Enzyme Function Initiative Tools

This website contains a collection of webtools for creating and interacting with sequence similarity networks (SSNs) and genome neighborhood networks (GNNs). These tools originated in the Enzyme Function Initiative, a NIH-funded research project to develop a sequence / structure-based strategy for facilitating discovery of in vitro enzymatic and in vivo metabolic / physiological functions of unknown enzymes discovered in genome projects.

The Enzyme Function Initiative tools are hosted at the Carl R. Woese Institute for Genomic Biology (IGB), at the University of Illinois at Urbana-Champaign. The development of these tools is headed by John A. Gerlt (PI), aided by scientist Rémi Zallot and software engineers Dan Davidson, David Slater, and Nils Oberg. The computational infrastracture is supported by the Computer and Network Resource Group at IGB.


John Gerlt

Rémi Zallot

Dan Davidson

David Slater

Nils Oberg

These webtools use NCBI BLAST and CD-HIT to create SSNs and GNNs. The data used originate from the UniProt Consortium databases and the InterPro and ENA databases from EMBL-EBI.

Need help or have suggestions or comments? Please click here.