Rapsyn_N 464 191
PF10602 RPN7 3,941 1,764
PF11698 V-ATPase_H_C 2,130 961
PF11701 UNC45-central 1,597 780
PF11817 Foie-gras_1 1,878 1,065
PF11846 Wzy_C_2 2,451 1,210
PF11865 DUF3385 2,140 996
PF12031 BAF250_C 1,412 688
PF12348 CLASP_N 6,356 3,343
PF12460 MMS19_C 1,603 897
PF12569 NARP1 2,555 1,282
PF12688 TPR_5 2,900 1,470
PF12717 Cnd1 3,012 1,825
PF12719 Cnd3 1,773 1,097
PF12741 SusD-like 3,184 1,349
PF12753 Nro1 168 120
PF12755 Vac14_Fab1_bd 2,612 1,329
PF12765 Cohesin_HEAT 2,410 1,415
PF12771 SusD-like_2 8,900 6,083
PF12830 Nipped-B_C 1,984 1,174
PF12854 PPR_1 21,418 13,645
PF12862 ANAPC5 2,322 1,529
PF12895 ANAPC3 11,035 6,474
PF12968 DUF3856 28 25
PF13041 PPR_2 70,022 44,610
PF13174 TPR_6 32,249 20,165
PF13176 TPR_7 22,317 13,190
PF13181 TPR_8 141,529 87,639
PF13251 DUF4042 988 532
PF13371 TPR_9 6,794 2,790
PF13374 TPR_10 28,167 20,875
PF13414 TPR_11 48,686 32,202
PF13424 TPR_12 83,046 57,119
PF13428 TPR_14 5,351 3,611
PF13429 TPR_15 5,306 2,968
PF13431 TPR_17 6,976 4,789
PF13432 TPR_16 151,824 96,497
PF13512 TPR_18 180 136
PF13513 HEAT_EZ 7,487 3,272
PF13525 YfiO 21,878 10,819
PF13646 HEAT_2 48,100 29,781
PF13812 PPR_3 17,990 12,089
PF13838 Clathrin_H_link 3,241 912
PF14322 SusD-like_3 56,060 30,855
PF14559 TPR_19 87,341 50,236
PF14561 TPR_20 12,120 4,860
PF14852 Fis1_TPR_N 1,671 780
PF14853 Fis1_TPR_C 2,191 1,113
PF14863 Alkyl_sulf_dimr 6,733 3,163
PF14938 SNAP 4,930 2,680
PF16186 Arm_3 4,675 1,710
PF16416 GUN4_N 320 163
PF16811 TAtT 1,338 1,028
PF16918 PknG_TPR 2,216 1,064
PF17004 SRP_TPR_like 1,598 852
PF17177 PPR_long 5,211 3,430
PF17432 DUF3458_C 10,177 4,124
PF17874 TPR_MalT 18,157 10,941
PF18028 Zmiz1_N 312 130
PF18381 YcaO_C 3,604 693
PF18391 CHIP_TPR_N 592 272
PF18581 SYCP2_ARLD 263 180
PF18710 ComR_TPR 757 200
CL0021 OB 1,283,718 491,536 PF00164 Ribosom_S12_S23 37,227 5,745
PF00181 Ribosomal_L2 38,770 9,289
PF00313 CSD 81,594 24,352
PF00366 Ribosomal_S17 32,048 10,765
PF00436 SSB 56,028 24,969
PF00575 S1 148,675 52,915
PF00900 Ribosomal_S4e 4,375 1,676
PF01132 EFP 30,586 9,009
PF01176 eIF-1a 35,321 6,729
PF01200 Ribosomal_S28e 3,148 957
PF01287 eIF-5a 3,571 1,464
PF01330 RuvA_N 26,755 11,209
PF01336 tRNA_anti-codon 108,350 41,664
PF01588 tRNA_bind 61,537 25,093
PF01796 OB_aCoA_assoc 18,698 10,346
PF01938 TRAM 45,130 18,746
PF01957 NfeD 23,230 12,028
PF02303 Phage_DNA_bind 315 192
PF02721 DUF223 1,629 1,313
PF02760 HIN 375 169
PF02765 POT1 1,758 1,086
PF03100 CcmE 11,236 5,359
PF03120 DNA_ligase_OB 31,972 14,113
PF03319 EutN_CcmL 5,765 2,784
PF03459 TOBE 32,973 12,874
PF03870 RNA_pol_Rpb8 1,937 805
PF03919 mRNA_cap_C 2,231 1,194
PF04057 Rep-A_N 2,055 1,201
PF04076 BOF 4,289 1,244
PF04679 DNA_ligase_A_C 25,852 13,722
PF06125 DUF961 2,248 291
PF07076 DUF1344 986 436
PF07290 DUF1449 2,402 981
PF07404 TEBP_beta 22 13
PF07497 Rho_RNA_bind 24,275 7,679
PF07717 OB_NTP_bind 28,344 12,413
PF08206 OB_RNB 18,877 6,697
PF08292 RNA_pol_Rbc25 1,789 901
PF08402 TOBE_2 75,470 30,195
PF08418 Pol_alpha_B_N 1,278 721
PF08585 RMI1_N 2,565 1,658
PF08646 Rep_fac-A_C 4,646 3,116
PF08661 Rep_fac-A_3 1,701 985
PF08804 gp32 866 454
PF09103 BRCA-2_OB1 1,131 727
PF09104 BRCA-2_OB3 438 263
PF09285 Elong-fact-P_C 30,744 9,143
PF09883 DUF2110 426 207
PF10246 MRP-S35 538 331
PF10341 TPP1 430 289
PF10447 EXOSC1 1,662 917
PF10451 Stn1 661 442
PF10991 DUF2815 1,766 831
PF11325 DUF3127 3,000 1,551
PF11506 DUF3217 18 8
PF11604 CusF_Ec 8,418 3,950
PF11736 DUF3299 4,734 1,861
PF11967 RecO_N 26,504 12,261
PF12658 Ten1 407 276
PF12667 NigD_N 1,412 418
PF12857 TOBE_3 5,774 1,313
PF12869 tRNA_anti-like 1,304 980
PF13114 RecO_N_2 739 153
PF13509 S1_2 8,687 3,088
PF13742 tRNA_anti_2 25,258 11,180
PF14444 S1-like 935 460
PF14481 Fimbrial_PilY2 49 23
PF14743 DNA_ligase_OB_2 2,943 1,710
PF15072 DUF4539 955 599
PF15490 Ten1_2 531 342
PF16099 RMI1_C 608 414
PF16100 RMI2 427 272
PF16450 Prot_ATP_ID_OB 13,869 3,403
PF16669 TTC5_OB 600 334
PF16686 POT1PC 1,163 737
PF16745 RsgA_N 8,258 3,582
PF16773 Phage_SSB 216 14
PF16853 CDC13_N 50 34
PF16900 REPA_OB_2 3,307 2,037
PF16992 RNA_pol_RpbG 77 50
PF17092 PCB_OB 11,053 4,109
PF17185 NlpE_C 1,378 395
PF17191 RecG_wedge 24,441 10,641
PF17207 MCM_OB 18,307 7,331
PF17215 Rrp44_S1 1,861 832
PF17216 Rrp44_CSD1 2,565 1,211
PF17244 CDC24_OB3 350 213
PF17245 CDC24_OB2 269 173
PF17246 CDC24_OB1 253 167
PF17746 SfsA_N 8,539 4,035
PF17758 Prot_ATP_OB_N 3,210 812
PF17768 RecJ_OB 24,785 11,110
PF17845 FbpC_C_terminal 39 6
PF17847 GlcV_C_terminal 44 19
PF17849 OB_Dis3 4,245 2,202
PF17850 CysA_C_terminal 2,197 761
PF17875 RPA43_OB 958 625
PF17876 CSD2 21,414 7,960
PF17878 ssDBP 3 3
PF17879 DNA_ligase_C 183 75
PF17912 OB_MalK 34,238 11,577
PF18018 DNA_pol_D_N 1,906 1,093
PF18352 Gp138_N 1,628 745
PF18543 ID 151 121
PF18614 RNase_II_C_S1 2,194 1,312
PF18691 Cdc13_OB2 24 12
PF18693 TRAM_2 16,632 6,407
CL0022 LRR 248,383 153,612 PF00560 LRR_1 34,506 24,383
PF01030 Recep_L_domain 5,157 2,712
PF03382 DUF285 6,025 4,592
PF05725 FNIP 1,878 1,521
PF07723 LRR_2 2,396 1,869
PF07725 LRR_3 2,568 1,844
PF12468 TTSSLRR 805 156
PF12799 LRR_4 18,143 11,040
PF13306 LRR_5 23,235 15,980
PF13516 LRR_6 50,750 33,587
PF13855 LRR_8 142,773 84,823
PF14580 LRR_9 11,934 6,812
CL0023 P-loop_NTPase 7,068,145 3,046,116 PF00004 AAA 319,248 130,982
PF00005 ABC_tran 1,937,692 807,820
PF00006 ATP-synt_ab 151,599 35,783
PF00009 GTP_EFTU 309,044 80,948
PF00025 Arf 26,141 10,160
PF00063 Myosin_head 35,185 15,364
PF00071 Ras 101,164 42,311
PF00142 Fer4_NifH 46,745 4,829
PF00154 RecA 50,718 10,606
PF00158 Sigma54_activat 158,818 69,226
PF00176 SNF2_N 89,670 48,568
PF00225 Kinesin 48,401 27,231
PF00265 TK 16,439 6,520
PF00270 DEAD 349,792 158,992
PF00271 Helicase_C 506,666 234,119
PF00308 Bac_DnaA 38,003 14,440
PF00350 Dynamin_N 33,419 16,528
PF00406 ADK 44,686 19,122
PF00437 T2SSE 101,984 46,609
PF00448 SRP54 68,914 26,217
PF00485 PRK 37,580 14,147
PF00488 MutS_V 55,410 25,883
PF00493 MCM 19,434 8,143
PF00503 G-alpha 13,557 5,835
PF00519 PPV_E1_C 3,343 844
PF00580 UvrD-helicase 86,824 39,379
PF00625 Guanylate_kin 46,764 19,560
PF00685 Sulfotransfer_1 22,760 14,531
PF00693 Herpes_TK 881 102
PF00709 Adenylsucc_synt 32,803 11,105
PF00735 Septin 13,489 4,655
PF00910 RNA_helicase 15,474 3,027
PF00931 NB-ARC 72,738 51,721
PF01057 Parvo_NS1 3,436 559
PF01078 Mg_chelatase 29,805 14,620
PF01121 CoaE 29,749 15,754
PF01202 SKI 42,983 20,423
PF01268 FTHFS 19,595 7,774
PF01443 Viral_helicase1 8,944 2,150
PF01580 FtsK_SpoIIIE 50,045 23,197
PF01583 APS_kinase 21,467 9,838
PF01591 6PF2K 5,950 2,533
PF01637 ATPase_2 6,437 3,878
PF01656 CbiA 60,018 28,635
PF01695 IstB_IS21 33,261 13,761
PF01712 dNK 14,205 6,237
PF01715 IPPT 33,465 17,414
PF01745 IPT 510 312
PF01926 MMR_HSR1 240,928 97,546
PF01935 DUF87 17,918 10,021
PF02223 Thymidylate_kin 32,370 16,876
PF02224 Cytidylate_kin 26,059 12,213
PF02263 GBP 4,557 2,533
PF02283 CobU 14,743 7,362
PF02367 TsaE 27,619 14,142
PF02374 ArsA_ATPase 15,317 6,883
PF02399 Herpes_ori_bp 989 549
PF02421 FeoB_N 21,108 9,666
PF02456 Adeno_IVa2 421 122
PF02463 SMC_N 81,486 37,861
PF02492 cobW 59,733 23,953
PF02499 DNA_pack_C 735 133
PF02500 DNA_pack_N 508 95
PF02534 T4SS-DNA_transf 17,535 7,154
PF02562 PhoH 38,757 13,194
PF02572 CobA_CobO_BtuR 15,409 6,100
PF02606 LpxK 16,479 8,679
PF02689 Herpes_Helicase 4,183 2,173
PF02702 KdpD 11,628 4,110
PF02841 GBP_C 2,737 1,420
PF03028 Dynein_heavy 9,025 5,725
PF03029 ATP_bind_1 15,699 5,972
PF03192 DUF257 324 261
PF03193 RsgA_GTPase 25,768 11,127
PF03205 MobB 9,411 4,678
PF03215 Rad17 2,033 1,303
PF03237 Terminase_6 12,239 6,222
PF03266 NTPase_1 2,765 1,737
PF03308 MeaB 17,474 8,974
PF03354 Terminase_1 10,463 4,582
PF03567 Sulfotransfer_2 11,890 7,339
PF03618 Kinase-PPPase 12,990 4,010
PF03668 ATP_bind_2 19,173 7,092
PF03796 DnaB_C 40,582 16,158
PF03846 SulA 2,846 770
PF03969 AFG1_ATPase 16,978 6,862
PF03976 PPK2 22,872 10,618
PF04257 Exonuc_V_gamma 9,880 4,084
PF04310 MukB 2,050 271
PF04317 DUF463 4,089 1,354
PF04466 Terminase_3 4,606 2,378
PF04548 AIG1 8,759 6,039
PF04665 Pox_A32 1,542 385
PF04670 Gtr1_RagA 3,766 1,618
PF04851 ResIII 105,032 47,419
PF05049 IIGP 1,273 948
PF05127 Helicase_RecD 5,355 2,556
PF05179 CDC73_C 1,878 993
PF05272 VirE 6,188 2,413
PF05496 RuvB_N 33,178 11,862
PF05609 LAP1C 674 376
PF05621 TniB 3,852 2,080
PF05625 PAXNEB 1,869 1,055
PF05673 DUF815 8,547 3,503
PF05707 Zot 2,619 1,635
PF05729 NACHT 30,572 23,932
PF05783 DLIC 2,535 1,237
PF05872 DUF853 10,936 4,582
PF05876 Terminase_GpA 5,924 2,847
PF05879 RHD3 2,670 1,637
PF05894 Podovirus_Gp16 74 54
PF05970 PIF1 15,966 11,758
PF06048 DUF927 3,497 1,923
PF06068 TIP49 4,456 1,592
PF06144 DNA_pol3_delta 23,962 10,280
PF06309 Torsin 1,563 870
PF06414 Zeta_toxin 6,334 3,578
PF06418 CTP_synth_N 32,328 10,630
PF06431 Polyoma_lg_T_C 2,255 163
PF06564 CBP_BcsQ 3,724 1,615
PF06733 DEAD_2 16,049 7,449
PF06745 ATPase 12,097 6,453
PF06858 NOG1 2,900 1,345
PF06990 Gal-3-0_sulfotr 1,685 1,080
PF07015 VirC1 1,735 772
PF07034 ORC3_N 1,654 1,024
PF07088 GvpD 213 132
PF07517 SecA_DEAD 36,235 14,017
PF07529 HSA 5,445 2,924
PF07652 Flavi_DEAD 32,178 870
PF07693 KAP_NTPase 7,319 5,197
PF07724 AAA_2 121,154 38,811
PF07726 AAA_3 42,035 17,851
PF07728 AAA_5 45,392 20,863
PF07755 DUF1611 3,745 2,100
PF07931 CPT 2,179 1,424
PF07999 RHSP 2,363 1,561
PF08298 AAA_PrkA 7,915 1,748
PF08303 tRNA_lig_kinase 929 578
PF08351 DUF1726 4,551 2,152
PF08423 Rad51 11,780 5,830
PF08433 KTI12 2,242 1,463
PF08438 MMR_HSR1_C 2,438 1,155
PF08477 Roc 4,586 2,996
PF09037 Sulphotransf 1,226 672
PF09140 MipZ 2,643 1,224
PF09439 SRPRB 1,905 1,065
PF09547 Spore_IV_A 3,100 1,014
PF09711 Cas_Csn2 746 359
PF09807 ELP6 990 612
PF09818 ABC_ATPase 2,423 1,294
PF09820 AAA-ATPase_like 10,709 5,857
PF09848 DUF2075 4,971 3,020
PF10088 DUF2326 1,365 929
PF10236 DAP3 1,889 1,104
PF10412 TrwB_AAD_bind 8,411 4,281
PF10443 RNA12 867 514
PF10483 Elong_Iki1 1,362 846
PF10609 ParA 41,532 18,156
PF10649 DUF2478 1,269 876
PF10662 PduV-EutP 2,606 816
PF10923 DUF2791 2,457 1,268
PF10996 Beta-Casp 19,267 9,965
PF11111 CENP-M 346 193
PF11398 DUF2813 1,991 595
PF11496 HDA2-3 476 338
PF11602 NTPase_P4 11 7
PF12128 DUF3584 891 452
PF12344 UvrB 28,468 9,226
PF12399 BCA_ABC_TP_C 65,661 25,134
PF12696 TraG-D_C 11,133 4,868
PF12774 AAA_6 9,960 6,246
PF12775 AAA_7 8,884 5,702
PF12780 AAA_8 9,006 5,790
PF12781 AAA_9 9,211 5,753
PF12846 AAA_10 8,326 2,701
PF12848 ABC_tran_Xtn 87,123 25,851
PF13086 AAA_11 29,745 18,243
PF13087 AAA_12 36,819 21,934
PF13166 AAA_13 4,052 2,857
PF13173 AAA_14 27,103 16,635
PF13175 AAA_15 19,508 13,713
PF13177 DNA_pol3_delta2 61,084 29,866
PF13189 Cytidylate_kin2 9,490 5,105
PF13191 AAA_16 42,522 28,396
PF13207 AAA_17 3,236 2,191
PF13238 AAA_18 12,323 6,674
PF13245 AAA_19 29,222 15,848
PF13304 AAA_21 32,947 21,691
PF13307 Helicase_C_2 33,319 13,758
PF13337 Lon_2 2,108 1,096
PF13361 UvrD_C 97,470 44,345
PF13401 AAA_22 27,620 16,208
PF13469 Sulfotransfer_3 21,658 14,589
PF13476 AAA_23 34,661 20,539
PF13479 AAA_24 4,600 2,417
PF13481 AAA_25 35,461 14,197
PF13500 AAA_26 30,922 13,070
PF13514 AAA_27 4,811 2,517
PF13521 AAA_28 12,113 6,261
PF13538 UvrD_C_2 35,340 16,452
PF13555 AAA_29 4,504 2,159
PF13558 SbcCD_C 20,450 9,336
PF13604 AAA_30 36,095 17,117
PF13614 AAA_31 98,917 42,449
PF13654 AAA_32 8,370 3,337
PF13671 AAA_33 30,162 16,512
PF13871 Helicase_C_4 3,465 1,662
PF13872 AAA_34 3,486 1,750
PF13892 DBINO 2,308 1,106
PF14396 CFTR_R 326 120
PF14417 MEDS 3,936 2,887
PF14516 AAA_35 4,095 2,867
PF14532 Sigma54_activ_2 3,949 2,068
PF14617 CMS1 1,304 746
PF16203 ERCC3_RAD25_C 6,816 2,478
PF16575 CLP1_P 4,372 2,710
PF16796 Microtub_bd 894 698
PF16813 Cas_St_Csn2 139 66
PF16834 CSM2 53 35
PF16836 PSY3 87 61
PF17213 Hydin_ADK 205 162
PF17784 Sulfotransfer_4 4,749 3,209
PF18128 HydF_dimer 2,649 1,415
PF18133 HydF_tetramer 2,703 1,456
PF18747 Ploopntkinase2 55 15
PF18748 Ploopntkinase1 67 13
PF18751 Ploopntkinase3 177 20
PF18766 SWI2_SNF2 18,465 9,230
CL0025 His_Kinase_A 1,106,276 568,796 PF00512 HisKA 578,956 297,983
PF02518 HATPase_c 887,637 445,453
PF02895 H-kinase_dim 19,473 9,633
PF07536 HWE_HK 10,595 6,300
PF07568 HisKA_2 16,348 9,412
PF07730 HisKA_3 99,150 56,422
PF10090 HPTransfase 2,520 1,277
PF13581 HATPase_c_2 56,718 32,338
PF13589 HATPase_c_3 52,551 27,437
PF14501 HATPase_c_5 14,368 7,237
CL0026 CU_oxidase 198,923 77,860 PF00116 COX2 82,023 20,804
PF00127 Copper-bind 15,938 9,247
PF00394 Cu-oxidase 45,103 18,938
PF00812 Ephrin 2,315 1,121
PF02298 Cu_bind_like 7,247 4,620
PF06481 COX_ARM 6,182 1,653
PF06525 SoxE 458 330
PF07731 Cu-oxidase_2 45,243 22,625
PF07732 Cu-oxidase_3 50,307 25,142
PF08526 PAD_N 598 301
PF08985 DP-EP 142 87
PF12306 PixA 928 432
PF13473 Cupredoxin_1 19,782 9,596
PF14699 hGDE_N 1,370 696
PF16986 CzcE 322 197
CL0027 RdRP 583,901 126,838 PF00078 RVT_1 453,897 93,553
PF00680 RdRP_1 39,403 4,950
PF00972 Flavi_NS5 11,037 565
PF00978 RdRP_2 7,379 1,316
PF00998 RdRP_3 38,966 1,658
PF02123 RdRP_4 4,640 682
PF04197 Birna_RdRp 894 38
PF05919 Mitovir_RNA_pol 526 365
PF07727 RVT_2 27,284 23,855
PF17501 Viral_RdRp_C 19 8
CL0028 AB_hydrolase 1,271,944 689,490 PF00135 COesterase 50,743 32,030
PF00151 Lipase 7,973 4,814
PF00326 Peptidase_S9 99,345 55,183
PF00450 Peptidase_S10 24,899 15,352
PF00561 Abhydrolase_1 245,165 127,780
PF00756 Esterase 59,163 28,893
PF00975 Thioesterase 37,053 20,341
PF01083 Cutinase 10,009 4,930
PF01674 Lipase_2 4,141 2,347
PF01738 DLH 52,746 28,168
PF01764 Lipase_3 23,504 14,713
PF02089 Palm_thioest 6,013 3,572
PF02129 Peptidase_S15 30,214 15,569
PF02230 Abhydrolase_2 24,943 13,638
PF02273 Acyl_transf_2 197 83
PF02450 LCAT 6,300 3,755
PF03096 Ndr 3,872 1,395
PF03283 PAE 3,932 2,281
PF03403 PAF-AH_p_II 7,570 4,893
PF03583 LIP 10,511 5,187
PF03893 Lipase3_N 1,240 698
PF03959 FSH1 6,506 4,156
PF04083 Abhydro_lipase 4,649 3,221
PF04301 DUF452 1,035 409
PF05057 DUF676 7,631 4,907
PF05277 DUF726 3,594 2,101
PF05448 AXE1 8,125 4,830
PF05576 Peptidase_S37 1,329 635
PF05577 Peptidase_S28 6,666 4,504
PF05677 DUF818 250 172
PF05705 DUF829 3,122 1,944
PF05728 UPF0227 8,578 3,159
PF05990 DUF900 5,006 3,061
PF06028 DUF915 3,918 1,440
PF06057 VirJ 2,662 932
PF06259 Abhydrolase_8 4,633 2,799
PF06342 DUF1057 393 285
PF06441 EHN 10,913 6,577
PF06500 DUF1100 4,320 1,974
PF06821 Ser_hydrolase 10,407 4,907
PF06850 PHB_depo_C 5,220 2,146
PF07082 DUF1350 1,015 585
PF07167 PhaC_N 9,581 4,237
PF07176 DUF1400 1,623 989
PF07224 Chlorophyllase 926 607
PF07519 Tannase 7,897 4,709
PF07819 PGAP1 6,298 3,755
PF07859 Abhydrolase_3 94,385 53,699
PF08237 PE-PPE 3,686 1,926
PF08386 Abhydrolase_4 11,841 7,724
PF08538 DUF1749 1,599 976
PF08840 BAAT_C 4,048 2,539
PF09752 DUF2048 1,758 830
PF09994 DUF2235 10,103 6,752
PF10081 Abhydrolase_9 2,693 1,344
PF10142 PhoPQ_related 1,417 856
PF10230 LIDHydrolase 1,833 1,135
PF10340 Say1_Mug180 446 307
PF10503 Esterase_phd 12,150 7,716
PF11144 DUF2920 401 246
PF11187 DUF2974 3,879 1,702
PF11288 DUF3089 1,869 1,310
PF11339 DUF3141 1,649 894
PF12048 DUF3530 1,916 863
PF12146 Hydrolase_4 114,796 60,191
PF12695 Abhydrolase_5 2,910 1,537
PF12697 Abhydrolase_6 174,101 98,280
PF12715 Abhydrolase_7 1,426 866
PF12740 Chlorophyllase2 3,227 2,087
PF16929 Asp2 929 392
CL0029 Cupin 934,281 465,068 PF00027 cNMP_binding 154,743 79,981
PF00190 Cupin_1 15,464 7,644
PF00908 dTDP_sugar_isom 26,167 14,491
PF01050 MannoseP_isomer 18,719 9,222
PF01238 PMI_typeI 16,283 7,348
PF01987 AIM24 16,330 6,318
PF02041 Auxin_BP 355 215
PF02311 AraC_binding 75,405 33,267
PF02373 JmjC 15,499 8,447
PF02375 JmjN 6,536 3,566
PF02668 TauD 43,193 21,969
PF02678 Pirin 39,082 17,011
PF03079 ARD 6,781 2,804
PF03171 2OG-FeII_Oxy 43,585 23,798
PF03336 Pox_C4_C10 257 59
PF04074 DUF386 8,392 2,749
PF04115 Ureidogly_lyase 6,664 2,878
PF04209 HgmA 11,345 4,119
PF04622 ERG2_Sigma1R 1,413 760
PF04831 Popeye 1,352 712
PF04962 KduI 12,154 4,705
PF05118 Asp_Arg_Hydrox 8,664 3,800
PF05523 FdtA 4,546 3,151
PF05721 PhyH 43,292 26,512
PF05726 Pirin_C 23,305 10,723
PF05899 Cupin_3 12,744 4,814
PF05962 HutD 5,871 2,744
PF05995 CDO_I 7,770 3,774
PF06052 3-HAO 4,015 1,964
PF06172 Cupin_5 7,188 4,102
PF06249 EutQ 2,662 1,051
PF06339 Ectoine_synth 3,762 1,292
PF06560 GPI 1,816 1,032
PF06719 AraC_N 12,670 5,305
PF06865 Ppnp 5,677 1,757
PF07350 DUF1479 2,871 1,185
PF07385 Lyx_isomer 2,017 946
PF07847 PCO_ADO 1,957 1,120
PF07883 Cupin_2 144,704 71,905
PF08007 Cupin_4 10,284 4,604
PF08487 VIT 7,172 4,685
PF08943 CsiD 1,204 272
PF09313 DUF1971 2,987 863
PF09859 Oxygenase-NA 3,236 1,665
PF10014 2OG-Fe_Oxy_2 3,276 1,552
PF10637 Ofd1_CTDD 1,525 947
PF11699 CENP-C_C 1,074 712
PF12851 Tet_JBP 1,081 587
PF12852 Cupin_6 13,489 6,548
PF12933 FTO_NTD 428 146
PF12973 Cupin_7 9,440 5,240
PF13532 2OG-FeII_Oxy_2 21,772 12,041
PF13621 Cupin_8 14,128 8,503
PF13640 2OG-FeII_Oxy_3 30,025 15,936
PF13661 2OG-FeII_Oxy_4 2,509 1,581
PF13757 VIT_2 345 222
PF13759 2OG-FeII_Oxy_5 4,173 3,032
PF14226 DIOX_N 40,163 22,078
PF14499 DUF4437 1,014 654
PF14525 AraC_binding_2 15,862 7,859
PF16161 DUF4867 1,074 479
PF16802 DUF5070 31 15
PF16867 DMSP_lyase 1,258 758
PF17954 Pirin_C_2 13,929 5,321
PF18637 AUDH_Cupin 77 63
CL0030 Ion_channel 191,790 94,756 PF00060 Lig_chan 17,065 9,205
PF00520 Ion_trans 74,573 36,858
PF01007 IRK 4,805 1,660
PF02386 TrkH 34,970 15,786
PF03814 KdpA 11,795 3,751
PF07885 Ion_trans_2 44,400 25,072
PF08016 PKD_channel 5,014 3,260
CL0031 Phosphatase 369,683 179,452 PF00102 Y_phosphatase 27,739 14,744
PF00581 Rhodanese 160,453 80,524
PF00782 DSPc 35,543 19,653
PF01451 LMWPc 52,626 26,919
PF02302 PTS_IIB 46,906 12,980
PF02383 Syja_N 8,957 4,885
PF03162 Y_phosphatase2 3,866 2,311
PF04179 Init_tRNA_PT 1,038 660
PF04273 DUF442 7,251 3,669
PF04722 Ssu72 1,798 859
PF05706 CDKN3 1,183 677
PF06602 Myotub-related 8,545 3,973
PF13350 Y_phosphatase3 14,538 7,833
PF14566 PTPlike_phytase 1,670 951
PF14671 DSPn 2,260 1,124
PF16809 NleF_casp_inhib 107 30
CL0032 Dim_A_B_barrel 334,943 146,252 PF01037 AsnC_trans_reg 109,116 35,169
PF02426 MIase 3,710 1,269
PF03795 YCII 38,621 20,022
PF03927 NapD 2,811 1,294
PF03992 ABM 58,273 28,232
PF04261 Dyp_perox 15,404 5,644
PF04486 SchA_CurD 584 290
PF04673 Cyclase_polyket 1,070 507
PF05336 rhaM 9,210 4,687
PF06778 Chlor_dismutase 6,735 2,435
PF07045 DUF1330 12,833 7,060
PF07110 EthD 7,418 4,324
PF07237 DUF1428 3,659 1,848
PF07682 SOR 82 45
PF07876 Dabb 13,675 7,817
PF07978 NIPSNAP 11,917 6,118
PF08734 GYD 3,753 2,067
PF08803 ydhR 1,941 803
PF09448 MmlI 680 390
PF11639 HapK 295 186
PF11695 DUF3291 2,072 1,410
PF13816 Dehydratase_hem 1,051 511
PF13826 DUF4188 2,107 1,284
PF14026 DUF4242 3,225 1,808
PF16291 DUF4937 1,188 283
PF17805 AsnC_trans_reg2 5,298 3,044
PF18075 FtsX_ECD 18,966 8,089
PF18232 Chalcone_N 81 42
CL0033 POZ 116,744 60,305 PF00651 BTB 84,697 46,648
PF02214 BTB_2 17,926 7,666
PF03931 Skp1_POZ 6,398 3,199
PF07707 BACK 29,332 12,082
PF11822 DUF3342 501 269
PF16017 BTB_3 847 315
CL0034 Amidohydrolase 557,001 264,862 PF00449 Urease_alpha 13,039 3,260
PF00962 A_deaminase 28,787 12,510
PF01026 TatD_DNase 51,634 23,870
PF01244 Peptidase_M19 22,019 11,371
PF01876 RNase_P_p30 2,586 1,593
PF01979 Amidohydro_1 212,877 96,938
PF02126 PTE 5,834 2,784
PF02614 UxaC 8,255 3,650
PF02811 PHP 82,163 37,529
PF04909 Amidohydro_2 71,380 38,497
PF07969 Amidohydro_3 65,063 32,210
PF12228 DUF3604 3,142 2,303
PF12890 DHOase 281 199
PF13263 PHP_C 6,643 4,022
CL0035 Peptidase_MH 459,996 220,167 PF00246 Peptidase_M14 40,145 23,498
PF00274 Glycolytic 10,306 4,474
PF00883 Peptidase_M17 32,823 14,902
PF01520 Amidase_3 46,832 22,944
PF01546 Peptidase_M20 196,572 86,274
PF02127 Peptidase_M18 12,448 5,511
PF04389 Peptidase_M28 52,214 31,219
PF04952 AstE_AspA 22,763 10,268
PF05013 FGase 13,935 7,386
PF05343 Peptidase_M42 20,514 8,202
PF05450 Nicastrin 1,223 688
PF05908 Gamma_PGA_hydro 1,992 806
PF07454 SpoIIP 4,199 1,887
PF10994 DUF2817 1,783 1,054
PF16254 DUF4910 1,313 839
PF17033 Peptidase_M99 878 275
PF18266 Ncstrn_small 939 529
CL0036 TIM_barrel 1,942,425 831,877 PF00121 TIM 39,633 16,275
PF00215 OMPdecase 36,529 15,500
PF00218 IGPS 28,032 11,567
PF00290 Trp_syntA 26,745 11,587
PF00478 IMPDH 43,652 12,695
PF00490 ALAD 25,059 9,074
PF00682 HMGL-like 88,706 35,385
PF00697 PRAI 23,716 12,057
PF00701 DHDPS 73,249 31,018
PF00724 Oxidored_FMN 78,840 34,301
PF00793 DAHP_synth_1 50,245 17,785
PF00809 Pterin_bind 54,368 23,753
PF00834 Ribul_P_3_epim 34,634 14,046
PF00923 TAL_FSA 34,519 12,965
PF00977 His_biosynth 52,549 19,970
PF01070 FMN_dh 35,976 16,073
PF01081 Aldolase 25,283 10,580
PF01116 F_bP_aldolase 36,014 11,492
PF01168 Ala_racemase_N 80,472 38,510
PF01180 DHO_dh 41,171 18,173
PF01207 Dus 53,855 22,333
PF01261 AP_endonuc_2 121,418 58,957
PF01474 DAHP_synth_2 11,724 3,904
PF01487 DHquinase_I 9,886 4,629
PF01645 Glu_synthase 38,317 13,957
PF01680 SOR_SNZ 10,695 2,833
PF01729 QRPTase_C 26,485 12,091
PF01791 DeoC 36,030 14,344
PF01884 PcrB 4,419 2,245
PF01964 ThiC_Rad_SAM 18,775 5,512
PF02007 MtrH 593 319
PF02581 TMP-TENI 36,137 17,975
PF02679 ComA 2,383 1,474
PF02784 Orn_Arg_deC_N 57,087 22,134
PF03060 NMO 45,447 20,042
PF03102 NeuB 13,097 8,222
PF03437 BtpA 3,341 1,782
PF03599 CdhD 2,926 1,952
PF03740 PdxJ 15,481 6,437
PF03786 UxuA 9,621 4,085
PF03851 UvdE 4,056 1,954
PF03932 CutC 11,213 4,945
PF04055 Radical_SAM 426,033 198,653
PF04095 NAPRTase 20,814 7,221
PF04131 NanE 5,765 2,151
PF04309 G3P_antiterm 4,125 1,431
PF04476 4HFCP_synth 1,390 818
PF04481 DUF561 765 434
PF04898 Glu_syn_central 23,813 8,066
PF05114 DUF692 8,640 4,613
PF05690 ThiG 18,345 5,971
PF06134 RhaA 3,751 1,342
PF06187 DUF993 2,566 1,172
PF07071 KDGP_aldolase 2,125 379
PF08013 Tagatose_6_P_K 3,345 1,150
PF09043 Lys-AminoMut_A 1,354 660
PF09863 DUF2090 3,127 992
PF16552 OAM_alpha 370 216
PF17285 PRMT5_TIM 1,939 999
CL0037 Lysozyme 266,610 122,990 PF00062 Lys 2,566 1,293
PF00182 Glyco_hydro_19 9,743 4,647
PF00912 Transgly 81,162 35,229
PF00959 Phage_lysozyme 12,071 5,242
PF01374 Glyco_hydro_46 1,382 763
PF01464 SLT 88,814 43,224
PF01832 Glucosaminidase 24,921 10,988
PF03998 Utp11 1,823 1,062
PF05497 Destabilase 692 520
PF05838 Glyco_hydro_108 4,266 2,361
PF06737 Transglycosylas 8,339 4,269
PF06871 TraH_2 362 198
PF10464 Peptidase_U40 37 6
PF11508 DUF3218 20 4
PF13406 SLT_2 22,949 10,579
PF13647 Glyco_hydro_80 19 6
PF13702 Lysozyme_like 4,216 921
PF16754 Pesticin 417 300
PF18013 Phage_lysozyme2 2,858 1,431
CL0039 HUP 1,096,771 496,317 PF00133 tRNA-synt_1 108,368 47,829
PF00579 tRNA-synt_1b 73,623 30,349
PF00582 Usp 123,690 64,737
PF00733 Asn_synthase 44,603 24,412
PF00749 tRNA-synt_1c 68,201 30,088
PF00750 tRNA-synt_1d 35,312 15,523
PF00764 Arginosuc_synth 27,212 8,006
PF00875 DNA_photolyase 25,641 14,292
PF01012 ETF 61,165 23,758
PF01171 ATP_bind_3 46,645 23,394
PF01406 tRNA-synt_1e 38,289 17,240
PF01467 CTP_transf_like 89,770 42,412
PF01507 PAPS_reduct 42,694 16,349
PF01747 ATP-sulfurylase 8,373 3,817
PF01902 Diphthami_syn_2 6,754 4,141
PF01921 tRNA-synt_1f 5,942 2,753
PF02540 NAD_synthase 62,440 24,922
PF02568 ThiI 12,591 4,864
PF02569 Pantoate_ligase 23,343 11,312
PF03054 tRNA_Me_trans 33,849 13,727
PF03720 UDPG_MGDP_dh_C 51,408 25,401
PF04244 DPRP 6,720 3,851
PF05636 HIGH_NTase1 6,147 2,617
PF06508 QueC 19,160 8,262
PF06574 FAD_syn 27,551 12,475
PF08218 Citrate_ly_lig 2,753 954
PF09334 tRNA-synt_1g 58,440 24,494
PF10079 BshC 4,154 2,416
PF13603 tRNA-synt_1_2 30,833 12,674
PF16581 HIGH_NTase1_ass 137 91
PF16715 CDPS 675 382
CL0040 tRNA_synt_II 460,770 190,495 PF00152 tRNA-synt_2 94,555 37,235
PF00587 tRNA-synt_2b 119,874 47,296
PF01409 tRNA-synt_2d 35,772 13,337
PF01411 tRNA-synt_2c 42,565 18,700
PF02091 tRNA-synt_2e 15,533 3,906
PF03099 BPL_LplA_LipB 63,632 31,039
PF03590 AsnA 5,487 1,620
PF04017 DUF366 415 262
PF13393 tRNA-synt_His 49,478 21,738
PF16917 BPL_LplA_LipB_2 864 583
PF17759 tRNA_synthFbeta 32,659 14,868
CL0041 Death 24,091 12,387 PF00531 Death 11,812 5,912
PF00619 CARD 6,796 3,710
PF01335 DED 2,206 1,053
PF02758 PYRIN 2,863 1,541
PF14786 Death_2 254 139
PF16739 CARD_2 810 440
PF18461 Atypical_Card 176 102
CL0042 Flavoprotein 198,674 86,242 PF00258 Flavodoxin_1 46,426 18,324
PF02525 Flavodoxin_2 44,399 17,563
PF03358 FMN_red 83,046 38,847
PF07972 Flavodoxin_NdrI 6,754 1,931
PF12641 Flavodoxin_3 2,037 993
PF12682 Flavodoxin_4 6,192 3,527
PF12724 Flavodoxin_5 9,852 5,265
CL0043 Chelatase 185,646 84,208 PF00148 Oxidored_nitro 19,919 8,230
PF00762 Ferrochelatase 24,378 10,343
PF01297 ZnuA 38,155 17,490
PF01497 Peripla_BP_2 86,814 39,772
PF01903 CbiX 12,916 6,923
PF06180 CbiK 3,371 1,432
PF11844 DUF3364 1,404 422
CL0044 Ferritin 221,240 92,075 PF00210 Ferritin 53,900 19,272
PF00268 Ribonuc_red_sm 27,242 7,047
PF01786 AOX 3,113 1,791
PF02332 Phenol_Hydrox 4,675 1,336
PF02915 Rubrerythrin 23,444 11,856
PF03232 COQ7 7,508 3,483
PF03405 FA_desaturase_2 6,037 1,935
PF03713 DUF305 13,738 8,032
PF04305 DUF455 5,237 2,840
PF05067 Mn_catalase 8,496 3,012
PF05138 PaaA_PaaC 12,894 4,890
PF05974 DUF892 7,636 3,550
PF06175 MiaE 5,996 2,078
PF07875 Coat_F 5,454 2,403
PF09537 DUF2383 4,817 2,545
PF09968 DUF2202 961 750
PF11266 Ald_deCOase 630 265
PF11553 DUF3231 3,143 1,684
PF11583 AurF 6,398 2,242
PF12902 Ferritin-like 1,460 945
PF13628 DUF4142 8,289 4,443
PF13668 Ferritin_2 5,974 3,787
PF13794 MiaE_2 2,296 821
PF14530 DUF4439 1,958 1,109
PF18536 DUF5623 124 88
CL0045 Rubredoxin 32,496 15,780 PF00301 Rubredoxin 16,151 6,754
PF01215 COX5B 1,964 1,064
PF06397 Desulfoferrod_N 2,713 1,605
PF08421 Methyltransf_13 5,082 3,183
PF10276 zf-CHCC 6,582 3,175
CL0046 Thiolase 342,939 146,837 PF00108 Thiolase_N 119,592 41,638
PF00109 ketoacyl-synt 131,550 64,394
PF00195 Chal_sti_synt_N 11,949 4,630
PF01154 HMG_CoA_synt_N 7,097 3,012
PF02797 Chal_sti_synt_C 11,980 4,846
PF02801 Ketoacyl-synt_C 126,885 61,389
PF02803 Thiolase_C 117,803 40,575
PF07451 SpoVAD 4,045 1,521
PF08392 FAE1_CUT1_RppA 4,351 2,291
PF08540 HMG_CoA_synt_C 6,811 2,839
PF08541 ACP_syn_III_C 51,543 22,050
PF08545 ACP_syn_III 45,962 19,179
PF08990 Docking 4,179 2,921
PF13723 Ketoacyl-synt_2 4,170 2,026
PF16197 KAsynt_C_assoc 40,011 26,273
PF18605 PikAIV_N 1,303 866
CL0047 CuAO_N2_N3 7,083 3,452 PF02727 Cu_amine_oxidN2 5,722 2,688
PF02728 Cu_amine_oxidN3 5,769 2,644
PF09248 DUF1965 541 364
CL0048 LolA_LolB 71,746 36,911 PF03548 LolA 17,481 8,145
PF03550 LolB 6,855 2,737
PF03888 MucB_RseB 5,498 2,204
PF04507 DUF576 1,401 348
PF07044 DUF1329 6,661 2,559
PF07161 LppX_LprAFG 1,431 782
PF07608 DUF1571 923 513
PF09697 Porph_ging 4,957 3,439
PF09865 DUF2092 1,342 982
PF11306 DUF3108 11,405 6,479
PF11659 DUF3261 1,715 814
PF14125 DUF4292 2,921 1,931
PF14371 DUF4412 1,024 858
PF16584 LolA_2 959 477
PF17131 LolA_like 7,088 4,627
PF18234 VioE 70 38
CL0049 Tudor 166,262 89,645 PF00385 Chromo 22,213 13,487
PF00565 SNase 22,704 14,234
PF00567 TUDOR 9,384 5,570
PF00855 PWWP 12,593 6,373
PF01393 Chromo_shadow 2,875 1,547
PF02294 7kD_DNA_binding 65 10
PF02820 MBT 4,305 1,950
PF04397 LytTR 62,522 32,425
PF05641 Agenet 4,354 2,271
PF06003 SMN 1,985 1,049
PF07039 DUF1325 1,772 965
PF08169 RBB1NT 814 389
PF08605 Rad9_Rad53_bind 219 160
PF09038 53-BP1_Tudor 414 225
PF09465 LBR_tudor 400 211
PF11160 Hva1_TUDOR 4,075 2,402
PF11515 Cul7 803 394
PF11717 Tudor-knot 6,247 3,166
PF12148 TTD 580 270
PF14061 Mtf2_C 737 257
PF15057 DUF4537 438 297
PF16090 DUF4819 468 298
PF16719 SAWADEE 867 536
PF17516 ProQ_C 1,880 345
PF18104 Tudor_2 1,864 707
PF18115 Tudor_3 928 526
PF18336 Tudor_FRX1 1,324 362
PF18337 Tudor_RapA 4,538 1,007
PF18339 Tudor_1_RapA 4,577 1,062
PF18358 Tudor_4 577 316
PF18359 TUDOR_5 538 310
PF18380 GEN1_C 676 473
PF18704 Chromo_2 335 234
CL0050 HotDog 359,058 165,503 PF01575 MaoC_dehydratas 63,593 28,327
PF01643 Acyl-ACP_TE 8,450 4,213
PF02551 Acyl_CoA_thio 435 243
PF03061 4HBT 130,251 57,829
PF03756 AfsA 1,830 1,167
PF07977 FabA 37,150 13,892
PF09500 YiiD_C 3,772 1,161
PF10862 FcoT 301 154
PF13279 4HBT_2 34,170 16,945
PF13452 MaoC_dehydrat_N 20,749 10,018
PF13622 4HBT_3 26,772 11,457
PF14539 DUF4442 9,037 4,127
PF14765 PS-DH 29,871 20,225
CL0051 NTF2 238,811 124,912 PF00866 Ring_hydroxyl_B 8,747 3,221
PF02136 NTF2 8,861 4,505
PF02982 Scytalone_dh 693 369
PF03284 PHZA_PHZB 410 191
PF04280 Tim44 11,761 5,466
PF04335 VirB8 8,706 2,570
PF05223 MecA_N 5,660 2,265
PF05494 MlaC 11,500 5,441
PF07080 DUF1348 6,139 2,502
PF07107 WI12 465 320
PF07366 SnoaL 15,290 9,210
PF07858 LEH 2,052 1,091
PF07961 MBA1 343 225
PF08332 CaMKII_AD 4,805 1,736
PF10184 DUF2358 2,365 1,442
PF10429 Mtr2 180 112
PF11393 T4BSS_DotI_IcmL 1,227 604
PF11533 DUF3225 2,033 903
PF12642 TpcC 2,660 885
PF12680 SnoaL_2 61,055 33,691
PF12707 DUF3804 51 33
PF12870 DUF4878 1,481 836
PF12883 DUF3828 2,758 887
PF12893 Lumazine_bd_2 4,529 2,854
PF13026 DUF3887 2,150 1,110
PF13474 SnoaL_3 12,864 7,493
PF13577 SnoaL_4 22,891 13,327
PF14254 DUF4348 551 229
PF14534 DUF4440 21,218 14,189
PF14729 DUF4467 338 92
PF15008 DUF4518 393 246
PF16022 DUF4783 1,013 648
PF16111 DUF4829 252 195
PF16156 DUF4864 1,599 1,023
PF16247 DUF4904 9 5
PF16800 Endopep_inhib 589 197
PF17117 DUF5104 361 213
PF17118 DUF5105 720 215
PF17775 UPF0225 9,852 4,849
PF18042 ORF_12_N 583 218
CL0052 NTN 297,192 127,545 PF00227 Proteasome 56,512 20,025
PF00310 GATase_2 24,622 8,460
PF01019 G_glu_transpept 41,101 20,681
PF01112 Asparaginase_2 15,398 8,044
PF01804 Penicil_amidase 17,266 9,648
PF02275 CBAH 9,322 3,837
PF03417 AAT 7,391 4,399
PF03577 Peptidase_C69 8,318 3,319
PF04916 Phospholip_B 1,875 1,147
PF07826 IMP_cyclohyd 1,870 908
PF09147 DUF1933 42 21
PF10584 Proteasome_A_N 14,435 4,713
PF12481 DUF3700 1,114 577
PF13230 GATase_4 10,577 3,814
PF13522 GATase_6 50,141 18,193
PF13537 GATase_7 51,547 24,918
CL0053 4H_Cytokine 11,766 4,595 PF00103 Hormone_1 2,661 743
PF00143 Interferon 1,815 776
PF00489 IL6 404 177
PF00714 IFN-gamma 357 118
PF00715 IL2 217 59
PF00726 IL10 897 331
PF00727 IL4 343 125
PF00758 EPO_TPO 400 206
PF01109 GM_CSF 112 48
PF01110 CNTF 153 72
PF01291 LIF_OSM 264 135
PF01415 IL7 261 91
PF02024 Leptin 379 120
PF02025 IL5 147 78
PF02059 IL3 70 29
PF02372 IL15 489 259
PF02404 SCF 414 172
PF02947 Flt3_lig 156 83
PF03039 IL12 262 125
PF03487 IL13 122 51
PF05337 CSF-1 253 120
PF06875 PRF 418 107
PF07400 IL11 182 86
PF14565 IL22 175 97
PF15036 IL34 184 91
PF15177 IL28A 288 154
PF15216 TSLP 72 38
PF16647 GCSF 153 66
PF16649 IL23 90 44
CL0054 Knottin_1 5,425 3,199 PF00304 Gamma-thionin 1,934 1,089
PF00451 Toxin_2 221 160
PF00537 Toxin_3 805 504
PF01097 Defensin_2 834 452
PF05294 Toxin_5 37 25
PF05453 Toxin_6 35 18
PF06876 SCRL 353 254
PF07333 SLR1-BP 575 391
PF08086 Toxin_17 33 17
PF09132 BmKX 15 14
PF10868 Defensin_like 214 121
PF11415 Toxin_37 165 28
PF14865 Macin 70 67
PF14866 Toxin_38 116 57
PF18251 Defensin_5 3 4
CL0055 Nucleoplasmin 178,540 18,350 PF00073 Rhv 71,304 3,565
PF00500 Late_protein_L1 5,762 1,365
PF00688 TGFb_propeptide 8,697 3,276
PF00718 Polyoma_coat 4,779 200
PF00729 Viral_coat 1,219 290
PF00738 Polyhedrin 590 64
PF00760 Cucumo_coat 2,404 471
PF00894 Luteo_coat 2,456 188
PF00915 Calici_coat 31,564 926
PF00983 Tymo_coat 436 100
PF01318 Bromo_coat 20 8
PF01766 Birna_VP2 4,106 125
PF01787 Ilar_coat 927 81
PF01829 Peptidase_A6 16 15
PF02226 Pico_P1A 18,355 611
PF02247 Como_LCP 248 70
PF02248 Como_SCP 236 51
PF02443 Circo_capsid 3,837 186
PF02956 TT_ORF1 4,797 955
PF03014 SP2 9,846 173
PF03066 Nucleoplasmin 1,374 677
PF03115 Astro_capsid_N 3,197 408
PF03340 Pox_Rif 151 39
PF03391 Nepo_coat 694 101
PF03566 Peptidase_A21 44 18
PF03678 Adeno_hexon_C 2,577 188
PF03688 Nepo_coat_C 706 98
PF03689 Nepo_coat_N 607 91
PF03898 TNV_CP 68 67
PF08435 Calici_coat_C 7,591 200
PF08462 Carmo_coat_C 65 4
PF08762 CRPV_capsid 1,114 418
PF08935 VP4_2 1,977 125
PF11175 DUF2961 3,479 1,967
PF11492 Dicistro_VP4 366 243
PF11729 Capsid-VNN 816 71
PF12264 Waikav_capsid_1 87 34
PF12944 HAV_VP 1,303 60
PF15414 DUF4621 27 7
PF16530 IHHNV_capsid 161 3
PF16903 Capsid_N 2,294 607
PF17800 NPL 2,635 1,663
CL0056 C_Lectin 90,298 57,321 PF00059 Lectin_C 33,692 22,428
PF00193 Xlink 3,615 1,873
PF01413 C4 2,340 1,350
PF03440 APT 318 74
PF03781 FGE-sulfatase 47,921 30,508
PF05473 UL45 235 120
PF05966 Chordopox_A33R 135 39
PF06482 Endostatin 1,381 857
PF07588 DUF1554 856 415
PF07979 Intimin_C 442 58
PF08391 Ly49 380 162
PF16825 DUF5075 200 109
CL0057 Met_repress 122,327 62,260 PF01340 MetJ 1,782 158
PF01402 RHH_1 24,182 12,693
PF02697 VAPB_antitox 1,191 879
PF03693 ParD_antitoxin 8,304 4,605
PF03869 Arc 5,303 2,799
PF04221 RelB 11,138 4,631
PF05509 TraY 962 446
PF05534 HicB 6,897 3,816
PF07181 VirC2 80 35
PF07362 CcdA 3,135 1,537
PF07704 PSK_trans_fac 2,074 1,274
PF07764 Omega_Repress 233 18
PF07878 RHH_5 1,248 863
PF08681 DUF1778 5,777 2,973
PF08870 DndE 1,018 666
PF08972 DUF1902 663 462
PF09274 ParG 641 285
PF09386 ParD 438 236
PF09957 VapB_antitoxin 4,644 2,748
PF10723 RepB-RCR_reg 745 186
PF10784 Plasmid_stab_B 904 154
PF10802 DUF2540 30 20
PF11020 DUF2610 166 70
PF11423 Repressor_Mnt 110 33
PF11903 ParD_like 3,608 1,557
PF12441 CopG_antitoxin 2,552 1,730
PF12651 RHH_3 1,626 757
PF13467 RHH_4 5,958 2,944
PF14384 BrnA_antitoxin 6,360 3,823
PF15919 HicB_lk_antitox 14,620 8,290
PF15970 HicB-like_2 384 192
PF16762 RHH_6 390 139
PF16777 RHH_7 608 33
PF17206 SeqA_N 1,936 487
PF17414 MatP_C 1,548 243
PF17723 RHH_8 1,000 507
PF18064 ParB_C 256 175
CL0058 Glyco_hydro_tim 695,708 355,860 PF00128 Alpha-amylase 149,898 66,097
PF00150 Cellulase 36,862 21,392
PF00232 Glyco_hydro_1 50,232 21,539
PF00331 Glyco_hydro_10 13,581 8,490
PF00332 Glyco_hydro_17 11,685 6,566
PF00704 Glyco_hydro_18 49,069 25,987
PF00728 Glyco_hydro_20 24,433 13,350
PF00933 Glyco_hydro_3 74,742 38,950
PF01055 Glyco_hydro_31 30,044 15,528
PF01120 Alpha_L_fucos 16,754 9,763
PF01183 Glyco_hydro_25 19,694 9,148
PF01229 Glyco_hydro_39 4,446 2,987
PF01301 Glyco_hydro_35 13,513 7,439
PF01373 Glyco_hydro_14 2,502 1,253
PF01630 Glyco_hydro_56 2,229 1,304
PF02055 Glyco_hydro_30 7,136 4,258
PF02057 Glyco_hydro_59 1,374 811
PF02065 Melibiase 13,053 6,875
PF02156 Glyco_hydro_26 6,754 4,224
PF02286 Dehydratase_LU 1,326 319
PF02324 Glyco_hydro_70 779 249
PF02446 Glyco_hydro_77 17,263 8,403
PF02449 Glyco_hydro_42 13,797 7,669
PF02638 GHL10 10,761 5,386
PF02836 Glyco_hydro_2_C 41,414 20,958
PF03198 Glyco_hydro_72 3,981 2,322
PF03537 Glyco_hydro_114 4,981 3,225
PF03644 Glyco_hydro_85 2,483 1,433
PF03659 Glyco_hydro_71 2,325 1,602
PF03662 Glyco_hydro_79n 1,731 1,050
PF05089 NAGLU 2,952 1,666
PF05691 Raffinose_syn 2,754 1,643
PF07555 NAGidase 3,573 1,824
PF07745 Glyco_hydro_53 4,473 2,332
PF08924 DUF1906 3,773 1,958
PF10566 Glyco_hydro_97 7,792 3,796
PF11308 Glyco_hydro_129 1,428 504
PF11790 Glyco_hydro_cc 4,061 2,773
PF12876 Cellulase-like 255 140
PF12891 Glyco_hydro_44 677 461
PF12905 Glyco_hydro_101 1,300 526
PF13199 Glyco_hydro_66 768 422
PF13200 DUF4015 3,498 2,155
PF13204 DUF4038 2,887 1,850
PF14307 Glyco_tran_WbsX 2,929 1,928
PF14488 DUF4434 1,744 717
PF14587 Glyco_hydr_30_2 2,169 1,252
PF14701 hDGE_amylase 1,945 1,069
PF14871 GHL6 1,334 985
PF14872 GHL5 194 137
PF14883 GHL13 2,284 573
PF14885 GHL15 701 508
PF16126 DUF4838 2,180 1,738
PF16141 DUF4849 1,171 388
PF16317 Glyco_hydro_99 1,293 728
PF16402 DUF5010 124 83
PF16499 Melibiase_2 9,932 6,021
CL0059 6_Hairpin 220,329 119,425 PF00432 Prenyltrans 9,666 6,020
PF00723 Glyco_hydro_15 19,872 9,556
PF00759 Glyco_hydro_9 11,779 6,965
PF01122 Cobalamin_bind 635 400
PF01204 Trehalase 11,071 5,379
PF01270 Glyco_hydro_8 6,351 2,734
PF01532 Glyco_hydro_47 11,096 6,517
PF02011 Glyco_hydro_48 1,654 704
PF03200 Glyco_hydro_63 5,028 2,742
PF03632 Glyco_hydro_65m 11,260 5,687
PF03663 Glyco_hydro_76 8,506 4,712
PF04685 DUF608 3,234 1,901
PF05147 LANC_like 7,767 4,993
PF06202 GDE_C 9,136 5,152
PF06662 C5-epim_C 1,313 759
PF06824 Glyco_hydro_125 5,067 2,167
PF07221 GlcNAc_2-epim 12,869 6,224
PF07470 Glyco_hydro_88 17,282 8,594
PF07678 TED_complement 10,792 5,595
PF07944 Glyco_hydro_127 12,081 7,041
PF09492 Pec_lyase 1,846 1,178
PF10091 Glycoamylase 7,339 4,214
PF12899 Glyco_hydro_100 2,310 1,211
PF13243 SQHop_cyclase_C 10,210 5,394
PF13249 SQHop_cyclase_N 7,947 3,966
PF17167 Glyco_hydro_36 7,860 4,255
PF17389 Bac_rhamnosid6H 14,160 9,112
PF17652 Glyco_hydro81C 2,882 1,833
PF18566 Ldi 576 426
CL0060 DNA_clamp 43,722 17,698 PF00705 PCNA_N 4,284 1,873
PF00712 DNA_pol3_beta 29,655 10,552
PF02144 Rad1 1,764 1,017
PF02282 Herpes_UL42 272 35
PF02747 PCNA_C 3,956 1,737
PF02767 DNA_pol3_beta_2 30,841 11,321
PF02768 DNA_pol3_beta_3 29,927 10,724
PF02916 DNA_PPF 1,011 145
PF03325 Herpes_PAP 115 17
PF04005 Hus1 1,870 1,034
PF04139 Rad9 1,966 1,233
PF04929 Herpes_DNAp_acc 67 26
PF09116 gp45-slide_C 432 206
CL0061 PLP_aminotran 1,019,386 441,075 PF00155 Aminotran_1_2 353,024 147,760
PF00202 Aminotran_3 168,192 67,719
PF00266 Aminotran_5 168,263 78,270
PF00282 Pyridoxal_deC 37,625 17,797
PF00464 SHMT 41,162 14,212
PF01041 DegT_DnrJ_EryC1 64,138 39,618
PF01053 Cys_Met_Meta_PP 85,711 33,725
PF01212 Beta_elim_lyase 28,887 13,661
PF01276 OKR_DC_1 19,179 5,896
PF02347 GDC-P 29,352 12,301
PF03841 SelA 11,441 4,925
PF04864 Alliinase_C 978 557
PF05889 SepSecS 1,221 680
PF06338 ComK 2,692 1,020
PF06838 Met_gamma_lyase 5,244 2,079
PF12897 Aminotran_MocR 3,384 1,470
CL0062 APC 694,133 268,326 PF00209 SNF 35,026 15,476
PF00324 AA_permease 78,006 23,808
PF00474 SSF 83,393 36,409
PF00860 Xan_ur_permease 69,014 19,533
PF00916 Sulfate_transp 54,964 25,136
PF00955 HCO3_cotransp 8,573 3,874
PF01235 Na_Ala_symp 29,569 10,352
PF01490 Aa_trans 34,477 18,917
PF01566 Nramp 29,832 12,612
PF02028 BCCT 25,108 9,305
PF02133 Transp_cyt_pur 31,556 11,706
PF02554 CstA 16,497 4,977
PF02705 K_trans 16,826 6,783
PF03222 Trp_Tyr_perm 12,905 3,079
PF03594 BenE 8,578 2,810
PF03845 Spore_permease 13,502 6,459
PF05525 Branch_AA_trans 13,768 3,580
PF13520 AA_permease_2 130,352 52,620
PF13906 AA_permease_C 5,147 2,802
PF16983 MFS_MOT1 1,753 1,077
CL0063 NADP_Rossmann 6,594,878 3,143,641 PF00044 Gp_dh_N 56,858 16,868
PF00056 Ldh_1_N 48,899 14,096
PF00070 Pyr_redox 555 454
PF00106 adh_short 410,900 212,628
PF00107 ADH_zinc_N 271,280 116,761
PF00145 DNA_methylase 39,678 24,671
PF00208 ELFV_dehydrog 42,507 16,527
PF00291 PALP 203,252 80,162
PF00398 RrnaAD 38,161 17,535
PF00479 G6PD_N 28,629 9,738
PF00670 AdoHcyase_NAD 23,681 7,901
PF00732 GMC_oxred_N 70,735 36,119
PF00743 FMO-like 34,640 19,267
PF00890 FAD_binding_2 97,584 39,032
PF00891 Methyltransf_2 23,309 14,485
PF00899 ThiF 71,002 33,440
PF00996 GDI 4,984 2,353
PF01073 3Beta_HSD 9,518 5,729
PF01113 DapB_N 33,155 13,934
PF01118 Semialdhyde_dh 64,478 23,638
PF01134 GIDA 35,816 14,582
PF01135 PCMT 31,325 16,986
PF01170 UPF0020 22,971 10,151
PF01175 Urocanase 14,267 4,297
PF01189 Methyltr_RsmB-F 45,916 22,334
PF01209 Ubie_methyltran 27,577 12,009
PF01210 NAD_Gly3P_dh_N 33,065 13,727
PF01225 Mur_ligase 86,779 38,982
PF01232 Mannitol_dh 21,172 8,032
PF01234 NNMT_PNMT_TEMT 1,102 747
PF01262 AlaDh_PNT_C 37,396 14,774
PF01266 DAO 191,705 87,741
PF01269 Fibrillarin 3,716 1,798
PF01358 PARP_regulatory 256 108
PF01370 Epimerase 222,364 120,234
PF01408 GFO_IDH_MocA 177,487 93,778
PF01488 Shikimate_DH 40,028 17,945
PF01494 FAD_binding_3 144,997 77,686
PF01555 N6_N4_Mtase 47,649 28,177
PF01564 Spermine_synth 27,669 13,256
PF01593 Amino_oxidase 91,532 49,370
PF01596 Methyltransf_3 24,227 11,389
PF01728 FtsJ 47,948 17,695
PF01739 CheR 29,612 15,067
PF01795 Methyltransf_5 31,196 13,980
PF01861 DUF43 984 562
PF01946 Thi4 4,598 1,953
PF02005 TRM 4,285 2,531
PF02056 Glyco_hydro_4 14,374 4,721
PF02086 MethyltransfD12 18,865 9,913
PF02153 PDH 27,063 11,994
PF02254 TrkA_N 75,689 31,902
PF02310 B12-binding 73,474 37,244
PF02353 CMAS 31,253 14,148
PF02384 N6_Mtase 52,327 29,708
PF02390 Methyltransf_4 28,027 12,438
PF02423 OCD_Mu_crystall 22,678 11,910
PF02475 Met_10 6,727 4,152
PF02527 GidB 26,228 12,433
PF02558 ApbA 33,158 16,294
PF02571 CbiJ 8,812 4,395
PF02593 DUF166 563 371
PF02629 CoA_binding 38,255 11,778
PF02636 Methyltransf_28 12,826 7,164
PF02670 DXP_reductoisom 23,627 10,283
PF02719 Polysacc_synt_2 25,635 13,412
PF02737 3HCDH_N 70,456 29,705
PF02826 2-Hacid_dh_C 139,441 63,584
PF02882 THF_DHG_CYH_C 36,370 15,051
PF03059 NAS 1,191 656
PF03141 Methyltransf_29 5,503 3,013
PF03269 DUF268 650 544
PF03275 GLF 8,080 3,430
PF03291 Pox_MCEL 2,636 1,503
PF03341 Pox_mRNA-cap 120 30
PF03435 Sacchrp_dh_NADP 27,634 13,052
PF03446 NAD_binding_2 87,947 37,482
PF03447 NAD_binding_3 36,890 13,815
PF03486 HI0933_like 27,511 13,117
PF03492 Methyltransf_7 4,291 2,719
PF03514 GRAS 8,947 4,805
PF03602 Cons_hypoth95 28,714 14,080
PF03686 UPF0146 506 353
PF03721 UDPG_MGDP_dh_N 55,227 27,757
PF03807 F420_oxidored 49,881 23,833
PF03808 Glyco_tran_WecB 14,739 7,997
PF03848 TehB 3,550 1,535
PF03853 YjeF_N 24,904 13,863
PF03949 Malic_M 40,208 13,724
PF04016 DUF364 2,324 1,586
PF04072 LCM 19,934 9,372
PF04127 DFP 29,066 13,127
PF04321 RmlD_sub_bind 32,438 18,689
PF04378 RsmJ 8,383 2,860
PF04445 SAM_MT 7,646 2,774
PF04536 TPM_phosphatase 22,383 11,584
PF04672 Methyltransf_19 8,586 4,820
PF04723 GRDA 1,150 364
PF04816 TrmK 4,559 1,610
PF04820 Trp_halogenase 10,812 6,581
PF04989 CmcI 1,965 1,087
PF05050 Methyltransf_21 23,824 17,958
PF05059 Orbi_VP4 569 57
PF05063 MT-A70 6,235 3,712
PF05088 Bac_GDH 9,916 4,116
PF05148 Methyltransf_8 1,940 1,262
PF05175 MTS 71,610 33,382
PF05185 PRMT5 2,132 1,161
PF05206 TRM13 1,196 760
PF05219 DREV 769 406
PF05368 NmrA 34,231 20,234
PF05401 NodS 3,294 1,685
PF05430 Methyltransf_30 10,584 5,340
PF05575 V_cholerae_RfbT 40 14
PF05711 TylF 4,413 2,760
PF05724 TPMT 7,589 4,462
PF05834 Lycopene_cycl 5,298 3,371
PF05891 Methyltransf_PK 2,144 1,247
PF05958 tRNA_U5-meth_tr 39,216 16,267
PF05971 Methyltransf_10 6,220 2,789
PF06016 Reovirus_L2 193 35
PF06039 Mqo 10,435 2,832
PF06080 DUF938 4,452 2,774
PF06100 MCRA 4,662 1,662
PF06325 PrmA 32,677 14,789
PF06460 NSP16 2,138 145
PF06471 NSP11 2,713 178
PF06690 DUF1188 69 47
PF06859 Bin3 1,623 1,006
PF06962 rRNA_methylase 4,686 1,975
PF07021 MetW 6,570 2,679
PF07055 Eno-Rase_FAD_bd 4,322 1,363
PF07091 FmrO 456 251
PF07109 Mg-por_mtran_C 1,271 691
PF07156 Prenylcys_lyase 1,690 1,000
PF07279 DUF1442 673 394
PF07669 Eco57I 7,779 5,472
PF07757 AdoMet_MTase 1,339 918
PF07942 N2227 2,467 1,512
PF07991 IlvN 25,843 6,337
PF07992 Pyr_redox_2 368,643 155,890
PF07993 NAD_binding_4 25,885 14,801
PF07994 NAD_binding_5 4,847 2,048
PF08003 Methyltransf_9 6,032 1,991
PF08123 DOT1 3,053 1,994
PF08241 Methyltransf_11 167,335 96,882
PF08242 Methyltransf_12 19,003 11,343
PF08484 Methyltransf_14 6,091 3,808
PF08485 Polysacc_syn_2C 2,961 1,403
PF08491 SE 2,408 1,320
PF08643 DUF1776 691 387
PF08659 KR 35,774 23,931
PF08704 GCD14 7,411 3,434
PF08732 HIM1 782 423
PF09243 Rsm22 3,561 2,199
PF09445 Methyltransf_15 2,908 1,842
PF10017 Methyltransf_33 8,821 5,004
PF10237 N6-adenineMlase 1,889 1,167
PF10294 Methyltransf_16 14,820 9,676
PF10354 DUF2431 2,285 1,609
PF10672 Methyltrans_SAM 27,029 10,240
PF10727 Rossmann-like 5,454 2,741
PF11017 DUF2855 1,543 990
PF11312 Methyltransf_34 785 514
PF11599 AviRa 133 101
PF11890 DUF3410 4,377 1,344
PF11968 Bmt2 1,106 649
PF12147 Methyltransf_20 2,341 652
PF12241 Enoyl_reductase 4,390 1,402
PF12242 Eno-Rase_NADH_b 4,314 1,353
PF12692 Methyltransf_17 723 356
PF12831 FAD_oxidored 17,845 11,018
PF12847 Methyltransf_18 2,623 1,482
PF13241 NAD_binding_7 18,980 8,472
PF13288 DXPR_C 23,571 10,205
PF13380 CoA_binding_2 32,524 17,153
PF13383 Methyltransf_22 1,374 992
PF13434 K_oxygenase 11,114 4,728
PF13450 NAD_binding_8 62,825 34,577
PF13454 NAD_binding_9 9,264 4,711
PF13460 NAD_binding_10 79,023 44,138
PF13478 XdhC_C 22,128 11,345
PF13489 Methyltransf_23 88,580 54,210
PF13561 adh_short_C2 465,708 211,788
PF13578 Methyltransf_24 15,852 10,520
PF13602 ADH_zinc_N_2 52,725 29,121
PF13649 Methyltransf_25 136,774 80,022
PF13679 Methyltransf_32 9,684 4,411
PF13727 CoA_binding_3 30,132 16,016
PF13738 Pyr_redox_3 33,860 17,089
PF13847 Methyltransf_31 61,925 35,865
PF14314 Methyltrans_Mon 1,199 230
PF16363 GDP_Man_Dehyd 93,420 47,272
PF16803 DRE2_N 704 408
PF16912 Glu_dehyd_C 2,075 1,229
PF17125 Methyltr_RsmF_N 11,288 5,281
PF17173 DUF5129 449 247
PF17174 DUF5130 1,038 424
PF17175 MOLO1 693 473
PF17396 DUF1611_N 3,514 1,962
PF17836 PglD_N 7,571 5,270
PF17930 LpxI_N 4,527 2,723
PF18321 3HCDH_RFF 2,052 684
PF18706 ISPD_C 195 97
CL0064 CPA_AT 259,380 112,747 PF00999 Na_H_Exchanger 109,525 48,666
PF01758 SBF 33,996 15,387
PF03547 Mem_trans 36,812 17,599
PF03601 Cons_hypoth698 15,992 6,919
PF03616 Glt_symporter 7,312 2,302
PF03812 KdgT 3,053 846
PF03956 Lys_export 5,181 1,711
PF03977 OAD_beta 7,917 2,854
PF05684 DUF819 4,159 2,147
PF05982 Sbt_1 2,867 1,464
PF06826 Asp-Al_Ex 9,038 2,752
PF06965 Na_H_antiport_1 14,411 6,688
PF13593 SBF_like 9,267 3,546
CL0065 Cyclin 51,635 27,846 PF00134 Cyclin_N 31,436 17,206
PF00382 TFIIB 9,249 4,214
PF01857 RB_B 1,691 793
PF01858 RB_A 1,731 817
PF02984 Cyclin_C 15,146 8,192
PF03261 CDK5_activator 688 354
PF08613 Cyclin 7,008 4,269
PF09080 K-cyclin_vir_C 14 4
PF09241 Herp-Cyclin 2 2
PF11934 DUF3452 1,465 668
PF16899 Cyclin_C_2 2,215 1,030
PF18542 TFIIB_C_1 29 17
CL0066 Trefoil 60,212 32,473 PF00167 FGF 6,052 2,245
PF00197 Kunitz_legume 2,187 1,098
PF00340 IL1 1,633 748
PF00652 Ricin_B_lectin 20,150 11,503
PF02815 MIR 8,246 3,999
PF03260 Lipoprotein_11 99 63
PF03498 CDtoxinA 626 224
PF04601 DUF569 1,008 639
PF05270 AbfB 2,773 1,587
PF05588 Botulinum_HA-17 59 19
PF06229 FRG1 1,399 795
PF06268 Fascin 1,373 599
PF07468 Agglutinin 261 185
PF07951 Toxin_R_bind_C 188 30
PF08470 NTNH_C 116 16
PF08709 Ins145_P3_rec 3,253 1,495
PF09270 BTD 1,863 768
PF10467 Inhibitor_I48 66 58
PF14200 RicinB_lectin_2 11,313 7,458
PF15095 IL33 162 58
PF16850 Inhibitor_I66 331 272
PF18021 Agglutinin_C 93 80
PF18022 Lectin_C_term 18 16
CL0067 SIS 224,001 83,882 PF00318 Ribosomal_S2 39,574 12,423
PF00342 PGI 34,842 13,285
PF01380 SIS 117,773 44,107
PF10432 bact-PGI_C 3,863 2,433
PF10740 DUF2529 1,166 348
PF12163 HobA 691 154
PF13580 SIS_2 25,897 11,720
PF15698 Phosphatase 1,291 423
CL0068 RIIa 5,774 3,268 PF02197 RIIa 2,676 1,307
PF05186 Dpy-30 3,096 1,961
CL0069 GFP 1,924 1,031 PF01353 GFP 679 240
PF07474 G2F 1,243 791
CL0070 ACT 220,829 76,402 PF00585 Thr_dehydrat_C 14,374 4,478
PF01842 ACT 89,057 31,578
PF04359 DUF493 8,683 3,295
PF08753 NikR_C 5,274 2,277
PF09383 NIL 20,759 6,057
PF10000 ACT_3 2,718 1,436
PF10369 ALS_ss_C 22,799 7,118
PF13291 ACT_4 33,615 11,108
PF13710 ACT_5 17,203 5,360
PF13740 ACT_6 16,535 5,684
PF13840 ACT_7 31,651 11,372
CL0071 His_phosphatase 156,849 75,498 PF00300 His_Phos_1 138,921 66,126
PF00328 His_Phos_2 17,926 9,373
CL0072 Ubiquitin 459,510 211,522 PF00174 Oxidored_molyb 35,715 17,896
PF00240 ubiquitin 37,850 18,086
PF00564 PB1 13,655 7,166
PF00778 DIX 2,917 1,249
PF00788 RA 15,350 7,103
PF00789 UBX 11,706 6,448
PF00794 PI3K_rbd 2,789 1,118
PF01378 IgG_binding_B 41 26
PF02017 CIDE-N 1,498 802
PF02192 PI3K_p85B 1,177 433
PF02196 RBD 2,955 1,204
PF02246 B1 6 5
PF02309 AUX_IAA 7,704 3,839
PF02597 ThiS 47,212 23,901
PF02821 Staphylokinase 307 41
PF02824 TGS 63,363 21,349
PF02991 Atg8 4,536 1,588
PF03607 DCX 3,041 1,667
PF03658 Ub-RnfH 6,661 3,018
PF03671 Ufm1 776 344
PF03990 DUF348 5,278 2,737
PF04106 APG5 1,923 1,016
PF04110 APG12 1,536 851
PF04663 Phenol_monoox 747 341
PF06071 YchF-GTPase_C 30,670 10,041
PF06234 TmoB 241 147
PF06251 Caps_synth_GfcC 3,557 1,822
PF06458 MucBP 5,638 2,727
PF06487 SAP18 1,591 824
PF06805 Lambda_tail_I 2,691 743
PF08154 NLE 3,118 1,560
PF08783 DWNN 2,210 1,283
PF08817 YukD 5,170 2,404
PF09138 Urm1 1,620 898
PF09379 FERM_N 13,563 5,635
PF09469 Cobl 832 383
PF09479 Flg_new 10,538 6,938
PF10302 DUF2407 760 488
PF10531 SLBB 61,166 29,778
PF11434 CHIPS 25 2
PF11470 TUG-UBL1 1,215 756
PF11543 UN_NPL4 1,077 545
PF11620 GABP-alpha 428 178
PF11973 NQRA_SLBB 5,126 2,315
PF11976 Rad60-SLD 5,392 2,940
PF12053 Par3_HAL_N_term 1,720 704
PF12436 USP7_ICP0_bdg 3,226 1,460
PF12754 Blt1 466 259
PF13019 Sde2_N_Ubi 1,596 1,018
PF13881 Rad60-SLD_2 2,125 1,157
PF14451 Ub-Mut7C 2,430 1,347
PF14452 Multi_ubiq 1,043 742
PF14453 ThiS-like 422 229
PF14454 Prok_Ub 945 385
PF14478 DUF4430 5,744 3,108
PF14533 USP7_C2 3,391 1,357
PF14560 Ubiquitin_2 2,820 1,470