EFI - Enzyme Similarity Tool

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RadicalSAM.org, our resource for investigating sequence-function space in the radical SAM superfamily, has been updated with sequences from the UniProt Release 2024_01 and InterPro Release 98 databases (January 24, 2024) !!

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Pfam Clans

These data are sourced from the UniProt and EMBL-EBI InterPro databases.

Download as tab-separated text file.
Clan ID Clan Short Name Clan Size UniRef90 Size UniRef50 Size
CL0001 EGF 445,052 197,116 69,569
CL0003 SAM 241,678 97,243 21,770
CL0004 Concanavalin 744,247 408,004 139,319
CL0005 Kazal 58,251 24,804 9,404
CL0007 KH 382,005 158,363 28,121
CL0010 SH3 2,172,853 1,031,955 296,068
CL0012 Histone 214,084 75,099 25,229
CL0013 Beta-lactamase 590,297 339,559 86,792
CL0014 Glutaminase_I 776,452 399,226 60,796
CL0015 MFS 2,323,635 1,171,963 273,798
CL0016 PKinase 2,811,635 1,456,287 494,695
CL0018 bZIP 124,686 54,411 18,882
CL0020 TPR 3,703,669 1,971,046 748,319
CL0021 OB 2,360,793 1,050,701 189,703
CL0022 LRR 913,608 499,425 213,504
CL0023 P-loop_NTPase 12,780,376 6,342,346 1,418,391
CL0025 His_Kinase_A 1,902,607 1,153,235 411,799
CL0026 CU_oxidase 342,046 154,240 36,882
CL0027 RdRP 1,054,829 534,310 254,154
CL0028 AB_hydrolase 2,356,510 1,399,110 377,047
CL0029 Cupin 1,713,722 936,693 231,948
CL0030 Ion_channel 517,835 257,326 75,060
CL0031 Phosphatase 777,923 405,398 95,849
CL0032 Dim_A_B_barrel 555,827 282,242 51,312
CL0033 POZ 360,990 155,364 60,544
CL0036 TIM_barrel 7,563,659 3,895,094 691,598
CL0037 Lysozyme 409,417 221,658 59,380
CL0039 HUP 1,853,693 983,794 170,428
CL0040 tRNA_synt_II 774,050 383,090 54,424
CL0041 Death 106,714 49,348 17,677
CL0042 Flavoprotein 299,084 153,703 26,274
CL0043 Chelatase 268,377 145,861 30,731
CL0044 Ferritin 359,540 176,211 31,354
CL0046 Thiolase 581,758 287,952 53,876
CL0047 CuAO_N2_N3 16,076 7,530 1,369
CL0048 LolA_LolB 140,894 86,159 30,420
CL0050 HotDog 578,385 312,423 64,992
CL0051 NTF2 436,257 258,195 74,064
CL0052 NTN 544,690 265,293 52,637
CL0053 4H_Cytokine 33,857 12,570 3,496
CL0054 Knottin_1 11,510 6,279 2,607
CL0055 Nucleoplasmin 268,163 43,110 15,393
CL0056 C_Lectin 253,817 164,531 71,123
CL0057 Met_repress 249,274 140,170 41,151
CL0059 6_Hairpin 558,095 317,913 83,102
CL0060 DNA_clamp 74,609 33,975 9,422
CL0061 PLP_aminotran 1,688,020 857,170 121,774
CL0062 APC 1,174,683 523,874 102,195
CL0063 NADP_Rossmann 12,589,345 6,731,958 1,297,662
CL0064 CPA_AT 454,188 225,024 45,438
CL0065 Cyclin 147,432 68,313 23,341
CL0066 Trefoil 178,148 88,750 26,452
CL0067 SIS 354,095 156,718 24,313
CL0068 RIIa 16,994 7,975 3,150
CL0069 GFP 6,063 3,038 633
CL0070 ACT 419,209 182,244 25,271
CL0071 His_phosphatase 280,652 149,816 39,427
CL0072 Ubiquitin 1,131,085 539,324 145,151
CL0073 P53-like 81,685 31,382 9,017
CL0074 Matrix 67,115 13,752 1,636
CL0075 Defensin 8,389 3,952 1,195
CL0077 FAD_PCMH 342,109 192,625 33,382
CL0079 Cystine-knot 94,725 31,515 9,607
CL0080 Beta-tent 174,183 96,218 16,986
CL0081 MBD-like 179,396 87,157 27,019
CL0082 MIF 46,243 23,777 4,955
CL0083 Omega_toxin 34,592 17,421 4,794
CL0084 ADP-ribosyl 127,486 73,569 27,928
CL0087 Acyl-CoA_dh 478,585 212,012 24,475
CL0088 Alk_phosphatase 528,398 322,766 80,916
CL0089 GlnB-like 162,357 78,175 14,385
CL0090 Globin 133,688 66,512 14,292
CL0091 NAD_Ferredoxin 253,814 124,750 22,527
CL0092 ADF 73,957 29,771 7,172
CL0093 Peptidase_CD 174,206 121,338 63,477
CL0094 Peptidase_ME 296,361 154,406 32,465
CL0095 Peptidase_ML 23,923 14,296 4,109
CL0096 Pept_Inhib_IE 187 119 57
CL0097 TypeIII_Chap 39,826 20,082 6,580
CL0098 SPOUT 330,884 177,126 32,249
CL0099 ALDH-like 561,799 257,028 32,127
CL0100 C1q_TNF 55,317 24,084 8,602
CL0101 PELOTA 157,314 73,518 14,745
CL0103 Gal_mutarotase 401,770 221,840 52,489
CL0104 Glyoxalase 544,168 308,244 45,003
CL0105 Hybrid 1,600,773 849,669 172,583
CL0106 6PGD_C 632,647 315,661 43,516
CL0108 Actin_ATPase 1,172,138 573,885 128,307
CL0109 CDA 336,678 183,259 33,159
CL0110 GT-A 1,583,375 927,887 278,902
CL0111 GT-C 290,878 188,293 84,128
CL0112 Yip1 46,728 24,060 8,639
CL0113 GT-B 1,407,426 885,711 297,953
CL0114 HMG-box 123,678 54,225 19,939
CL0115 Steroid_dh 107,745 66,245 18,883
CL0116 Calycin 185,290 104,152 34,506
CL0117 uPAR_Ly6_toxin 44,026 20,277 7,193
CL0118 Ribokinase 375,994 203,399 42,281
CL0122 UTRA 98,298 43,251 9,512
CL0123 HTH 11,491,619 5,871,219 1,524,730
CL0124 Peptidase_PA 538,123 279,768 100,478
CL0125 Peptidase_CA 921,611 482,257 177,739
CL0126 Peptidase_MA 1,225,626 700,621 205,540
CL0127 ClpP_crotonase 836,647 405,703 71,134
CL0128 vWA-like 473,221 257,657 77,953
CL0129 Peptidase_AA 580,775 268,965 103,489
CL0130 Peptidase_AD 70,759 41,567 13,641
CL0131 DoxD-like 152,375 93,352 21,106
CL0132 AbrB 94,770 53,670 14,039
CL0133 AT14A-like 15,975 8,083 2,594
CL0135 Arrestin_N-like 57,466 26,386 9,280
CL0136 Plasmid_toxin 181,444 117,977 29,452
CL0137 HAD 1,274,560 666,175 150,820
CL0139 GADPH_aa-bio_dh 745,781 372,858 49,426
CL0140 Viral_NABP 2,110 389 125
CL0141 MtN3-like 80,716 42,984 12,318
CL0142 Membrane_trans 721,798 343,315 54,357
CL0143 B_Fructosidase 150,585 87,558 18,728
CL0144 Periplas_BP 754,417 366,735 88,637
CL0145 Golgi-transport 166,918 62,069 12,707
CL0146 Herpes_glyco 562 110 53
CL0148 Viral_Gag 108,344 29,190 8,610
CL0149 CoA-acyltrans 335,390 197,711 65,513
CL0153 dUTPase 80,576 37,878 6,007
CL0154 C2 455,134 200,910 51,387
CL0155 CBM_14_19 35,745 23,046 12,735
CL0156 Nucleocapsid 37,005 1,144 519
CL0157 Kleisin 42,985 23,992 4,843
CL0158 GH_CE 264,245 158,800 46,754
CL0159 E-set 3,315,312 1,842,533 758,204
CL0161 GAF 663,524 375,286 121,173
CL0163 Calcineurin 616,220 344,625 92,605
CL0164 CUB 93,583 42,556 16,903
CL0165 Cache 250,551 133,501 49,674
CL0166 PRD 32,896 13,385 4,883
CL0167 Zn_Beta_Ribbon 1,243,899 607,057 158,510
CL0168 PAN 74,737 42,778 19,912
CL0169 Rep 123,235 60,354 27,041
CL0170 Peptidase_MD 74,530 44,070 13,584
CL0171 Phospoesterase 162,189 81,746 14,473
CL0172 Thioredoxin 1,691,598 923,401 212,410
CL0173 STIR 117,905 73,488 35,200
CL0174 TetR_C 482,279 262,860 56,835
CL0175 TRASH 174,701 97,604 34,014
CL0176 Chemosens_recp 42,931 31,572 17,920
CL0177 PBP 2,491,580 1,211,374 254,537
CL0178 PUA 313,062 156,796 30,654
CL0179 ATP-grasp 848,868 427,435 77,638
CL0181 ABC-2 517,579 285,051 71,211
CL0182 IT 409,001 201,022 35,930
CL0183 PAS_Fold 871,034 544,107 225,639
CL0184 DMT 760,042 398,231 93,471
CL0186 Beta_propeller 2,948,472 1,542,012 561,465
CL0187 LysM 212,343 128,075 47,053
CL0188 CH 178,538 72,150 18,621
CL0190 HSP20 172,028 93,609 27,418
CL0191 POTRA 102,681 59,761 20,773
CL0192 GPCR_A 1,059,763 496,313 166,166
CL0193 MBB 1,255,222 720,697 240,242
CL0194 DNA_pol_B-like 53,110 26,181 9,131
CL0195 DBL 16,154 9,911 2,130
CL0196 DSRM 218,974 113,135 41,235
CL0197 GME 71,216 35,252 6,760
CL0198 HHH 811,336 418,616 80,871
CL0199 DPBB 493,821 268,409 59,426
CL0200 Prefoldin 37,492 19,198 5,723
CL0201 Peptidase_SH 21,302 11,298 4,444
CL0202 GBD 720,750 392,963 126,227
CL0203 CBD 46,606 28,423 10,140
CL0204 Adhesin 69,157 25,463 10,266
CL0205 Di-copper 35,775 18,627 6,683
CL0207 Rhomboid-like 123,054 70,673 20,335
CL0208 UBC 185,831 77,921 23,571
CL0209 Bet_v_1_like 435,427 237,976 55,858
CL0210 HNOX-like 39,708 20,838 6,551
CL0212 SNARE 7,015 3,079 910
CL0213 ShK-like 17,015 11,727 6,778
CL0214 UBA 259,702 114,398 28,019
CL0217 Rotavirus_VP7 19,300 772 91
CL0219 RNase_H 1,971,123 1,174,844 475,836
CL0220 EF_hand 695,896 314,146 107,237
CL0221 RRM 773,634 340,288 104,359
CL0222 MviN_MATE 329,075 191,031 63,405
CL0223 MACRO 116,861 59,523 14,261
CL0224 DHQS 206,818 102,282 13,738
CL0225 FtsL 55,362 31,046 10,481
CL0226 M6PR 23,956 11,959 4,120
CL0227 Enolase_N 180,694 80,809 9,212
CL0228 Acyltransferase 290,891 156,165 39,194
CL0229 RING 1,368,496 635,187 214,540
CL0230 HO 58,414 30,724 6,422
CL0231 MazG 110,930 59,146 8,532
CL0232 NifU 110,096 53,975 6,663
CL0233 SufE_NifU 138,024 73,019 11,649
CL0234 CTPT 59,543 32,712 8,648
CL0235 PspA 72,354 30,576 7,463
CL0236 PDDEXK 923,319 518,215 167,728
CL0237 HD_PDEase 551,454 311,790 81,681
CL0238 PP2C 277,682 156,289 50,148
CL0239 Insulin 8,498 3,903 1,585
CL0240 PFK 224,931 113,523 22,349
CL0241 ABC_membrane 504,114 259,460 54,869
CL0242 DNA_primase_lrg 8,300 4,530 1,589
CL0243 AEP 39,059 23,425 5,130
CL0244 PGBD 128,566 77,056 26,146
CL0245 EDD 106,744 51,884 10,502
CL0247 2H 65,708 41,796 15,241
CL0248 ParB_Srx 107,357 64,203 18,791
CL0249 Phage_tail_L 6,007 1,829 658
CL0250 GAD 47,682 20,678 1,900
CL0251 MORN 68,741 41,150 20,744
CL0254 THDP-binding 678,414 330,003 38,033
CL0255 ATP_synthase 185,994 90,795 24,620
CL0257 Acetyltrans 1,409,966 833,734 224,719
CL0258 DALR 339,124 172,556 20,514
CL0259 OstA 53,388 31,664 11,228
CL0260 NTP_transf 596,584 340,450 96,813
CL0261 NUDIX 502,769 283,483 63,017
CL0262 Trigger_C 97,696 56,628 18,581
CL0263 His-Me_finger 254,465 148,260 59,564
CL0264 SGNH_hydrolase 336,316 206,515 70,214
CL0265 HIT 152,627 83,898 15,031
CL0266 PH 1,065,434 444,383 106,300
CL0267 S11_L18p 160,254 60,161 10,111
CL0268 Pec_lyase-like 428,166 269,793 118,808
CL0269 Maf 116,930 66,595 11,003
CL0270 Iso_DH 260,117 115,272 11,732
CL0271 F-box 357,967 206,015 98,700
CL0272 RGS 67,990 26,335 7,246
CL0273 CYTH 61,593 36,350 11,196
CL0274 WRKY-GCM1 99,787 58,144 26,724
CL0276 Nucleot_cyclase 752,175 456,496 184,807
CL0277 FAD-oxidase_C 187,694 102,228 18,024
CL0278 AIG2 55,657 31,527 8,865
CL0279 GatB_YqeY 80,916 41,117 5,338
CL0280 PIN 444,314 272,327 74,921
CL0281 CCT 27,464 12,452 3,833
CL0282 Serum_albumin 2,848 1,069 225
CL0283 LigB 53,210 30,666 6,408
CL0284 Allatostatin 241 136 78
CL0285 YycI_YycH 5,326 2,884 1,140
CL0286 GCS 262,672 110,236 15,747
CL0287 Transthyretin 595,974 368,545 134,443
CL0288 DAP_epimerase 112,973 61,696 9,239
CL0289 FBD 150,574 80,786 13,265
CL0290 EPT_RTPC 115,908 57,474 8,647
CL0291 KNTase_C 150,743 99,557 35,786
CL0292 LysE 611,980 321,455 61,625
CL0293 CDC 31,912 14,346 5,105
CL0296 GroES 631,145 309,078 43,112
CL0297 PhoU 79,375 39,527 8,260
CL0298 tRNA_bind_arm 138,292 64,971 6,133
CL0299 Peptidase_SF 186,686 102,127 27,721
CL0300 TAT 30,551 15,747 5,373
CL0301 PA14 32,536 21,822 9,631
CL0302 Arginase 159,530 81,965 15,796
CL0303 H2TH 136,853 62,545 9,285
CL0304 CheY 2,020,516 1,092,662 294,070
CL0305 PTH2 18,909 10,210 2,283
CL0306 HeH 142,551 65,025 19,589
CL0307 FUSC 87,059 42,249 11,441
CL0308 DMSO_reductase 35,863 18,859 3,129
CL0310 DinB 170,785 115,960 24,279
CL0311 SCP2 82,281 44,485 9,731
CL0312 HemS_ChuX 7,796 3,839 844
CL0314 PP-binding 320,257 189,952 74,364
CL0315 Gx_transp 145,989 80,228 19,565
CL0316 Acyl_transf_3 196,030 122,819 50,528
CL0317 Multiheme_cytos 89,953 61,400 20,763
CL0318 Cytochrome-c 369,061 238,109 59,206
CL0319 SHS2 131,655 69,511 17,067
CL0320 PepSY 105,077 57,667 20,814
CL0321 PLAT 36,261 17,320 5,774
CL0322 RND_permease 423,448 222,693 47,132
CL0323 Patatin 272,466 161,081 47,159
CL0324 Homing_endonuc 39,550 24,155 10,545
CL0326 Reo_sigma 3,067 575 226
CL0327 Pilus 84,412 54,809 19,363
CL0328 2heme_cytochrom 591,753 195,073 39,024
CL0329 S5 913,747 415,140 64,541
CL0330 AVL9 50,786 22,091 4,981
CL0331 EpsM 59,423 35,877 14,997
CL0333 gCrystallin 29,626 13,727 4,235
CL0334 THBO-biosyn 163,903 80,877 10,756
CL0335 FumRed-TM 56,640 25,974 4,695
CL0336 FMN-binding 423,070 253,116 62,128
CL0337 RF 127,227 59,459 6,376
CL0339 PFL-like 136,329 59,130 9,718
CL0340 PTase-anion_tr 94,961 41,338 9,745
CL0341 LDH_C 99,672 36,508 4,627
CL0342 TolB_N 100,583 56,359 17,292
CL0343 MHC 140,570 32,154 5,355
CL0344 4Fe-4S 1,074,700 557,627 93,207
CL0345 Aerolisin_ETX 3,319 1,962 1,015
CL0346 Ribo_L29 52,380 22,863 4,361
CL0347 TSPAN_4TM-like 82,856 38,503 13,674
CL0348 Phage_tail 28,381 13,647 6,033
CL0349 SLOG 148,216 82,814 17,928
CL0350 PRC-barrel 131,888 71,128 14,941
CL0351 CHCH 39,365 19,971 5,904
CL0352 EsxAB 64,114 37,362 13,256
CL0353 TIMP-like 26,298 10,353 2,899
CL0354 bBprotInhib 2,962 1,398 388
CL0355 CheC-like 35,792 18,827 4,871
CL0356 AMP_N-like 116,831 60,324 11,233
CL0357 SMAD-FHA 220,686 123,469 45,147
CL0359 Intron-mat_II 151,920 21,310 4,820
CL0360 MTH1187-YkoF 16,764 8,946 1,295
CL0361 C2H2-zf 1,055,602 544,230 241,612
CL0362 RAMPS-Cas5-like 52,423 39,432 15,218
CL0363 H-int 45,769 30,882 14,744
CL0364 Leu-IlvD 564,338 270,363 40,159
CL0365 MurF-HprK_N 218,235 119,149 17,958
CL0366 JAB 120,059 56,884 15,628
CL0367 CI-2 10,960 6,067 2,064
CL0368 PhosC-NucP1 52,887 32,663 10,822
CL0369 GHD 419,708 224,466 45,800
CL0370 Uteroglobin 1,810 1,041 389
CL0371 Inovirus-Coat 825 574 340
CL0373 Phage-coat 73,820 36,076 11,388
CL0374 PEP-carboxyk 65,162 29,539 3,669
CL0375 Transporter 117,675 45,159 13,112
CL0376 Oxa1 126,902 58,504 10,878
CL0377 FAH 141,643 74,584 8,767
CL0378 ANL 769,205 431,052 106,202
CL0379 PgaPase 13,869 7,414 2,029
CL0380 IDO-like 24,763 12,722 2,262
CL0381 Metallo-HOrase 608,744 355,521 72,939
CL0382 DNA-mend 407,147 234,663 80,007
CL0383 PheT-TilS 81,695 46,256 11,362
CL0385 Hydrophilin 8,676 3,819 1,004
CL0387 DHFred 144,141 87,345 13,940
CL0388 FadR-C 235,412 113,343 24,942
CL0389 TRAF 61,307 28,536 10,661
CL0391 CAP_C-like 14,864 7,033 2,401
CL0392 Chaperone-J 314,035 158,739 46,838
CL0394 DsrEFH-like 50,055 27,396 5,197
CL0395 Tubby_C 48,329 24,191 7,952
CL0396 Marvel-like 49,822 23,647 6,494
CL0397 TusA-like 48,741 27,445 4,829
CL0398 RMMBL_DRMBL 77,954 39,047 6,693
CL0399 Asp-glut_race 89,725 49,112 8,482
CL0400 GG-leader 2,678 1,338 694
CL0402 Cdc48_2-like 32,576 13,165 2,686
CL0403 ADC-like 18,480 11,476 2,633
CL0404 BPD_transp_1 1,893,402 893,304 135,934
CL0405 DNA_b-psBarrel 48,649 24,665 10,065
CL0406 YjbJ-CsbD-like 34,953 15,727 2,697
CL0407 TBP-like 182,593 87,474 13,842
CL0408 PUP 221,248 117,516 24,025
CL0409 GAP 174,790 72,822 17,867
CL0410 LEF-8-like 101,712 28,635 4,235
CL0411 Vir 19,918 12,378 4,193
CL0412 Frag1-like 26,315 16,085 5,688
CL0413 Toprim-like 340,540 156,077 29,595
CL0414 TerB 37,411 20,168 5,087
CL0416 Anoctamin-like 59,469 27,605 7,953
CL0417 BIR-like 21,257 11,178 4,884
CL0418 GIY-YIG 129,184 80,749 22,640
CL0419 T3SS-Chaperone 15,406 8,354 3,344
CL0420 GlpM-like 3,268 1,115 271
CL0421 LppaM 11,015 5,412 3,336
CL0422 Fibrinogen_C 63,154 31,030 11,293
CL0423 AhpD-like 126,270 66,342 9,756
CL0424 T3SS-hook 51,896 33,737 15,847
CL0425 ComplexI-N 569,060 186,541 24,626
CL0426 HRDC-like 80,038 39,590 8,258
CL0428 TolA-TonB-Cterm 99,652 65,368 31,406
CL0429 UcrQ-like 3,764 1,960 565
CL0430 CopD_like 76,729 43,372 9,705
CL0431 PF 189,114 72,258 17,907
CL0433 SPFH 203,874 98,317 17,229
CL0435 NPR 7,530 3,433 1,186
CL0436 FliG 62,882 31,865 6,547
CL0437 EF-G_C 248,327 92,091 9,553
CL0439 NusG-like 63,108 27,255 5,386
CL0441 AlbA 50,311 30,552 10,279
CL0442 Tubulin_C 115,371 39,859 6,151
CL0445 SNARE-fusion 97,979 42,212 12,249
CL0446 Bacteriocin_TLN 2,432 1,406 520
CL0447 Hypoth_1 11,792 6,102 1,230
CL0448 Cargo_bd_muHD 43,071 15,254 3,660
CL0449 G-PATCH 53,078 26,729 9,295
CL0451 FnI-like 52,958 22,142 6,948
CL0452 Tropomyosin-lke 23,446 8,749 1,926
CL0453 Apoptosis-Inhib 52,937 23,342 4,499
CL0456 Golgi_traff 8,806 3,738 1,330
CL0457 4HB_MCP 85,158 44,649 14,375
CL0458 IIaaRS-ABD 226,023 107,195 12,520
CL0459 BRCT-like 117,849 62,488 16,909
CL0461 Metallothionein 6,193 2,721 759
CL0462 TPA-repeat 6,285 2,354 589
CL0464 5_3_exonuc_C 85,581 45,066 9,410
CL0465 Ank 696,553 387,059 180,083
CL0466 PDZ-like 539,999 278,729 69,490
CL0469 l-integrase_N 225,816 125,107 35,806
CL0470 ThrE 28,529 13,151 3,482
CL0471 DUF362 36,981 27,156 7,239
CL0472 Peptidase_U 137,334 88,687 38,312
CL0474 SICA_like 976 633 469
CL0475 Cyclophil-like 222,100 116,686 24,168
CL0476 tRNA-IECD_N 9,195 5,313 1,498
CL0477 TRD 63,153 53,922 29,550
CL0478 ATPase_I_AtpR 16,118 8,608 3,291
CL0479 PLD 231,355 126,922 31,251
CL0481 HUH 65,961 43,358 15,093
CL0482 Prolamin 51,306 24,658 8,741
CL0484 Peroxisome 42,043 18,387 5,009
CL0486 Fer2 389,699 200,203 26,060
CL0487 FKBP 368,104 191,753 49,764
CL0488 FixH-like 17,604 11,625 4,278
CL0489 SAF 232,578 128,214 43,389
CL0490 PepSY_TM-like 41,618 24,200 5,563
CL0491 LYR-like 34,284 18,149 5,461
CL0492 S4 303,382 134,825 17,227
CL0493 PTS_EIIC 92,691 31,330 4,505
CL0494 DnaA_N 83,358 41,241 7,779
CL0496 Tad-like 61,640 43,914 17,687
CL0497 GST_C 275,940 139,867 25,492
CL0498 Nribosyltransf 26,212 14,626 4,476
CL0499 O-anti_assembly 87,881 63,396 36,316
CL0500 Glycine-zipper 85,694 42,308 10,745
CL0502 STAS 202,167 116,731 34,352
CL0504 Phage_barrel 164,758 68,597 24,182
CL0505 Pentapeptide 96,679 60,970 28,801
CL0506 Succ_CoA_synth 138,433 57,239 7,839
CL0507 Fungal_trans 258,129 151,615 58,305
CL0508 YkuD 132,547 76,132 18,431
CL0509 RBP11-like 83,548 26,197 4,372
CL0511 Retroviral_zf 212,659 112,142 57,391
CL0512 CRAL_TRIO 92,066 44,261 13,851
CL0513 LCCL-domain 12,695 5,304 1,672
CL0515 LTXXQ-like 22,685 14,252 7,319
CL0516 ISP-domain 206,953 108,988 20,230
CL0517 MBOAT-like 65,342 36,273 10,108
CL0520 Keratin_assoc 6,207 3,933 1,667
CL0521 GOLD-like 46,286 20,222 5,307
CL0522 YbjQ-like 26,592 13,373 2,341
CL0523 GAG-polyprotein 226,208 174,901 98,133
CL0524 MPT63-MPB63 10,038 6,355 3,420
CL0525 pap2 190,872 108,744 34,779
CL0526 SUKH 40,862 23,616 9,551
CL0528 DUF1214 17,911 11,781 2,832
CL0529 FMN-dep-NRtase 163,057 94,347 18,432
CL0530 DNase_I-like 316,250 185,126 68,052
CL0531 AMP-binding_C 569,372 315,523 65,755
CL0532 LIG 21,318 13,096 5,276
CL0533 PRTase-like 376,723 171,603 25,906
CL0534 YjgF-like 158,660 81,709 11,292
CL0535 CBM 15,363 7,890 2,283
CL0536 HEXAPEP 349,198 180,908 30,477
CL0537 CCCH_zf 127,320 58,384 20,635
CL0539 RNase_III 73,720 40,163 9,307
CL0540 GCP 23,673 11,189 4,229
CL0541 SH2-like 155,893 54,890 12,927
CL0542 RAS_GEF_N 45,326 18,367 4,584
CL0543 Viral_gly_cn_dm 53,017 3,686 1,578
CL0544 AcylCoA_ox_dh_N 432,634 189,406 20,200
CL0545 APCOP-app_sub 40,208 18,843 4,808
CL0546 Hexosaminidase 51,888 30,285 8,308
CL0547 GF_recep_C-rich 39,224 15,155 3,123
CL0548 IHF-likeDNA-bdg 116,881 45,283 8,852
CL0550 SRCR 43,082 24,850 10,152
CL0551 BCLiA 19,098 8,003 2,770
CL0552 Hect 84,500 39,332 11,161
CL0559 CBD9-like 41,489 28,230 12,011
CL0560 Chalcone-like 12,861 7,835 2,577
CL0561 LisH 40,230 15,485 4,201
CL0562 Holin-V 1,880 1,175 324
CL0563 Holin-II 3,967 976 395
CL0564 Holin-III 5,467 1,480 555
CL0567 Phage_TACs 24,934 11,751 4,164
CL0568 Man_lectin 18,204 10,552 4,647
CL0570 PPP-I 98,892 54,587 16,498
CL0571 30K_movement 9,277 3,051 1,298
CL0572 TIKI 44,688 28,418 9,530
CL0573 KA1-like 43,007 17,404 4,557
CL0576 STARBD 15,028 7,931 2,922
CL0577 Paramyxovirin_C 646 69 34
CL0578 AbiEI 7,591 5,108 1,973
CL0580 YqgF 74,407 36,783 5,673
CL0582 TrkA_C 134,406 66,439 12,127
CL0584 FF 15,423 6,360 1,812
CL0586 CTC1 1,897 864 386
CL0587 STAND_N 7,512 6,013 3,545
CL0588 Ribos_L15p_L18e 63,016 27,602 3,375
CL0589 KIX_like 10,970 6,151 2,215
CL0590 OML_zippers 5,572 1,540 722
CL0591 TKC_like 307,758 141,325 11,869
CL0592 beta_Roll 68,322 55,237 37,989
CL0593 G5 18,349 11,454 4,437
CL0595 Fusion_gly 27,239 3,070 1,495
CL0596 VPS23_C 17,297 7,399 2,241
CL0597 Post-HMGL 109,319 45,800 3,375
CL0598 B_GA 8,498 5,066 3,539
CL0599 GH57_38_middle 36,805 20,956 5,220
CL0600 S15_NS1 141,942 24,496 2,451
CL0601 Cob_adeno_trans 33,744 17,311 2,432
CL0602 Kringle 35,637 14,321 4,262
CL0603 AA_dh_N 260,218 121,154 14,042
CL0604 post-AAA 147,417 75,914 13,787
CL0605 ssDNA_NP_VP 17,220 4,120 1,240
CL0606 Phage_fibre 19,435 8,680 2,792
CL0607 TNF_receptor 53,158 24,474 7,213
CL0608 Reductase_C 233,251 109,146 13,211
CL0609 sPC4_like 33,860 15,114 4,522
CL0611 Hexon 16,470 2,436 789
CL0612 PHM_PNGase_F 21,035 12,516 4,921
CL0613 Terp_synthase 343,434 193,053 42,550
CL0614 L27 31,442 11,106 1,879
CL0615 ALDC 33,361 17,384 4,840
CL0616 SPOC 47,552 23,038 6,176
CL0617 Peroxidase 112,768 58,497 14,438
CL0618 MCR 5,650 969 148
CL0619 Mog1p_PsbP 29,249 16,227 5,237
CL0620 Antihemostatic 3,548 1,746 969
CL0621 Colipase 16,272 9,323 4,814
CL0622 Acylphosphatase 86,518 50,038 11,629
CL0623 SRP9_14 7,603 3,632 985
CL0625 eIF4e 20,060 9,375 3,066
CL0626 Levi_coat 412 96 40
CL0627 Antibiotic_NAT 11,340 6,768 1,646
CL0628 EspA_CesA 934 185 74
CL0629 PLA2 23,637 11,751 4,611
CL0630 PSI 61,980 25,388 5,450
CL0631 YgaC_TfoX-N 86,851 57,741 10,548
CL0632 FERM_M 120,406 50,131 10,042
CL0633 NusB 73,476 39,847 7,791
CL0634 CheY-binding 8,218 4,146 818
CL0635 DmpA_ArgJ 183,557 103,867 18,282
CL0636 Leukocidin 4,168 1,733 388
CL0637 KaiA_RbsU 2,444 1,394 335
CL0639 Rof 9,380 4,801 1,425
CL0640 Colicin_D_E5 551 452 374
CL0642 SOCS_box 36,051 12,048 3,302
CL0643 YqbG 12,758 6,371 2,653
CL0644 Fz 49,699 18,731 5,426
CL0645 Anti-sigma_N 56,850 38,616 17,487
CL0646 T3SS 4,702 1,587 478
CL0647 FG_rpt 9,670 5,179 2,005
CL0648 Aha1_BPI 55,433 28,535 9,665
CL0649 PseudoU_synth 363,463 199,027 38,682
CL0650 AOC_barrel 29,437 17,008 4,949
CL0651 Mad2 22,439 10,246 3,441
CL0652 S24e_L23_L15e 66,998 24,393 2,731
CL0653 VCCI 927 146 71
CL0654 WYL 80,232 46,074 10,576
CL0655 PilP 18,887 11,948 4,830
CL0656 VSA 5,031 3,734 581
CL0658 OB_enterotoxin 2,706 868 323
CL0659 CAP 89,756 57,709 26,324
CL0660 SHOCT 61,831 37,176 11,857
CL0661 Gain 89,827 41,677 12,198
CL0662 Triple_barrel 37,947 20,322 7,179
CL0663 CNF1_YfiH 47,358 29,002 6,813
CL0664 UB2H 91,462 40,364 5,024
CL0665 BET 18,137 7,881 2,262
CL0666 Vault 2,090 873 267
CL0667 Fer2_BFD 106,391 51,098 7,033
CL0668 Pre-PUA 25,604 11,742 2,659
CL0669 NOG1_N 10,884 5,257 1,708
CL0670 4PPT 72,113 43,172 14,184
CL0671 AAA_lid 1,240,650 590,942 96,416
CL0672 p35 119,280 68,236 19,132
CL0673 GYF 28,931 16,598 6,759
CL0674 Triple_B_spiral 1,677 254 135
CL0676 SLATT 8,914 5,925 2,836
CL0677 GHMP_C 122,015 66,550 13,122
CL0678 CLIP 6,116 4,076 1,986
CL0679 TACC 7,341 2,946 1,020
CL0680 WW 99,408 47,385 13,597
CL0681 HAMP 492,694 274,095 90,054
CL0682 MBG 7,154 6,321 5,018
CL0683 MICOS 2,668 1,411 461
CL0684 NFACT_RNA-bind 27,121 15,626 4,094
CL0685 AmpE_CobD-like 25,833 13,712 2,234
CL0686 aG_PT 1,876 1,208 488
CL0687 Zn_chelatase 11,971 9,474 5,035
CL0688 BECR 4,691 3,203 2,041
CL0689 TSP3 42,251 28,109 16,450
CL0690 TrbC_VirB2 32,882 17,518 8,364
CL0691 Tail_Terminator 26,063 12,058 5,065
CL0692 TSP1 95,642 42,663 13,949
CL0693 Cas9_lobe 2,152 1,599 728
CL0694 Choline_binding 17,438 8,608 4,889
CL0695 EndoU 13,681 4,637 2,151
CL0696 Vmethyltransf 9,907 1,960 948
CL0697 SDH_beta 85,098 40,049 6,228
CL0698 TrbL 17,156 6,941 2,388
CL0700 ArdcN 20,663 10,313 3,760
CL0701 NAD_kinase_C 135,110 70,103 15,415
CL0702 UIM 19,308 7,358 2,027
CL0703 YtcA 8,749 2,815 617
CL0704 HMA 221,338 123,107 24,585
CL0705 VBS-like 40,766 14,772 3,847
CL0706 EMC6 9,249 4,377 1,311
CL0707 Saposin_like 14,182 6,922 2,407
CL0708 Polo-box 9,092 3,612 1,207
CL0709 STING 1,812 1,007 458
CL0710 YeeE 42,281 26,483 3,619
CL0713 Acyl-CoA_desat 192,488 102,007 19,557
CL0714 COX1-like 1,820,284 168,534 28,431
CL0715 Nckap1_CYFIP1-2 13,123 4,245 1,580
CL0716 Aquaporin-like 117,700 53,978 11,429
CL0717 YbaB 42,272 20,592 3,730
CL0718 Perilipin_sf 7,603 3,702 1,085
CL0719 Moesin_tail 10,169 2,139 419
CL0720 Lag3_N 1,922 1,030 323
CL0721 LAMP 8,415 3,913 1,100
CL0722 SDH_alpha 71,242 34,583 6,089
CL0723 TRADD-N 4,587 1,837 617
CL0724 Kinetochore 14,959 7,789 2,787
CL0725 Apolipoprotein 7,780 3,768 1,237
CL0726 Resistin 1,408 674 178
CL0727 Nucleosidase 49,139 26,491 6,330
CL0728 Cas2 34,206 21,707 4,569
CL0729 Kre28-like_sf 1,982 1,050 336
CL0730 IL8 25,556 13,088 4,086
CL0731 SPOCS 6,875 4,055 1,582
CL0732 RMP1-like 3,370 2,030 913
CL0733 Ribosomal_L25 87,205 45,869 7,232
CL0734 Rpp14-Pop5-like 8,578 5,068 1,894
CL0735 GatC-like 38,179 20,071 3,749
CL0736 Get5_C_sf 857 378 124
CL0737 Mtd 4,817 2,465 1,077
CL0738 Arg_repressor_C 34,092 15,216 2,132
CL0740 GCV_T_C 300,249 112,950 14,854
CL0741 RGM 35,022 20,630 8,823
CL0742 PTS_IIA-like 5,297 2,598 680
CL0743 Spectrin 95,023 39,369 9,777
CL0745 MIT 34,344 13,637 3,373
CL0746 AFF4_CHD 7,046 2,965 821
CL0747 THUMP 54,492 25,506 5,303
CL0748 DNA_prim_N 53,612 29,674 7,584
CL0749 GH127_M 39,208 24,934 5,759
CL0750 ADAM_CR_sf 59,421 25,981 5,794
CL0751 Secretin_N0 91,689 53,481 21,810
CL0752 PsbQ-like 27,819 14,547 3,555
CL0753 ATPD-E_C 33,832 9,545 1,302
CL0754 PGM_I-III 145,441 70,994 10,124
CL0755 SASP 12,605 5,457 1,311
CL0756 GMC 2,888 954 211
CL0757 TRAP 4,185 1,889 594
CL0758 L31 48,785 18,521 2,177
CL0759 Nop_N_sf 9,810 4,052 699
CL0760 RBG 116,320 66,994 28,373
CL0761 ABC_sf 181 28 24
CL0762 GlyR 60,639 30,363 6,687
CL0763 GpW_gp25-like 52,989 23,244 5,196
CL0764 PHP14-like 36,411 16,172 2,151
CL0765 PAC 6,882 3,851 1,413
CL0766 NCPF 9,034 5,355 1,333
CL0767 MXAN_049 4,740 3,242 1,519
CL0768 DUF960 2,152 1,083 408
CL0769 SsdA_imm 4,648 3,150 818
CL0770 GH84_C 3,386 1,816 573
CL0771 UDG-like 133,050 77,729 12,089
CL0772 YqiB 5,494 2,358 713
CL0773 STD 2,401 1,439 537
CL0774 MTHFR_C-like 6,503 2,620 514
CL0775 MlaD-like 90,620 48,492 9,971
CL0776 PBP_NTD 105,671 55,432 10,897
CL0777 XRCC4_N 7,979 4,313 1,711
CL0778 BON 54,056 31,388 9,913
CL0779 Head_shaft 21,666 13,092 4,805
CL0780 LppM-like 2,425 1,430 580
CL0781 NadN_C 58,510 30,833 8,018
CL0782 BBOX 109,082 52,525 16,100
CL0783 WWE 28,672 13,310 4,744
CL0785 VPS9 22,783 10,901 3,198
CL0786 H-NS_histone_C 17,021 6,814 1,594
CL0787 NADAR-like 15,054 9,438 3,537
CL0788 CorA-like 83,937 43,654 12,671
CL0789 SUD_C-like 4,562 227 13
CL0790 Cas9_WED-like 386 214 61
CL0791 Ago_N 24,466 10,585 2,975
CL0792 MLKL_N-like 15,765 7,337 2,157
CL0793 GspE_N-like 57,746 34,541 6,902
CL0794 Mur_ligase_C_sf 239,050 135,201 23,273
CL0795 NSUN_ferredox 45,266 24,210 4,997
CL0796 Mu-transpos_C 30,254 17,593 5,821
CL0797 RXXXE-like 3,143 2,682 1,852
CL0798 INSIG-like 14,851 8,674 2,339
CL0799 PRMT_C 28,144 11,269 3,084
CL0800 LiaI-LiaF-TM 13,957 9,730 4,184
CL0801 OST_core 10,259 4,705 1,315
CL0802 MinC_N 11,746 5,400 994
CL0803 PBP_GOBP 13,960 9,401 4,684
CL0804 PurM_N-like 161,453 84,636 9,684
CL0805 PWI-like 44,575 18,953 3,486
CL0806 SNaCT 3,116 1,276 338
CL0807 WY-like 5,152 2,925 1,872
CL0808 Sufu_N 14,199 7,450 2,634
CL0809 CXC 46,717 22,361 6,923
CL0810 GRIP-like 12,117 5,616 2,116
CL0812 YKT-like_S 30,837 18,418 7,286
CL0813 COMMD_HN 8,884 3,900 1,165
CL0814 Brichos_S 9,710 3,759 1,107
CL0815 BACOVA_03322_C 1,574 860 276
CL0816 TBC-like 113,729 48,825 14,007
CL0817 SPMIP5_TBD 2,668 1,508 496
CL0818 GT-D-like 1,565 1,027 598
CL0819 TIL 21,815 14,379 7,050
CL0820 RBAF-like 3,076 1,673 539
CL0821 C4-like 64,921 34,510 8,351
CL0822 WIV 710 97 47
CL0823 XPD_ARCH 9,242 4,322 1,260
CL0824 HHD 5,014 1,835 421
CL0825 CTLH 25,753 10,876 3,136
CL0826 NuiA-like 1,768 1,256 496
CL0827 bHLH 236,011 99,370 30,160
CL0828 PABC-like 18,672 7,492 1,898
CL0829 PAH 16,917 8,634 3,156
CL0831 SAND 12,648 4,897 1,563
CL0832 CobW_C 51,358 24,514 4,281
CL0833 Nup120_hel_sf 3,352 1,450 385
CL0834 BAAB_hairpin 5,664 3,203 1,221
CL0835 MYCPN_LP 137 43 26
CL0836 TMEM126 1,704 883 339
CL0838 Phage_portal 65,244 32,816 12,987
CL0839 Tbcl_zf 551,312 229,089 54,398
CL0840 H_lectin 9,536 5,572 2,943
CL0841 Wzc_PBSD 12,017 5,096 1,066
CL0842 UPA-like 13,543 4,698 1,342
CL0843 MFPT-like 6,024 4,333 2,028
CL0844 Matrix_Mononaga 3,436 302 88
CL0845 Beta_tulip 7,112 3,507 1,401
CL0846 HVO_1158-like 1,140 794 321
CL0847 Ice_binding 10,317 8,145 4,413
CL0848 YphA 3,281 2,170 710
CL0849 3b-a_propeller 5,818 4,074 2,489
CL0850 INO80_complex 5,207 2,619 985
CL0851 YhhM-like 3,343 1,474 444
CL0852 DH-like 142,610 63,952 15,962
CL0853 TMD0-like 15,554 7,787 1,727
CL0854 DGR_Avd-like 38,127 29,825 6,588
CL0855 TMMD-like 13,662 9,017 4,288
CL0856 Imm33 2,871 1,698 598
CL0857 APA-like 892 626 183
CL0858 ColE3imm-like 1,004 686 285
CL0859 DMP12-like 3,307 2,118 1,012
CL0860 LMG18311-like 1,454 659 263
CL0861 MavL-like_sf 873 615 277
CL0862 LTE-like 25,298 14,881 4,612
CL0864 NACHT_N 11,668 9,417 5,318
CL0865 ZnExoPePases 761,665 423,477 90,058
CL0866 ALR_C-like 960,564 371,594 52,876
CL0867 NqrA_FMN-like 79,119 40,546 4,236
CL0868 p22phox-like 2,217 1,102 229
CL0869 AraA_N-like 13,341 5,592 579
CL0870 EXR-like 23,954 17,858 11,128
CL0871 YefM-like 59,249 37,418 9,329
CL0872 PfC-like 24,931 14,050 4,389
CL0873 RBM_T3SS-Flag 31,328 16,679 4,691
CL0874 PMD-like 41,246 31,382 14,304
CL0875 MscS_C_sf 85,404 48,677 12,501
CL0876 SLD5_C-like 14,154 6,248 1,782
CL0877 RHS_sf 52,259 37,342 21,503
CL0878 CamS-like 2,544 1,077 241
CL0879 R3H-like 48,626 24,811 5,955
CL0880 SLC44-like 40,346 19,341 5,672
CL0881 SUEL-RBL_sf 27,623 13,156 3,880
CL0882 Agd3_CE_sf 6,572 1,979 507
CL0883 CBM87 6,273 1,843 438
CL0884 MmeI_HD-like 44,829 27,125 3,884
CL0885 L9_N_sp 58,448 31,045 7,508
CL0886 ADH_DHQS_C-like 131,990 65,708 10,136
CL0887 MliC_ACP-like 8,066 4,039 1,700
CL0888 CoiA_N-like 5,525 2,975 1,645
CL0889 DmsR_N-like 10,849 6,743 1,990
CL0890 Haemocyanin_C 3,931 2,217 760
CL0891 Cry1_MapZ 1,881 773 396
CL0892 SNYG 4,528 2,828 1,212
CL0893 AD 18,879 8,171 1,414
CL0894 BPTI 35,352 20,382 9,369
CL0895 DnaJ_CRD 75,293 31,937 4,107
CL0896 Pseudo_EF-hand 12,350 5,205 1,097
CL0897 Bestrophin 36,148 20,501 7,185
CL0898 AraD-like 102,721 49,602 8,226
CL0899 HR1 19,990 7,194 1,148

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