EFI - Enzyme Similarity Tool

Pfam Families

These data are sourced from the UniProt and EMBL-EBI InterPro databases.

Clan ID Clan Short Name Clan Size Clan UniRef90 Size Pfam ID Pfam Short Name Pfam Size Pfam UniRef90 Size
CL0001 EGF 123,696 66,483 PF00008 EGF 35,980 19,942
PF00053 Laminin_EGF 17,072 9,544
PF00084 Sushi 23,844 13,206
PF00594 Gla 3,428 1,782
PF01414 DSL 2,715 1,438
PF04863 EGF_alliinase 375 205
PF06247 Plasmod_Pvs28 385 60
PF07645 EGF_CA 37,012 21,186
PF07974 EGF_2 8,126 4,144
PF09014 Sushi_2 427 240
PF09064 Tme5_EGF_like 217 163
PF09289 FOLN 1,594 545
PF09443 CFC 357 207
PF12661 hEGF 12,678 6,796
PF12662 cEGF 9,784 4,986
PF12946 EGF_MSP1_1 2,284 156
PF12947 EGF_3 8,448 3,833
PF14670 FXa_inhibition 15,373 7,693
PF18193 Fibrillin_U_N 690 286
PF18372 I-EGF_1 2,398 1,012
PF18720 EGF_Tenascin 1,794 947
CL0003 SAM 63,419 28,026 PF00536 SAM_1 33,969 15,487
PF01698 SAM_LFY 1,452 256
PF02198 SAM_PNT 5,092 2,023
PF04904 NCD1 866 333
PF07647 SAM_2 21,511 9,384
PF09235 SAM_Ste50p 56 38
PF09597 IGR 1,094 635
PF13543 SAM_KSR1 829 368
PF18016 SAM_3 2,883 1,261
PF18017 SAM_4 772 448
PF18255 SAM_DrpA 675 82
PF18609 SAM_Exu 255 139
CL0004 Concanavalin 319,289 176,832 PF00054 Laminin_G_1 6,103 3,456
PF00139 Lectin_legB 8,481 5,338
PF00262 Calreticulin 5,567 2,714
PF00337 Gal-bind_lectin 8,143 4,493
PF00354 Pentaxin 4,776 2,715
PF00426 VP4_haemagglut 6,887 266
PF00457 Glyco_hydro_11 3,831 2,007
PF00622 SPRY 37,568 20,537
PF00629 MAM 11,243 5,958
PF00722 Glyco_hydro_16 35,477 20,526
PF00840 Glyco_hydro_7 7,168 2,175
PF01670 Glyco_hydro_12 3,463 1,838
PF01828 Peptidase_A4 1,870 1,236
PF02210 Laminin_G_2 21,137 10,442
PF02973 Sialidase 651 180
PF03388 Lectin_leg-like 4,163 2,136
PF03935 SKN1 2,652 1,790
PF05592 Bac_rhamnosid 9,567 5,939
PF05735 TSP_C 2,364 970
PF06439 DUF1080 22,703 15,428
PF06955 XET_C 5,371 2,522
PF07081 DUF1349 6,606 2,983
PF07177 Neuralized 2,476 1,222
PF07622 DUF1583 101 72
PF07675 Cleaved_Adhesin 1,349 1,039
PF07953 Toxin_R_bind_N 309 50
PF08244 Glyco_hydro_32C 20,050 8,930
PF08787 Alginate_lyase2 4,001 1,849
PF08978 Reoviridae_Vp9 38 14
PF09101 Exotox-A_bind 205 42
PF09206 ArabFuran-catal 1,342 746
PF09224 DUF1961 538 334
PF09264 Sial-lect-inser 72 26
PF10287 DUF2401 793 498
PF11476 TgMIC1 19 5
PF11958 DUF3472 1,508 808
PF12248 Methyltransf_FA 1,429 918
PF13385 Laminin_G_3 48,343 33,899
PF13765 PRY 19,700 12,259
PF14099 Polysacc_lyase 2,317 1,555
PF15493 YrpD 146 49
PF16346 DUF4975 623 275
PF16451 Spike_NTD 1,040 51
PF17689 Arabino_trans_N 2,636 874
PF17851 GH43_C2 15,023 7,668
PF17974 GalBD_like 1,144 428
PF18239 HA1 6 4
PF18271 GH131_N 1,153 766
PF18483 Bact_lectin 2,765 1,835
CL0005 Kazal 18,920 9,943 PF00050 Kazal_1 6,340 3,822
PF07648 Kazal_2 13,843 6,821
PF18434 Kazal_3 373 177
CL0006 C1 51,912 24,418 PF00130 C1_1 29,370 12,373
PF00569 ZZ 16,423 8,024
PF03107 C1_2 4,613 3,268
PF07975 C1_4 1,508 757
CL0007 KH 212,139 76,300 PF00013 KH_1 82,045 32,018
PF04025 DUF370 5,682 2,158
PF07650 KH_2 62,426 18,839
PF09869 DUF2096 128 96
PF13083 KH_4 22,144 8,671
PF13184 KH_5 30,426 9,752
PF14611 SLS 716 470
PF14955 MRP-S24 572 344
PF15985 KH_6 3,729 1,944
PF16005 MOEP19 411 204
PF17214 KH_7 1,490 613
PF17903 KH_8 2,836 1,404
PF17904 KH_9 1,846 533
PF17905 KH_10 65 52
CL0009 ENTH_VHS 26,629 13,411 PF00790 VHS 10,666 5,414
PF01417 ENTH 6,901 3,783
PF07651 ANTH 9,062 4,218
CL0010 SH3 259,898 118,004 PF00018 SH3_1 62,435 28,403
PF01302 CAP_GLY 12,394 6,809
PF02736 Myosin_N 9,758 3,854
PF03831 PhnA 13,535 4,359
PF06347 SH3_4 6,474 3,869
PF06372 Gemin6 434 252
PF07563 DUF1541 1,422 710
PF07653 SH3_2 25,517 11,391
PF07866 DUF1653 6,351 2,744
PF08239 SH3_3 38,493 19,759
PF08460 SH3_5 2,267 761
PF08810 KapB 1,145 397
PF11095 Gemin7 425 277
PF11302 DUF3104 176 128
PF11607 DUF3247 296 125
PF11623 NdhS 624 269
PF12208 DUF3601 161 58
PF12913 SH3_6 2,533 908
PF13457 GW 2,355 1,054
PF14603 hSH3 755 444
PF14604 SH3_9 41,081 19,731
PF14627 DUF4453 75 56
PF15505 DUF4648 139 51
PF17384 DUF150_C 21,747 8,491
PF17902 SH3_10 3,947 1,451
PF18103 SH3_11 38 17
PF18129 SH3_12 1,672 961
PF18335 SH3_13 9,498 3,840
PF18343 SH3_14 155 17
PF18346 SH3_15 1,625 685
PF18348 SH3_16 6,188 3,501
PF18350 SH3_17 35 7
PF18354 SH3_18 42 22
PF18597 SH3_19 363 196
PF18697 MLVIN_C 1,107 615
CL0011 Ig 253,958 125,350 PF00047 ig 17,487 8,273
PF01537 Herpes_glycop_D 616 103
PF01688 Herpes_gI 384 49
PF02124 Marek_A 622 74
PF02440 Adeno_E3_CR1 336 66
PF02480 Herpes_gE 839 113
PF02960 K1 1,184 91
PF03921 ICAM_N 866 452
PF05790 C2-set 564 203
PF07654 C1-set 43,934 12,860
PF07679 I-set 86,470 41,077
PF07686 V-set 74,082 46,104
PF08204 V-set_CD47 461 168
PF08205 C2-set_2 16,067 8,394
PF09085 Adhes-Ig_like 173 78
PF09191 CD4-extracel 232 83
PF09291 DUF1968 163 104
PF10430 Ig_Tie2_1 234 64
PF11465 Receptor_2B4 283 178
PF13895 Ig_2 18,835 10,516
PF13927 Ig_3 69,498 35,502
PF15028 PTCRA 100 62
PF15910 V-set_2 426 182
PF16680 Ig_4 430 264
PF16681 Ig_5 245 149
PF16706 Izumo-Ig 163 84
PF16758 UL141 153 12
PF17736 Ig_C17orf99 654 308
PF17737 Ig_C19orf38 117 79
PF18452 Ig_6 1,813 800
PF18589 ObR_Ig 490 196
CL0012 Histone 107,948 32,833 PF00125 Histone 61,152 9,518
PF00808 CBFD_NFYB_HMF 17,351 8,969
PF02269 TFIID-18kDa 3,305 1,658
PF02291 TFIID-31kDa 2,103 1,082
PF02969 TAF 2,577 1,168
PF03540 TFIID_30kDa 1,830 972
PF03847 TFIID_20kDa 2,288 1,290
PF04719 TAFII28 1,947 1,160
PF05236 TAF4 2,832 1,580
PF07524 Bromo_TP 4,187 2,234
PF09123 DUF1931 553 172
PF09415 CENP-X 1,156 727
PF15510 CENP-W 281 158
PF15511 CENP-T_C 4,913 1,345
PF15630 CENP-S 1,269 753
PF15715 PAF 300 149
PF17027 Bromo_TP_like 41 32
CL0013 Beta-lactamase 421,815 192,348 PF00144 Beta-lactamase 135,037 74,388
PF00768 Peptidase_S11 55,988 22,223
PF00905 Transpeptidase 167,769 69,091
PF02113 Peptidase_S13 17,627 9,011
PF04960 Glutaminase 15,071 4,931
PF13354 Beta-lactamase2 30,438 12,839
CL0014 Glutaminase_I 524,294 219,919 PF00117 GATase 199,365 76,397
PF01174 SNO 10,964 5,053
PF01965 DJ-1_PfpI 113,127 45,765
PF02016 Peptidase_S66 19,406 8,934
PF03575 Peptidase_S51 15,878 8,141
PF04204 HTS 10,500 3,565
PF06283 ThuA 18,255 10,429
PF07090 GATase1_like 3,903 1,824
PF07685 GATase_3 35,582 15,037
PF07722 Peptidase_C26 22,000 10,534
PF08532 Glyco_hydro_42M 11,380 5,955
PF09822 ABC_transp_aux 9,981 6,079
PF09825 BPL_N 2,342 1,386
PF13507 GATase_5 32,258 12,351
PF13709 DUF4159 6,913 4,103
PF17124 ThiJ_like 1,667 800
PF17385 LBP_M 1,328 457
PF18011 Catalase_C 9,457 3,208
CL0015 MFS 1,457,621 632,738 PF00083 Sugar_tr 191,110 85,777
PF00854 PTR2 42,558 18,546
PF01306 LacY_symp 3,655 855
PF01733 Nucleoside_tran 5,193 2,982
PF01770 Folate_carrier 2,061 1,277
PF03092 BT1 5,652 2,997
PF03137 OATP 6,383 3,604
PF03209 PUCC 3,127 1,480
PF03219 TLC 2,553 1,592
PF03825 Nuc_H_symport 7,178 2,421
PF05631 MFS_5 1,950 1,078
PF05977 MFS_3 45,130 22,511
PF05978 UNC-93 4,045 2,414
PF06609 TRI12 3,025 1,875
PF06779 MFS_4 9,681 3,838
PF06813 Nodulin-like 4,053 2,276
PF06963 FPN1 2,269 1,401
PF07672 MFS_Mycoplasma 110 55
PF07690 MFS_1 1,068,478 454,419
PF11700 ATG22 14,768 7,586
PF12832 MFS_1_like 14,077 6,613
PF13000 Acatn 4,332 2,190
PF13347 MFS_2 39,077 17,012
CL0016 PKinase 1,261,906 682,220 PF00069 Pkinase 697,221 385,088
PF00454 PI3_PI4_kinase 25,811 13,496
PF01163 RIO1 12,988 6,453
PF01504 PIP5K 12,379 6,206
PF01633 Choline_kinase 10,791 5,547
PF01636 APH 140,301 73,719
PF02816 Alpha_kinase 3,981 2,502
PF02958 EcKinase 8,182 5,483
PF03109 ABC1 43,240 19,402
PF03770 IPK 6,579 3,698
PF03881 Fructosamin_kin 11,008 5,978
PF04183 IucA_IucC 12,142 4,752
PF04655 APH_6_hur 5,881 3,013
PF05445 Pox_ser-thr_kin 155 46
PF06090 Ins_P5_2-kin 2,028 1,271
PF06176 WaaY 1,462 347
PF06293 Kdo 17,096 7,075
PF06315 AceK 5,134 1,372
PF06702 Fam20C 1,713 852
PF06734 UL97 515 32
PF07387 Seadorna_VP7 47 31
PF07714 Pkinase_Tyr 188,608 107,739
PF07804 HipA_C 19,639 10,399
PF07914 DUF1679 1,208 987
PF08757 CotH 12,406 8,757
PF09192 Act-Frag_cataly 421 209
PF10009 DUF2252 7,025 3,354
PF10140 YukC 1,337 398
PF10707 YrbL-PhoP_reg 1,490 630
PF12260 PIP49_C 2,161 940
PF12330 Haspin_kinase 8,942 4,859
PF13095 FTA2 549 349
PF13575 DUF4135 2,494 1,540
PF14531 Kinase-like 632 194
PF16474 KIND 1,484 869
PF17667 Pkinase_fungal 7,373 6,446
PF18101 Pan3_PK 1,949 935
PF18762 Kinase-PolyVal 339 213
CL0018 bZIP 49,089 24,831 PF00170 bZIP_1 32,434 15,958
PF03131 bZIP_Maf 4,735 2,041
PF07716 bZIP_2 11,919 6,963
CL0020 TPR 1,240,832 688,654 PF00514 Arm 27,161 11,584
PF00515 TPR_1 61,511 34,012
PF00613 PI3Ka 7,826 3,623
PF00637 Clathrin 9,554 4,079
PF00806 PUF 9,449 5,060
PF01239 PPTA 4,961 2,921
PF01347 Vitellogenin_N 5,078 3,046
PF01394 Clathrin_propel 2,869 779
PF01535 PPR 83,371 50,178
PF01602 Adaptin_N 22,053 9,465
PF01603 B56 6,637 2,771
PF01749 IBB 5,240 1,847
PF01816 LRV 932 658
PF01851 PC_rep 4,885 1,831
PF02020 W2 7,601 3,238
PF02071 NSF 4 4
PF02184 HAT 1,906 857
PF02259 FAT 7,707 4,209
PF02847 MA3 9,007 4,552
PF02854 MIF4G 13,523 6,922
PF02985 HEAT 10,417 5,379
PF03130 HEAT_PBS 5,315 3,682
PF03224 V-ATPase_H_N 2,550 1,174
PF03377 TAL_effector 512 173
PF03378 CAS_CSE1 2,177 1,055
PF03704 BTAD 28,125 19,262
PF03810 IBN_N 19,802 8,460
PF04049 ANAPC8 1,702 867
PF04050 Upf2 1,931 913
PF04184 ST7 1,790 554
PF04733 Coatomer_E 2,676 1,337
PF04826 Arm_2 1,532 722
PF04910 Tcf25 2,117 1,311
PF05004 IFRD 2,428 1,120
PF05484 LRV_FeS 471 293
PF05536 Neurochondrin 1,277 693
PF05804 KAP 1,510 784
PF05843 Suf 3,845 2,031
PF05918 API5 1,277 631
PF06041 DUF924 8,733 4,558
PF06367 Drf_FH3 6,683 3,343
PF06371 Drf_GBD 6,835 3,370
PF06552 TOM20_plant 981 637
PF06920 DHR-2 8,036 3,338
PF06957 COPI_C 2,541 1,053
PF07219 HemY_N 9,313 3,587
PF07571 TAF6_C 2,431 1,189
PF07719 TPR_2 40,996 25,195
PF07720 TPR_3 2,118 850
PF07721 TPR_4 5,084 3,625
PF07980 SusD_RagB 65,481 35,319
PF08144 CPL 1,725 958
PF08167 RIX1 1,545 966
PF08238 Sel1 67,367 36,362
PF08321 PPP5 2,774 1,303
PF08389 Xpo1 9,751 4,437
PF08506 Cse1 4,088 1,776
PF08569 Mo25 3,097 1,317
PF08579 RPM2 123 91
PF08623 TIP120 2,253 988
PF08631 SPO22 1,131 801
PF08713 DNA_alkylation 18,717 9,527
PF08767 CRM1_C 2,979 1,071
PF08852 DUF1822 1,318 928
PF09088 MIF4G_like 2,062 1,002
PF09090 MIF4G_like_2 2,181 1,069
PF09127 Leuk-A4-hydro_C 4,397 2,296
PF09246 PHAT 132 78
PF09268 Clathrin-link 2,559 640
PF09295 ChAPs 2,093 1,019
PF09311 Rab5-bind 1,093 449
PF09450 DUF2019 417 292
PF09613 HrpB1_HrpK 551 195
PF09759 Atx10homo_assoc 1,757 1,020
PF09976 TPR_21 13,976 6,537
PF09986 DUF2225 2,023 1,138
PF10037 MRP-S27 873 492
PF10255 Paf67 2,311 763
PF10274 ParcG 1,466 798
PF10300 DUF3808 3,774 2,027
PF10345 Cohesin_load 1,698 845
PF10366 Vps39_1 2,700 1,421
PF10373 EST1_DNA_bind 4,586 2,586
PF10374 EST1 3,240 1,704
PF10508 Proteasom_PSMB 1,280 660
PF10516 SHNi-TPR 1,940 1,110
PF10579 Rapsyn_N 519 204
PF10602 RPN7 4,321 1,888
PF11698 V-ATPase_H_C 2,352 1,027
PF11701 UNC45-central 1,799 841
PF11817 Foie-gras_1 2,128 1,174
PF11846 Wzy_C_2 2,681 1,324
PF11865 DUF3385 2,378 1,069
PF12031 BAF250_C 1,673 823
PF12348 CLASP_N 7,208 3,662
PF12460 MMS19_C 1,790 968
PF12569 NARP1 2,890 1,387
PF12688 TPR_5 3,137 1,594
PF12717 Cnd1 3,403 2,005
PF12719 Cnd3 1,975 1,179
PF12741 SusD-like 3,570 1,510
PF12753 Nro1 171 125
PF12755 Vac14_Fab1_bd 2,932 1,435
PF12765 Cohesin_HEAT 2,727 1,556
PF12771 SusD-like_2 9,980 6,632
PF12830 Nipped-B_C 2,239 1,290
PF12854 PPR_1 25,217 14,922
PF12862 ANAPC5 2,577 1,664
PF12895 ANAPC3 12,153 6,958
PF12968 DUF3856 30 26
PF13041 PPR_2 81,311 48,430
PF13174 TPR_6 35,414 21,938
PF13176 TPR_7 25,288 14,436
PF13181 TPR_8 156,384 94,952
PF13251 DUF4042 1,117 584
PF13371 TPR_9 7,568 3,065
PF13374 TPR_10 31,248 22,798
PF13414 TPR_11 52,961 34,644
PF13424 TPR_12 92,132 62,531
PF13428 TPR_14 6,106 4,026
PF13429 TPR_15 5,773 3,237
PF13431 TPR_17 7,703 5,186
PF13432 TPR_16 169,193 104,927
PF13512 TPR_18 197 148
PF13513 HEAT_EZ 8,340 3,527
PF13525 YfiO 23,898 11,633
PF13646 HEAT_2 52,568 32,577
PF13812 PPR_3 20,525 13,014
PF13838 Clathrin_H_link 3,665 995
PF14322 SusD-like_3 63,170 33,674
PF14559 TPR_19 97,315 54,834
PF14561 TPR_20 13,606 5,266
PF14852 Fis1_TPR_N 1,826 843
PF14853 Fis1_TPR_C 2,370 1,193
PF14863 Alkyl_sulf_dimr 7,416 3,377
PF14938 SNAP 5,565 2,931
PF16186 Arm_3 5,357 1,892
PF16416 GUN4_N 334 172
PF16811 TAtT 1,421 1,107
PF16918 PknG_TPR 2,398 1,141
PF17004 SRP_TPR_like 1,752 910
PF17177 PPR_long 6,034 3,683
PF17432 DUF3458_C 11,713 4,433
PF17874 TPR_MalT 21,133 12,390
PF18028 Zmiz1_N 426 155
PF18381 YcaO_C 4,249 778
PF18391 CHIP_TPR_N 676 298
PF18581 SYCP2_ARLD 311 216
PF18710 ComR_TPR 814 203
CL0021 OB 1,421,200 527,540 PF00164 Ribosom_S12_S23 40,297 6,101
PF00181 Ribosomal_L2 41,935 9,838
PF00313 CSD 89,477 26,110
PF00366 Ribosomal_S17 34,415 11,404
PF00436 SSB 61,831 26,779
PF00575 S1 163,350 56,683
PF00900 Ribosomal_S4e 4,710 1,801
PF01132 EFP 33,138 9,536
PF01176 eIF-1a 38,103 7,125
PF01200 Ribosomal_S28e 3,391 1,035
PF01287 eIF-5a 3,890 1,593
PF01330 RuvA_N 29,051 11,891
PF01336 tRNA_anti-codon 118,387 44,580
PF01588 tRNA_bind 67,942 26,756
PF01796 OB_aCoA_assoc 20,129 11,164
PF01938 TRAM 49,281 19,978
PF01957 NfeD 25,702 13,002
PF02303 Phage_DNA_bind 345 212
PF02721 DUF223 2,428 1,877
PF02760 HIN 419 195
PF02765 POT1 1,943 1,175
PF03100 CcmE 12,675 5,762
PF03120 DNA_ligase_OB 35,721 15,082
PF03319 EutN_CcmL 6,463 3,098
PF03459 TOBE 37,581 13,903
PF03870 RNA_pol_Rpb8 2,106 864
PF03919 mRNA_cap_C 2,440 1,264
PF04057 Rep-A_N 2,332 1,324
PF04076 BOF 4,801 1,355
PF04679 DNA_ligase_A_C 29,718 14,892
PF06125 DUF961 2,787 291
PF07076 DUF1344 1,534 453
PF07290 DUF1449 2,745 1,041
PF07404 TEBP_beta 22 13
PF07497 Rho_RNA_bind 26,270 8,219
PF07717 OB_NTP_bind 32,124 13,450
PF08206 OB_RNB 20,712 7,156
PF08292 RNA_pol_Rbc25 1,949 961
PF08402 TOBE_2 89,747 32,878
PF08418 Pol_alpha_B_N 1,434 790
PF08585 RMI1_N 2,848 1,781
PF08646 Rep_fac-A_C 5,610 3,659
PF08661 Rep_fac-A_3 1,861 1,064
PF08804 gp32 943 472
PF09103 BRCA-2_OB1 1,255 794
PF09104 BRCA-2_OB3 479 293
PF09285 Elong-fact-P_C 33,352 9,698
PF09883 DUF2110 452 218
PF10246 MRP-S35 597 372
PF10341 TPP1 480 325
PF10447 EXOSC1 1,798 967
PF10451 Stn1 736 481
PF10991 DUF2815 1,973 897
PF11325 DUF3127 3,269 1,654
PF11506 DUF3217 19 8
PF11604 CusF_Ec 9,228 4,247
PF11736 DUF3299 5,538 2,039
PF11967 RecO_N 28,736 13,022
PF12658 Ten1 449 297
PF12667 NigD_N 1,493 431
PF12857 TOBE_3 6,611 1,437
PF12869 tRNA_anti-like 1,400 1,051
PF13114 RecO_N_2 905 167
PF13509 S1_2 9,415 3,261
PF13742 tRNA_anti_2 27,857 11,910
PF14444 S1-like 1,066 524
PF14481 Fimbrial_PilY2 53 23
PF14743 DNA_ligase_OB_2 3,192 1,819
PF15072 DUF4539 1,052 653
PF15490 Ten1_2 629 384
PF16099 RMI1_C 694 462
PF16100 RMI2 492 303
PF16450 Prot_ATP_ID_OB 15,020 3,648
PF16669 TTC5_OB 697 369
PF16686 POT1PC 1,301 804
PF16745 RsgA_N 8,945 3,788
PF16773 Phage_SSB 233 14
PF16853 CDC13_N 46 34
PF16900 REPA_OB_2 3,725 2,248
PF16992 RNA_pol_RpbG 80 52
PF17092 PCB_OB 12,348 4,390
PF17185 NlpE_C 1,644 429
PF17191 RecG_wedge 26,725 11,273
PF17207 MCM_OB 19,889 7,837
PF17215 Rrp44_S1 2,094 907
PF17216 Rrp44_CSD1 2,905 1,348
PF17244 CDC24_OB3 407 231
PF17245 CDC24_OB2 317 188
PF17246 CDC24_OB1 295 181
PF17746 SfsA_N 9,389 4,308
PF17758 Prot_ATP_OB_N 3,447 862
PF17768 RecJ_OB 27,358 11,895
PF17845 FbpC_C_terminal 40 6
PF17847 GlcV_C_terminal 44 19
PF17849 OB_Dis3 4,741 2,400
PF17850 CysA_C_terminal 2,370 829
PF17875 RPA43_OB 1,059 671
PF17876 CSD2 23,710 8,492
PF17878 ssDBP 5 4
PF17879 DNA_ligase_C 193 80
PF17912 OB_MalK 39,809 12,382
PF18018 DNA_pol_D_N 2,084 1,163
PF18352 Gp138_N 1,957 809
PF18543 ID 155 125
PF18614 RNase_II_C_S1 2,441 1,419
PF18691 Cdc13_OB2 20 12
PF18693 TRAM_2 18,583 6,886
CL0022 LRR 286,453 171,564 PF00560 LRR_1 39,935 27,157
PF01030 Recep_L_domain 5,995 3,111
PF03382 DUF285 6,289 4,834
PF05725 FNIP 2,025 1,668
PF07723 LRR_2 2,770 2,010
PF07725 LRR_3 3,040 2,159
PF12468 TTSSLRR 2,081 198
PF12799 LRR_4 19,434 11,978
PF13306 LRR_5 26,022 17,113
PF13516 LRR_6 59,382 38,466
PF13855 LRR_8 165,105 94,826
PF14580 LRR_9 13,729 7,674
CL0023 P-loop_NTPase 7,872,617 3,293,095 PF00004 AAA 353,505 141,076
PF00005 ABC_tran 2,177,213 870,053
PF00006 ATP-synt_ab 164,649 38,219
PF00009 GTP_EFTU 336,379 86,019
PF00025 Arf 29,497 11,359
PF00063 Myosin_head 40,705 17,633
PF00071 Ras 114,846 46,870
PF00142 Fer4_NifH 48,401 4,960
PF00154 RecA 53,737 11,318
PF00158 Sigma54_activat 178,028 75,402
PF00176 SNF2_N 100,882 52,990
PF00225 Kinesin 56,254 30,419
PF00265 TK 18,051 7,051
PF00270 DEAD 386,858 170,514
PF00271 Helicase_C 561,990 251,795
PF00308 Bac_DnaA 41,454 15,318
PF00350 Dynamin_N 38,037 18,099
PF00406 ADK 48,593 20,547
PF00437 T2SSE 113,220 50,363
PF00448 SRP54 75,713 28,184
PF00485 PRK 41,459 15,111
PF00488 MutS_V 60,829 27,713
PF00493 MCM 21,127 8,719
PF00503 G-alpha 15,353 6,331
PF00519 PPV_E1_C 3,368 842
PF00580 UvrD-helicase 96,356 42,205
PF00625 Guanylate_kin 53,186 21,634
PF00685 Sulfotransfer_1 26,532 16,284
PF00693 Herpes_TK 990 106
PF00709 Adenylsucc_synt 36,062 11,934
PF00735 Septin 15,303 5,200
PF00910 RNA_helicase 16,382 3,146
PF00931 NB-ARC 85,166 58,032
PF01057 Parvo_NS1 3,581 581
PF01078 Mg_chelatase 32,992 15,659
PF01121 CoaE 32,732 16,917
PF01202 SKI 47,582 21,879
PF01268 FTHFS 21,156 8,202
PF01443 Viral_helicase1 9,668 2,288
PF01580 FtsK_SpoIIIE 55,131 24,788
PF01583 APS_kinase 23,835 10,671
PF01591 6PF2K 6,862 2,792
PF01637 ATPase_2 7,042 4,073
PF01656 CbiA 66,456 30,725
PF01695 IstB_IS21 37,494 14,810
PF01712 dNK 15,314 6,780
PF01715 IPPT 36,698 18,615
PF01745 IPT 519 320
PF01926 MMR_HSR1 263,525 104,271
PF01935 DUF87 20,642 10,837
PF02223 Thymidylate_kin 35,371 18,096
PF02224 Cytidylate_kin 28,434 13,071
PF02263 GBP 5,217 2,824
PF02283 CobU 16,655 7,901
PF02367 TsaE 30,010 15,044
PF02374 ArsA_ATPase 16,689 7,392
PF02399 Herpes_ori_bp 1,029 568
PF02421 FeoB_N 23,302 10,338
PF02456 Adeno_IVa2 443 123
PF02463 SMC_N 89,426 40,465
PF02492 cobW 66,828 25,594
PF02499 DNA_pack_C 774 141
PF02500 DNA_pack_N 536 99
PF02534 T4SS-DNA_transf 20,575 7,758
PF02562 PhoH 42,284 14,190
PF02572 CobA_CobO_BtuR 17,083 6,469
PF02606 LpxK 18,434 9,355
PF02689 Herpes_Helicase 4,619 2,325
PF02702 KdpD 13,319 4,410
PF02841 GBP_C 3,180 1,605
PF03028 Dynein_heavy 10,250 6,450
PF03029 ATP_bind_1 17,382 6,433
PF03192 DUF257 324 261
PF03193 RsgA_GTPase 28,097 11,916
PF03205 MobB 10,541 5,048
PF03215 Rad17 2,263 1,408
PF03237 Terminase_6 14,513 6,684
PF03266 NTPase_1 3,019 1,861
PF03308 MeaB 18,902 9,598
PF03354 Terminase_1 12,148 5,006
PF03567 Sulfotransfer_2 13,455 8,121
PF03618 Kinase-PPPase 14,161 4,339
PF03668 ATP_bind_2 20,811 7,594
PF03796 DnaB_C 44,795 17,339
PF03846 SulA 3,187 824
PF03969 AFG1_ATPase 19,274 7,454
PF03976 PPK2 25,616 11,539
PF04257 Exonuc_V_gamma 11,202 4,429
PF04310 MukB 2,590 299
PF04317 DUF463 4,867 1,459
PF04466 Terminase_3 5,150 2,561
PF04548 AIG1 11,388 7,958
PF04665 Pox_A32 1,575 398
PF04670 Gtr1_RagA 4,169 1,750
PF04851 ResIII 116,114 50,770
PF05049 IIGP 1,733 1,288
PF05127 Helicase_RecD 6,274 2,738
PF05179 CDC73_C 2,076 1,058
PF05272 VirE 7,375 2,612
PF05496 RuvB_N 36,041 12,552
PF05609 LAP1C 781 438
PF05621 TniB 4,352 2,328
PF05625 PAXNEB 2,036 1,142
PF05673 DUF815 9,636 3,731
PF05707 Zot 2,893 1,777
PF05729 NACHT 35,994 27,769
PF05783 DLIC 2,839 1,328
PF05872 DUF853 12,334 4,997
PF05876 Terminase_GpA 8,055 3,199
PF05879 RHD3 3,113 1,900
PF05894 Podovirus_Gp16 83 60
PF05970 PIF1 18,055 12,868
PF06048 DUF927 4,204 2,145
PF06068 TIP49 4,852 1,702
PF06144 DNA_pol3_delta 26,247 10,907
PF06309 Torsin 1,822 1,003
PF06414 Zeta_toxin 6,966 3,884
PF06418 CTP_synth_N 35,083 11,309
PF06431 Polyoma_lg_T_C 2,298 163
PF06564 CBP_BcsQ 4,371 1,794
PF06733 DEAD_2 17,875 8,044
PF06745 ATPase 13,285 6,937
PF06858 NOG1 3,178 1,440
PF06990 Gal-3-0_sulfotr 1,994 1,278
PF07015 VirC1 2,016 835
PF07034 ORC3_N 1,822 1,106
PF07088 GvpD 232 149
PF07517 SecA_DEAD 39,374 14,951
PF07529 HSA 6,118 3,188
PF07652 Flavi_DEAD 33,663 919
PF07693 KAP_NTPase 8,740 5,829
PF07724 AAA_2 133,621 41,667
PF07726 AAA_3 45,930 19,310
PF07728 AAA_5 50,611 22,499
PF07755 DUF1611 3,926 2,218
PF07931 CPT 2,450 1,558
PF07999 RHSP 3,291 2,113
PF08298 AAA_PrkA 8,879 1,910
PF08303 tRNA_lig_kinase 1,005 609
PF08351 DUF1726 5,399 2,297
PF08423 Rad51 12,908 6,300
PF08433 KTI12 2,463 1,576
PF08438 MMR_HSR1_C 2,610 1,232
PF08477 Roc 5,332 3,377
PF09037 Sulphotransf 1,516 733
PF09140 MipZ 2,903 1,303
PF09439 SRPRB 2,090 1,144
PF09547 Spore_IV_A 3,396 1,052
PF09711 Cas_Csn2 821 385
PF09807 ELP6 1,092 659
PF09818 ABC_ATPase 2,720 1,409
PF09820 AAA-ATPase_like 13,627 6,656
PF09848 DUF2075 5,456 3,294
PF10088 DUF2326 1,564 1,030
PF10236 DAP3 2,091 1,197
PF10412 TrwB_AAD_bind 9,472 4,502
PF10443 RNA12 928 542
PF10483 Elong_Iki1 1,492 909
PF10609 ParA 45,561 19,491
PF10649 DUF2478 1,383 943
PF10662 PduV-EutP 3,096 876
PF10923 DUF2791 2,814 1,414
PF10996 Beta-Casp 21,142 10,774
PF11111 CENP-M 409 215
PF11398 DUF2813 2,275 639
PF11496 HDA2-3 506 354
PF11602 NTPase_P4 11 7
PF12128 DUF3584 997 489
PF12344 UvrB 31,170 9,794
PF12399 BCA_ABC_TP_C 73,965 27,311
PF12696 TraG-D_C 12,570 5,222
PF12774 AAA_6 11,311 7,049
PF12775 AAA_7 10,060 6,402
PF12780 AAA_8 10,201 6,498
PF12781 AAA_9 10,458 6,486
PF12846 AAA_10 9,520 2,819
PF12848 ABC_tran_Xtn 95,637 27,528
PF13086 AAA_11 33,514 19,843
PF13087 AAA_12 41,378 23,860
PF13166 AAA_13 4,704 3,138
PF13173 AAA_14 30,102 17,683
PF13175 AAA_15 22,119 15,105
PF13177 DNA_pol3_delta2 67,002 31,768
PF13189 Cytidylate_kin2 11,015 5,432
PF13191 AAA_16 47,485 30,932
PF13207 AAA_17 3,544 2,391
PF13238 AAA_18 13,375 7,146
PF13245 AAA_19 32,611 17,165
PF13304 AAA_21 37,836 24,053
PF13307 Helicase_C_2 36,983 14,990
PF13337 Lon_2 2,354 1,185
PF13361 UvrD_C 108,340 47,647
PF13401 AAA_22 30,608 17,728
PF13469 Sulfotransfer_3 24,286 15,881
PF13476 AAA_23 38,849 22,349
PF13479 AAA_24 4,975 2,601
PF13481 AAA_25 39,581 15,236
PF13500 AAA_26 34,751 14,052
PF13514 AAA_27 5,214 2,718
PF13521 AAA_28 13,477 6,755
PF13538 UvrD_C_2 39,584 17,922
PF13555 AAA_29 5,330 2,333
PF13558 SbcCD_C 23,307 10,164
PF13604 AAA_30 40,425 18,386
PF13614 AAA_31 109,651 45,577
PF13654 AAA_32 9,243 3,591
PF13671 AAA_33 33,694 18,010
PF13871 Helicase_C_4 3,960 1,843
PF13872 AAA_34 3,972 1,928
PF13892 DBINO 2,598 1,211
PF14396 CFTR_R 408 146
PF14417 MEDS 4,254 3,095
PF14516 AAA_35 4,481 3,102
PF14532 Sigma54_activ_2 4,348 2,213
PF14617 CMS1 1,449 804
PF16203 ERCC3_RAD25_C 7,452 2,702
PF16575 CLP1_P 4,823 2,926
PF16796 Microtub_bd 1,120 824
PF16813 Cas_St_Csn2 160 71
PF16834 CSM2 47 35
PF16836 PSY3 81 60
PF17213 Hydin_ADK 248 197
PF17784 Sulfotransfer_4 5,357 3,384
PF18128 HydF_dimer 2,974 1,496
PF18133 HydF_tetramer 3,036 1,541
PF18747 Ploopntkinase2 64 17
PF18748 Ploopntkinase1 77 16
PF18751 Ploopntkinase3 221 20
PF18766 SWI2_SNF2 20,511 9,849
CL0025 His_Kinase_A 1,236,892 618,036 PF00512 HisKA 645,327 321,576
PF02518 HATPase_c 992,084 484,163
PF02895 H-kinase_dim 21,284 10,308
PF07536 HWE_HK 13,185 6,790
PF07568 HisKA_2 17,719 10,052
PF07730 HisKA_3 110,274 61,701
PF10090 HPTransfase 2,889 1,366
PF13581 HATPase_c_2 62,712 35,066
PF13589 HATPase_c_3 58,733 29,583
PF14501 HATPase_c_5 16,339 7,732
CL0026 CU_oxidase 217,727 83,808 PF00116 COX2 88,063 22,256
PF00127 Copper-bind 17,544 9,896
PF00394 Cu-oxidase 49,357 20,195
PF00812 Ephrin 2,885 1,370
PF02298 Cu_bind_like 8,355 4,962
PF06481 COX_ARM 7,086 1,810
PF06525 SoxE 572 351
PF07731 Cu-oxidase_2 51,305 24,535
PF07732 Cu-oxidase_3 56,426 27,020
PF08526 PAD_N 708 348
PF08985 DP-EP 150 94
PF12306 PixA 1,060 473
PF13473 Cupredoxin_1 21,409 10,225
PF14699 hGDE_N 1,526 762
PF16986 CzcE 346 211
CL0027 RdRP 626,304 148,982 PF00078 RVT_1 482,767 107,741
PF00680 RdRP_1 41,203 5,122
PF00972 Flavi_NS5 12,060 606
PF00978 RdRP_2 7,942 1,399
PF00998 RdRP_3 40,535 1,726
PF02123 RdRP_4 4,861 736
PF04197 Birna_RdRp 925 38
PF05919 Mitovir_RNA_pol 607 398
PF07727 RVT_2 35,561 31,392
PF17501 Viral_RdRp_C 19 8
CL0028 AB_hydrolase 1,413,918 743,549 PF00135 COesterase 55,722 34,383
PF00151 Lipase 8,603 5,175
PF00326 Peptidase_S9 111,238 60,271
PF00450 Peptidase_S10 28,604 16,837
PF00561 Abhydrolase_1 271,512 137,460
PF00756 Esterase 65,932 31,252
PF00975 Thioesterase 41,721 22,080
PF01083 Cutinase 10,623 5,191
PF01674 Lipase_2 4,510 2,509
PF01738 DLH 58,718 30,339
PF01764 Lipase_3 26,076 15,785
PF02089 Palm_thioest 6,607 3,874
PF02129 Peptidase_S15 33,432 16,750
PF02230 Abhydrolase_2 27,219 14,692
PF02273 Acyl_transf_2 205 90
PF02450 LCAT 6,944 4,073
PF03096 Ndr 4,570 1,619
PF03283 PAE 4,678 2,585
PF03403 PAF-AH_p_II 8,377 5,279
PF03583 LIP 11,289 5,510
PF03893 Lipase3_N 1,402 763
PF03959 FSH1 7,043 4,432
PF04083 Abhydro_lipase 4,982 3,376
PF04301 DUF452 1,206 443
PF05057 DUF676 8,532 5,318
PF05277 DUF726 4,080 2,278
PF05448 AXE1 9,041 5,272
PF05576 Peptidase_S37 1,490 688
PF05577 Peptidase_S28 7,500 4,879
PF05677 DUF818 256 177
PF05705 DUF829 3,522 2,099
PF05728 UPF0227 9,447 3,407
PF05990 DUF900 5,949 3,285
PF06028 DUF915 3,964 1,504
PF06057 VirJ 3,054 1,022
PF06259 Abhydrolase_8 5,062 3,022
PF06342 DUF1057 412 298
PF06441 EHN 12,235 7,063
PF06500 DUF1100 4,826 2,093
PF06821 Ser_hydrolase 11,657 5,280
PF06850 PHB_depo_C 5,904 2,311
PF07082 DUF1350 1,107 627
PF07167 PhaC_N 10,714 4,552
PF07176 DUF1400 1,692 1,043
PF07224 Chlorophyllase 993 642
PF07519 Tannase 8,754 5,006
PF07819 PGAP1 6,853 4,055
PF07859 Abhydrolase_3 105,239 57,872
PF08237 PE-PPE 3,748 1,975
PF08386 Abhydrolase_4 13,246 8,477
PF08538 DUF1749 1,733 1,033
PF08840 BAAT_C 4,905 2,922
PF09752 DUF2048 1,937 923
PF09994 DUF2235 11,310 7,302
PF10081 Abhydrolase_9 2,903 1,438
PF10142 PhoPQ_related 1,989 958
PF10230 LIDHydrolase 2,033 1,245
PF10340 Say1_Mug180 462 319
PF10503 Esterase_phd 13,277 8,267
PF11144 DUF2920 1,256 313
PF11187 DUF2974 4,211 1,786
PF11288 DUF3089 1,969 1,382
PF11339 DUF3141 1,802 975
PF12048 DUF3530 2,239 961
PF12146 Hydrolase_4 127,494 64,705
PF12695 Abhydrolase_5 3,149 1,674
PF12697 Abhydrolase_6 193,254 105,932
PF12715 Abhydrolase_7 1,597 939
PF12740 Chlorophyllase2 3,529 2,253
PF16929 Asp2 965 404
CL0029 Cupin 1,048,787 501,844 PF00027 cNMP_binding 171,964 86,741
PF00190 Cupin_1 17,333 8,209
PF00908 dTDP_sugar_isom 28,985 15,624
PF01050 MannoseP_isomer 21,359 9,989
PF01238 PMI_typeI 17,762 7,863
PF01987 AIM24 18,124 6,817
PF02041 Auxin_BP 386 225
PF02311 AraC_binding 86,542 36,058
PF02373 JmjC 18,009 9,386
PF02375 JmjN 7,647 3,978
PF02668 TauD 47,467 23,511
PF02678 Pirin 43,376 18,249
PF03079 ARD 7,401 3,030
PF03171 2OG-FeII_Oxy 48,860 25,412
PF03336 Pox_C4_C10 264 62
PF04074 DUF386 9,783 2,994
PF04115 Ureidogly_lyase 7,485 3,063
PF04209 HgmA 12,757 4,456
PF04622 ERG2_Sigma1R 1,549 821
PF04831 Popeye 1,513 789
PF04962 KduI 13,862 5,068
PF05118 Asp_Arg_Hydrox 10,017 4,110
PF05523 FdtA 5,119 3,456
PF05721 PhyH 46,434 27,905
PF05726 Pirin_C 26,185 11,682
PF05899 Cupin_3 15,800 5,228
PF05962 HutD 6,795 3,012
PF05995 CDO_I 8,515 4,040
PF06052 3-HAO 4,394 2,127
PF06172 Cupin_5 8,033 4,400
PF06249 EutQ 3,116 1,139
PF06339 Ectoine_synth 4,104 1,378
PF06560 GPI 2,005 1,101
PF06719 AraC_N 14,369 5,703
PF06865 Ppnp 6,209 1,872
PF07350 DUF1479 3,436 1,281
PF07385 Lyx_isomer 2,408 1,007
PF07847 PCO_ADO 2,275 1,257
PF07883 Cupin_2 163,261 77,366
PF08007 Cupin_4 11,426 4,953
PF08487 VIT 8,197 5,382
PF08943 CsiD 1,513 302
PF09313 DUF1971 3,427 915
PF09859 Oxygenase-NA 3,773 1,797
PF10014 2OG-Fe_Oxy_2 3,602 1,655
PF10637 Ofd1_CTDD 1,668 1,013
PF11699 CENP-C_C 1,187 772
PF12851 Tet_JBP 1,260 670
PF12852 Cupin_6 15,597 7,092
PF12933 FTO_NTD 507 178
PF12973 Cupin_7 10,326 5,597
PF13532 2OG-FeII_Oxy_2 24,566 12,967
PF13621 Cupin_8 15,801 9,212
PF13640 2OG-FeII_Oxy_3 33,146 17,217
PF13661 2OG-FeII_Oxy_4 2,749 1,692
PF13757 VIT_2 448 290
PF13759 2OG-FeII_Oxy_5 4,366 3,153
PF14226 DIOX_N 44,923 23,537
PF14499 DUF4437 1,228 705
PF14525 AraC_binding_2 18,030 8,500
PF16161 DUF4867 1,237 497
PF16802 DUF5070 30 15
PF16867 DMSP_lyase 1,604 821
PF17954 Pirin_C_2 15,506 5,761
PF18637 AUDH_Cupin 83 68
CL0030 Ion_channel 218,618 105,307 PF00060 Lig_chan 19,954 10,230
PF00520 Ion_trans 86,600 41,903
PF01007 IRK 5,948 2,015
PF02386 TrkH 38,194 16,943
PF03814 KdpA 13,514 4,077
PF07885 Ion_trans_2 49,548 27,343
PF08016 PKD_channel 5,803 3,734
CL0031 Phosphatase 410,483 194,690 PF00102 Y_phosphatase 32,551 16,583
PF00581 Rhodanese 176,290 86,656
PF00782 DSPc 40,651 21,798
PF01451 LMWPc 57,951 28,949
PF02302 PTS_IIB 51,386 13,914
PF02383 Syja_N 10,230 5,355
PF03162 Y_phosphatase2 4,232 2,502
PF04179 Init_tRNA_PT 1,133 701
PF04273 DUF442 7,913 3,885
PF04722 Ssu72 1,958 917
PF05706 CDKN3 1,335 749
PF06602 Myotub-related 9,978 4,518
PF13350 Y_phosphatase3 15,839 8,452
PF14566 PTPlike_phytase 1,929 1,042
PF14671 DSPn 2,602 1,246
PF16809 NleF_casp_inhib 122 31
CL0032 Dim_A_B_barrel 376,520 157,326 PF01037 AsnC_trans_reg 123,277 37,781
PF02426 MIase 4,232 1,377
PF03795 YCII 43,568 21,617
PF03927 NapD 3,176 1,415
PF03992 ABM 64,772 30,356
PF04261 Dyp_perox 17,267 6,133
PF04486 SchA_CurD 646 302
PF04673 Cyclase_polyket 1,180 544
PF05336 rhaM 10,706 5,059
PF06778 Chlor_dismutase 7,212 2,634
PF07045 DUF1330 14,633 7,507
PF07110 EthD 8,098 4,599
PF07237 DUF1428 4,280 2,016
PF07682 SOR 84 46
PF07876 Dabb 15,733 8,448
PF07978 NIPSNAP 13,872 6,615
PF08734 GYD 4,373 2,201
PF08803 ydhR 2,145 857
PF09448 MmlI 735 410
PF11639 HapK 316 198
PF11695 DUF3291 2,253 1,519
PF13816 Dehydratase_hem 1,201 560
PF13826 DUF4188 2,306 1,390
PF14026 DUF4242 3,709 1,960
PF16291 DUF4937 1,270 299
PF17805 AsnC_trans_reg2 5,766 3,318
PF18075 FtsX_ECD 20,541 8,573
PF18232 Chalcone_N 88 42
CL0033 POZ 133,248 66,669 PF00651 BTB 96,357 51,318
PF02214 BTB_2 21,356 8,799
PF03931 Skp1_POZ 7,098 3,473
PF07707 BACK 33,629 13,482
PF11822 DUF3342 583 303
PF16017 BTB_3 992 358
CL0034 Amidohydrolase 617,540 284,541 PF00449 Urease_alpha 14,286 3,460
PF00962 A_deaminase 32,424 13,641
PF01026 TatD_DNase 57,205 25,786
PF01244 Peptidase_M19 24,606 12,262
PF01876 RNase_P_p30 2,810 1,706
PF01979 Amidohydro_1 236,485 104,016
PF02126 PTE 6,553 3,043
PF02614 UxaC 9,398 3,948
PF02811 PHP 90,005 40,038
PF04909 Amidohydro_2 78,190 41,283
PF07969 Amidohydro_3 73,247 34,736
PF12228 DUF3604 3,300 2,396
PF12890 DHOase 309 223
PF13263 PHP_C 7,156 4,363
CL0035 Peptidase_MH 512,987 238,068 PF00246 Peptidase_M14 44,900 25,786
PF00274 Glycolytic 11,361 4,772
PF00883 Peptidase_M17 36,441 16,040
PF01520 Amidase_3 51,683 24,665
PF01546 Peptidase_M20 218,826 93,078
PF02127 Peptidase_M18 13,897 5,849
PF04389 Peptidase_M28 57,803 33,930
PF04952 AstE_AspA 26,385 11,223
PF05013 FGase 16,234 7,925
PF05343 Peptidase_M42 22,500 8,857
PF05450 Nicastrin 1,411 762
PF05908 Gamma_PGA_hydro 2,106 861
PF07454 SpoIIP 4,605 2,023
PF10994 DUF2817 2,079 1,160
PF16254 DUF4910 1,577 913
PF17033 Peptidase_M99 1,113 293
PF18266 Ncstrn_small 1,049 583
CL0036 TIM_barrel 2,158,340 893,068 PF00121 TIM 43,129 17,378
PF00215 OMPdecase 40,204 16,609
PF00218 IGPS 31,051 12,435
PF00290 Trp_syntA 29,530 12,443
PF00478 IMPDH 47,725 13,587
PF00490 ALAD 27,677 9,743
PF00682 HMGL-like 100,707 37,917
PF00697 PRAI 26,364 12,942
PF00701 DHDPS 81,742 33,382
PF00724 Oxidored_FMN 88,401 37,085
PF00793 DAHP_synth_1 55,459 19,152
PF00809 Pterin_bind 60,606 25,500
PF00834 Ribul_P_3_epim 38,413 15,036
PF00923 TAL_FSA 38,090 13,941
PF00977 His_biosynth 58,031 21,428
PF01070 FMN_dh 39,985 17,344
PF01081 Aldolase 28,316 11,404
PF01116 F_bP_aldolase 39,730 12,297
PF01168 Ala_racemase_N 89,331 41,244
PF01180 DHO_dh 45,686 19,593
PF01207 Dus 59,620 23,900
PF01261 AP_endonuc_2 137,898 63,622
PF01474 DAHP_synth_2 13,243 4,227
PF01487 DHquinase_I 10,957 4,996
PF01645 Glu_synthase 42,612 15,047
PF01680 SOR_SNZ 11,614 3,024
PF01729 QRPTase_C 29,328 13,055
PF01791 DeoC 39,939 15,486
PF01884 PcrB 4,672 2,412
PF01964 ThiC_Rad_SAM 21,090 5,895
PF02007 MtrH 658 358
PF02581 TMP-TENI 40,274 19,266
PF02679 ComA 2,566 1,560
PF02784 Orn_Arg_deC_N 63,153 23,788
PF03060 NMO 49,397 21,442
PF03102 NeuB 14,361 8,673
PF03437 BtpA 3,959 1,955
PF03599 CdhD 3,239 2,125
PF03740 PdxJ 17,098 6,878
PF03786 UxuA 10,814 4,371
PF03851 UvdE 4,340 2,117
PF03932 CutC 12,673 5,322
PF04055 Radical_SAM 470,890 212,544
PF04095 NAPRTase 23,120 7,770
PF04131 NanE 6,620 2,342
PF04309 G3P_antiterm 4,437 1,529
PF04476 4HFCP_synth 1,633 876
PF04481 DUF561 822 469
PF04898 Glu_syn_central 26,536 8,628
PF05114 DUF692 9,686 5,038
PF05690 ThiG 20,414 6,416
PF06134 RhaA 4,316 1,453
PF06187 DUF993 3,095 1,267
PF07071 KDGP_aldolase 2,601 435
PF08013 Tagatose_6_P_K 4,231 1,241
PF09043 Lys-AminoMut_A 1,444 691
PF09863 DUF2090 3,810 1,073
PF16552 OAM_alpha 394 228
PF17285 PRMT5_TIM 2,159 1,079
CL0037 Lysozyme 300,666 132,757 PF00062 Lys 2,799 1,426
PF00182 Glyco_hydro_19 11,746 5,173
PF00912 Transgly 90,133 37,696
PF00959 Phage_lysozyme 15,242 5,816
PF01374 Glyco_hydro_46 1,530 829
PF01464 SLT 100,717 46,732
PF01832 Glucosaminidase 26,836 11,786
PF03998 Utp11 1,985 1,144
PF05497 Destabilase 732 551
PF05838 Glyco_hydro_108 5,078 2,629
PF06737 Transglycosylas 8,972 4,555
PF06871 TraH_2 409 219
PF10464 Peptidase_U40 37 6
PF11508 DUF3218 18 4
PF13406 SLT_2 25,954 11,370
PF13647 Glyco_hydro_80 19 6
PF13702 Lysozyme_like 4,822 973
PF16754 Pesticin 485 349
PF18013 Phage_lysozyme2 3,202 1,547
CL0039 HUP 1,207,908 532,173 PF00133 tRNA-synt_1 119,224 51,034
PF00579 tRNA-synt_1b 80,409 32,417
PF00582 Usp 136,396 70,193
PF00733 Asn_synthase 49,357 26,214
PF00749 tRNA-synt_1c 75,308 32,157
PF00750 tRNA-synt_1d 38,600 16,570
PF00764 Arginosuc_synth 29,950 8,587
PF00875 DNA_photolyase 28,147 15,320
PF01012 ETF 68,217 25,374
PF01171 ATP_bind_3 51,717 24,930
PF01406 tRNA-synt_1e 41,894 18,437
PF01467 CTP_transf_like 98,271 45,265
PF01507 PAPS_reduct 47,499 17,547
PF01747 ATP-sulfurylase 9,127 4,138
PF01902 Diphthami_syn_2 7,339 4,463
PF01921 tRNA-synt_1f 6,610 2,925
PF02540 NAD_synthase 68,372 26,596
PF02568 ThiI 13,837 5,240
PF02569 Pantoate_ligase 26,026 12,212
PF03054 tRNA_Me_trans 37,380 14,681
PF03720 UDPG_MGDP_dh_C 56,911 27,479
PF04244 DPRP 7,161 4,071
PF05636 HIGH_NTase1 6,651 2,799
PF06508 QueC 21,206 8,965
PF06574 FAD_syn 30,238 13,362
PF08218 Citrate_ly_lig 3,266 1,020
PF09334 tRNA-synt_1g 63,887 26,033
PF10079 BshC 4,461 2,634
PF13603 tRNA-synt_1_2 33,774 13,470
PF16581 HIGH_NTase1_ass 142 94
PF16715 CDPS 769 421
CL0040 tRNA_synt_II 504,138 203,452 PF00152 tRNA-synt_2 103,647 39,923
PF00587 tRNA-synt_2b 130,704 50,340
PF01409 tRNA-synt_2d 38,876 14,215
PF01411 tRNA-synt_2c 46,913 20,010
PF02091 tRNA-synt_2e 17,113 4,214
PF03099 BPL_LplA_LipB 69,402 33,184
PF03590 AsnA 6,108 1,726
PF04017 DUF366 437 274
PF13393 tRNA-synt_His 54,115 23,180
PF16917 BPL_LplA_LipB_2 955 615
PF17759 tRNA_synthFbeta 35,941 15,866
CL0041 Death 28,968 15,036 PF00531 Death 13,867 6,877
PF00619 CARD 8,477 4,710
PF01335 DED 2,599 1,251
PF02758 PYRIN 3,626 2,054
PF14786 Death_2 259 143
PF16739 CARD_2 966 515
PF18461 Atypical_Card 212 128
CL0042 Flavoprotein 221,357 92,795 PF00258 Flavodoxin_1 51,331 19,679
PF02525 Flavodoxin_2 50,535 19,190
PF03358 FMN_red 92,045 41,598
PF07972 Flavodoxin_NdrI 7,357 2,083
PF12641 Flavodoxin_3 2,306 1,040
PF12682 Flavodoxin_4 6,873 3,773
PF12724 Flavodoxin_5 10,947 5,653
CL0043 Chelatase 205,076 90,543 PF00148 Oxidored_nitro 22,139 8,742
PF00762 Ferrochelatase 26,910 11,140
PF01297 ZnuA 42,145 18,822
PF01497 Peripla_BP_2 95,963 42,857
PF01903 CbiX 13,873 7,439
PF06180 CbiK 3,952 1,525
PF11844 DUF3364 1,678 441
CL0044 Ferritin 243,780 99,029 PF00210 Ferritin 58,981 20,819
PF00268 Ribonuc_red_sm 29,567 7,547
PF01786 AOX 3,362 1,907
PF02332 Phenol_Hydrox 5,106 1,420
PF02915 Rubrerythrin 25,411 12,559
PF03232 COQ7 8,195 3,744
PF03405 FA_desaturase_2 6,534 2,072
PF03713 DUF305 15,159 8,594
PF04305 DUF455 5,714 3,052
PF05067 Mn_catalase 9,498 3,225
PF05138 PaaA_PaaC 14,062 5,286
PF05974 DUF892 9,394 3,906
PF06175 MiaE 6,813 2,262
PF07875 Coat_F 5,843 2,575
PF09537 DUF2383 5,299 2,720
PF09968 DUF2202 1,039 817
PF11266 Ald_deCOase 653 279
PF11553 DUF3231 3,399 1,850
PF11583 AurF 7,031 2,416
PF12902 Ferritin-like 1,604 1,032
PF13628 DUF4142 9,966 4,870
PF13668 Ferritin_2 6,622 4,046
PF13794 MiaE_2 2,490 869
PF14530 DUF4439 2,118 1,193
PF18536 DUF5623 154 104
CL0045 Rubredoxin 35,769 16,768 PF00301 Rubredoxin 17,890 7,168
PF01215 COX5B 2,168 1,173
PF06397 Desulfoferrod_N 2,995 1,693
PF08421 Methyltransf_13 5,485 3,346
PF10276 zf-CHCC 7,227 3,389
CL0046 Thiolase 378,128 158,510 PF00108 Thiolase_N 131,338 44,859
PF00109 ketoacyl-synt 143,865 68,860
PF00195 Chal_sti_synt_N 13,145 5,055
PF01154 HMG_CoA_synt_N 7,623 3,221
PF02797 Chal_sti_synt_C 13,271 5,327
PF02801 Ketoacyl-synt_C 138,388 65,616
PF02803 Thiolase_C 130,188 44,047
PF07451 SpoVAD 4,431 1,614
PF08392 FAE1_CUT1_RppA 5,069 2,551
PF08540 HMG_CoA_synt_C 7,339 3,045
PF08541 ACP_syn_III_C 57,550 23,905
PF08545 ACP_syn_III 50,952 20,649
PF08990 Docking 4,582 3,178
PF13723 Ketoacyl-synt_2 4,660 2,184
PF16197 KAsynt_C_assoc 43,233 28,159
PF18605 PikAIV_N 1,408 933
CL0047 CuAO_N2_N3 7,923 3,741 PF02727 Cu_amine_oxidN2 6,410 2,911
PF02728 Cu_amine_oxidN3 6,405 2,851
PF09248 DUF1965 615 403
CL0048 LolA_LolB 79,724 40,338 PF03548 LolA 19,439 8,740
PF03550 LolB 7,554 2,956
PF03888 MucB_RseB 6,153 2,379
PF04507 DUF576 892 317
PF07044 DUF1329 8,396 3,236
PF07161 LppX_LprAFG 1,520 846
PF07608 DUF1571 1,025 584
PF09697 Porph_ging 5,689 3,839
PF09865 DUF2092 1,514 1,078
PF11306 DUF3108 12,567 6,980
PF11659 DUF3261 1,896 889
PF14125 DUF4292 3,214 2,080
PF14371 DUF4412 1,105 924
PF16584 LolA_2 1,052 507
PF17131 LolA_like 7,618 4,970
PF18234 VioE 75 40
CL0049 Tudor 187,932 98,556 PF00385 Chromo 25,501 15,113
PF00565 SNase 25,640 15,408
PF00567 TUDOR 10,485 6,179
PF00855 PWWP 14,812 7,215
PF01393 Chromo_shadow 3,238 1,695
PF02294 7kD_DNA_binding 65 10
PF02820 MBT 5,133 2,296
PF04397 LytTR 69,501 35,113
PF05641 Agenet 5,125 2,537
PF06003 SMN 2,206 1,160
PF07039 DUF1325 1,933 1,034
PF08169 RBB1NT 946 462
PF08605 Rad9_Rad53_bind 226 166
PF09038 53-BP1_Tudor 511 282
PF09465 LBR_tudor 492 254
PF11160 Hva1_TUDOR 4,481 2,554
PF11515 Cul7 935 453
PF11717 Tudor-knot 6,889 3,398
PF12148 TTD 714 314
PF14061 Mtf2_C 871 309
PF15057 DUF4537 525 349
PF16090 DUF4819 533 336
PF16719 SAWADEE 1,015 593
PF17516 ProQ_C 2,071 375
PF18104 Tudor_2 2,307 901
PF18115 Tudor_3 1,061 596
PF18336 Tudor_FRX1 1,540 417
PF18337 Tudor_RapA 5,128 1,068
PF18339 Tudor_1_RapA 5,176 1,124
PF18358 Tudor_4 659 360
PF18359 TUDOR_5 619 354
PF18380 GEN1_C 740 513
PF18704 Chromo_2 381 263
CL0050 HotDog 393,170 177,287 PF01575 MaoC_dehydratas 70,493 30,365
PF01643 Acyl-ACP_TE 9,304 4,540
PF02551 Acyl_CoA_thio 520 297
PF03061 4HBT 142,322 61,967
PF03756 AfsA 2,083 1,276
PF07977 FabA 40,551 14,888
PF09500 YiiD_C 4,243 1,280
PF10862 FcoT 314 163
PF13279 4HBT_2 37,559 18,105
PF13452 MaoC_dehydrat_N 22,315 10,678
PF13622 4HBT_3 29,300 12,197
PF14539 DUF4442 9,798 4,449
PF14765 PS-DH 32,190 21,647
CL0051 NTF2 266,463 134,244 PF00866 Ring_hydroxyl_B 9,596 3,463
PF02136 NTF2 9,832 4,867
PF02982 Scytalone_dh 732 386
PF03284 PHZA_PHZB 484 216
PF04280 Tim44 13,137 5,801
PF04335 VirB8 10,197 2,775
PF05223 MecA_N 6,118 2,425
PF05494 MlaC 12,436 5,825
PF07080 DUF1348 6,863 2,661
PF07107 WI12 543 348
PF07366 SnoaL 16,919 9,858
PF07858 LEH 2,151 1,149
PF07961 MBA1 369 237
PF08332 CaMKII_AD 5,803 2,017
PF10184 DUF2358 2,564 1,538
PF10429 Mtr2 178 116
PF11393 T4BSS_DotI_IcmL 1,439 655
PF11533 DUF3225 2,227 987
PF12642 TpcC 3,032 927
PF12680 SnoaL_2 68,466 36,165
PF12707 DUF3804 51 33
PF12870 DUF4878 1,584 891
PF12883 DUF3828 3,529 963
PF12893 Lumazine_bd_2 5,140 3,128
PF13026 DUF3887 2,297 1,165
PF13474 SnoaL_3 14,327 8,113
PF13577 SnoaL_4 25,208 14,282
PF14254 DUF4348 586 240
PF14534 DUF4440 23,852 15,331
PF14729 DUF4467 300 89
PF15008 DUF4518 441 274
PF16022 DUF4783 1,093 690
PF16111 DUF4829 262 205
PF16156 DUF4864 1,843 1,058
PF16247 DUF4904 8 5
PF16800 Endopep_inhib 642 223
PF17117 DUF5104 406 224
PF17118 DUF5105 728 222
PF17775 UPF0225 10,857 5,216
PF18042 ORF_12_N 589 229
CL0052 NTN 328,764 137,197 PF00227 Proteasome 61,727 21,566
PF00310 GATase_2 27,432 9,063
PF01019 G_glu_transpept 45,810 22,372
PF01112 Asparaginase_2 17,144 8,749
PF01804 Penicil_amidase 19,359 10,578
PF02275 CBAH 10,397 4,119
PF03417 AAT 8,209 4,758
PF03577 Peptidase_C69 9,418 3,572
PF04916 Phospholip_B 2,087 1,256
PF07826 IMP_cyclohyd 2,113 949
PF09147 DUF1933 45 24
PF10584 Proteasome_A_N 15,658 5,019
PF12481 DUF3700 1,283 644
PF13230 GATase_4 11,683 4,090
PF13522 GATase_6 55,161 19,389
PF13537 GATase_7 56,785 26,547
CL0053 4H_Cytokine 13,426 5,322 PF00103 Hormone_1 2,980 839
PF00143 Interferon 2,110 931
PF00489 IL6 476 208
PF00714 IFN-gamma 370 124
PF00715 IL2 221 59
PF00726 IL10 1,006 379
PF00727 IL4 355 132
PF00758 EPO_TPO 507 252
PF01109 GM_CSF 121 49
PF01110 CNTF 194 96
PF01291 LIF_OSM 312 156
PF01415 IL7 277 95
PF02024 Leptin 404 133
PF02025 IL5 157 81
PF02059 IL3 77 32
PF02372 IL15 563 307
PF02404 SCF 502 215
PF02947 Flt3_lig 172 89
PF03039 IL12 324 160
PF03487 IL13 130 52
PF05337 CSF-1 304 144
PF06875 PRF 448 115
PF07400 IL11 244 107
PF14565 IL22 206 117
PF15036 IL34 247 113
PF15177 IL28A 338 180
PF15216 TSLP 79 40
PF16647 GCSF 174 76
PF16649 IL23 101 47
CL0054 Knottin_1 5,861 3,339 PF00304 Gamma-thionin 2,154 1,153
PF00451 Toxin_2 223 162
PF00537 Toxin_3 826 508
PF01097 Defensin_2 853 465
PF05294 Toxin_5 37 25
PF05453 Toxin_6 35 18
PF06876 SCRL 396 271
PF07333 SLR1-BP 685 424
PF08086 Toxin_17 33 17
PF09132 BmKX 14 14
PF10868 Defensin_like 234 127
PF11415 Toxin_37 165 27
PF14865 Macin 71 68
PF14866 Toxin_38 117 58
PF18251 Defensin_5 3 4
CL0055 Nucleoplasmin 187,110 19,585 PF00073 Rhv 74,290 3,647
PF00500 Late_protein_L1 5,941 1,377
PF00688 TGFb_propeptide 10,207 3,834
PF00718 Polyoma_coat 4,871 202
PF00729 Viral_coat 1,247 306
PF00738 Polyhedrin 597 66
PF00760 Cucumo_coat 2,584 503
PF00894 Luteo_coat 2,548 202
PF00915 Calici_coat 32,867 940
PF00983 Tymo_coat 457 107
PF01318 Bromo_coat 21 8
PF01766 Birna_VP2 4,331 124
PF01787 Ilar_coat 975 87
PF01829 Peptidase_A6 18 17
PF02226 Pico_P1A 19,492 625
PF02247 Como_LCP 260 70
PF02248 Como_SCP 252 53
PF02443 Circo_capsid 4,015 194
PF02956 TT_ORF1 4,902 991
PF03014 SP2 10,189 175
PF03066 Nucleoplasmin 1,567 792
PF03115 Astro_capsid_N 3,274 416
PF03340 Pox_Rif 159 39
PF03391 Nepo_coat 714 106
PF03566 Peptidase_A21 44 18
PF03678 Adeno_hexon_C 2,635 191
PF03688 Nepo_coat_C 713 99
PF03689 Nepo_coat_N 624 94
PF03898 TNV_CP 69 68
PF08435 Calici_coat_C 7,772 204
PF08462 Carmo_coat_C 65 4
PF08762 CRPV_capsid 1,167 438
PF08935 VP4_2 2,098 128
PF11175 DUF2961 3,803 2,126
PF11492 Dicistro_VP4 376 252
PF11729 Capsid-VNN 853 74
PF12264 Waikav_capsid_1 87 34
PF12944 HAV_VP 1,340 61
PF15414 DUF4621 32 7
PF16530 IHHNV_capsid 162 3
PF16903 Capsid_N 2,426 640
PF17800 NPL 2,869 1,761
CL0056 C_Lectin 104,823 66,679 PF00059 Lectin_C 41,643 28,187
PF00193 Xlink 4,652 2,485
PF01413 C4 2,721 1,610
PF03440 APT 327 78
PF03781 FGE-sulfatase 52,923 33,137
PF05473 UL45 248 130
PF05966 Chordopox_A33R 140 39
PF06482 Endostatin 1,660 1,050
PF07588 DUF1554 855 428
PF07979 Intimin_C 499 65
PF08391 Ly49 424 181
PF16825 DUF5075 241 131
CL0057 Met_repress 137,860 66,954 PF01340 MetJ 1,909 180
PF01402 RHH_1 26,696 13,659
PF02697 VAPB_antitox 1,244 923
PF03693 ParD_antitoxin 9,593 4,923
PF03869 Arc 6,323 3,202
PF04221 RelB 12,417 4,906
PF05509 TraY 1,156 481
PF05534 HicB 7,648 4,111
PF07181 VirC2 88 38
PF07362 CcdA 3,664 1,662
PF07704 PSK_trans_fac 2,451 1,374
PF07764 Omega_Repress 262 20
PF07878 RHH_5 1,341 922
PF08681 DUF1778 6,838 3,211
PF08870 DndE 1,179 743
PF08972 DUF1902 762 505
PF09274 ParG 713 311
PF09386 ParD 466 250
PF09957 VapB_antitoxin 5,101 2,984
PF10723 RepB-RCR_reg 954 213
PF10784 Plasmid_stab_B 1,161 172
PF10802 DUF2540 30 20
PF11020 DUF2610 172 74
PF11423 Repressor_Mnt 171 39
PF11903 ParD_like 3,959 1,643
PF12441 CopG_antitoxin 2,739 1,843
PF12651 RHH_3 1,720 815
PF13467 RHH_4 7,062 3,130
PF14384 BrnA_antitoxin 7,200 4,075
PF15919 HicB_lk_antitox 16,393 8,846
PF15970 HicB-like_2 430 209
PF16762 RHH_6 425 146
PF16777 RHH_7 691 33
PF17206 SeqA_N 2,142 532
PF17414 MatP_C 1,669 257
PF17723 RHH_8 1,075 546
PF18064 ParB_C 272 182
CL0058 Glyco_hydro_tim 779,127 385,397 PF00128 Alpha-amylase 167,988 71,097
PF00150 Cellulase 41,432 23,061
PF00232 Glyco_hydro_1 56,770 23,746
PF00331 Glyco_hydro_10 15,045 9,124
PF00332 Glyco_hydro_17 13,420 7,088
PF00704 Glyco_hydro_18 53,886 28,008
PF00728 Glyco_hydro_20 27,025 14,394
PF00933 Glyco_hydro_3 83,710 42,070
PF01055 Glyco_hydro_31 34,499 16,939
PF01120 Alpha_L_fucos 18,724 10,655
PF01183 Glyco_hydro_25 22,334 9,793
PF01229 Glyco_hydro_39 4,952 3,279
PF01301 Glyco_hydro_35 15,418 8,271
PF01373 Glyco_hydro_14 2,864 1,393
PF01630 Glyco_hydro_56 2,849 1,626
PF02055 Glyco_hydro_30 7,998 4,639
PF02057 Glyco_hydro_59 1,571 896
PF02065 Melibiase 14,515 7,427
PF02156 Glyco_hydro_26 7,483 4,566
PF02286 Dehydratase_LU 1,566 340
PF02324 Glyco_hydro_70 830 259
PF02446 Glyco_hydro_77 19,465 9,068
PF02449 Glyco_hydro_42 15,361 8,343
PF02638 GHL10 11,834 5,818
PF02836 Glyco_hydro_2_C 46,272 22,637
PF03198 Glyco_hydro_72 4,300 2,447
PF03537 Glyco_hydro_114 5,481 3,500
PF03644 Glyco_hydro_85 2,761 1,555
PF03659 Glyco_hydro_71 2,490 1,693
PF03662 Glyco_hydro_79n 2,005 1,167
PF05089 NAGLU 3,389 1,823
PF05691 Raffinose_syn 3,073 1,779
PF07555 NAGidase 4,052 1,985
PF07745 Glyco_hydro_53 4,986 2,559
PF08924 DUF1906 4,026 2,115
PF10566 Glyco_hydro_97 8,702 4,105
PF11308 Glyco_hydro_129 1,530 540
PF11790 Glyco_hydro_cc 4,628 3,012
PF12876 Cellulase-like 304 165
PF12891 Glyco_hydro_44 710 490
PF12905 Glyco_hydro_101 1,447 575
PF13199 Glyco_hydro_66 879 485
PF13200 DUF4015 3,712 2,268
PF13204 DUF4038 3,279 2,079
PF14307 Glyco_tran_WbsX 3,333 2,133
PF14488 DUF4434 1,903 761
PF14587 Glyco_hydr_30_2 2,395 1,357
PF14701 hDGE_amylase 2,187 1,174
PF14871 GHL6 1,438 1,054
PF14872 GHL5 207 147
PF14883 GHL13 2,551 618
PF14885 GHL15 759 557
PF16126 DUF4838 2,345 1,849
PF16141 DUF4849 1,261 406
PF16317 Glyco_hydro_99 1,501 824
PF16402 DUF5010 142 95
PF16499 Melibiase_2 11,055 6,517
CL0059 6_Hairpin 248,838 130,516 PF00432 Prenyltrans 10,699 6,584
PF00723 Glyco_hydro_15 22,186 10,336
PF00759 Glyco_hydro_9 12,981 7,549
PF01122 Cobalamin_bind 717 446
PF01204 Trehalase 12,509 5,785
PF01270 Glyco_hydro_8 7,104 2,961
PF01532 Glyco_hydro_47 12,537 7,093
PF02011 Glyco_hydro_48 1,750 739
PF03200 Glyco_hydro_63 5,541 2,965
PF03632 Glyco_hydro_65m 12,340 6,147
PF03663 Glyco_hydro_76 9,250 5,035
PF04685 DUF608 3,691 2,104
PF05147 LANC_like 8,635 5,465
PF06202 GDE_C 10,316 5,586
PF06662 C5-epim_C 1,453 842
PF06824 Glyco_hydro_125 5,508 2,362
PF07221 GlcNAc_2-epim 14,857 6,823
PF07470 Glyco_hydro_88 19,625 9,400
PF07678 TED_complement 13,283 6,506
PF07944 Glyco_hydro_127 14,121 7,682
PF09492 Pec_lyase 2,027 1,246
PF10091 Glycoamylase 8,517 4,550
PF12899 Glyco_hydro_100 2,654 1,355
PF13243 SQHop_cyclase_C 11,331 5,942
PF13249 SQHop_cyclase_N 8,953 4,385
PF17167 Glyco_hydro_36 8,950 4,669
PF17389 Bac_rhamnosid6H 15,991 9,974
PF17652 Glyco_hydro81C 3,229 2,016
PF18566 Ldi 618 449
CL0060 DNA_clamp 47,659 18,960 PF00705 PCNA_N 4,600 2,017
PF00712 DNA_pol3_beta 32,195 11,203
PF02144 Rad1 1,924 1,082
PF02282 Herpes_UL42 278 35
PF02747 PCNA_C 4,252 1,865
PF02767 DNA_pol3_beta_2 33,517 12,036
PF02768 DNA_pol3_beta_3 32,589 11,445
PF02916 DNA_PPF 1,099 148
PF03325 Herpes_PAP 119 17
PF04005 Hus1 2,060 1,112
PF04139 Rad9 2,204 1,347
PF04929 Herpes_DNAp_acc 84 28
PF09116 gp45-slide_C 457 206
CL0061 PLP_aminotran 1,139,207 475,758 PF00155 Aminotran_1_2 395,124 159,451
PF00202 Aminotran_3 190,242 73,222
PF00266 Aminotran_5 186,180 84,308
PF00282 Pyridoxal_deC 42,305 19,379
PF00464 SHMT 45,535 15,303
PF01041 DegT_DnrJ_EryC1 71,107 42,602
PF01053 Cys_Met_Meta_PP 95,414 36,301
PF01212 Beta_elim_lyase 32,183 14,780
PF01276 OKR_DC_1 21,837 6,294
PF02347 GDC-P 32,384 13,226
PF03841 SelA 13,434 5,354
PF04864 Alliinase_C 1,158 630
PF05889 SepSecS 1,340 743
PF06338 ComK 2,721 1,082
PF06838 Met_gamma_lyase 5,671 2,198
PF12897 Aminotran_MocR 3,764 1,553
CL0062 APC 773,334 291,080 PF00209 SNF 39,824 17,135
PF00324 AA_permease 86,796 25,953
PF00474 SSF 91,862 39,423
PF00860 Xan_ur_permease 76,218 21,051
PF00916 Sulfate_transp 61,159 27,305
PF00955 HCO3_cotransp 10,212 4,461
PF01235 Na_Ala_symp 32,504 10,987
PF01490 Aa_trans 39,094 20,684
PF01566 Nramp 33,212 13,570
PF02028 BCCT 27,232 9,977
PF02133 Transp_cyt_pur 35,530 12,586
PF02554 CstA 18,486 5,324
PF02705 K_trans 19,720 7,474
PF03222 Trp_Tyr_perm 14,915 3,285
PF03594 BenE 10,114 3,094
PF03845 Spore_permease 14,553 7,053
PF05525 Branch_AA_trans 14,691 3,835
PF13520 AA_permease_2 144,711 56,847
PF13906 AA_permease_C 6,088 3,179
PF16983 MFS_MOT1 1,964 1,187
CL0063 NADP_Rossmann 7,332,923 3,380,767 PF00044 Gp_dh_N 61,705 17,908
PF00056 Ldh_1_N 52,673 15,136
PF00070 Pyr_redox 606 491
PF00106 adh_short 454,870 228,972
PF00107 ADH_zinc_N 301,670 125,080
PF00145 DNA_methylase 45,836 27,225
PF00208 ELFV_dehydrog 46,455 17,796
PF00291 PALP 226,293 86,236
PF00398 RrnaAD 41,648 18,657
PF00479 G6PD_N 31,634 10,481
PF00670 AdoHcyase_NAD 25,994 8,481
PF00732 GMC_oxred_N 79,622 38,436
PF00743 FMO-like 38,344 20,650
PF00890 FAD_binding_2 108,035 42,145
PF00891 Methyltransf_2 25,925 15,704
PF00899 ThiF 78,817 36,006
PF00996 GDI 5,618 2,601
PF01073 3Beta_HSD 10,498 6,247
PF01113 DapB_N 36,274 14,808
PF01118 Semialdhyde_dh 70,501 25,178
PF01134 GIDA 39,372 15,570
PF01135 PCMT 35,184 18,342
PF01170 UPF0020 25,192 10,894
PF01175 Urocanase 15,991 4,644
PF01189 Methyltr_RsmB-F 51,324 23,944
PF01209 Ubie_methyltran 30,124 12,905
PF01210 NAD_Gly3P_dh_N 36,084 14,653
PF01225 Mur_ligase 95,083 41,555
PF01232 Mannitol_dh 24,606 8,556
PF01234 NNMT_PNMT_TEMT 1,218 809
PF01262 AlaDh_PNT_C 41,299 15,942
PF01266 DAO 223,058 94,971
PF01269 Fibrillarin 4,012 1,906
PF01358 PARP_regulatory 281 118
PF01370 Epimerase 247,330 128,925
PF01408 GFO_IDH_MocA 199,324 100,778
PF01488 Shikimate_DH 43,900 19,228
PF01494 FAD_binding_3 162,265 83,709
PF01555 N6_N4_Mtase 54,047 30,419
PF01564 Spermine_synth 30,310 14,274
PF01593 Amino_oxidase 101,071 53,307
PF01596 Methyltransf_3 26,545 12,271
PF01728 FtsJ 52,777 18,989
PF01739 CheR 32,591 16,239
PF01795 Methyltransf_5 34,251 14,928
PF01861 DUF43 1,064 610
PF01946 Thi4 4,985 2,060
PF02005 TRM 4,740 2,747
PF02056 Glyco_hydro_4 16,417 5,094
PF02086 MethyltransfD12 21,670 10,744
PF02153 PDH 29,828 12,836
PF02254 TrkA_N 82,989 34,245
PF02310 B12-binding 81,134 39,929
PF02353 CMAS 34,671 15,117
PF02384 N6_Mtase 58,609 31,978
PF02390 Methyltransf_4 30,864 13,335
PF02423 OCD_Mu_crystall 26,122 12,966
PF02475 Met_10 7,314 4,405
PF02527 GidB 28,790 13,272
PF02558 ApbA 36,696 17,419
PF02571 CbiJ 10,203 4,751
PF02593 DUF166 615 408
PF02629 CoA_binding 41,913 12,534
PF02636 Methyltransf_28 14,297 7,689
PF02670 DXP_reductoisom 25,833 10,930
PF02719 Polysacc_synt_2 28,451 14,414
PF02737 3HCDH_N 78,539 31,941
PF02826 2-Hacid_dh_C 155,367 68,437
PF02882 THF_DHG_CYH_C 40,201 16,118
PF03059 NAS 1,392 712
PF03141 Methyltransf_29 6,609 3,362
PF03269 DUF268 679 571
PF03275 GLF 9,305 3,681
PF03291 Pox_MCEL 2,942 1,633
PF03341 Pox_mRNA-cap 127 30
PF03435 Sacchrp_dh_NADP 30,962 14,083
PF03446 NAD_binding_2 98,073 40,170
PF03447 NAD_binding_3 40,989 14,759
PF03486 HI0933_like 30,445 14,062
PF03492 Methyltransf_7 4,897 2,986
PF03514 GRAS 10,222 5,200
PF03602 Cons_hypoth95 31,678 15,110
PF03686 UPF0146 531 373
PF03721 UDPG_MGDP_dh_N 60,855 29,754
PF03807 F420_oxidored 55,287 25,686
PF03808 Glyco_tran_WecB 16,344 8,585
PF03848 TehB 3,969 1,654
PF03853 YjeF_N 27,930 14,925
PF03949 Malic_M 44,310 14,750
PF04016 DUF364 2,518 1,702
PF04072 LCM 21,129 9,921
PF04127 DFP 32,067 14,041
PF04321 RmlD_sub_bind 35,881 20,170
PF04378 RsmJ 9,463 3,070
PF04445 SAM_MT 8,511 3,009
PF04536 TPM_phosphatase 24,804 12,412
PF04672 Methyltransf_19 9,516 5,215
PF04723 GRDA 1,198 383
PF04816 TrmK 4,970 1,757
PF04820 Trp_halogenase 11,622 7,015
PF04989 CmcI 2,165 1,171
PF05050 Methyltransf_21 26,048 19,106
PF05059 Orbi_VP4 621 66
PF05063 MT-A70 7,091 3,995
PF05088 Bac_GDH 11,195 4,477
PF05148 Methyltransf_8 2,126 1,359
PF05175 MTS 79,657 35,914
PF05185 PRMT5 2,372 1,250
PF05206 TRM13 1,325 825
PF05219 DREV 862 441
PF05368 NmrA 39,228 21,699
PF05401 NodS 3,784 1,822
PF05430 Methyltransf_30 12,169 5,699
PF05575 V_cholerae_RfbT 41 15
PF05711 TylF 4,805 2,960
PF05724 TPMT 8,410 4,885
PF05834 Lycopene_cycl 5,727 3,622
PF05891 Methyltransf_PK 2,397 1,347
PF05958 tRNA_U5-meth_tr 43,754 17,426
PF05971 Methyltransf_10 7,103 3,057
PF06016 Reovirus_L2 206 38
PF06039 Mqo 11,577 3,085
PF06080 DUF938 4,819 2,982
PF06100 MCRA 5,080 1,779
PF06325 PrmA 36,564 15,948
PF06460 NSP16 2,258 158
PF06471 NSP11 2,832 190
PF06690 DUF1188 72 49
PF06859 Bin3 1,828 1,107
PF06962 rRNA_methylase 5,027 2,120
PF07021 MetW 7,279 2,841
PF07055 Eno-Rase_FAD_bd 4,841 1,511
PF07091 FmrO 501 275
PF07109 Mg-por_mtran_C 1,342 728
PF07156 Prenylcys_lyase 1,909 1,115
PF07279 DUF1442 784 431
PF07669 Eco57I 8,938 5,932
PF07757 AdoMet_MTase 1,473 986
PF07942 N2227 2,697 1,615
PF07991 IlvN 28,280 6,775
PF07992 Pyr_redox_2 409,666 167,611
PF07993 NAD_binding_4 28,062 15,833
PF07994 NAD_binding_5 5,300 2,242
PF08003 Methyltransf_9 7,049 2,159
PF08123 DOT1 3,306 2,115
PF08241 Methyltransf_11 184,602 104,265
PF08242 Methyltransf_12 20,908 12,068
PF08484 Methyltransf_14 6,723 4,056
PF08485 Polysacc_syn_2C 3,367 1,527
PF08491 SE 2,637 1,434
PF08643 DUF1776 745 410
PF08659 KR 38,773 25,706
PF08704 GCD14 8,038 3,691
PF08732 HIM1 825 451
PF09243 Rsm22 4,154 2,378
PF09445 Methyltransf_15 3,228 2,007
PF10017 Methyltransf_33 9,581 5,409
PF10237 N6-adenineMlase 2,112 1,283
PF10294 Methyltransf_16 16,577 10,568
PF10354 DUF2431 2,536 1,737
PF10672 Methyltrans_SAM 30,166 11,004
PF10727 Rossmann-like 5,936 2,935
PF11017 DUF2855 1,654 1,049
PF11312 Methyltransf_34 850 545
PF11599 AviRa 147 111
PF11890 DUF3410 5,068 1,492
PF11968 Bmt2 1,186 695
PF12147 Methyltransf_20 2,984 735
PF12241 Enoyl_reductase 4,861 1,526
PF12242 Eno-Rase_NADH_b 4,721 1,446
PF12692 Methyltransf_17 895 375
PF12831 FAD_oxidored 20,138 11,920
PF12847 Methyltransf_18 2,891 1,551
PF13241 NAD_binding_7 20,913 9,067
PF13288 DXPR_C 25,911 10,918
PF13380 CoA_binding_2 36,194 18,465
PF13383 Methyltransf_22 1,490 1,071
PF13434 K_oxygenase 12,507 5,106
PF13450 NAD_binding_8 69,483 37,021
PF13454 NAD_binding_9 10,685 5,108
PF13460 NAD_binding_10 87,555 47,577
PF13478 XdhC_C 24,949 12,322
PF13489 Methyltransf_23 98,015 58,173
PF13561 adh_short_C2 522,385 228,685
PF13578 Methyltransf_24 17,153 11,224
PF13602 ADH_zinc_N_2 59,336 31,916
PF13649 Methyltransf_25 151,528 86,589
PF13679 Methyltransf_32 10,881 4,767
PF13727 CoA_binding_3 33,585 17,288
PF13738 Pyr_redox_3 37,844 18,403
PF13847 Methyltransf_31 68,075 38,291
PF14314 Methyltrans_Mon 1,228 243
PF16363 GDP_Man_Dehyd 103,880 50,817
PF16803 DRE2_N 757 432
PF16912 Glu_dehyd_C 2,233 1,308
PF17125 Methyltr_RsmF_N 12,785 5,638
PF17173 DUF5129 471 262
PF17174 DUF5130 1,093 448
PF17175 MOLO1 730 495
PF17396 DUF1611_N 3,685 2,066
PF17836 PglD_N 8,261 5,695
PF17930 LpxI_N 5,007 2,898
PF18321 3HCDH_RFF 2,295 756
PF18706 ISPD_C 249 129
CL0064 CPA_AT 291,390 121,672 PF00999 Na_H_Exchanger 121,952 52,530
PF01758 SBF 36,891 16,471
PF03547 Mem_trans 41,031 18,927
PF03601 Cons_hypoth698 17,735 7,518
PF03616 Glt_symporter 8,201 2,484
PF03812 KdgT 3,611 925
PF03956 Lys_export 5,600 1,811
PF03977 OAD_beta 11,994 3,042
PF05684 DUF819 4,492 2,319
PF05982 Sbt_1 3,041 1,558
PF06826 Asp-Al_Ex 10,041 2,985
PF06965 Na_H_antiport_1 16,519 7,366
PF13593 SBF_like 10,443 3,884
CL0065 Cyclin 57,848 30,315 PF00134 Cyclin_N 35,462 18,849
PF00382 TFIIB 10,103 4,522
PF01857 RB_B 2,013 904
PF01858 RB_A 2,073 940
PF02984 Cyclin_C 17,142 8,954
PF03261 CDK5_activator 858 403
PF08613 Cyclin 7,621 4,498
PF09080 K-cyclin_vir_C 14 4
PF09241 Herp-Cyclin 2 2
PF11934 DUF3452 1,769 778
PF16899 Cyclin_C_2 2,443 1,099
PF18542 TFIIB_C_1 35 18
CL0066 Trefoil 69,122 36,332 PF00167 FGF 7,580 2,739
PF00197 Kunitz_legume 2,398 1,179
PF00340 IL1 1,872 864
PF00652 Ricin_B_lectin 23,293 12,808
PF02815 MIR 9,215 4,489
PF03260 Lipoprotein_11 101 63
PF03498 CDtoxinA 747 252
PF04601 DUF569 1,223 708
PF05270 AbfB 3,181 1,789
PF05588 Botulinum_HA-17 61 21
PF06229 FRG1 1,535 864
PF06268 Fascin 1,569 664
PF07468 Agglutinin 293 191
PF07951 Toxin_R_bind_C 188 30
PF08470 NTNH_C 115 16
PF08709 Ins145_P3_rec 3,790 1,815
PF09270 BTD 2,111 863
PF10467 Inhibitor_I48 77 69
PF14200 RicinB_lectin_2 12,662 8,232
PF15095 IL33 170 59
PF16850 Inhibitor_I66 349 283
PF18021 Agglutinin_C 100 86
PF18022 Lectin_C_term 18 16
CL0067 SIS 248,789 89,856 PF00318 Ribosomal_S2 43,022 13,238
PF00342 PGI 38,207 14,274
PF01380 SIS 132,604 47,308
PF10432 bact-PGI_C 4,159 2,597
PF10740 DUF2529 1,196 373
PF12163 HobA 780 163
PF13580 SIS_2 28,532 12,534
PF15698 Phosphatase 1,454 454
CL0068 RIIa 6,599 3,643 PF02197 RIIa 3,072 1,450
PF05186 Dpy-30 3,525 2,193
CL0069 GFP 2,192 1,222 PF01353 GFP 704 262
PF07474 G2F 1,486 960
CL0070 ACT 243,113 82,131 PF00585 Thr_dehydrat_C 16,015 4,843
PF01842 ACT 97,993 34,008
PF04359 DUF493 9,487 3,528
PF08753 NikR_C 5,741 2,441
PF09383 NIL 23,060 6,541
PF10000 ACT_3 3,188 1,540
PF10369 ALS_ss_C 24,888 7,600
PF13291 ACT_4 36,745 11,910
PF13710 ACT_5 18,645 5,693
PF13740 ACT_6 18,139 6,063
PF13840 ACT_7 34,827 12,212
CL0071 His_phosphatase 173,255 81,147 PF00300 His_Phos_1 153,057 71,007
PF00328 His_Phos_2 20,196 10,141
CL0072 Ubiquitin 513,906 230,428 PF00174 Oxidored_molyb 39,620 19,181
PF00240 ubiquitin 42,378 19,807
PF00564 PB1 15,776 7,865
PF00778 DIX 3,448 1,453
PF00788 RA 18,438 8,403
PF00789 UBX 12,973 6,946
PF00794 PI3K_rbd 3,346 1,328
PF01378 IgG_binding_B 43 26
PF02017 CIDE-N 1,765 920
PF02192 PI3K_p85B 1,412 511
PF02196 RBD 3,496 1,437
PF02246 B1 6 5
PF02309 AUX_IAA 9,091 4,233
PF02597 ThiS 51,824 25,626
PF02821 Staphylokinase 300 39
PF02824 TGS 68,799 22,719
PF02991 Atg8 5,161 1,804
PF03607 DCX 3,698 2,036
PF03658 Ub-RnfH 7,277 3,239
PF03671 Ufm1 876 393
PF03990 DUF348 5,663 2,940
PF04106 APG5 2,100 1,091
PF04110 APG12 1,685 923
PF04663 Phenol_monoox 819 366
PF06071 YchF-GTPase_C 33,415 10,651
PF06234 TmoB 261 161
PF06251 Caps_synth_GfcC 4,189 1,995
PF06458 MucBP 5,136 2,897
PF06487 SAP18 1,743 870
PF06805 Lambda_tail_I 3,777 845
PF08154 NLE 3,399 1,672
PF08783 DWNN 2,449 1,401
PF08817 YukD 5,501 2,551
PF09138 Urm1 1,773 977
PF09379 FERM_N 16,411 6,741
PF09469 Cobl 1,070 493
PF09479 Flg_new 11,137 7,409
PF10302 DUF2407 824 521
PF10531 SLBB 69,085 32,014
PF11434 CHIPS 22 2
PF11470 TUG-UBL1 1,344 821
PF11543 UN_NPL4 1,182 587
PF11620 GABP-alpha 473 191
PF11973 NQRA_SLBB 5,480 2,454
PF11976 Rad60-SLD 5,977 3,186
PF12053 Par3_HAL_N_term 2,111 870
PF12436 USP7_ICP0_bdg 3,939 1,593
PF12754 Blt1 515 276
PF13019 Sde2_N_Ubi 1,747 1,088
PF13881 Rad60-SLD_2 2,394 1,250
PF14451 Ub-Mut7C 2,681 1,470
PF14452 Multi_ubiq 1,254 832
PF14453 ThiS-like 516 238
PF14454 Prok_Ub 1,075 411
PF14478 DUF4430 6,283 3,365
PF14533 USP7_C2 4,112 1,482
PF14560 Ubiquitin_2