EFI - Enzyme Similarity Tool

This web resource is supported by a Research Resource from the National Institute of General Medical Sciences (R24GM141196-01).

Pfam Families

These data are sourced from the UniProt and EMBL-EBI InterPro databases.

Clan ID Short Name Size UniRef90 Size UniRef50 Size Pfam ID Short Name Size UniRef90 Size UniRef50 Size
CL0001 EGF 352,462 149,820 51,413 PF00008 EGF 100,894 44,780 15,547
PF00053 Laminin_EGF 47,385 21,295 5,601
PF00084 Sushi 64,572 29,369 10,786
PF00594 Gla 10,539 3,726 746
PF01414 DSL 7,930 3,006 993
PF04863 EGF_alliinase 652 337 100
PF06247 Plasmod_Pvs28 434 64 26
PF07645 EGF_CA 99,516 42,468 13,592
PF07699 Ephrin_rec_like 23,239 9,668 4,314
PF07974 EGF_2 22,798 8,920 3,668
PF09014 Sushi_2 1,147 442 91
PF09064 Tme5_EGF_like 649 399 120
PF09289 FOLN 4,731 1,091 190
PF09443 CFC 1,001 538 154
PF12661 hEGF 36,738 15,540 4,896
PF12662 cEGF 27,742 11,302 2,872
PF12946 EGF_MSP1_1 2,684 266 91
PF12947 EGF_3 25,680 10,706 3,678
PF14670 FXa_inhibition 43,983 16,227 4,089
PF18193 Fibrillin_U_N 2,099 894 91
PF18372 I-EGF_1 8,333 2,147 382
PF18720 EGF_Tenascin 5,717 2,575 591
CL0003 SAM 166,593 60,725 15,266 PF00536 SAM_1 92,003 34,848 8,808
PF01698 SAM_LFY 1,678 317 59
PF02198 SAM_PNT 13,487 3,608 1,074
PF04904 NCD1 2,412 648 229
PF07647 SAM_2 60,074 23,200 5,450
PF09235 SAM_Ste50p 69 48 24
PF09597 IGR 1,662 918 295
PF13543 SAM_KSR1 2,317 1,078 180
PF18016 SAM_3 8,669 2,837 601
PF18017 SAM_4 1,378 634 267
PF18255 SAM_DrpA 752 97 13
PF18609 SAM_Exu 258 162 63
CL0004 Concanavalin 589,990 304,585 103,766 PF00054 Laminin_G_1 18,529 8,499 2,361
PF00139 Lectin_legB 15,020 8,692 3,093
PF00262 Calreticulin 10,536 4,336 1,087
PF00337 Gal-bind_lectin 17,016 7,796 2,762
PF00354 Pentaxin 12,064 5,563 1,702
PF00426 VP4_haemagglut 8,920 516 50
PF00457 Glyco_hydro_11 5,260 2,660 581
PF00622 SPRY 91,426 43,397 11,937
PF00629 MAM 32,013 13,336 5,134
PF00722 Glyco_hydro_16 54,011 30,470 9,855
PF00840 Glyco_hydro_7 8,768 2,959 590
PF01670 Glyco_hydro_12 5,422 2,747 839
PF01828 Peptidase_A4 2,997 1,874 783
PF02210 Laminin_G_2 57,273 23,754 5,655
PF02973 Sialidase 744 224 102
PF03388 Lectin_leg-like 7,722 3,245 983
PF03935 SKN1_KRE6_Sbg1 4,276 2,713 777
PF05592 Bac_rhamnosid 14,751 9,230 2,315
PF05735 TSP_C 8,638 2,268 430
PF06439 3keto-disac_hyd 35,685 24,910 6,413
PF06955 XET_C 9,496 4,075 705
PF07081 DUF1349 8,896 4,169 970
PF07177 Neuralized 6,265 2,525 936
PF07622 DUF1583 128 98 69
PF07675 Cleaved_Adhesin 1,847 1,472 972
PF07953 Toxin_R_bind_N 336 55 30
PF08244 Glyco_hydro_32C 25,697 11,812 2,793
PF08787 Alginate_lyase2 5,249 2,570 674
PF08978 Reoviridae_Vp9 40 14 9
PF09101 Exotox-A_bind 297 48 20
PF09206 ArabFuran-catal 2,117 1,150 272
PF09224 DUF1961 778 495 143
PF09264 Sial-lect-inser 97 35 21
PF10287 YJL171C_Tos1_C 1,136 650 183
PF11476 TgMIC1 19 4 4
PF11958 DUF3472 1,992 1,196 414
PF12248 Methyltransf_FA 3,180 1,861 935
PF13385 Laminin_G_3 83,603 58,326 33,403
PF13765 PRY 50,147 26,109 6,483
PF14099 Polysacc_lyase 3,228 2,221 1,177
PF15493 YrpD 147 52 34
PF16346 DUF4975 437 182 47
PF16451 bCoV_S1_N 3,205 251 40
PF17689 Arabino_trans_N 3,322 1,277 175
PF17851 GH43_C2 20,869 10,703 1,933
PF17974 GalBD_like 1,485 552 173
PF18239 HA1 7 4 3
PF18271 GH131_N 1,966 1,107 297
PF18483 Bact_lectin 3,658 2,350 1,513
PF19763 DUF6250 1,008 523 148
PF20407 DUF1583_N 124 96 70
CL0005 Kazal 49,143 19,805 7,293 PF00050 Kazal_1 14,966 7,640 3,509
PF07648 Kazal_2 36,169 13,575 4,722
PF18434 Kazal_3 1,268 370 45
CL0006 C1 134,984 56,779 14,029 PF00130 C1_1 83,006 32,119 5,810
PF00569 ZZ 39,441 17,556 5,339
PF03107 C1_2 9,798 6,025 2,663
PF07975 C1_4 2,743 1,089 229
CL0007 KH 326,181 120,791 21,586 PF00013 KH_1 144,587 54,280 12,102
PF04025 DUF370 7,146 3,030 499
PF07650 KH_2 86,456 28,464 3,087
PF09869 DUF2096 320 215 61
PF13083 KH_4 29,022 12,233 2,182
PF13184 KH_5 41,394 14,439 1,722
PF14611 SLS 1,015 617 347
PF14955 MRP-S24 1,178 654 186
PF15985 KH_6 7,314 3,496 912
PF16005 MOEP19 835 412 172
PF17214 KH_7 3,378 1,507 210
PF17903 KH_8 4,559 2,016 396
PF17904 KH_9 5,141 1,495 221
PF17905 KH_10 73 45 26
CL0009 ENTH_VHS 57,224 23,247 5,409 PF00790 VHS 23,145 8,982 2,014
PF01417 ENTH 13,465 5,755 1,666
PF07651 ANTH 20,619 8,520 1,735
CL0010 SH3 627,203 237,293 60,849 PF00018 SH3_1 174,690 65,955 15,398
PF00552 IN_DBD_C 67,352 6,610 921
PF01302 CAP_GLY 28,049 12,822 3,992
PF02736 Myosin_N 26,084 9,933 1,320
PF03217 SlpA 3,473 1,592 858
PF03831 YjdM 16,827 5,933 260
PF04319 NifZ 2,203 1,080 151
PF06107 DUF951 6,610 2,963 270
PF06347 SH3_4 8,222 5,160 1,772
PF07563 DUF1541 1,608 813 126
PF07653 SH3_2 65,899 26,548 6,465
PF07866 DUF1653 7,690 3,589 765
PF08239 SH3_3 49,446 27,974 14,048
PF08460 SH3_5 2,600 802 396
PF08810 KapB 1,186 488 54
PF09671 Spore_GerQ 1,589 752 142
PF10842 DUF2642 1,090 550 244
PF11095 Gemin7 918 579 242
PF11302 DUF3104 252 172 75
PF11347 DUF3148 985 506 116
PF11607 DUF3247 361 167 39
PF11623 NdhS 962 376 63
PF12208 DUF3601 185 81 47
PF12913 SH3_6 3,409 1,233 414
PF13457 GW 2,894 1,239 681
PF13973 DUF4222 2,045 536 123
PF14192 DUF4314 1,755 845 284
PF14603 hSH3 2,271 915 211
PF14604 SH3_9 100,672 38,827 9,396
PF14627 DUF4453 107 75 44
PF15505 Vexin 303 95 30
PF16277 DUF4926 2,801 1,791 552
PF17375 DUF5397 190 107 35
PF17384 DUF150_C 28,616 12,344 2,393
PF17902 SH3_10 12,636 3,888 731
PF18103 SH3_11 176 19 4
PF18129 SH3_12 3,372 1,607 506
PF18335 SH3_13 12,300 5,396 1,138
PF18343 SH3_14 337 19 7
PF18346 SH3_15 3,878 1,477 424
PF18348 SH3_16 8,626 5,214 1,133
PF18350 SH3_17 53 16 1
PF18354 SH3_18 57 27 8
PF18597 SH3_19 1,420 677 62
PF18697 MLVIN_C 1,968 1,225 731
PF19087 DUF5776 1,939 1,004 562
PF20297 MSSS 11,291 4,838 1,051
CL0011 Ig 643,308 299,005 93,584 PF00047 ig 47,208 19,684 7,980
PF01537 Herpes_glycop_D 724 140 71
PF01688 Herpes_gI 435 59 35
PF02124 Marek_A 765 74 33
PF02440 Adeno_E3_CR1 391 72 28
PF02480 Herpes_gE 757 104 42
PF02960 K1 1,288 111 11
PF03921 ICAM_N 2,426 1,307 454
PF05790 C2-set 1,238 403 79
PF07654 C1-set 80,569 28,199 7,214
PF07679 I-set 242,475 98,877 31,084
PF07686 V-set 199,010 114,652 31,834
PF08204 V-set_CD47 1,339 424 134
PF08205 C2-set_2 39,271 17,401 6,553
PF08779 bCoV_NS7A 515 40 9
PF09085 Adhes-Ig_like 355 199 49
PF09191 CD4-extracel 499 195 79
PF09291 DUF1968 291 187 61
PF10430 Ig_Tie2_1 855 203 32
PF11465 Receptor_2B4 790 470 215
PF12093 bCoV_NS8 306 21 8
PF13895 Ig_2 44,040 22,587 9,791
PF13927 Ig_3 184,637 80,623 27,109
PF15028 PTCRA 244 153 56
PF15910 V-set_2 1,281 442 140
PF16680 Ig_4 1,017 529 118
PF16681 Ig_5 857 508 117
PF16706 Izumo-Ig 442 206 78
PF16758 UL141 184 13 6
PF17736 Ig_C17orf99 1,762 658 219
PF17737 Ig_C19orf38 275 152 65
PF18452 Ig_6 3,999 1,133 249
PF18589 ObR_Ig 1,462 496 94
PF19081 Ig_7 6,791 6,061 3,935
CL0012 Histone 177,443 58,210 20,080 PF00125 Histone 96,382 22,062 7,547
PF00808 CBFD_NFYB_HMF 27,768 13,342 4,707
PF02269 TFIID-18kDa 5,914 2,408 767
PF02291 TFIID-31kDa 3,584 1,651 566
PF02969 TAF 4,858 1,911 748
PF03540 TFIID_30kDa 3,142 1,459 461
PF03847 TFIID_20kDa 3,993 1,898 757
PF04719 TAFII28 3,426 1,724 638
PF05236 TAF4 5,704 2,430 818
PF07524 Bromo_TP 7,886 3,442 1,240
PF09123 DUF1931 831 264 73
PF09415 CENP-X 2,068 1,251 489
PF15510 CENP-W 796 393 107
PF15511 CENP-T_C 8,121 2,633 1,003
PF15630 CENP-S 2,383 1,281 478
PF15715 PAF 818 446 139
PF17027 Bromo_TP_like 53 40 33
CL0013 Beta-lactamase 569,344 281,113 72,125 PF00144 Beta-lactamase 190,280 110,614 33,086
PF00768 Peptidase_S11 69,634 30,202 7,622
PF00905 Transpeptidase 221,973 100,057 20,601
PF02113 Peptidase_S13 25,122 13,703 4,293
PF04960 Glutaminase 21,317 7,430 1,165
PF13354 Beta-lactamase2 41,160 19,269 5,439
CL0014 Glutaminase_I 730,874 327,775 49,866 PF00117 GATase 277,532 112,827 12,144
PF01174 SNO 16,041 7,836 884
PF01965 DJ-1_PfpI 149,500 64,565 8,660
PF02016 Peptidase_S66 25,454 12,796 2,256
PF03575 Peptidase_S51 23,092 12,479 2,886
PF04204 HTS 12,676 4,536 419
PF06283 ThuA 28,015 16,499 3,328
PF07090 GATase1_like 5,773 2,900 1,093
PF07685 GATase_3 47,345 20,897 2,325
PF07722 Peptidase_C26 30,698 15,551 4,159
PF08532 Glyco_hydro_42M 16,260 8,821 2,009
PF09822 ABC_transp_aux 14,793 9,314 3,540
PF09825 BPL_N 3,707 2,174 856
PF13507 GATase_5 44,733 18,644 1,686
PF13709 DUF4159 10,532 6,510 1,342
PF14258 DUF4350 8,709 5,349 1,906
PF17124 ThiJ_like 2,281 1,129 194
PF17385 LBP_M 1,527 554 86
PF18011 Catalase_C 12,231 4,549 302
CL0015 MFS 2,125,044 937,583 226,132 PF00083 Sugar_tr 300,628 127,567 34,178
PF00854 PTR2 65,042 28,034 6,336
PF01306 LacY_symp 3,860 930 242
PF01733 Nucleoside_tran 10,703 4,951 1,628
PF01770 Folate_carrier 4,885 2,325 760
PF02487 CLN3 3,837 2,120 797
PF03092 BT1 9,240 4,892 1,706
PF03137 OATP 15,682 6,536 2,473
PF03209 PUCC 3,949 2,085 376
PF03219 TLC 3,752 2,381 1,078
PF03825 Nuc_H_symport 9,729 3,471 632
PF04884 UVB_sens_prot 5,613 3,043 1,179
PF05631 MFS_5 4,154 1,962 807
PF05977 MFS_3 63,532 33,772 9,129
PF05978 UNC-93 9,852 4,925 1,717
PF06609 TRI12 4,475 2,641 940
PF06779 MFS_4 11,877 4,924 1,133
PF06813 Nodulin-like 7,435 3,694 1,065
PF06963 FPN1 4,207 2,108 849
PF07672 MFS_Mycoplasma 133 68 30
PF07690 MFS_1 1,508,304 662,756 153,740
PF11700 ATG22 21,127 11,213 1,931
PF12832 MFS_1_like 19,809 9,827 3,906
PF13000 Acatn 6,876 3,284 1,084
PF13347 MFS_2 56,067 24,362 7,131
PF18943 DUF5690 1,826 1,014 224
CL0016 PKinase 2,318,909 1,135,538 388,239 PF00069 Pkinase 1,341,317 658,532 239,039
PF00454 PI3_PI4_kinase 52,275 23,416 6,764
PF01163 RIO1 22,129 10,639 2,615
PF01504 PIP5K 26,173 10,762 3,335
PF01633 Choline_kinase 16,526 7,967 2,833
PF01636 APH 195,560 108,956 32,527
PF02816 Alpha_kinase 10,290 5,165 2,283
PF02958 EcKL 12,473 8,516 3,898
PF03109 ABC1 68,250 31,644 8,066
PF03770 IPK 12,474 5,620 2,096
PF03881 Fructosamin_kin 16,494 8,891 2,219
PF04183 IucA_IucC 15,473 6,391 1,152
PF04655 APH_6_hur 8,260 4,419 945
PF05445 Pox_ser-thr_kin 188 55 27
PF06090 Ins_P5_2-kin 3,761 1,905 938
PF06176 WaaY 1,849 291 162
PF06293 Kdo 22,183 9,947 3,532
PF06315 AceK_kinase 6,250 1,759 226
PF06702 Fam20C 4,847 1,803 471
PF06734 UL97 521 29 16
PF07387 Seadorna_VP7 60 35 18
PF07714 PK_Tyr_Ser-Thr 397,929 189,400 70,376
PF07804 HipA_C 25,667 14,078 3,354
PF07914 DUF1679 1,418 1,108 714
PF08757 CotH 16,529 12,127 6,560
PF09192 Act-Frag_cataly 793 363 154
PF10009 DUF2252 10,415 4,947 930
PF10140 YukC 1,416 462 212
PF10707 YrbL-PhoP_reg 1,955 834 369
PF12260 PIP49_C 6,193 1,788 559
PF12330 Haspin_kinase 7,997 3,954 1,632
PF13095 FTA2 840 514 269
PF13575 DUF4135 3,277 2,069 1,157
PF14531 Kinase-like 658 191 124
PF16474 KIND 4,129 2,067 513
PF17667 Pkinase_fungal 11,714 9,846 6,110
PF18101 Pan3_PK 3,748 1,586 470
PF18762 Kinase-PolyVal 451 284 129
PF19250 DUF5898 71 67 53
PF19974 TCAD9 412 353 239
CL0018 bZIP 99,005 40,489 14,558 PF00170 bZIP_1 64,396 26,367 9,150
PF03131 bZIP_Maf 12,155 3,857 1,107
PF07716 bZIP_2 22,465 10,556 4,914
CL0020 TPR 2,453,215 1,267,455 500,798 PF00244 14-3-3 18,550 5,498 1,698
PF00514 Arm 64,685 22,209 6,422
PF00515 TPR_1 109,514 55,470 29,747
PF00613 PI3Ka 17,934 6,785 1,598
PF00637 Clathrin 19,372 6,854 1,886
PF00806 PUF 20,081 9,910 3,587
PF00888 Cullin 28,148 11,259 3,950
PF01239 PPTA 9,691 4,975 1,769
PF01347 Vitellogenin_N 9,627 4,725 1,993
PF01365 RYDR_ITPR 12,273 7,690 1,031
PF01394 Clathrin_propel 6,231 1,723 271
PF01535 PPR 161,789 89,527 35,439
PF01602 Adaptin_N 44,398 18,362 4,008
PF01603 B56 15,579 5,620 1,265
PF01749 IBB 12,332 3,217 767
PF01816 LRV 1,330 948 502
PF01843 DIL 17,108 7,836 1,403
PF01851 PC_rep 8,336 2,847 582
PF02020 W2 17,628 6,659 1,490
PF02071 NSF 7 8 8
PF02184 HAT 3,566 1,312 254
PF02259 FAT 14,630 7,658 2,134
PF02847 MA3 20,338 8,972 2,405
PF02854 MIF4G 28,035 12,642 4,068
PF02985 HEAT 22,009 9,921 4,314
PF03097 BRO1 13,296 5,533 1,767
PF03130 HEAT_PBS 9,441 6,350 3,519
PF03224 V-ATPase_H_N 4,907 1,861 576
PF03377 TAL_effector 635 311 112
PF03378 CAS_CSE1 4,047 1,540 533
PF03635 Vps35 4,959 1,758 631
PF03704 BTAD 45,732 31,900 13,024
PF03810 IBN_N 38,623 13,688 3,447
PF04049 ANAPC8 3,170 1,235 378
PF04050 Upf2 3,594 1,473 411
PF04054 Not1 5,276 2,581 650
PF04078 Rcd1 4,850 1,776 597
PF04097 Nic96 4,102 1,607 594
PF04118 Dopey_N 4,570 2,075 542
PF04177 TAP42 3,703 1,933 684
PF04184 ST7 4,983 1,454 305
PF04190 GET4 3,572 1,523 504
PF04437 RINT1_TIP1 3,973 1,743 657
PF04733 Coatomer_E 4,530 2,032 829
PF04818 CID 22,076 9,577 3,056
PF04826 Arm_2 3,478 1,277 452
PF04840 Vps16_C 4,723 1,938 706
PF04869 Uso1_p115_head 4,275 1,808 493
PF04910 Tcf25 3,935 2,005 709
PF05004 IFRD 5,085 1,858 668
PF05282 AAR2 3,289 1,640 719
PF05470 eIF-3c_N 4,245 1,923 653
PF05484 LRV_FeS 626 386 45
PF05536 Neurochondrin 2,458 1,066 446
PF05804 KAP 2,951 1,093 480
PF05843 Suf 6,482 2,812 1,092
PF05918 API5 2,648 998 453
PF06041 DUF924 11,631 6,362 1,186
PF06292 MUN 16,542 7,854 1,238
PF06367 Drf_FH3 17,462 7,933 1,493
PF06371 Drf_GBD 17,488 7,919 1,444
PF06552 TOM20_plant 1,704 991 423
PF06920 DHR-2_Lobe_A 21,806 9,562 1,346
PF06957 COPI_C 4,645 1,737 454
PF07219 HemY_N 11,942 4,899 1,247
PF07571 TAF6_C 4,310 1,720 576
PF07719 TPR_2 67,828 40,967 25,757
PF07720 TPR_3 3,024 1,351 874
PF07721 TPR_4 8,328 6,079 4,440
PF07817 GLE1 3,518 1,734 762
PF07980 SusD_RagB 86,294 48,191 9,962
PF08144 CPL 3,225 1,460 417
PF08163 DNAPKcs_CC3 1,874 1,095 345
PF08167 RIX1 2,648 1,388 552
PF08216 CTNNBL 3,760 1,708 522
PF08238 Sel1 92,602 49,647 25,168
PF08311 Mad3_BUB1_I 4,976 2,676 938
PF08321 PPP5 5,814 2,325 449
PF08324 PUL 4,905 2,348 705
PF08389 Xpo1 18,164 6,556 1,992
PF08453 Peptidase_M9_N 3,111 893 229
PF08454 RIH_assoc 10,996 7,045 869
PF08506 Cse1 8,401 2,785 829
PF08514 STAG 6,976 2,443 662
PF08558 TRF 2,479 1,152 355
PF08568 Kinetochor_Ybp2 3,136 1,427 544
PF08569 Mo25 5,847 1,997 590
PF08579 RPM2 152 106 63
PF08609 Fes1 3,371 1,652 461
PF08623 TIP120 4,511 1,506 474
PF08631 SPO22 2,138 1,262 500
PF08713 DNA_alkylation 24,571 13,798 3,010
PF08767 CRM1_C 5,295 1,593 487
PF08852 DUF1822 2,390 1,480 686
PF09088 MIF4G_like 3,625 1,433 402
PF09090 MIF4G_like_2 3,742 1,493 448
PF09127 Leuk-A4-hydro_C 8,822 3,837 715
PF09246 PHAT 211 91 39
PF09268 Clathrin-link 5,407 1,463 200
PF09295 ChAPs 2,803 1,373 685
PF09450 DUF2019 534 368 147
PF09477 Type_III_YscG 217 49 15
PF09613 HrpB1_HrpK 638 245 123
PF09759 Atx10homo_assoc 2,935 1,502 622
PF09770 PAT1 3,128 1,263 288
PF09790 Hyccin 3,819 1,284 378
PF09976 TPR_21 18,309 9,403 3,815
PF09986 DUF2225 2,627 1,617 607
PF10037 MRP-S27 2,083 877 277
PF10189 Ints3_N 2,148 961 407
PF10255 Paf67 4,182 1,273 377
PF10257 RAI16-like 6,306 2,526 680
PF10274 ParcG 3,515 1,622 536
PF10300 Iml2-TPR_39 8,354 3,269 1,143
PF10345 Cohesin_load 3,433 1,510 524
PF10366 Vps39_1 5,091 2,047 619
PF10373 EST1_DNA_bind 9,246 4,173 1,553
PF10374 EST1 6,834 2,915 983
PF10508 Proteasom_PSMB 2,262 936 430
PF10516 SHNi-TPR 3,362 1,610 566
PF10579 Rapsyn_N 1,305 307 110
PF10602 RPN7 7,944 2,831 827
PF11107 FANCF 855 479 168
PF11229 Focadhesin 1,263 541 143
PF11510 FA_FANCE 1,419 653 219
PF11698 V-ATPase_H_C 4,358 1,556 389
PF11701 UNC45-central 4,151 1,422 347
PF11791 Aconitase_B_N 12,373 2,580 162
PF11817 Foie-gras_1 4,323 1,781 642
PF11841 ELMO_ARM 5,602 1,649 308
PF11846 Wzy_C_2 3,262 1,678 610
PF11865 DUF3385 4,138 1,763 488
PF11935 SYMPK_PTA1_N 3,893 1,852 532
PF12031 BAF250_C 4,585 2,143 392
PF12243 CTK3 1,232 607 192
PF12348 CLASP_N 16,735 9,973 2,038
PF12460 MMS19_C 4,034 1,718 538
PF12530 DUF3730 1,939 878 319
PF12569 NatA_aux_su 6,056 2,234 696
PF12688 TPR_5 4,298 2,391 763
PF12717 Cnd1 6,554 3,382 1,226
PF12719 Cnd3 3,746 1,777 699
PF12741 SusD-like 4,200 1,867 488
PF12753 Nro1 210 150 65
PF12755 Vac14_Fab1_bd 5,380 2,188 620
PF12765 Cohesin_HEAT 4,750 2,330 965
PF12771 SusD-like_2 14,262 9,605 1,947
PF12830 Nipped-B_C 4,330 2,124 730
PF12854 PPR_1 44,549 24,630 9,801
PF12862 ANAPC5 4,730 2,604 1,566
PF12895 ANAPC3 19,952 9,943 5,268
PF12922 Cnd1_N 3,263 1,545 378
PF12968 DUF3856 62 46 17
PF13041 PPR_2 153,472 83,386 30,304
PF13174 TPR_6 53,192 33,194 19,013
PF13176 TPR_7 46,402 25,646 16,284
PF13181 TPR_8 264,396 152,493 83,969
PF13251 DUF4042 2,295 1,022 375
PF13281 MAP3K_TRAF_bd 4,150 1,900 336
PF13371 TPR_9 9,885 4,495 1,911
PF13374 TPR_10 64,007 43,092 26,051
PF13414 TPR_11 86,242 54,673 31,240
PF13424 TPR_12 185,681 118,064 65,394
PF13428 TPR_14 9,516 6,355 4,584
PF13429 TPR_15 5,658 3,458 2,111
PF13431 TPR_17 10,212 6,902 5,031
PF13432 TPR_16 260,735 161,435 84,513
PF13512 TPR_18 520 170 110
PF13513 HEAT_EZ 14,914 5,262 1,404
PF13525 YfiO 32,462 17,356 5,822
PF13646 HEAT_2 87,367 53,852 25,957
PF13812 PPR_3 44,872 26,574 13,654
PF13838 Clathrin_H_link 7,229 2,071 395
PF14322 SusD-like_3 83,563 46,284 9,314
PF14559 TPR_19 149,241 87,569 47,232
PF14561 TPR_20 18,647 7,727 1,314
PF14674 FANCI_S1-cap 964 260 22
PF14675 FANCI_S1 1,961 796 285
PF14676 FANCI_S2 2,002 827 294
PF14677 FANCI_S3 1,513 557 159
PF14678 FANCI_S4 2,106 890 357
PF14679 FANCI_HD1 1,707 653 196
PF14680 FANCI_HD2 2,071 869 312
PF14718 SLT_L 7,918 2,663 678
PF14852 Fis1_TPR_N 2,905 1,264 333
PF14853 Fis1_TPR_C 3,583 1,652 595
PF14863 Alkyl_sulf_dimr 9,965 4,723 881
PF14929 TAF1_subA 1,573 677 309
PF14938 SNAP 10,876 4,899 2,142
PF15787 DUF4704 9,093 5,375 1,063
PF16186 Arm_3 12,884 3,321 766
PF16399 Aquarius_N 4,374 1,669 509
PF16415 CNOT1_CAF1_bind 5,129 2,695 739
PF16416 GUN4_N 517 242 34
PF16417 CNOT1_TTP_bind 4,803 2,469 586
PF16419 CNOT1_HEAT_N 128 84 23
PF16782 SIL1 468 267 136
PF16804 DUF5071 622 456 269
PF16811 TAtT 2,205 1,721 743
PF16854 VPS53_C 183 113 53
PF16918 PknG_TPR 3,550 1,787 343
PF16997 Wap1 53 40 27
PF17004 SRP_TPR_like 3,250 1,233 380
PF17127 DUF5106 1,955 1,254 548
PF17177 PPR_long 13,798 7,876 3,842
PF17432 DUF3458_C 15,008 6,187 863
PF17826 DUF5588 700 364 118
PF17874 TPR_MalT 30,104 18,176 10,326
PF18028 Zmiz1_N 1,320 354 107
PF18055 RPN6_N 4,111 1,228 294
PF18071 HMW1C_N 549 248 52
PF18381 YcaO_C 5,172 1,043 95
PF18391 CHIP_TPR_N 1,388 496 163
PF18529 MIX 44 11 4
PF18581 SYCP2_ARLD 800 434 142
PF18710 ComR_TPR 890 225 100
PF18768 RNPP_C 2,038 642 302
PF18770 Arm_vescicular 2,352 832 160
PF18773 Importin_rep 1,805 593 137
PF18777 CRM1_repeat 4,529 1,245 231
PF18786 Importin_rep_2 1,364 291 21
PF18787 CRM1_repeat_3 4,867 1,342 275
PF18794 HSM3_C 112 76 51
PF18795 HSM3_N 271 141 71
PF18797 APC_rep 2,412 914 182
PF18806 Importin_rep_3 2,332 779 242
PF18808 Importin_rep_4 4,333 1,592 468
PF18816 Importin_rep_5 2,012 619 101
PF18817 HEAT_UF 41 25 2
PF18829 Importin_rep_6 4,224 1,465 391
PF18833 TPR_22 1,157 567 125
PF18944 DUF5691 2,623 1,456 471
PF19189 Mtf2 1,250 767 421
PF19427 Insc_C 1,315 448 185
PF19440 TTC7_N 3,242 1,147 277
PF19704 DNAPKcs_CC5 1,998 1,170 388
PF19867 DUF6340 1,188 725 335
PF19904 DUF6377 2,927 1,161 414
PF19964 EAD11 336 327 301
PF20023 WSLR 1,221 403 88
PF20168 PDS5 10,636 4,356 1,816
PF20206 Tra1_ring 4,637 2,657 852
PF20210 Laa1_Sip1_HTR5 5,301 2,669 505
PF20225 DUF6584 742 396 135
PF20308 TPR-S 1,513 1,221 626
PF20421 DHR-2_Lobe_C 21,673 9,385 1,270
PF20425 Neurobeachin 5,618 3,294 414
PF20431 E_motif 61,375 32,275 8,556
PF20468 HPS6_C 734 197 51
PF20500 DNA-PKcs_N 1,919 1,140 396
PF20502 DNAPKcs_CC1-2 1,858 1,103 366
PF20518 Apc1_MidN 2,344 1,142 305
CL0021 OB 2,050,050 807,755 145,851 PF00164 Ribosom_S12_S23 62,265 9,721 1,146
PF00181 Ribosomal_L2 64,037 14,881 1,064
PF00313 CSD 123,878 39,014 6,566
PF00366 Ribosomal_S17 48,744 17,371 2,207
PF00436 SSB 82,493 37,613 8,006
PF00575 S1 219,378 82,331 13,277
PF00900 Ribosomal_S4e 8,655 3,492 934
PF01132 EFP 43,438 13,456 1,125
PF01176 eIF-1a 56,258 11,355 1,525
PF01200 Ribosomal_S28e 6,343 2,190 484
PF01287 eIF-5a 7,275 2,831 650
PF01330 RuvA_N 38,869 17,040 2,492
PF01336 tRNA_anti-codon 169,153 68,300 9,514
PF01588 tRNA_bind 91,003 38,987 5,267
PF01796 OB_aCoA_assoc 30,371 17,545 3,710
PF01938 TRAM 68,108 29,978 4,940
PF01957 NfeD 36,995 20,375 5,488
PF02303 Phage_DNA_bind 420 256 108
PF02721 DUF223 4,034 2,877 1,827
PF02760 HIN 815 334 162
PF02765 POT1 3,341 1,754 832
PF03100 CcmE 17,683 8,595 1,442
PF03120 DNA_ligase_OB 48,188 21,867 2,503
PF03319 EutN_CcmL 9,512 4,905 724
PF03459 TOBE 41,052 17,631 2,784
PF03870 RNA_pol_Rpb8 3,634 1,338 404
PF03919 mRNA_cap_C 4,201 1,910 632
PF04057 Rep-A_N 4,699 2,070 718
PF04076 BOF 5,649 1,594 488
PF04679 DNA_ligase_A_C 46,683 24,090 3,618
PF04717 Phage_base_V 38,414 17,712 4,806
PF06125 DUF961 2,735 296 95
PF06714 Gp5_OB 877 268 153
PF07076 DUF1344 1,657 510 158
PF07290 DUF1449 3,633 1,478 456
PF07404 TEBP_beta 24 17 12
PF07497 Rho_RNA_bind 35,806 11,987 1,062
PF07717 OB_NTP_bind 56,498 21,640 4,310
PF08206 OB_RNB 26,096 9,744 1,598
PF08292 RNA_pol_Rbc25 3,468 1,481 463
PF08402 TOBE_2 118,201 46,960 5,852
PF08418 Pol_alpha_B_N 2,506 1,172 355
PF08585 RMI1_N 5,322 2,721 1,201
PF08646 Rep_fac-A_C 11,312 6,309 3,040
PF08661 Rep_fac-A_3 3,195 1,661 613
PF08804 gp32 1,486 597 221
PF09103 BRCA-2_OB1 2,286 1,360 628
PF09104 BRCA-2_OB3 1,151 684 233
PF09285 Elong-fact-P_C 44,032 13,866 1,154
PF09883 DUF2110 876 444 111
PF10246 MRP-S35 1,233 662 240
PF10341 TPP1 884 479 263
PF10447 EXOSC1 3,318 1,504 382
PF10451 Stn1 1,139 684 321
PF10991 DUF2815 2,762 1,159 405
PF11325 DUF3127 4,493 2,309 412
PF11506 DUF3217 23 10 7
PF11604 CusF_Ec 11,190 5,333 1,385
PF11736 DUF3299 6,581 2,741 871
PF11967 RecO_N 38,086 18,272 4,932
PF12658 Ten1 634 390 131
PF12667 NigD_N 1,554 496 172
PF12857 TOBE_3 7,214 1,953 150
PF12869 tRNA_anti-like 2,011 1,539 940
PF13114 RecO_N_2 1,140 235 34
PF13509 S1_2 11,328 4,360 579
PF13742 tRNA_anti_2 37,602 17,402 3,285
PF14444 S1-like 2,420 840 257
PF14481 Fimbrial_PilY2 66 27 17
PF14743 DNA_ligase_OB_2 4,637 2,617 804
PF15072 HROB 1,980 1,227 651
PF15490 Ten1_2 1,368 680 293
PF16099 RMI1_C 1,523 753 298
PF16100 RMI2 1,143 603 218
PF16450 Prot_ATP_ID_OB 25,428 6,083 898
PF16669 TTC5_OB 1,388 609 240
PF16686 POT1PC 2,295 1,210 574
PF16745 RsgA_N 11,031 5,094 593
PF16773 Phage_SSB 291 19 7
PF16853 CDC13_N 55 40 27
PF16900 REPA_OB_2 7,133 3,633 1,670
PF16992 RNA_pol_RpbG 194 131 80
PF17092 PCB_OB 16,112 6,141 685
PF17185 NlpE_C 2,122 596 233
PF17191 RecG_wedge 36,131 16,234 2,716
PF17207 MCM_OB 34,407 12,323 3,103
PF17215 Rrp44_S1 4,007 1,344 258
PF17216 Rrp44_CSD1 5,765 2,154 567
PF17244 CDC24_OB3 703 372 181
PF17245 CDC24_OB2 481 247 89
PF17246 CDC24_OB1 460 250 102
PF17746 SfsA_N 12,434 6,152 999
PF17758 Prot_ATP_OB_N 5,194 1,317 133
PF17768 RecJ_OB 35,663 16,677 3,649
PF17845 FbpC_C_terminal 49 8 2
PF17847 GlcV_C_terminal 73 26 9
PF17849 OB_Dis3 8,868 3,658 1,068
PF17850 CysA_C_terminal 3,132 1,157 159
PF17875 RPA43_OB 2,253 1,243 459
PF17876 CSD2 30,001 11,714 1,753
PF17878 ssDBP 5 5 1
PF17879 DNA_ligase_C 356 120 19
PF17912 OB_MalK 52,342 17,664 1,305
PF18018 DNA_pol_D_N 3,628 1,701 541
PF18313 TLP1_add_C 3,589 1,818 311
PF18352 Gp138_N 2,857 1,054 397
PF18543 ID 163 130 33
PF18614 RNase_II_C_S1 3,725 2,220 229
PF18691 Cdc13_OB2 27 16 12
PF18693 TRAM_2 25,468 10,202 1,260
PF18914 DUF5666 5,488 3,809 2,282
PF19913 WCOB 1,344 458 111
PF20093 DUF6484 949 500 158
CL0022 LRR 583,867 294,036 127,735 PF00560 LRR_1 73,331 43,632 20,614
PF01030 Recep_L_domain 15,355 6,919 2,110
PF03382 DUF285 9,565 7,424 5,198
PF05725 FNIP 2,808 2,397 1,610
PF07723 LRR_2 5,657 3,536 1,781
PF07725 LRR_3 5,016 3,221 1,582
PF12468 TTSSLRR 1,320 119 66
PF12799 LRR_4 31,010 17,351 10,400
PF13306 LRR_5 38,781 22,399 16,004
PF13516 LRR_6 130,683 71,883 34,416
PF13855 LRR_8 347,474 163,857 63,023
PF14580 LRR_9 29,196 13,082 4,400
PF18779 LRR_RI_capping 543 137 32
PF18791 Transp_inhibit 2,556 1,017 188
PF18805 LRR_10 229 57 16
PF18831 LRR_11 188 63 4
PF18837 LRR_12 1,189 216 28
PF19729 FBXL18_LRR 1,053 257 115
CL0023 P-loop_NTPase 11,774,118 5,172,579 1,161,468 PF00004 AAA 545,347 222,344 45,250
PF00005 ABC_tran 2,990,995 1,282,163 192,801
PF00006 ATP-synt_ab 231,387 58,227 4,649
PF00009 GTP_EFTU 468,772 135,861 17,816
PF00025 Arf 62,164 22,379 7,003
PF00063 Myosin_head 97,537 41,172 9,603
PF00071 Ras 250,367 88,646 27,544
PF00142 Fer4_NifH 52,195 9,457 797
PF00154 RecA 66,727 16,706 1,984
PF00158 Sigma54_activat 239,634 112,134 23,168
PF00176 SNF2-rel_dom 172,506 87,631 26,273
PF00225 Kinesin 121,682 59,250 19,011
PF00265 TK 25,115 10,337 1,385
PF00270 DEAD 590,379 261,497 55,999
PF00271 Helicase_C 867,460 389,198 85,059
PF00308 Bac_DnaA 55,431 22,064 4,309
PF00350 Dynamin_N 69,129 30,288 9,502
PF00406 ADK 74,046 32,591 6,661
PF00437 T2SSE 158,896 75,696 12,921
PF00448 SRP54 106,188 42,254 6,063
PF00485 PRK 58,526 22,343 4,170
PF00488 MutS_V 86,202 40,610 9,560
PF00493 MCM 36,454 13,814 3,874
PF00503 G-alpha 32,244 10,540 3,185
PF00519 PPV_E1_C 3,447 904 232
PF00580 UvrD-helicase 129,626 60,847 18,073
PF00625 Guanylate_kin 99,101 40,211 6,313
PF00685 Sulfotransfer_1 57,009 28,809 12,682
PF00693 Herpes_TK 1,258 125 61
PF00709 Adenylsucc_synt 52,131 18,197 2,462
PF00735 Septin 33,419 9,123 2,260
PF00910 RNA_helicase 23,754 4,885 2,624
PF00931 NB-ARC 130,082 87,171 37,884
PF01057 Parvo_NS1 5,223 1,116 605
PF01078 Mg_chelatase 47,773 23,750 3,064
PF01121 CoaE 45,236 24,407 5,722
PF01202 SKI 64,716 31,573 7,352
PF01268 FTHFS 29,669 11,753 1,252
PF01443 Viral_helicase1 17,822 3,827 1,704
PF01580 FtsK_SpoIIIE 73,413 36,281 7,226
PF01583 APS_kinase 35,062 16,104 2,528
PF01591 6PF2K 15,522 5,116 1,041
PF01637 ATPase_2 10,924 6,410 2,274
PF01656 CbiA 95,154 47,111 11,016
PF01695 IstB_IS21 47,619 20,599 6,917
PF01712 dNK 23,459 10,489 2,102
PF01715 IPPT 50,868 27,172 5,219
PF01745 IPT 748 493 351
PF01926 MMR_HSR1 371,841 156,819 27,780
PF01935 DUF87 27,802 16,275 4,978
PF02223 Thymidylate_kin 49,996 26,687 5,698
PF02224 Cytidylate_kin 37,778 18,572 2,677
PF02263 GBP 12,923 5,511 2,239
PF02283 CobU 21,386 10,735 1,801
PF02367 TsaE 40,179 21,690 4,725
PF02374 ArsA_ATPase 26,563 11,880 2,366
PF02399 Herpes_ori_bp 1,263 664 377
PF02421 FeoB_N 31,766 15,489 2,200
PF02456 Adeno_IVa2 694 183 65
PF02463 SMC_N 129,518 60,950 15,178
PF02492 cobW 89,030 36,201 5,679
PF02499 DNA_pack_C 880 151 42
PF02500 DNA_pack_N 611 105 36
PF02534 T4SS-DNA_transf 25,039 9,815 3,501
PF02562 PhoH 56,482 20,288 1,829
PF02572 CobA_CobO_BtuR 23,341 9,456 1,229
PF02606 LpxK 24,525 13,257 3,648
PF02689 Herpes_Helicase 1,821 442 279
PF02702 KdpD 17,150 6,110 745
PF02841 GBP_C 8,289 3,118 964
PF03028 Dynein_heavy 24,513 13,685 3,526
PF03029 ATP_bind_1 28,608 9,984 1,704
PF03192 DUF257 642 395 155
PF03193 RsgA_GTPase 37,738 17,220 2,705
PF03205 MobB 14,375 7,494 1,857
PF03215 Rad17 4,020 2,145 985
PF03237 Terminase_6N 20,841 9,762 2,995
PF03266 NTPase_1 5,996 3,698 1,646
PF03308 MeaB 28,922 15,387 2,046
PF03354 TerL_ATPase 13,288 5,615 1,297
PF03567 Sulfotransfer_2 26,041 13,195 6,771
PF03618 Kinase-PPPase 17,831 6,106 830
PF03668 ATP_bind_2 27,575 11,030 1,457
PF03796 DnaB_C 59,582 24,233 6,424
PF03846 SulA 3,764 1,054 284
PF03969 AFG1_ATPase 25,980 10,469 1,952
PF03976 PPK2 35,259 17,332 1,561
PF04257 Exonuc_V_gamma 11,211 4,528 1,403
PF04310 MukB 3,172 384 106
PF04317 DUF463 6,273 1,928 289
PF04466 Terminase_3 7,471 3,879 1,304
PF04548 AIG1 22,922 15,487 7,047
PF04665 Pox_A32 1,947 645 338
PF04670 Gtr1_RagA 8,444 3,134 968
PF04851 ResIII 165,099 75,392 17,826
PF05049 IIGP 3,882 2,645 1,106
PF05127 Helicase_RecD 9,427 3,905 1,098
PF05179 CDC73_C 3,595 1,516 485
PF05272 VirE 9,224 3,423 1,553
PF05496 RuvB_N 48,427 18,181 1,332
PF05609 LAP1_C 1,991 906 238
PF05621 TniB 5,473 2,981 1,343
PF05625 PAXNEB 3,683 1,861 614
PF05673 DUF815 12,134 5,042 597
PF05707 Zot 3,929 2,458 1,144
PF05729 NACHT 76,416 51,556 23,768
PF05763 DUF835 2,256 1,576 746
PF05783 DLIC 6,246 2,185 730
PF05872 HerA_C 15,983 6,908 855
PF05876 GpA_ATPase 8,449 3,829 1,362
PF05879 RHD3_GTPase 6,441 3,786 1,422
PF05894 Podovirus_Gp16 279 224 125
PF05970 PIF1 32,916 22,467 11,647
PF06048 DUF927 5,127 2,716 1,377
PF06068 TIP49 8,451 2,678 680
PF06144 DNA_pol3_delta 34,438 15,511 4,840
PF06309 Torsin 5,088 1,989 524
PF06414 Zeta_toxin 9,659 5,738 2,383
PF06418 CTP_synth_N 50,310 17,044 1,274
PF06431 Polyoma_lg_T_C 2,440 239 91
PF06564 CBP_BcsQ 4,574 1,786 686
PF06733 DEAD_2 27,800 12,557 3,796
PF06745 ATPase 24,738 13,853 4,231
PF06858 NOG1 5,788 2,275 485
PF06911 Senescence 4,494 1,998 731
PF06990 Gal-3-0_sulfotr 4,863 2,528 1,171
PF07015 VirC1 2,619 1,067 295
PF07034 ORC3_N 3,528 1,638 621
PF07088 GvpD_P-loop 517 338 181
PF07517 SecA_DEAD 52,684 22,411 3,395
PF07652 Flavi_DEAD 39,466 3,564 373
PF07693 KAP_NTPase 14,123 9,014 4,932
PF07724 AAA_2 181,398 60,189 7,059
PF07726 AAA_3 66,746 30,147 2,171
PF07728 AAA_5 67,349 32,232 8,996
PF07755 DUF1611 5,829 3,353 402
PF07931 CPT 3,301 2,121 592
PF07999 RHSP 2,454 1,578 469
PF08245 Mur_ligase_M 247,017 117,080 21,397
PF08298 AAA_PrkA 11,199 2,562 389
PF08303 tRNA_lig_kinase 1,455 809 226
PF08351 TmcA_N 7,885 3,226 803
PF08423 Rad51 25,257 11,730 3,875
PF08433 KTI12 4,356 2,487 950
PF08438 MMR_HSR1_C 5,158 2,513 308
PF08477 Roc 11,735 6,538 3,431
PF09037 Sulphotransf 1,909 1,070 535
PF09140 MipZ 3,838 1,805 401
PF09439 SRPRB 3,604 1,772 608
PF09547 SpoIVA_ATPase 3,761 1,274 101
PF09711 Cas_Csn2 877 428 256
PF09807 ELP6 2,183 1,134 416
PF09818 ABC_ATPase 3,774 2,034 456
PF09820 AAA-ATPase_like 16,517 8,575 2,813
PF09848 DUF2075 7,512 4,637 1,394
PF10088 DUF2326 1,997 1,333 558
PF10236 DAP3 3,888 1,838 656
PF10412 TrwB_AAD_bind 12,473 6,430 2,278
PF10443 RNA12 1,342 726 204
PF10483 Elong_Iki1 2,415 1,338 450
PF10609 ParA 66,524 30,045 6,102
PF10649 DUF2478 1,820 1,274 363
PF10662 PduV-EutP 3,732 1,063 274
PF10923 BrxC_BrxD 4,000 2,145 559
PF10996 Beta-Casp 32,398 16,504 2,650
PF11111 CENP-M 1,111 477 129
PF11398 DUF2813 2,811 805 283
PF11496 HDA2-3 695 436 199
PF11602 NTPase_P4 14 10 8
PF12128 DUF3584 1,284 616 291
PF12344 UvrB 42,135 14,296 671
PF12399 BCA_ABC_TP_C 98,361 39,789 3,898
PF12696 TraG-D_C 15,804 6,864 2,584
PF12774 AAA_6 26,238 15,146 4,524
PF12775 AAA_7 24,218 13,982 3,972
PF12780 AAA_8 25,299 14,326 4,129
PF12781 AAA_9 25,239 14,063 4,010
PF12846 AAA_10 6,449 1,916 762
PF12848 ABC_tran_Xtn 124,479 38,121 3,978
PF13086 AAA_11 56,506 31,047 12,777
PF13087 AAA_12 67,608 36,711 14,764
PF13166 AAA_13 6,063 4,055 1,742
PF13173 AAA_14 43,751 27,218 6,350
PF13175 AAA_15 28,686 20,162 9,709
PF13177 DNA_pol3_delta2 91,258 45,856 11,451
PF13189 Cytidylate_kin2 15,178 8,315 2,629
PF13191 AAA_16 76,826 50,181 21,281
PF13207 AAA_17 6,531 4,193 1,569
PF13238 AAA_18 21,365 11,413 3,702
PF13245 AAA_19 47,326 25,279 7,286
PF13304 AAA_21 51,909 34,489 14,448
PF13307 Helicase_C_2 53,013 22,626 6,013
PF13337 BrxL_ATPase 3,408 1,800 341
PF13361 UvrD_C 148,790 69,994 19,935
PF13401 AAA_22 46,513 27,681 11,051
PF13469 Sulfotransfer_3 38,832 25,769 12,707
PF13476 AAA_23 55,498 32,964 15,457
PF13479 AAA_24 7,185 3,811 1,440
PF13481 AAA_25 54,422 22,293 7,197
PF13500 AAA_26 47,348 20,483 3,663
PF13514 AAA_27 6,856 3,928 2,137
PF13521 AAA_28 18,227 9,743 2,518
PF13538 UvrD_C_2 50,247 23,839 6,224
PF13555 AAA_29 6,818 3,137 1,109
PF13558 SbcC_Walker_B 30,970 14,131 5,109
PF13604 AAA_30 54,446 26,255 7,854
PF13614 AAA_31 147,284 65,362 16,543
PF13654 AAA_32 10,467 4,364 944
PF13671 AAA_33 52,357 28,019 8,086
PF13871 Helicase_C_4 7,518 3,358 953
PF13872 AAA_34 7,275 3,497 957
PF14396 CFTR_R 1,458 471 29
PF14417 MEDS 6,840 5,047 1,959
PF14516 AAA_35 7,816 5,127 1,960
PF14532 Sigma54_activ_2 5,887 3,106 1,058
PF14617 CMS1 2,777 1,266 396
PF16203 ERCC3_RAD25_C 12,064 4,244 680
PF16260 DUF4914 662 435 44
PF16575 CLP1_P 8,857 4,783 2,000
PF16796 Microtub_bd 1,761 1,385 961
PF16813 Cas_St_Csn2 182 81 47
PF16834 CSM2 56 40 24
PF16836 PSY3 100 73 45
PF17213 Hydin_ADK 730 529 174
PF17784 Sulfotransfer_4 8,830 5,518 2,495
PF18082 NAT_N 1,399 954 371
PF18128 HydF_dimer 3,760 2,062 195
PF18133 HydF_tetramer 3,850 2,123 234
PF18747 Ploopntkinase2 125 25 12
PF18748 Ploopntkinase1 145 25 16
PF18751 Ploopntkinase3 300 46 18
PF18766 SWI2_SNF2 27,452 13,977 2,053
PF19044 P-loop_TraG 23,724 7,816 1,831
PF19263 DUF5906 12,643 6,608 3,497
PF19518 RhoGAP_pG1_pG2 2,568 650 168
PF19557 DUF6079 1,257 944 463
PF19568 Spore_III_AA 7,280 3,837 804
PF19798 Sulfotransfer_5 3,820 2,550 549
PF19842 YqeC 3,225 1,667 779
PF19975 DO-GTPase1 706 497 236
PF19993 DO-GTPase2 1,949 1,302 585
PF19995 iSTAND 361 296 204
PF20030 bpMoxR 5,590 2,043 651
PF20307 divDNAB 164 79 51
PF20454 GpA_nuclease 8,038 3,674 1,278
CL0025 His_Kinase_A 1,742,024 925,469 326,671 PF00512 HisKA 883,647 473,756 175,861
PF02518 HATPase_c 1,372,803 716,240 257,947
PF02895 H-kinase_dim 28,089 14,575 3,067
PF07536 HWE_HK 17,790 10,025 3,165
PF07568 HisKA_2 26,282 15,236 6,737
PF07730 HisKA_3 161,018 94,807 29,624
PF10090 HPTransfase 3,840 1,938 484
PF13581 HATPase_c_2 95,232 53,455 16,346
PF13589 HATPase_c_3 80,379 40,560 10,493
PF13749 HATPase_c_4 19,081 11,973 3,722
PF14501 HATPase_c_5 18,576 9,274 5,157
CL0026 CU_oxidase 307,263 125,447 29,903 PF00116 COX2 113,165 31,675 3,942
PF00127 Copper-bind 24,886 14,570 4,969
PF00394 Cu-oxidase 68,051 28,310 5,341
PF00812 Ephrin 7,296 2,737 808
PF02298 Cu_bind_like 15,610 8,810 3,287
PF06481 COX_ARM 8,640 2,380 212
PF06525 SoxE 903 562 270
PF07731 Cu-oxidase_2 78,934 36,977 7,760
PF07732 Cu-oxidase_3 85,983 40,361 7,805
PF08526 PAD_N 2,424 780 91
PF08985 DP-EP 208 122 50
PF12306 PixA 1,263 575 214
PF13473 Cupredoxin_1 29,557 15,512 5,209
PF14699 hGDE_N 3,132 1,217 220
PF16986 CzcE 514 315 152
CL0027 RdRP 923,804 452,929 216,038 PF00078 RVT_1 696,663 361,825 166,609
PF00680 RdRP_1 60,355 8,522 3,447
PF00972 Flavi_NS5 14,299 1,694 218
PF00978 RdRP_2 11,190 2,083 985
PF00998 RdRP_3 49,448 6,634 1,207
PF02123 RdRP_4 6,811 1,106 692
PF04197 Birna_RdRp_palm 1,183 53 32
PF05919 Mitovir_RNA_pol 1,813 1,334 1,023
PF07727 RVT_2 79,612 68,358 41,513
PF20049 DUF6451 2,485 2,174 1,147
PF20483 Flavi_NS5_thumb 12,964 1,456 142
PF20488 Birna_VP1_thumb 312 22 14
CL0028 AB_hydrolase 2,106,116 1,123,943 307,082 PF00135 COesterase 90,253 51,608 18,951
PF00151 Lipase 18,670 9,166 3,778
PF00326 Peptidase_S9 165,724 89,946 22,878
PF00450 Peptidase_S10 48,156 26,470 8,576
PF00561 Abhydrolase_1 397,849 209,195 50,843
PF00756 Esterase 89,510 45,417 11,154
PF00975 Thioesterase 57,823 31,597 13,269
PF01083 Cutinase 14,665 7,117 1,940
PF01674 Lipase_2 6,502 3,699 1,044
PF01738 DLH 80,147 42,861 9,477
PF01764 Lipase_3 41,869 24,064 10,176
PF02089 Palm_thioest 9,848 5,074 1,765
PF02129 Peptidase_S15 47,792 24,859 5,638
PF02230 Abhydrolase_2 40,486 22,239 6,146
PF02273 Acyl_transf_2 284 144 81
PF02450 LCAT 11,542 6,198 2,724
PF03096 Ndr 11,021 3,312 886
PF03283 PAE 8,353 4,362 1,788
PF03403 PAF-AH_p_II 13,469 8,059 2,737
PF03583 LIP 14,989 7,655 2,034
PF03893 Lipase3_N 2,452 1,141 205
PF03959 FSH1 11,383 6,683 2,975
PF04083 Abhydro_lipase 8,938 5,581 2,232
PF04301 DUF452 1,434 539 242
PF05057 DUF676 15,014 8,501 3,585
PF05277 DUF726 6,539 3,360 1,147
PF05448 AXE1 12,334 7,376 2,195
PF05576 Peptidase_S37 2,240 1,039 229
PF05577 Peptidase_S28 13,454 7,803 3,140
PF05677 DUF818 385 266 185
PF05705 DUF829 6,437 3,498 1,504
PF05728 UPF0227 11,757 4,516 1,018
PF05990 DUF900 7,767 4,444 1,853
PF06028 DUF915 4,914 1,717 648
PF06057 VirJ 3,779 1,340 414
PF06259 Abhydrolase_8 7,242 4,284 1,286
PF06342 DUF1057 563 397 242
PF06441 EHN 20,171 11,078 1,613
PF06500 FrsA-like 6,363 2,819 728
PF06821 Ser_hydrolase 14,890 7,141 1,611
PF06850 PHB_depo_C 7,858 3,253 260
PF07082 DUF1350 2,032 1,029 346
PF07167 PhaC_N 13,984 6,494 743
PF07176 DUF1400 2,545 1,415 453
PF07224 Chlorophyllase 1,877 1,171 482
PF07519 Tannase 13,174 7,333 2,309
PF07819 PGAP1 10,860 6,214 2,861
PF07859 Abhydrolase_3 112,485 59,764 17,193
PF08237 PE-PPE 4,359 2,346 808
PF08386 Abhydrolase_4 20,775 13,071 5,289
PF08538 DUF1749 2,528 1,405 497
PF08840 BAAT_C 8,325 4,190 1,430
PF09752 ABHD18 3,399 1,516 603
PF09994 DUF2235 16,146 10,169 3,646
PF10081 Abhydrolase_9 3,889 2,065 407
PF10142 PhoPQ_related 3,470 1,733 842
PF10230 LIDHydrolase 3,652 1,936 866
PF10340 Say1_Mug180 670 432 253
PF10503 Esterase_PHB 18,201 11,385 3,738
PF10605 3HBOH 1,837 936 156
PF11144 DUF2920 2,173 487 162
PF11187 Mbeg1-like 4,233 1,829 1,055
PF11288 DUF3089 2,872 2,070 624
PF11339 DUF3141 2,441 1,341 246
PF12048 DUF3530 2,545 1,159 458
PF12146 Hydrolase_4 177,704 94,683 30,908
PF12695 Abhydrolase_5 3,637 2,024 756
PF12697 Abhydrolase_6 276,031 156,319 43,552
PF12715 Abhydrolase_7 2,382 1,516 478
PF12740 Chlorophyllase2 5,060 3,229 1,381
PF16929 Asp2 1,178 450 196
PF19878 DUF6351 1,374 986 316
PF20091 Abhydrolase_10 3,821 2,489 811
PF20408 Abhydrolase_11 13,887 7,375 1,409
PF20434 BD-FAE 55,141 33,992 10,596
CL0029 Cupin 1,533,124 751,187 188,692 PF00027 cNMP_binding 266,558 135,774 41,230
PF00190 Cupin_1 26,663 12,438 3,545
PF00908 dTDP_sugar_isom 38,492 22,034 2,094
PF01050 MannoseP_isomer 28,904 14,011 2,153
PF01238 PMI_typeI_C 5,139 1,439 260
PF01987 AIM24 26,217 10,102 1,620
PF02041 Auxin_BP 656 383 131
PF02311 AraC_binding 106,965 47,989 15,315
PF02373 JmjC 42,687 18,716 5,708
PF02375 JmjN 17,552 8,220 1,952
PF02668 TauD 65,314 32,380 8,318
PF02678 Pirin 59,368 26,469 2,686
PF03079 ARD 9,995 4,258 728
PF03171 2OG-FeII_Oxy 77,010 37,766 8,493
PF03336 Pox_C4_C10 312 75 46
PF04074 DUF386 11,922 3,818 1,276
PF04115 Ureidogly_lyase 9,380 4,084 745
PF04209 HgmA_C 14,406 4,795 438
PF04622 ERG2_Sigma1R 2,695 1,238 277
PF04831 Popeye 3,670 1,275 472
PF04962 KduI 18,377 7,215 660
PF05118 Asp_Arg_Hydrox 15,179 6,585 2,249
PF05523 FdtA 6,598 4,599 838
PF05721 PhyH 74,830 43,239 11,547
PF05726 Pirin_C 36,124 16,631 1,643
PF05899 Cupin_3 20,926 7,593 1,593
PF05962 HutD 8,342 3,974 1,180
PF05995 CDO_I 11,616 5,635 1,247
PF06052 3-HAO 6,589 3,070 389
PF06172 Cupin_5 11,207 6,293 1,020
PF06249 EutQ 4,002 1,516 359
PF06339 Ectoine_synth 5,513 1,897 160
PF06560 GPI 2,957 1,751 439
PF06719 AraC_N 18,069 7,429 1,274
PF06865 Ppnp 7,761 2,556 210
PF07350 DUF1479 4,844 1,764 387
PF07385 Lyx_isomer 3,091 1,406 146
PF07847 PCO_ADO 4,084 2,046 750
PF07883 Cupin_2 227,124 116,015 24,468
PF08007 JmjC_2 16,277 7,417 2,409
PF08487 VIT 18,757 10,228 3,550
PF08943 CsiD 1,859 335 74
PF09313 DUF1971 4,312 1,223 274
PF09859 Oxygenase-NA 4,902 2,498 185
PF10014 2OG-Fe_Oxy_2 4,651 2,281 521
PF10637 Ofd1_CTDD 2,974 1,487 454
PF11699 CENP-C_C 2,218 1,205 517
PF12851 Tet_JBP 3,262 1,686 415
PF12852 Cupin_6 20,974 10,083 1,893
PF12933 FTO_NTD 1,441 418 143
PF12973 Cupin_7 14,262 7,920 1,613
PF13532 2OG-FeII_Oxy_2 38,382 19,938 4,839
PF13621 Cupin_8 27,344 14,897 5,719
PF13640 2OG-FeII_Oxy_3 54,964 27,917 9,525
PF13661 2OG-FeII_Oxy_4 4,240 2,393 838
PF13757 VIT_2 1,370 633 135
PF13759 2OG-FeII_Oxy_5 6,080 4,402 1,992
PF14226 DIOX_N 71,209 35,340 7,809
PF14499 DUF4437 1,871 1,180 372
PF14525 AraC_binding_2 23,089 11,597 4,157
PF16161 DUF4867 1,394 588 130
PF16802 DUF5070 26 15 3
PF16867 DMSP_lyase 1,993 1,115 363
PF17954 Pirin_C_2 20,212 8,192 1,053
PF18637 AUDH_Cupin 302 163 71
PF19480 DUF6016 1,962 833 183
PF20510 HgmA_N 17,636 6,226 622
PF20511 PMI_typeI_cat 23,775 10,840 2,145
PF20515 2OG-FeII_Oxy_6 1,437 1,011 680
CL0030 Ion_channel 449,507 207,499 60,679 PF00060 Lig_chan 48,727 20,671 7,100
PF00520 Ion_trans 217,608 102,716 28,075
PF01007 IRK 16,066 3,862 1,010
PF02386 TrkH 49,958 23,555 5,027
PF03814 KdpA 17,232 5,594 577
PF07885 Ion_trans_2 85,774 44,744 16,446
PF08016 PKD_channel 14,727 7,245 3,268
PF20519 Polycystin_dom 8,734 4,922 2,309
CL0031 Phosphatase 641,346 299,039 72,287 PF00102 Y_phosphatase 86,265 37,050 10,919
PF00581 Rhodanese 253,185 128,105 27,685
PF00782 DSPc 72,159 32,163 11,124
PF01451 LMWPc 79,465 42,359 7,265
PF02302 PTS_IIB 59,490 16,732 2,587
PF02383 Syja_N 20,365 8,765 2,348
PF03162 Y_phosphatase2 5,978 3,422 1,369
PF04179 Init_tRNA_PT 1,825 1,008 309
PF04273 BLH_phosphatase 10,037 5,207 1,267
PF04722 Ssu72 3,559 1,442 416
PF05706 CDKN3 3,105 1,609 668
PF06602 Myotub-related 26,946 9,245 2,355
PF13350 Y_phosphatase3 22,382 12,324 4,324
PF14566 PTPlike_phytase 3,560 1,587 576
PF14671 DSPn 6,331 2,582 762
PF16809 NleF_casp_inhib 91 31 17
CL0032 Dim_A_B_barrel 525,609 235,655 43,347 PF01037 AsnC_trans_reg 167,308 55,942 7,771
PF02426 MIase 5,488 2,011 355
PF03795 YCII 60,749 31,927 4,703
PF03927 NapD 4,096 1,882 608
PF03992 ABM 87,897 44,047 10,022
PF04261 Dyp_perox 21,898 8,310 1,157
PF04486 SchA_CurD 948 410 43
PF04673 Cyclase_polyket 1,711 728 58
PF05336 rhaM 14,751 7,260 844
PF06778 Chlor_dismutase 10,506 4,215 435
PF07045 DUF1330 19,102 10,187 1,993
PF07110 EthD 12,351 7,198 2,203
PF07237 DUF1428 5,721 3,025 248
PF07682 SOR 113 61 16
PF07876 Dabb 22,103 12,096 2,987
PF07978 NIPSNAP 20,114 9,555 1,836
PF08734 GYD 6,981 3,800 766
PF08803 ydhR 2,798 1,205 291
PF09448 MmlI 61 29 6
PF11639 HapK 486 308 67
PF11695 DUF3291 3,378 2,258 412
PF11746 DUF3303 3,332 1,800 545
PF13816 Dehydratase_hem 1,719 781 207
PF13826 DUF4188 3,336 2,058 423
PF14026 DUF4242 5,700 3,299 498
PF14114 DUF4286 6,747 4,040 1,297
PF16291 DUF4937 1,579 394 125
PF17805 AsnC_trans_reg2 8,298 4,962 739
PF18075 FtsX_ECD 27,374 12,278 2,783
PF18232 Chalcone_N 103 56 11
CL0033 POZ 292,020 115,374 45,227 PF00651 BTB 210,007 87,682 35,602
PF02214 BTB_2 55,798 16,988 5,269
PF03931 Skp1_POZ 12,194 5,535 2,133
PF07707 BACK 75,801 22,823 7,586
PF11822 SANBR_BTB 1,298 556 237
PF16017 BTB_3 2,815 833 160
CL0034 Amidohydrolase 908,459 444,486 87,628 PF00449 Urease_alpha 18,228 4,476 480
PF00962 A_deaminase 42,230 17,912 3,460
PF01026 TatD_DNase 80,064 37,991 7,515
PF01244 Peptidase_M19 35,067 18,393 3,853
PF01876 RNase_P_p30 5,379 3,043 1,120
PF01979 Amidohydro_1 329,815 153,614 25,470
PF02126 PTE 10,249 4,891 1,207
PF02614 UxaC 12,520 5,628 557
PF02811 PHP 136,172 67,142 13,102
PF04909 Amidohydro_2 118,315 64,772 14,488
PF07969 Amidohydro_3 104,770 53,520 12,255
PF12228 DUF3604 5,358 4,010 1,390
PF12890 DHOase 595 423 164
PF13263 PHP_C 11,271 7,298 2,256
PF19326 AMP_deaminase 10,735 3,577 822
PF19567 CpsB_CapC 10,660 5,946 1,991
PF19799 DUF6282 2,554 1,575 435
CL0035 Peptidase_MH 733,488 355,611 77,370 PF00246 Peptidase_M14 79,791 42,885 12,535
PF00274 Glycolytic 18,090 7,274 1,088
PF00883 Peptidase_M17 51,814 23,781 4,107
PF01520 Amidase_3 65,991 34,073 11,238
PF01546 Peptidase_M20 300,110 136,364 21,864
PF02127 Peptidase_M18 18,999 8,065 1,364
PF04389 Peptidase_M28 94,832 54,526 14,706
PF04952 AstE_AspA 34,789 15,358 3,322
PF05013 FGase 21,586 11,368 1,965
PF05343 Peptidase_M42 29,930 13,370 2,409
PF05450 Nicastrin 3,048 1,264 493
PF05908 Gamma_PGA_hydro 2,500 1,177 412
PF07454 SpoIIP 5,160 2,628 965
PF10994 DUF2817 2,864 1,682 552
PF16254 DUF4910 2,389 1,423 340
PF17033 Peptidase_M99 1,491 418 127
PF18266 Ncstrn_small 2,459 1,001 404
CL0036 TIM_barrel 3,027,364 1,343,136 206,946 PF00121 TIM 60,149 25,901 3,739
PF00215 OMPdecase 55,447 24,493 3,274
PF00218 IGPS 41,844 18,191 2,543
PF00290 Trp_syntA 40,607 18,345 2,382
PF00478 IMPDH 68,396 20,526 1,967
PF00490 ALAD 38,734 14,455 1,119
PF00682 HMGL-like 142,416 56,921 5,531
PF00697 PRAI 35,905 18,908 3,757
PF00701 DHDPS 113,727 49,064 7,383
PF00724 Oxidored_FMN 117,345 51,977 7,615
PF00793 DAHP_synth_1 72,987 27,638 2,296
PF00809 Pterin_bind 86,392 39,079 4,930
PF00834 Ribul_P_3_epim 53,037 22,096 3,214
PF00923 TAL_FSA 52,728 20,605 2,501
PF00977 His_biosynth 80,796 32,223 3,683
PF01070 FMN_dh 58,004 25,659 4,546
PF01081 Aldolase 37,229 16,226 2,375
PF01116 F_bP_aldolase 52,445 17,470 2,081
PF01168 Ala_racemase_N 122,385 60,334 9,603
PF01180 DHO_dh 64,359 29,315 4,150
PF01207 Dus 81,917 34,311 5,921
PF01261 AP_endonuc_2 212,703 105,460 20,254
PF01474 DAHP_synth_2 19,069 6,260 734
PF01487 DHquinase_I 15,513 7,357 2,382
PF01645 Glu_synthase 58,802 23,384 2,209
PF01680 SOR_SNZ 17,086 4,809 334
PF01729 QRPTase_C 41,713 19,856 2,217
PF01791 DeoC 56,451 23,400 2,563
PF01884 PcrB 7,170 3,947 516
PF01964 ThiC_Rad_SAM 28,549 9,419 772
PF02007 MtrH 1,508 865 230
PF02581 TMP-TENI 52,318 26,799 5,343
PF02679 ComA 4,081 2,421 450
PF02784 Orn_Arg_deC_N 87,804 35,404 5,150
PF03060 NMO 66,900 30,601 3,493
PF03102 NeuB 20,273 12,218 2,092
PF03437 BtpA 5,987 3,032 643
PF03599 CdhD 5,833 3,891 714
PF03740 PdxJ 22,944 9,969 596
PF03786 UxuA 14,331 6,162 719
PF03851 UvdE 5,663 3,116 618
PF03932 CutC 16,780 7,430 1,589
PF04055 Radical_SAM 672,681 327,815 62,860
PF04095 NAPRTase 31,515 11,104 1,108
PF04131 NanE 8,205 3,012 329
PF04309 G3P_antiterm 5,017 2,006 401
PF04476 4HFCP_synth 2,582 1,423 431
PF04481 DUF561 1,255 654 141
PF04898 Glu_syn_central 36,398 13,411 1,362
PF05114 DUF692 13,136 7,121 1,007
PF05690 ThiG 25,911 8,523 468
PF06134 RhaA 4,686 1,690 152
PF06187 DUF993 4,389 1,855 114
PF07071 KDGP_aldolase 3,232 524 72
PF08013 GatZ_KbaZ-like 5,175 1,701 309
PF09043 Lys-AminoMut_A 2,250 1,151 118
PF09863 DUF2090 4,825 1,489 208
PF16154 DUF4862 1,462 362 109
PF16552 OAM_alpha 550 351 37
PF17285 PRMT5_TIM 3,686 1,605 476
PF19238 Radical_SAM_2 4,615 2,655 513
CL0037 Lysozyme 402,366 188,386 49,877 PF00062 Lys 4,999 2,593 951
PF00182 Glyco_hydro_19 15,978 6,875 2,152
PF00912 Transgly 119,989 54,611 10,046
PF00959 Phage_lysozyme 19,706 7,668 2,317
PF01374 Glyco_hydro_46 2,218 1,180 266
PF01464 SLT 134,447 66,315 20,734
PF01832 Glucosaminidase 31,987 14,291 5,045
PF03998 Utp11 3,503 1,764 479
PF05497 Destabilase 1,233 918 443
PF05838 Glyco_hydro_108 6,800 3,637 1,194
PF06737 Transglycosylas 12,912 6,615 1,277
PF06871 TraH_2 562 298 39
PF10464 Peptidase_U40 37 5 3
PF11508 DUF3218 30 4 2
PF13406 SLT_2 33,563 15,633 2,785
PF13647 Glyco_hydro_80 18 6 3
PF13702 Lysozyme_like 4,680 1,067 391
PF16754 Pesticin 570 405 265
PF18013 Phage_lysozyme2 3,897 1,977 1,204
PF18896 SLT_3 539 425 248
PF19489 SLT_4 4,763 2,171 216
CL0039 HUP 1,721,056 801,047 141,358 PF00133 tRNA-synt_1 172,601 80,131 11,641
PF00579 tRNA-synt_1b 113,559 48,298 4,994
PF00582 Usp 193,871 104,004 29,643
PF00733 Asn_synthase 70,929 39,657 12,768
PF00749 tRNA-synt_1c 104,838 48,031 5,757
PF00750 tRNA-synt_1d 55,227 24,995 4,011
PF00764 Arginosuc_synth 42,320 12,998 1,267
PF00875 DNA_photolyase 43,914 22,983 3,847
PF01012 ETF 96,322 38,717 4,829
PF01171 ATP_bind_3 69,970 35,901 10,403
PF01406 tRNA-synt_1e 61,607 28,343 3,630
PF01467 CTP_transf_like 141,853 67,536 12,757
PF01507 PAPS_reduct 66,091 25,865 4,080
PF01747 ATP-sulfurylase 15,469 6,812 782
PF01902 Diphthami_syn_2 12,507 7,574 1,882
PF01921 tRNA-synt_1f 10,037 4,779 720
PF02540 NAD_synthase 95,520 39,436 4,423
PF02568 ThiI 18,906 8,160 1,722
PF02569 Pantoate_ligase 35,737 17,926 2,307
PF02677 QueH 10,104 4,224 779
PF03054 tRNA_Me_trans 50,223 21,159 2,915
PF03720 UDPG_MGDP_dh_C 79,539 39,880 3,819
PF04244 DPRP 10,026 5,692 599
PF05636 HIGH_NTase1 7,715 3,479 1,096
PF06508 QueC 28,444 13,024 1,906
PF06574 FAD_syn 40,508 19,379 4,107
PF08218 Citrate_ly_lig 4,129 1,265 369
PF09334 tRNA-synt_1g 91,615 40,492 5,200
PF10079 BshC 6,044 3,919 1,230
PF13603 tRNA-synt_1_2 46,351 20,352 1,529
PF16581 HIGH_NTase1_ass 254 126 17
PF16715 CDPS 924 518 225
CL0040 tRNA_synt_II 689,641 294,112 42,519 PF00152 tRNA-synt_2 147,408 60,365 7,593
PF00587 tRNA-synt_2b 188,290 76,670 6,304
PF01409 tRNA-synt_2d 55,545 21,848 2,374
PF01411 tRNA-synt_2c 67,333 30,713 4,909
PF02091 tRNA-synt_2e 22,385 6,168 421
PF03099 BPL_LplA_LipB 73,161 37,064 10,363
PF03590 AsnA 7,328 2,302 168
PF04017 DUF366 697 408 90
PF13393 tRNA-synt_His 75,693 34,248 5,433
PF16917 BPL_LplA_LipB_2 1,035 679 188
PF17759 tRNA_synthFbeta 50,844 23,734 4,780
CL0041 Death 79,213 33,998 11,279 PF00531 Death 41,058 17,211 5,126
PF00619 CARD 22,240 9,621 3,613
PF01335 DED 6,553 2,894 877
PF02758 PYRIN 8,129 4,070 1,765
PF14786 Death_2 302 192 94
PF16739 CARD_2 3,068 1,222 313
PF18461 Atypical_Card 730 263 36
CL0042 Flavoprotein 293,381 130,721 22,804 PF00258 Flavodoxin_1 72,680 28,476 5,231
PF02525 Flavodoxin_2 62,006 25,092 3,867
PF03358 FMN_red 124,262 60,331 9,236
PF07972 Flavodoxin_NdrI 8,732 2,641 250
PF12641 Flavodoxin_3 2,594 1,297 468
PF12682 Flavodoxin_4 7,864 4,425 1,463
PF12724 Flavodoxin_5 15,275 8,704 2,797
CL0043 Chelatase 269,790 125,952 26,699 PF00148 Oxidored_nitro 29,436 11,522 1,734
PF00762 Ferrochelatase 37,049 16,090 2,314
PF01297 ZnuA 55,520 26,876 6,585
PF01497 Peripla_BP_2 123,344 58,717 13,134
PF01903 CbiX 19,456 10,742 2,334
PF06180 CbiK 4,888 1,986 596
PF11844 DUF3364 2,094 575 27
CL0044 Ferritin 339,202 147,609 26,948 PF00210 Ferritin 80,565 30,843 4,209
PF00268 Ribonuc_red_sm 40,984 10,825 1,480
PF01786 AOX 5,387 2,943 760
PF02332 Phenol_Hydrox 6,542 1,983 256
PF02915 Rubrerythrin 36,581 19,331 3,659
PF03232 COQ7 11,359 5,363 728
PF03405 FA_desaturase_2 9,577 3,185 509
PF03713 DUF305 22,167 12,890 2,674
PF04305 DUF455 8,380 4,619 764
PF05067 Mn_catalase 11,463 4,198 437
PF05138 PaaA_PaaC 19,911 8,085 1,129
PF05974 DUF892 12,951 6,055 1,291
PF06175 MiaE 8,906 3,094 290
PF07875 Coat_F 6,604 3,373 710
PF09537 DUF2383 7,313 4,065 1,019
PF09968 DUF2202 1,733 1,311 666
PF11266 Ald_deCOase 889 369 53
PF11553 DUF3231 3,834 2,428 566
PF11583 AurF 9,430 3,344 577
PF12902 Ferritin-like 2,517 1,614 576
PF13628 DUF4142 13,669 7,353 2,463
PF13668 Ferritin_2 10,925 6,805 1,614
PF13794 MiaE_2 3,840 1,398 186
PF14530 DUF4439 3,194 1,892 426
PF18536 DUF5623 144 102 46
PF19825 DUF6306 476 246 73
PF20402 DUF6692 139 64 22
CL0045 Rubredoxin 50,771 24,898 3,643 PF00301 Rubredoxin 24,630 10,617 1,114
PF01215 COX5B 3,690 1,830 474
PF06397 Desulfoferrod_N 4,738 2,883 299
PF08421 Methyltransf_13 7,409 4,635 887
PF10276 zf-CHCC 10,300 4,934 871
CL0046 Thiolase 525,310 230,964 45,157 PF00108 Thiolase_N 186,192 67,465 5,396
PF00109 ketoacyl-synt 199,727 100,117 26,990
PF00195 Chal_sti_synt_N 17,901 7,317 1,171
PF01154 HMG_CoA_synt_N 11,557 4,414 685
PF02797 Chal_sti_synt_C 18,189 7,699 1,255
PF02801 Ketoacyl-synt_C 190,991 94,753 24,197
PF02803 Thiolase_C 178,680 63,098 3,978
PF07451 SpoVAD 4,877 2,074 207
PF08392 FAE1_CUT1_RppA 8,664 3,975 984
PF08540 HMG_CoA_synt_C 11,216 4,203 726
PF08541 ACP_syn_III_C 80,535 35,249 4,032
PF08545 ACP_syn_III 68,028 29,383 3,183
PF13723 Ketoacyl-synt_2 5,863 2,940 784
PF16197 KAsynt_C_assoc 64,612 41,770 16,315
CL0047 CuAO_N2_N3 13,310 5,806 1,062 PF02727 Cu_amine_oxidN2 11,007 4,627 822
PF02728 Cu_amine_oxidN3 10,916 4,526 702
PF09248 DUF1965 993 564 142
CL0048 LolA_LolB 113,703 61,964 21,983 PF03548 LolA 23,652 11,728 3,726
PF03550 LolB 9,378 3,982 1,361
PF03888 MucB_RseB 8,117 3,497 1,155
PF04507 DUF576 1,318 392 100
PF04788 DUF620 2,858 1,186 258
PF07044 DUF1329 9,521 3,958 716
PF07161 LppX_LprAFG 2,474 1,485 512
PF07608 DUF1571 1,420 901 448
PF09697 Porph_ging 7,502 5,119 2,028
PF09865 DUF2092 2,197 1,585 755
PF11306 DUF3108 17,228 10,283 3,908
PF11659 DUF3261 2,251 1,096 425
PF14125 DUF4292 4,336 2,879 1,227
PF14371 DUF4412 1,900 1,574 987
PF16584 LolA_2 1,347 701 248
PF17131 LolA_like 11,094 7,637 2,426
PF18234 VioE 83 43 8
PF19574 LolA_3 2,890 1,409 402
PF19630 DUF6134 1,612 1,253 642
PF20316 DUF6612 2,510 1,355 826
CL0049 Tudor 327,259 161,581 55,617 PF00385 Chromo 55,380 28,963 11,798
PF00565 SNase 37,027 22,750 9,777
PF00567 TUDOR 22,011 11,017 4,642
PF00855 PWWP 36,217 15,066 4,554
PF01393 Chromo_shadow 6,086 2,687 1,116
PF02294 7kD_DNA_binding 102 19 5
PF02820 MBT 14,540 4,532 1,281
PF04397 LytTR 90,778 49,080 14,525
PF05641 Agenet 11,183 4,792 1,931
PF06003 SMN 5,066 1,997 751
PF07039 DUF1325 3,357 1,600 601
PF08169 RBB1NT 2,419 1,120 222
PF08605 Rad9_Rad53_bind 315 200 102
PF09038 53-BP1_Tudor 1,280 561 142
PF09465 LBR_tudor 1,154 304 90
PF11160 Hva1_TUDOR 6,441 3,686 585
PF11515 Cul7 2,565 1,126 196
PF11717 Tudor-knot 12,808 5,353 1,634
PF12148 TTD 2,340 776 125
PF14061 Mtf2_C 2,506 587 152
PF15057 DUF4537 1,376 731 336
PF16090 DUF4819 1,311 659 223
PF16719 SAWADEE 1,909 983 418
PF17516 ProQ_C 2,524 464 52
PF18104 Tudor_2 7,216 2,716 390
PF18115 Tudor_3 2,232 1,048 343
PF18336 Tudor_FRX1 4,056 1,188 178
PF18337 Tudor_RapA 6,237 1,405 228
PF18339 Tudor_1_RapA 6,302 1,464 246
PF18358 Tudor_4 1,657 863 263
PF18359 Tudor_5 1,543 825 293
PF18380 GEN1_C 1,126 707 239
PF18704 Chromo_2 1,027 547 149
CL0050 HotDog 537,465 255,550 54,413 PF01575 MaoC_dehydratas 94,052 42,580 6,511
PF01643 Acyl-ACP_TE 12,663 6,504 2,348
PF02551 Acyl_CoA_thio 630 368 223
PF03061 4HBT 194,828 90,658 17,296
PF03756 AfsA 2,928 1,729 694
PF07977 FabA 52,177 20,795 3,172
PF09500 YiiD_C 5,208 1,713 453
PF10862 FcoT 463 251 70
PF13279 4HBT_2 50,144 25,267 5,925
PF13452 MaoC_dehydrat_N 27,695 13,844 2,545
PF13622 4HBT_3 40,222 17,493 3,548
PF14539 DUF4442 13,178 6,268 1,143
PF14765 PS-DH 50,067 32,485 13,105
PF18238 LnmK_N_HDF 116 72 24
PF19315 MC_hydratase 129 44 2
CL0051 NTF2 389,087 207,839 58,757 PF00866 Ring_hydroxyl_B 11,862 4,586 842
PF02136 NTF2 18,680 7,801 2,488
PF02982 Scytalone_dh 1,120 546 138
PF03284 PHZA_PHZB 638 242 59
PF04280 Tim44 18,961 8,556 1,835
PF04335 VirB8 12,208 3,386 983
PF05223 MecA_N 7,914 3,561 703
PF05494 MlaC 16,274 8,191 2,515
PF07080 DUF1348 9,177 3,904 244
PF07107 WI12 978 592 152
PF07366 SnoaL 25,214 15,741 5,156
PF07858 LEH 2,855 1,584 452
PF07961 MBA1 555 311 160
PF08294 TIM21 3,158 1,687 544
PF08332 CaMKII_AD 15,182 6,975 969
PF08695 Coa1 3,895 2,272 912
PF10184 DUF2358 4,594 2,624 968
PF10429 Mtr2 232 142 54
PF11393 T4BSS_DotI_IcmL 1,717 765 371
PF11533 DUF3225 2,921 1,365 165
PF12642 TpcC 3,311 1,170 481
PF12680 SnoaL_2 93,707 53,478 13,840
PF12707 DUF3804 64 44 27
PF12870 DUF4878 1,392 930 601
PF12883 DUF3828 4,153 1,173 496
PF12893 Lumazine_bd_2 7,244 4,568 1,286
PF13026 DUF3887 2,748 1,565 724
PF13211 DUF4019 1,957 1,291 572
PF13355 ARC6-like_IMS 1,792 955 314
PF13474 SnoaL_3 20,545 12,120 4,387
PF13577 SnoaL_4 34,849 20,443 6,289
PF14254 DUF4348 683 312 138
PF14534 DUF4440 34,342 22,869 8,582
PF14729 DUF4467 343 92 26
PF15008 DUF4518 909 483 174
PF16022 DUF4783 1,647 1,113 475
PF16111 DUF4829 356 276 168
PF16156 DUF4864 2,519 1,525 546
PF16247 DUF4904 10 6 2
PF16800 Endopep_inhib 632 257 133
PF17117 DUF5104 439 245 140
PF17118 DUF5105 775 277 169
PF17775 UPF0225 14,271 7,243 1,076
PF18042 ORF_12_N 750 337 88
PF20409 SnoaL_5 1,742 1,158 230
PF20462 DUF6715 338 175 94
CL0052 NTN 498,654 217,847 43,998 PF00227 Proteasome 100,870 35,670 6,096
PF00310 GATase_2 38,029 14,360 1,809
PF01019 G_glu_transpept 67,337 33,809 6,725
PF01112 Asparaginase_2 27,064 13,479 2,667
PF01804 Penicil_amidase 27,846 16,297 4,740
PF02275 CBAH 14,239 5,633 1,497
PF03417 AAT 12,023 7,328 2,514
PF03577 Peptidase_C69 13,967 5,230 1,268
PF04916 Phospholip_B 4,578 2,174 929
PF05742 TANGO2 13,701 7,539 2,072
PF07826 IMP_cyclohyd 2,705 1,283 189
PF09147 CarA_N 52 28 13
PF10584 Proteasome_A_N 27,573 8,443 1,438
PF12481 DUF3700 2,328 1,058 291
PF13230 GATase_4 16,797 6,579 1,237
PF13522 GATase_6 81,175 29,895 3,758
PF13537 GATase_7 75,679 38,232 9,089
CL0053 4H_Cytokine 31,771 11,323 3,152 PF00103 Hormone_1 5,684 1,479 380
PF00143 Interferon 5,384 2,198 594
PF00489 IL6 997 384 141
PF00714 IFN-gamma 852 249 64
PF00715 IL2 295 80 14
PF00726 IL10 2,557 824 179
PF00727 IL4 525 182 48
PF00758 EPO_TPO 1,477 596 169
PF01109 GM_CSF 214 82 24
PF01110 CNTF 718 251 74
PF01291 LIF_OSM 876 298 107
PF01415 IL7 777 182 49
PF02024 Leptin 625 200 61
PF02025 IL5 324 152 30
PF02059 IL3 110 45 20
PF02372 IL15 1,637 723 297
PF02404 SCF 1,245 401 110
PF02947 Flt3_lig 399 176 48
PF03039 IL12 656 319 93
PF03487 IL13 223 91 23
PF05337 CSF-1 1,020 407 90
PF06875 PRF 899 228 63
PF07400 IL11 554 254 94
PF14565 IL22 717 249 54
PF15036 IL34 852 322 89
PF15177 IL28A 1,026 508 127
PF15216 TSLP 145 85 49
PF16647 GCSF 623 208 56
PF16649 IL23 335 171 30
CL0054 Knottin_1 8,659 4,576 1,863 PF00304 Gamma-thionin 3,319 1,756 639
PF00451 Toxin_2 232 168 65
PF00537 Toxin_3 1,043 597 172
PF01097 Defensin_2 1,180 670 329
PF05294 Toxin_5 39 26 5
PF05453 Toxin_6 35 18 6
PF06876 SCRL 633 319 157
PF07333 SLR1-BP 1,297 612 322
PF08086 Toxin_17 34 18 2
PF09132 BmKX 15 13 9
PF10868 Defensin_like 414 194 80
PF11415 Toxin_37 165 28 5
PF14865 Macin 114 95 56
PF14866 Toxin_38 118 59 20
PF18251 Defensin_5 6 6 5
CL0055 Nucleoplasmin 247,734 30,541 9,043 PF00073 Rhv 94,847 5,694 1,253
PF00500 Late_protein_L1 6,586 1,480 185
PF00688 TGFb_propeptide 21,703 6,078 1,875
PF00718 Polyoma_coat 5,455 271 118
PF00729 Viral_coat 1,780 655 456
PF00738 Polyhedrin 647 74 15
PF00760 Cucumo_coat 2,959 756 197
PF00894 Luteo_coat 3,456 250 81
PF00915 Calici_coat 41,945 1,414 359
PF00983 Tymo_coat 588 138 62
PF01318 Bromo_coat 24 8 3
PF01766 Birna_VP2 4,986 292 44
PF01787 Ilar_coat 1,206 106 33
PF01829 Peptidase_A6 24 21 10
PF02226 Pico_P1A 24,306 959 88
PF02247 Como_LCP 335 87 54
PF02248 Como_SCP 268 60 37
PF02443 Circo_capsid 5,256 264 106
PF02956 TT_ORF1 5,419 1,324 384
PF03014 SP2 12,600 355 56
PF03066 Nucleoplasmin 3,650 1,494 399
PF03115 Astro_capsid_N 4,614 597 208
PF03340 Pox_Rif 183 42 12