This website contains a collection of webtools for creating and interacting with sequence similarity networks (SSNs) and genome neighborhood networks (GNNs). These tools originated in the Enzyme Function Initiative, a NIH-funded research project to develop a sequence / structure-based strategy for facilitating discovery of in vitro enzymatic and in vivo metabolic / physiological functions of unknown enzymes discovered in genome projects.
The Enzyme Function Initiative tools are hosted at the Carl R. Woese Institute for Genomic Biology (IGB), at the University of Illinois at Urbana-Champaign. The development of these tools is headed by John A. Gerlt (PI), aided by scientist Rémi Zallot and software engineers Dan Davidson, David Slater, and Nils Oberg. The computational infrastracture is supported by the Computer and Network Resource Group at IGB.
|SSN Creation SSN creation from sequences, PFam or InterPro famil(ies), and UniProt and/or NCBI protein accession IDs.||GNN Creation GNN creation from sequence similarity networks.|
|Genome neighborhood diagrams Genome neighborhood diagrams from sequences, sequence IDs, or GNNs.|