EFI - Enzyme Similarity Tool

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RadicalSAM.org, our resource for investigating sequence-function space in the radical SAM superfamily, has been updated with sequences from the UniProt Release 2024_01 and InterPro Release 98 databases (January 24, 2024) !!

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Pfam Clans

These data are sourced from the UniProt and EMBL-EBI InterPro databases.

Download as tab-separated text file.
Clan ID Clan Short Name Clan Size UniRef90 Size UniRef50 Size
CL0001 EGF 397,434 173,054 62,719
CL0003 SAM 227,469 87,857 20,118
CL0004 Concanavalin 713,900 387,538 134,489
CL0005 Kazal 56,029 22,861 8,696
CL0007 KH 362,492 147,699 25,394
CL0010 SH3 1,978,489 889,836 233,688
CL0012 Histone 204,013 70,338 23,811
CL0013 Beta-lactamase 589,952 334,425 86,294
CL0014 Glutaminase_I 761,810 387,893 58,822
CL0015 MFS 2,284,299 1,122,885 266,737
CL0016 PKinase 2,659,251 1,364,219 473,359
CL0018 bZIP 116,745 49,976 17,728
CL0020 TPR 3,291,539 1,760,277 685,857
CL0021 OB 2,315,848 1,010,961 179,194
CL0022 LRR 728,271 383,440 167,789
CL0023 P-loop_NTPase 12,555,789 6,121,285 1,362,386
CL0025 His_Kinase_A 1,882,649 1,127,202 406,317
CL0026 CU_oxidase 330,651 147,375 35,390
CL0027 RdRP 1,003,848 465,044 223,792
CL0028 AB_hydrolase 2,303,644 1,352,642 367,063
CL0029 Cupin 1,668,334 903,512 225,191
CL0030 Ion_channel 496,422 242,676 71,492
CL0031 Phosphatase 761,834 391,600 93,147
CL0032 Dim_A_B_barrel 546,270 275,594 49,907
CL0033 POZ 338,588 140,387 55,490
CL0036 TIM_barrel 7,478,180 3,794,375 678,872
CL0037 Lysozyme 413,573 220,352 59,355
CL0039 HUP 1,825,186 953,097 164,900
CL0040 tRNA_synt_II 772,701 375,330 53,837
CL0041 Death 94,047 43,168 16,244
CL0042 Flavoprotein 298,437 151,142 25,994
CL0043 Chelatase 269,748 143,814 30,463
CL0044 Ferritin 356,030 173,092 30,460
CL0045 Rubredoxin 75,516 41,519 5,249
CL0046 Thiolase 574,794 278,360 52,801
CL0047 CuAO_N2_N3 15,402 7,107 1,260
CL0048 LolA_LolB 137,669 82,826 29,252
CL0050 HotDog 575,261 307,029 64,116
CL0051 NTF2 421,388 245,981 70,347
CL0052 NTN 537,312 259,395 51,635
CL0053 4H_Cytokine 33,324 12,103 3,464
CL0054 Knottin_1 9,535 5,148 2,147
CL0055 Nucleoplasmin 262,730 35,311 10,714
CL0056 C_Lectin 232,616 146,719 61,351
CL0057 Met_repress 245,291 136,284 40,156
CL0059 6_Hairpin 548,365 311,385 82,910
CL0060 DNA_clamp 73,744 33,252 9,239
CL0061 PLP_aminotran 1,679,969 833,934 120,221
CL0062 APC 1,155,055 502,965 99,227
CL0063 NADP_Rossmann 12,392,058 6,547,476 1,273,861
CL0064 CPA_AT 449,777 219,377 44,606
CL0065 Cyclin 138,977 63,328 22,083
CL0066 Trefoil 157,537 76,956 23,139
CL0067 SIS 353,857 155,024 24,085
CL0068 RIIa 16,250 7,443 2,962
CL0069 GFP 5,871 2,874 592
CL0070 ACT 403,121 170,726 23,171
CL0071 His_phosphatase 276,493 145,503 38,549
CL0072 Ubiquitin 1,051,025 496,950 135,954
CL0073 P53-like 76,305 27,960 8,092
CL0074 Matrix 67,161 10,213 1,571
CL0075 Defensin 8,394 3,903 1,214
CL0077 FAD_PCMH 337,224 187,322 32,841
CL0079 Cystine-knot 91,788 28,604 9,062
CL0080 Beta-tent 162,222 88,603 14,842
CL0081 MBD-like 168,782 81,199 25,469
CL0082 MIF 45,974 23,292 4,762
CL0083 Omega_toxin 33,609 16,641 4,600
CL0084 ADP-ribosyl 122,121 69,181 25,857
CL0087 Acyl-CoA_dh 473,401 206,316 24,158
CL0088 Alk_phosphatase 522,118 316,130 79,354
CL0089 GlnB-like 162,335 77,515 14,320
CL0090 Globin 131,999 64,836 14,053
CL0091 NAD_Ferredoxin 250,272 121,131 22,021
CL0092 ADF 68,724 26,991 6,613
CL0093 Peptidase_CD 169,770 117,875 62,417
CL0094 Peptidase_ME 295,172 151,463 32,050
CL0095 Peptidase_ML 24,087 14,177 4,099
CL0096 Pept_Inhib_IE 208 133 71
CL0097 TypeIII_Chap 39,423 19,697 6,518
CL0098 SPOUT 330,412 174,745 31,674
CL0099 ALDH-like 558,188 248,602 31,411
CL0100 C1q_TNF 51,261 22,213 7,888
CL0101 PELOTA 155,139 71,895 14,437
CL0103 Gal_mutarotase 396,046 216,573 51,570
CL0104 Glyoxalase 529,971 300,242 44,372
CL0105 Hybrid 3,303,544 1,606,682 312,701
CL0106 6PGD_C 630,681 309,611 42,984
CL0108 Actin_ATPase 1,159,599 560,468 126,113
CL0109 CDA 327,438 177,168 31,560
CL0110 GT-A 1,549,832 903,700 273,464
CL0111 GT-C 285,977 183,615 83,420
CL0112 Yip1 45,708 23,397 8,510
CL0113 GT-B 1,347,966 848,509 288,432
CL0114 HMG-box 117,945 50,390 18,998
CL0115 Steroid_dh 105,777 64,586 18,530
CL0116 Calycin 175,998 96,763 31,670
CL0117 uPAR_Ly6_toxin 38,363 17,158 6,242
CL0118 Ribokinase 374,580 199,644 41,798
CL0122 UTRA 100,450 44,005 9,836
CL0123 HTH 11,069,761 5,571,157 1,443,281
CL0124 Peptidase_PA 489,064 248,445 90,645
CL0125 Peptidase_CA 863,050 444,950 165,017
CL0126 Peptidase_MA 1,193,735 677,404 200,236
CL0127 ClpP_crotonase 823,875 394,400 69,551
CL0128 vWA-like 454,539 244,571 74,550
CL0129 Peptidase_AA 567,625 231,410 90,935
CL0130 Peptidase_AD 69,794 40,643 13,448
CL0131 DoxD-like 137,294 82,480 18,560
CL0132 AbrB 95,003 53,378 13,926
CL0133 AT14A-like 13,448 6,907 2,290
CL0135 Arrestin_N-like 55,430 24,762 8,923
CL0136 Plasmid_toxin 228,319 146,856 36,695
CL0137 HAD 1,239,763 641,951 146,191
CL0139 GADPH_aa-bio_dh 742,946 366,436 48,761
CL0140 Viral_NABP 2,107 382 118
CL0141 MtN3-like 71,776 37,938 10,756
CL0142 Membrane_trans 722,725 338,574 53,989
CL0143 B_Fructosidase 145,616 83,427 17,510
CL0144 Periplas_BP 741,161 355,425 86,005
CL0145 Golgi-transport 161,217 57,714 12,223
CL0146 Herpes_glyco 558 109 52
CL0147 Traffic 21,926 9,551 2,860
CL0148 Viral_Gag 107,712 24,879 8,031
CL0149 CoA-acyltrans 326,451 188,009 63,656
CL0153 dUTPase 79,941 37,234 5,773
CL0154 C2 407,120 175,820 46,112
CL0155 CBM_14_19 32,757 20,830 11,725
CL0156 Nucleocapsid 36,937 1,094 508
CL0157 Kleisin 42,496 23,450 4,744
CL0158 GH_CE 262,836 156,263 46,441
CL0159 E-set 3,097,913 1,710,866 715,235
CL0161 GAF 635,548 359,288 118,111
CL0163 Calcineurin 607,306 336,682 91,309
CL0164 CUB 86,406 37,976 15,201
CL0165 Cache 246,163 128,420 47,862
CL0166 PRD 34,018 13,322 4,861
CL0167 Zn_Beta_Ribbon 1,467,075 687,189 181,537
CL0168 PAN 66,784 38,082 18,333
CL0169 Rep 90,641 35,382 14,111
CL0170 Peptidase_MD 74,669 43,567 13,436
CL0171 Phospoesterase 160,548 80,333 14,280
CL0172 Thioredoxin 1,661,116 898,468 207,248
CL0173 STIR 111,641 69,219 33,730
CL0174 TetR_C 472,475 255,119 56,100
CL0175 TRASH 161,718 91,076 32,279
CL0176 Chemosens_recp 38,499 28,509 16,392
CL0177 PBP 2,494,371 1,193,528 252,525
CL0178 PUA 304,435 151,165 29,452
CL0179 ATP-grasp 836,712 415,085 75,751
CL0181 ABC-2 508,579 277,683 69,924
CL0182 IT 410,308 196,168 35,772
CL0183 PAS_Fold 840,939 520,074 219,303
CL0184 DMT 748,241 387,433 91,858
CL0186 Beta_propeller 2,727,756 1,409,787 524,039
CL0187 LysM 211,336 125,081 46,503
CL0188 CH 171,277 67,255 17,443
CL0190 HSP20 163,061 88,211 25,907
CL0191 POTRA 102,757 59,174 20,635
CL0192 GPCR_A 1,027,401 466,486 157,490
CL0193 MBB 1,241,106 692,308 229,728
CL0194 DNA_pol_B-like 51,379 24,975 8,762
CL0195 DBL 16,155 9,911 2,114
CL0196 DSRM 202,916 101,790 35,639
CL0197 GME 70,732 34,386 6,694
CL0198 HHH 808,122 411,604 79,443
CL0199 DPBB 470,797 254,417 56,628
CL0200 Prefoldin 35,738 18,204 5,516
CL0201 Peptidase_SH 21,091 11,258 4,433
CL0202 GBD 642,734 350,466 113,283
CL0203 CBD 40,011 25,723 9,645
CL0204 Adhesin 69,447 24,579 9,729
CL0205 Di-copper 34,255 17,644 6,440
CL0207 Rhomboid-like 120,081 68,630 19,980
CL0208 UBC 176,297 73,099 22,133
CL0209 Bet_v_1_like 419,761 227,090 53,533
CL0210 HNOX-like 38,784 20,310 6,428
CL0212 SNARE 6,769 2,938 872
CL0213 ShK-like 15,734 10,786 6,336
CL0214 UBA 235,020 102,204 25,389
CL0217 Rotavirus_VP7 19,299 764 87
CL0219 RNase_H 1,885,327 1,104,935 439,979
CL0220 EF_hand 629,063 281,097 100,513
CL0221 RRM 715,757 306,326 96,113
CL0222 MviN_MATE 332,800 191,430 65,564
CL0223 MACRO 114,854 57,799 13,789
CL0224 DHQS 212,402 104,405 15,830
CL0225 FtsL 55,604 30,890 10,460
CL0226 M6PR 19,773 10,045 3,694
CL0227 Enolase_N 179,329 77,232 9,172
CL0228 Acyltransferase 287,783 153,037 38,591
CL0229 RING 1,290,433 586,306 197,661
CL0230 HO 57,980 29,952 6,363
CL0231 MazG 110,680 58,525 8,976
CL0232 NifU 109,172 53,122 6,593
CL0233 SufE_NifU 136,965 71,637 11,444
CL0234 CTPT 59,338 32,107 8,594
CL0235 PspA 69,162 28,987 6,916
CL0236 PDDEXK 911,914 505,091 162,987
CL0237 HD_PDEase 547,145 304,887 79,840
CL0238 PP2C 264,218 148,785 49,015
CL0239 Insulin 8,169 3,637 1,484
CL0240 PFK 220,689 110,535 21,964
CL0241 ABC_membrane 498,430 253,299 53,813
CL0242 DNA_primase_lrg 7,991 4,310 1,537
CL0243 AEP 37,796 22,284 4,679
CL0244 PGBD 127,016 74,909 25,759
CL0245 EDD 107,471 51,375 10,479
CL0247 2H 63,493 40,390 14,842
CL0248 ParBc 135,186 79,356 24,605
CL0249 Phage_tail_L 6,090 1,854 651
CL0250 GAD 47,943 20,548 1,903
CL0251 MORN 64,947 38,902 19,975
CL0254 THDP-binding 674,620 325,441 37,648
CL0255 ATP_synthase 184,850 89,524 24,310
CL0257 Acetyltrans 1,385,720 809,497 219,155
CL0258 DALR 339,380 169,950 20,334
CL0259 OstA 53,893 31,580 11,237
CL0260 NTP_transf 592,523 334,091 95,277
CL0261 NUDIX 496,955 277,360 61,848
CL0262 Trigger_C 98,506 56,051 18,575
CL0263 His-Me_finger 251,829 144,855 58,474
CL0264 SGNH_hydrolase 316,215 195,243 67,490
CL0265 HIT 151,327 82,104 14,716
CL0266 PH 939,559 382,534 92,106
CL0267 S11_L18p 157,394 58,782 9,859
CL0268 Pec_lyase-like 406,806 256,077 114,188
CL0269 Maf 116,966 65,927 10,913
CL0270 Iso_DH 260,536 112,900 11,663
CL0271 F-box 324,508 184,985 90,686
CL0272 RGS 65,409 24,129 6,591
CL0273 CYTH 57,465 33,410 9,960
CL0274 WRKY-GCM1 88,046 51,210 23,586
CL0276 Nucleot_cyclase 748,853 448,876 183,112
CL0277 FAD-oxidase_C 183,729 98,434 17,585
CL0278 AIG2 54,683 30,778 8,658
CL0279 GatB_YqeY 80,731 40,396 5,327
CL0280 PIN 433,080 263,409 72,372
CL0281 CCT 23,987 10,847 3,476
CL0282 Serum_albumin 2,831 1,011 223
CL0283 LigB 52,784 30,242 6,331
CL0284 Allatostatin 223 126 71
CL0285 YycI_YycH 5,488 2,878 1,131
CL0286 GCS 262,035 106,683 15,940
CL0287 Transthyretin 566,208 351,438 128,917
CL0288 DAP_epimerase 112,569 60,716 9,128
CL0289 FBD 150,341 79,548 13,151
CL0290 EPT_RTPC 115,982 55,810 8,587
CL0291 KNTase_C 150,305 98,358 35,543
CL0292 LysE 618,831 321,068 61,860
CL0293 CDC 49,297 24,078 8,149
CL0296 GroES 621,942 301,347 42,207
CL0297 PhoU 79,235 39,246 8,224
CL0298 tRNA_bind_arm 133,360 61,366 5,595
CL0299 Peptidase_SF 186,636 101,129 27,396
CL0300 TAT 30,278 15,481 5,308
CL0301 PA14 32,315 21,352 9,410
CL0302 Arginase 157,529 80,015 15,525
CL0303 H2TH 135,940 61,686 9,104
CL0304 CheY 2,014,219 1,077,580 292,044
CL0305 PTH2 18,159 9,731 2,178
CL0306 HeH 126,561 55,515 16,170
CL0307 FUSC 85,959 40,922 11,166
CL0308 DMSO_reductase 36,010 18,590 3,150
CL0310 DinB 167,492 113,002 24,061
CL0311 SCP2 73,163 40,015 9,218
CL0312 HemS_ChuX 7,460 3,525 789
CL0314 PP-binding 317,631 185,452 73,325
CL0315 Gx_transp 147,372 79,793 19,511
CL0316 Acyl_transf_3 192,689 119,260 49,271
CL0317 Multiheme_cytos 96,328 64,187 21,876
CL0318 Cytochrome-c 370,371 236,667 59,026
CL0319 SHS2 131,002 67,801 16,877
CL0320 PepSY 103,562 55,833 20,227
CL0321 PLAT 33,462 15,747 5,314
CL0322 RND_permease 429,273 222,409 48,211
CL0323 Patatin 269,947 157,243 46,337
CL0324 Homing_endonuc 39,239 23,890 10,467
CL0326 Reo_sigma 2,980 545 208
CL0327 Pilus 84,903 54,330 19,226
CL0328 2heme_cytochrom 587,262 190,678 38,344
CL0329 S5 902,908 405,138 62,887
CL0330 AVL9 48,974 20,639 4,661
CL0331 EpsM 58,730 35,470 14,826
CL0333 gCrystallin 28,478 12,970 4,046
CL0334 THBO-biosyn 163,894 80,043 10,598
CL0335 FumRed-TM 56,336 25,634 4,613
CL0336 FMN-binding 310,641 183,121 33,728
CL0337 RF 126,690 58,649 6,175
CL0339 PFL-like 136,324 58,483 9,584
CL0340 PTase-anion_tr 95,726 40,706 9,647
CL0341 LDH_C 98,470 35,364 4,517
CL0342 TolB_N 101,994 55,984 17,313
CL0343 MHC 140,658 31,860 5,155
CL0344 4Fe-4S 1,073,234 550,839 92,716
CL0345 Aerolisin_ETX 3,167 1,837 958
CL0346 Ribo_L29 51,769 22,482 4,280
CL0347 TSPAN_4TM-like 78,805 35,923 12,868
CL0348 Phage_tail 28,712 13,663 5,982
CL0349 SLOG 147,340 81,680 17,748
CL0350 PRC-barrel 126,499 66,952 13,942
CL0351 CHCH 37,340 18,726 5,615
CL0352 EsxAB 59,776 32,921 11,276
CL0353 TIMP-like 23,896 9,148 2,590
CL0354 bBprotInhib 3,002 1,385 385
CL0355 CheC-like 36,130 18,693 4,845
CL0356 AMP_N-like 114,963 58,428 10,911
CL0357 SMAD-FHA 215,143 118,849 44,136
CL0359 Intron-mat_II 150,892 20,629 4,669
CL0360 MTH1187-YkoF 16,599 8,796 1,263
CL0361 C2H2-zf 961,215 482,583 217,601
CL0362 RAMPS-Cas5-like 52,283 39,087 15,171
CL0363 H-int 44,643 30,028 14,531
CL0364 Leu-IlvD 475,995 235,123 37,203
CL0365 MurF-HprK_N 219,654 116,502 17,872
CL0366 JAB 117,739 55,589 15,352
CL0367 CI-2 10,186 5,669 1,952
CL0368 PhosC-NucP1 52,163 31,913 10,727
CL0369 GHD 408,750 216,849 44,590
CL0370 Uteroglobin 1,810 1,026 385
CL0371 Inovirus-Coat 816 574 346
CL0373 Phage-coat 65,552 30,855 9,514
CL0374 PEP-carboxyk 65,063 29,164 3,620
CL0375 Transporter 110,407 41,295 12,180
CL0376 Oxa1 125,801 56,030 10,671
CL0377 FAH 140,448 73,327 8,645
CL0378 ANL 761,363 422,385 105,417
CL0379 PgaPase 13,664 7,211 1,996
CL0380 IDO-like 24,382 12,399 2,208
CL0381 Metallo-HOrase 601,016 348,172 71,863
CL0382 DNA-mend 409,238 232,265 78,919
CL0383 PheT-TilS 82,063 45,868 11,334
CL0385 Hydrophilin 8,609 3,712 963
CL0387 DHFred 142,612 85,707 13,750
CL0388 FadR-C 233,483 111,766 24,803
CL0389 TRAF 53,354 24,189 9,301
CL0391 CAP_C-like 14,145 6,571 2,295
CL0392 Chaperone-J 302,631 151,535 45,297
CL0394 DsrEFH-like 49,992 27,180 5,173
CL0395 Tubby_C 42,818 21,476 7,222
CL0396 Marvel-like 46,044 21,667 5,956
CL0397 TusA-like 48,632 27,051 4,800
CL0398 RMMBL_DRMBL 76,896 38,261 6,559
CL0399 Asp-glut_race 89,756 48,534 8,376
CL0400 GG-leader 2,634 1,283 661
CL0401 AsmA-like 84,681 50,101 22,875
CL0402 Cdc48_2-like 29,167 11,682 2,525
CL0403 ADC-like 18,269 11,249 2,587
CL0404 BPD_transp_1 1,889,375 882,049 135,680
CL0405 DNA_b-psBarrel 42,086 21,454 8,862
CL0406 YjbJ-CsbD-like 34,838 15,422 2,637
CL0407 TBP-like 65,208 30,851 7,650
CL0408 PUP 218,999 114,927 23,417
CL0409 GAP 168,188 68,008 16,892
CL0410 LEF-8-like 100,658 28,079 4,173
CL0411 Vir 19,917 12,373 4,253
CL0412 Frag1-like 25,630 15,383 5,504
CL0413 Toprim-like 340,533 153,980 29,089
CL0414 TerB 37,610 20,061 5,104
CL0416 Anoctamin-like 56,618 25,873 7,470
CL0417 BIR-like 20,225 10,444 4,621
CL0418 GIY-YIG 128,140 79,372 22,105
CL0419 T3SS-Chaperone 15,622 8,286 3,324
CL0420 GlpM-like 3,311 1,104 293
CL0421 LppaM 13,149 6,701 4,036
CL0422 Fibrinogen_C 60,095 28,129 10,427
CL0423 AhpD-like 124,833 64,905 9,602
CL0424 T3SS-hook 52,413 33,368 15,780
CL0425 ComplexI-N 565,697 181,398 24,385
CL0426 HRDC-like 79,008 38,568 8,041
CL0428 TolA-TonB-Cterm 100,851 65,158 31,317
CL0429 UcrQ-like 3,583 1,854 537
CL0430 CopD_like 76,373 42,520 9,615
CL0431 PF 179,230 67,735 17,033
CL0433 SPFH 201,287 96,002 16,929
CL0435 NPR 7,348 3,312 1,141
CL0436 FliG 63,409 31,250 6,548
CL0437 EF-G_C 245,467 89,851 9,175
CL0439 NusG-like 62,920 26,896 5,357
CL0441 AlbA 49,665 29,957 10,081
CL0442 Tubulin_C 112,078 34,943 5,884
CL0445 SNARE-fusion 55,636 23,443 6,834
CL0446 Bacteriocin_TLN 2,557 1,418 512
CL0447 Hypoth_1 11,832 6,063 1,214
CL0448 Cargo_bd_muHD 41,005 14,052 3,521
CL0449 G-PATCH 50,540 24,950 8,771
CL0451 FnI-like 44,623 18,257 5,637
CL0452 Tropomyosin-lke 22,722 8,242 1,804
CL0453 Apoptosis-Inhib 52,142 22,724 4,396
CL0456 Golgi_traff 8,403 3,531 1,271
CL0457 4HB_MCP 85,961 44,158 14,234
CL0458 IIaaRS-ABD 223,933 103,766 12,279
CL0459 BRCT-like 114,490 59,752 16,145
CL0461 Metallothionein 5,940 2,576 715
CL0462 TPA-repeat 6,021 2,204 564
CL0464 5_3_exonuc_C 84,598 44,013 9,126
CL0465 Ank 660,214 361,525 170,885
CL0466 PDZ-like 526,046 266,794 67,030
CL0469 l-integrase_N 223,712 122,646 35,215
CL0470 ThrE 28,803 12,983 3,465
CL0471 DUF362 36,922 27,038 7,225
CL0472 Peptidase_U 136,711 87,331 38,043
CL0474 SICA_like 976 633 470
CL0475 Cyclophil-like 217,939 113,402 23,565
CL0476 tRNA-IECD_N 8,847 4,999 1,428
CL0477 TRD 64,504 54,394 29,484
CL0478 ATPase_I_AtpR 15,043 7,895 3,102
CL0479 PLD 224,575 120,955 30,048
CL0481 HUH 66,081 43,232 14,979
CL0482 Prolamin 44,453 21,279 7,767
CL0484 Peroxisome 34,267 15,536 4,257
CL0486 Fer2 387,142 196,859 25,660
CL0487 FKBP 361,698 186,328 48,690
CL0488 FixH-like 17,851 11,570 4,266
CL0489 SAF 223,300 121,281 41,388
CL0490 PepSY_TM-like 41,998 23,873 5,578
CL0491 LYR-like 32,286 16,845 5,146
CL0492 S4 303,056 132,796 16,835
CL0493 PTS_EIIC 95,062 30,560 4,473
CL0494 DnaA_N 83,400 40,445 7,678
CL0496 Tad-like 61,339 43,163 17,562
CL0497 GST_C 270,632 135,189 24,678
CL0498 Nribosyltransf 22,851 12,939 3,926
CL0499 O-anti_assembly 88,490 62,907 36,216
CL0500 Glycine-zipper 85,728 41,688 10,546
CL0502 STAS 197,811 112,694 33,003
CL0504 Phage_barrel 132,998 56,069 19,614
CL0505 Pentapeptide 93,321 59,693 28,611
CL0506 Succ_CoA_synth 136,704 55,939 7,783
CL0507 Fungal_trans 259,273 149,308 57,586
CL0508 YkuD 132,429 75,047 18,391
CL0509 RBP11-like 82,375 25,677 4,280
CL0511 Retroviral_zf 198,441 99,894 52,483
CL0512 CRAL_TRIO 85,886 40,852 13,031
CL0513 LCCL-domain 12,387 5,065 1,622
CL0515 LTXXQ-like 22,823 14,188 7,288
CL0516 ISP-domain 204,848 106,630 19,989
CL0517 MBOAT-like 64,259 34,897 9,867
CL0520 Keratin_assoc 6,224 3,836 1,565
CL0521 GOLD-like 40,796 17,362 4,729
CL0522 YbjQ-like 22,549 11,146 1,795
CL0523 GAG-polyprotein 187,579 147,114 83,450
CL0524 MPT63-MPB63 10,164 6,271 3,364
CL0525 pap2 186,693 104,924 34,190
CL0526 SUKH 39,968 22,640 9,342
CL0528 DUF1214 17,986 11,622 2,799
CL0529 FMN-dep-NRtase 163,396 93,188 18,214
CL0530 DNase_I-like 302,046 174,102 63,044
CL0531 AMP-binding_C 486,361 267,506 56,881
CL0532 LIG 20,606 12,517 5,060
CL0533 PRTase-like 373,517 167,845 24,847
CL0534 YjgF-like 157,918 80,440 10,987
CL0535 CBM 15,302 7,584 2,251
CL0536 HEXAPEP 302,155 157,691 27,519
CL0537 CCCH_zf 108,245 47,977 17,763
CL0539 RNase_III 72,851 39,234 8,949
CL0540 GCP 22,684 10,591 4,039
CL0541 SH2-like 149,738 50,818 12,177
CL0542 RAS_GEF_N 43,998 17,263 4,367
CL0543 Viral_gly_cn_dm 52,971 4,493 1,626
CL0544 AcylCoA_ox_dh_N 428,071 184,418 19,989
CL0545 APCOP-app_sub 38,867 18,181 4,710
CL0546 Hexosaminidase 50,365 29,344 8,182
CL0547 GF_recep_C-rich 37,855 14,180 2,936
CL0548 IHF-likeDNA-bdg 117,253 44,935 8,765
CL0550 SRCR 41,366 23,341 9,494
CL0551 BCLiA 18,461 7,540 2,645
CL0552 Hect 80,739 36,799 10,636
CL0559 CBD9-like 40,543 27,518 11,750
CL0560 Chalcone-like 12,447 7,551 2,505
CL0561 LisH 32,601 11,883 3,330
CL0562 Holin-V 1,928 1,177 320
CL0563 Holin-II 3,886 974 388
CL0564 Holin-III 5,492 1,485 549
CL0567 Phage_TACs 21,164 10,246 3,315
CL0568 Man_lectin 16,886 9,727 4,293
CL0570 PPP-I 92,337 50,667 15,716
CL0571 30K_movement 8,475 2,385 1,091
CL0572 TIKI 44,275 27,882 9,445
CL0573 KA1-like 39,476 15,782 4,217
CL0576 STARBD 14,822 7,643 2,883
CL0577 Paramyxovirin_C 648 70 37
CL0578 AbiEI 7,627 5,090 1,966
CL0580 YqgF 74,409 36,511 5,572
CL0582 TrkA_C 133,193 65,089 12,027
CL0584 FF 14,563 5,856 1,656
CL0586 CTC1 1,795 798 356
CL0587 STAND_N 7,453 5,921 3,481
CL0588 Ribos_L15p_L18e 63,508 27,925 3,521
CL0589 KIX_like 10,275 5,696 2,038
CL0590 OML_zippers 5,596 1,510 707
CL0591 TKC_like 306,393 139,275 11,744
CL0592 beta_Roll 68,312 54,901 37,756
CL0593 G5 18,586 11,322 4,404
CL0595 Fusion_gly 26,698 2,818 1,277
CL0596 VPS23_C 16,439 6,929 2,118
CL0597 Post-HMGL 109,132 45,223 3,305
CL0598 B_GA 9,769 5,673 3,905
CL0599 GH57_38_middle 35,847 20,233 5,104
CL0600 S15_NS1 140,796 23,647 2,345
CL0601 Cob_adeno_trans 33,680 17,175 2,397
CL0602 Kringle 34,543 13,467 4,045
CL0603 AA_dh_N 258,628 118,511 13,816
CL0604 post-AAA 145,272 73,198 13,429
CL0605 ssDNA_NP_VP 16,758 3,858 1,130
CL0606 Phage_fibre 19,881 8,861 2,951
CL0607 TNF_receptor 49,858 22,083 6,349
CL0608 Reductase_C 230,374 103,874 12,669
CL0609 sPC4_like 29,429 12,779 3,458
CL0611 Hexon 12,997 1,778 494
CL0612 PHM_PNGase_F 14,182 8,229 3,509
CL0613 Terp_synthase 336,150 187,398 41,276
CL0614 L27 30,144 10,494 1,796
CL0615 ALDC 31,233 16,343 4,649
CL0616 SPOC 42,517 20,258 4,924
CL0617 Peroxidase 103,316 53,933 13,341
CL0618 MCR 5,620 963 145
CL0619 Mog1p_PsbP 24,057 12,426 4,286
CL0620 Antihemostatic 3,393 1,638 911
CL0621 Colipase 4,750 1,948 532
CL0622 Acylphosphatase 84,914 48,384 11,103
CL0623 SRP9_14 7,260 3,439 934
CL0625 eIF4e 19,208 8,892 2,969
CL0626 Levi_coat 400 97 41
CL0627 Antibiotic_NAT 11,315 6,599 1,650
CL0628 EspA_CesA 941 185 73
CL0629 PLA2 22,775 11,092 4,225
CL0630 PSI 59,289 23,583 5,139
CL0631 YgaC_TfoX-N 83,014 54,691 9,563
CL0632 FERM_M 115,707 47,044 9,606
CL0633 NusB 73,687 39,396 7,770
CL0634 CheY-binding 8,311 4,088 806
CL0635 DmpA_ArgJ 181,996 101,982 18,083
CL0636 Leukocidin 4,283 1,725 386
CL0637 KaiA_RbsU 2,472 1,385 329
CL0639 Rof 9,176 4,631 1,384
CL0640 Colicin_D_E5 554 445 365
CL0642 SOCS_box 34,607 10,864 3,076
CL0643 YqbG 11,964 6,026 2,492
CL0644 Fz 46,052 16,977 5,023
CL0645 Anti-sigma_N 56,041 37,901 17,345
CL0646 T3SS 4,594 1,524 483
CL0647 FG_rpt 9,417 4,905 1,901
CL0648 Aha1_BPI 47,195 23,725 8,465
CL0649 PseudoU_synth 363,627 196,342 38,243
CL0650 AOC_barrel 26,590 15,544 4,614
CL0651 Mad2 21,340 9,613 3,328
CL0652 S24e_L23_L15e 65,933 23,981 2,641
CL0653 VCCI 909 147 72
CL0654 WYL 83,809 47,972 11,980
CL0655 PilP 17,874 11,287 4,521
CL0656 VSA 5,032 3,733 574
CL0658 OB_enterotoxin 2,743 847 324
CL0659 CAP 83,412 54,129 25,082
CL0660 SHOCT 60,015 35,908 11,558
CL0661 Gain 86,157 38,993 11,409
CL0662 Triple_barrel 36,186 19,137 6,817
CL0663 CNF1_YfiH 47,615 28,742 6,779
CL0664 UB2H 92,337 40,211 5,003
CL0665 BET 16,813 7,211 2,118
CL0666 Vault 1,996 816 253
CL0667 Fer2_BFD 106,459 50,420 7,081
CL0668 Pre-PUA 19,850 8,876 1,980
CL0669 NOG1_N 10,419 5,077 1,669
CL0670 4PPT 71,733 42,342 13,978
CL0671 AAA_lid 929,823 415,256 61,877
CL0672 p35 123,726 71,220 21,760
CL0673 GYF 27,141 15,649 6,511
CL0674 Triple_B_spiral 1,669 245 129
CL0676 SLATT 8,604 5,805 2,808
CL0677 GHMP_C 121,258 65,384 12,932
CL0678 CLIP 5,586 3,719 1,823
CL0679 TACC 7,213 2,775 946
CL0680 WW 93,683 43,642 12,777
CL0681 HAMP 496,047 270,560 89,699
CL0682 MBG 7,212 6,321 5,008
CL0683 MICOS 2,572 1,342 454
CL0684 NFACT_RNA-bind 26,961 15,331 4,017
CL0685 AmpE_CobD-like 25,891 13,553 2,242
CL0686 aG_PT 1,777 1,182 483
CL0687 Zn_chelatase 11,322 8,993 4,896
CL0688 BECR 5,208 3,499 2,089
CL0689 TSP3 41,846 27,724 16,346
CL0690 TrbC_VirB2 33,311 17,450 8,388
CL0691 Phage_tail_2 18,808 9,216 3,656
CL0692 TSP1 91,911 39,664 13,103
CL0693 Cas9_lobe 2,211 1,605 737
CL0694 Choline_binding 17,803 8,642 4,916
CL0695 EndoU 13,310 4,402 2,070
CL0696 Vmethyltransf 9,854 1,922 927
CL0697 SDH_beta 85,189 38,881 6,189
CL0698 TrbL 17,593 6,709 2,389
CL0700 ArdcN 20,669 10,108 3,694
CL0701 NAD_kinase_C 132,873 68,278 15,184
CL0702 UIM 17,281 6,365 1,731
CL0703 YtcA 8,825 2,780 605
CL0704 HMA 180,721 98,163 21,364
CL0705 VBS-like 35,479 12,302 3,230
CL0706 EMC6 8,782 4,103 1,249
CL0707 Saposin_like 13,252 6,369 2,317
CL0708 Polo-box 8,718 3,355 1,167
CL0709 STING 2,016 1,060 446
CL0710 YeeE 42,422 26,260 3,615
CL0713 Acyl-CoA_desat 188,566 98,637 19,031
CL0714 COX1-like 1,814,738 165,099 27,744
CL0715 Nckap1_CYFIP1-2 12,490 3,982 1,493
CL0716 Aquaporin-like 114,138 51,916 10,993
CL0717 YbaB 42,179 20,368 3,681
CL0718 Perilipin_sf 7,409 3,350 1,056
CL0719 Moesin_tail 9,706 1,970 401
CL0720 Lag3_N 1,841 973 310
CL0721 LAMP 8,131 3,585 1,037
CL0722 SDH_alpha 71,753 33,539 6,065
CL0723 TRADD-N 4,401 1,712 581
CL0724 Kinetochore 13,726 7,020 2,517
CL0725 Apolipoprotein 7,479 3,560 1,156
CL0726 Resistin 1,363 629 170
CL0727 Nucleosidase 48,835 25,912 6,184
CL0728 Cas2 33,939 21,493 4,500
CL0729 Kre28-like_sf 1,972 1,012 325
CL0730 IL8 24,896 12,527 3,905
CL0731 SPOCS 6,015 3,523 1,408
CL0732 RMP1-like 3,218 1,912 862
CL0733 Ribosomal_L25 87,008 45,296 7,199
CL0734 Rpp14-Pop5-like 8,288 4,835 1,816
CL0735 GatC-like 38,150 19,869 3,696
CL0736 Get5_C_sf 822 360 146
CL0737 Mtd 4,565 2,332 1,040
CL0738 Arg_repressor_C 34,092 15,050 2,101
CL0740 GCV_T_C 286,482 102,242 13,033
CL0741 RGM 33,452 19,188 8,157
CL0742 PTS_IIA-like 5,304 2,547 670
CL0743 Spectrin 69,073 27,678 7,138
CL0745 MIT 31,569 12,089 3,131
CL0746 AFF4_CHD 5,143 2,113 494
CL0747 THUMP 54,556 25,000 5,142
CL0748 DNA_prim_N 47,316 25,962 6,449
CL0749 GH127_M 38,935 24,495 5,725
CL0750 ADAM_CR_sf 57,205 24,375 5,348
CL0751 Secretin_N0 92,323 53,000 21,593
CL0752 PsbQ-like 5,556 2,907 832
CL0753 ATPD-E_C 33,496 9,423 1,269
CL0754 PGM_I-III 144,965 69,183 10,085
CL0755 SASP 12,586 5,345 1,165
CL0756 GMC 2,803 893 221
CL0757 TRAP 4,126 1,775 587
CL0758 L31 48,560 18,243 2,164
CL0759 Nop_N_sf 9,293 3,821 685
CL0760 RBG 33,208 18,147 6,541
CL0761 ABC_sf 181 28 24
CL0763 GpW_gp25-like 52,838 22,891 5,152
CL0764 PHP14-like 36,560 15,954 2,112
CL0765 PAC 6,603 3,669 1,356
CL0766 NCPF 9,071 5,247 1,307
CL0767 MXAN_049 4,848 3,259 1,518
CL0768 DUF960 2,249 1,086 407
CL0769 SsdA_imm 4,606 3,096 820
CL0770 GH84_C 1,749 920 231
CL0771 YaaA-like 23,506 11,872 2,137
CL0772 YqiB 5,533 2,343 714
CL0773 STD 2,374 1,389 510
CL0774 MTHFR_C-like 6,293 2,494 489
CL0775 MlaD-like 91,075 47,835 9,898
CL0776 PBP_NTD 106,380 54,983 10,883
CL0777 XRCC4_N 7,644 4,058 1,631
CL0778 BON 53,702 30,846 9,815
CL0779 Head_shaft 21,613 12,991 4,774
CL0780 LppM-like 2,424 1,414 580
CL0781 NadN_C 58,729 30,380 7,900
CL0782 BBOX 103,153 48,161 15,008
CL0783 WWE 23,392 10,568 3,884
CL0785 VPS9 21,832 10,122 3,004
CL0786 H-NS_histone_C 17,208 6,789 1,593
CL0787 NADAR-like 14,456 9,071 3,393
CL0788 CorA-like 82,780 42,631 12,454
CL0789 SUD_C-like 4,559 216 13
CL0790 Cas9_WED-like 401 209 59
CL0791 Ago_N 20,031 8,819 2,552
CL0792 MLKL_N-like 6,810 3,508 1,367
CL0793 GspE_N-like 58,219 34,260 6,898
CL0794 Mur_ligase_C_sf 240,505 132,007 23,148
CL0795 NSUN_ferredox 45,375 23,681 4,922
CL0796 Mu-transpos_C 30,484 17,562 5,926
CL0797 RXXXE-like 3,168 2,678 1,854
CL0798 INSIG-like 14,057 8,021 2,110
CL0799 PRMT_C 26,580 10,520 2,932
CL0800 LiaI-LiaF-TM 14,005 9,693 4,162
CL0801 OST_core 9,747 4,442 1,296
CL0802 MinC_N 11,893 5,367 1,003
CL0803 PBP_GOBP 13,143 8,806 4,420
CL0804 PurM_N-like 161,319 83,868 9,634
CL0805 PWI-like 43,960 18,340 3,362
CL0806 SNaCT 3,184 1,264 358
CL0807 WY-like 5,037 2,820 1,817
CL0808 Sufu_N 14,155 7,192 2,626
CL0809 CXC 43,715 20,477 6,430
CL0810 GRIP-like 11,592 5,249 1,992
CL0811 B215_Zf 2,563 1,665 661
CL0812 YKT-like_S 26,478 15,914 6,436
CL0813 COMMD_HN 8,491 3,620 1,057
CL0814 Brichos_S 9,382 3,545 1,103
CL0815 BACOVA_03322_C 1,586 858 272
CL0816 TBC-like 107,412 44,997 13,111
CL0817 SPMIP5_TBD 2,557 1,416 463
CL0818 GT-D-like 1,601 1,027 590
CL0819 TIL 20,767 13,475 6,546
CL0820 RBAF-like 2,987 1,598 531
CL0821 C4-like 65,251 34,280 8,254
CL0822 WIV 131 53 36

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