EFI - Enzyme Similarity Tool

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RadicalSAM.org, our resource for investigating sequence-function space in the radical SAM superfamily, has been updated with sequences from the UniProt Release 2024_01 and InterPro Release 98 databases (January 24, 2024) !!

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Pfam Clans

These data are sourced from the UniProt and EMBL-EBI InterPro databases.

Download as tab-separated text file.
Clan ID Clan Short Name Clan Size UniRef90 Size UniRef50 Size
CL0001 EGF 431,306 191,100 67,944
CL0003 SAM 239,958 96,031 21,494
CL0004 Concanavalin 737,130 403,275 137,809
CL0005 Kazal 57,747 24,518 9,232
CL0007 KH 380,385 157,415 27,966
CL0010 SH3 2,098,319 972,325 263,725
CL0012 Histone 211,348 73,882 24,903
CL0013 Beta-lactamase 592,536 339,347 86,721
CL0014 Glutaminase_I 777,409 398,162 60,822
CL0015 MFS 2,321,166 1,166,190 272,531
CL0016 PKinase 2,774,549 1,436,025 490,594
CL0018 bZIP 122,358 53,287 18,632
CL0020 TPR 3,584,881 1,914,331 732,143
CL0021 OB 2,355,016 1,041,998 186,250
CL0022 LRR 889,748 484,762 209,359
CL0023 P-loop_NTPase 12,757,080 6,310,280 1,410,716
CL0025 His_Kinase_A 1,897,525 1,145,972 408,643
CL0026 CU_oxidase 339,153 152,306 36,547
CL0027 RdRP 1,041,232 523,011 249,014
CL0028 AB_hydrolase 2,350,420 1,391,854 375,477
CL0029 Cupin 1,703,308 929,351 230,206
CL0030 Ion_channel 513,431 254,345 74,164
CL0031 Phosphatase 772,001 400,940 95,111
CL0032 Dim_A_B_barrel 556,572 281,635 51,086
CL0033 POZ 354,455 151,670 59,393
CL0036 TIM_barrel 7,564,560 3,882,645 689,043
CL0037 Lysozyme 410,934 221,437 59,303
CL0039 HUP 1,851,456 979,231 169,759
CL0040 tRNA_synt_II 774,089 381,731 54,263
CL0041 Death 105,653 48,514 17,286
CL0042 Flavoprotein 299,749 153,291 26,278
CL0043 Chelatase 269,045 145,394 30,676
CL0044 Ferritin 359,683 175,649 31,308
CL0046 Thiolase 582,064 287,717 53,869
CL0047 CuAO_N2_N3 15,915 7,447 1,346
CL0048 LolA_LolB 140,721 85,854 30,348
CL0050 HotDog 579,099 311,783 65,008
CL0051 NTF2 436,266 257,256 73,856
CL0052 NTN 543,341 264,008 52,392
CL0053 4H_Cytokine 33,693 12,499 3,458
CL0054 Knottin_1 11,137 6,020 2,529
CL0055 Nucleoplasmin 274,823 44,437 15,919
CL0056 C_Lectin 252,252 163,089 70,383
CL0057 Met_repress 247,627 139,014 40,957
CL0059 6_Hairpin 555,838 316,006 82,660
CL0060 DNA_clamp 74,467 33,851 9,360
CL0061 PLP_aminotran 1,688,917 854,638 121,250
CL0062 APC 1,172,163 520,743 101,565
CL0063 NADP_Rossmann 12,510,590 6,682,399 1,290,759
CL0064 CPA_AT 453,502 223,761 45,178
CL0065 Cyclin 144,579 66,917 23,023
CL0066 Trefoil 177,241 87,876 26,144
CL0067 SIS 354,865 156,419 24,271
CL0068 RIIa 16,826 7,853 3,113
CL0069 GFP 6,021 2,993 624
CL0070 ACT 418,960 181,492 25,202
CL0071 His_phosphatase 280,287 149,179 39,247
CL0072 Ubiquitin 1,103,451 527,189 142,409
CL0073 P53-like 78,787 29,819 8,437
CL0074 Matrix 67,090 13,446 1,613
CL0075 Defensin 8,363 3,924 1,200
CL0077 FAD_PCMH 341,625 191,896 33,260
CL0079 Cystine-knot 93,910 30,904 9,543
CL0080 Beta-tent 170,577 94,594 16,449
CL0081 MBD-like 175,899 85,109 26,558
CL0082 MIF 46,294 23,729 4,855
CL0083 Omega_toxin 34,446 17,350 4,775
CL0084 ADP-ribosyl 127,229 73,290 27,870
CL0087 Acyl-CoA_dh 479,308 211,551 24,430
CL0088 Alk_phosphatase 527,751 321,451 80,587
CL0089 GlnB-like 162,488 78,000 14,348
CL0090 Globin 133,626 66,219 14,333
CL0091 NAD_Ferredoxin 253,858 124,312 22,395
CL0092 ADF 73,094 29,322 7,111
CL0093 Peptidase_CD 173,445 120,785 63,247
CL0094 Peptidase_ME 296,302 153,907 32,342
CL0095 Peptidase_ML 23,998 14,280 4,103
CL0096 Pept_Inhib_IE 184 117 57
CL0097 TypeIII_Chap 39,853 20,015 6,565
CL0098 SPOUT 330,899 176,536 32,038
CL0099 ALDH-like 562,668 256,585 31,985
CL0100 C1q_TNF 54,448 23,403 8,381
CL0101 PELOTA 156,849 73,173 14,666
CL0103 Gal_mutarotase 401,593 221,109 52,367
CL0104 Glyoxalase 545,304 307,595 44,976
CL0105 Hybrid 1,624,680 860,340 174,159
CL0106 6PGD_C 633,413 314,831 43,343
CL0108 Actin_ATPase 1,171,806 571,969 127,919
CL0109 CDA 334,880 182,027 32,900
CL0110 GT-A 1,577,767 922,915 277,728
CL0111 GT-C 290,193 187,456 83,937
CL0112 Yip1 46,503 23,901 8,608
CL0113 GT-B 1,400,382 880,740 296,983
CL0114 HMG-box 122,328 53,423 19,670
CL0115 Steroid_dh 107,353 65,906 18,851
CL0116 Calycin 184,831 103,496 34,325
CL0117 uPAR_Ly6_toxin 43,579 19,983 7,137
CL0118 Ribokinase 376,346 202,797 42,206
CL0122 UTRA 98,987 43,306 9,501
CL0123 HTH 11,468,495 5,835,274 1,512,498
CL0124 Peptidase_PA 534,210 277,674 99,424
CL0125 Peptidase_CA 914,810 477,195 176,088
CL0126 Peptidase_MA 1,220,568 694,797 203,695
CL0127 ClpP_crotonase 836,807 404,500 70,911
CL0128 vWA-like 471,100 255,761 77,553
CL0129 Peptidase_AA 577,488 265,806 102,232
CL0130 Peptidase_AD 70,444 41,278 13,560
CL0131 DoxD-like 152,392 93,088 21,032
CL0132 AbrB 94,564 53,478 13,947
CL0133 AT14A-like 15,219 7,696 2,529
CL0135 Arrestin_N-like 57,089 26,179 9,208
CL0136 Plasmid_toxin 181,945 117,988 29,418
CL0137 HAD 1,271,132 662,237 149,971
CL0139 GADPH_aa-bio_dh 746,267 371,883 49,283
CL0140 Viral_NABP 2,110 386 119
CL0141 MtN3-like 79,379 42,245 12,152
CL0142 Membrane_trans 723,716 342,787 54,314
CL0143 B_Fructosidase 150,605 87,358 18,725
CL0144 Periplas_BP 755,226 365,388 88,364
CL0145 Golgi-transport 165,797 61,402 12,619
CL0146 Herpes_glyco 562 110 52
CL0148 Viral_Gag 108,003 28,650 8,425
CL0149 CoA-acyltrans 333,913 196,232 65,268
CL0153 dUTPase 80,629 37,794 5,978
CL0154 C2 449,488 197,765 50,681
CL0155 CBM_14_19 34,975 22,519 12,469
CL0156 Nucleocapsid 37,003 1,138 520
CL0157 Kleisin 42,874 23,855 4,824
CL0158 GH_CE 264,713 158,513 46,653
CL0159 E-set 3,274,400 1,814,332 748,802
CL0161 GAF 663,272 373,614 120,617
CL0163 Calcineurin 614,814 342,993 92,313
CL0164 CUB 92,713 42,029 16,581
CL0165 Cache 251,587 133,406 49,650
CL0166 PRD 33,182 13,412 4,895
CL0167 Zn_Beta_Ribbon 1,237,797 602,770 157,557
CL0168 PAN 72,887 41,673 19,570
CL0169 Rep 123,233 60,164 26,813
CL0170 Peptidase_MD 74,745 44,009 13,558
CL0171 Phospoesterase 161,931 81,357 14,422
CL0172 Thioredoxin 1,686,300 918,128 211,476
CL0173 STIR 115,887 71,927 34,741
CL0174 TetR_C 485,310 262,829 56,815
CL0175 TRASH 173,014 96,551 33,800
CL0176 Chemosens_recp 41,841 30,685 17,391
CL0177 PBP 2,500,536 1,209,579 254,106
CL0178 PUA 312,134 155,893 30,401
CL0179 ATP-grasp 849,128 426,142 77,272
CL0181 ABC-2 516,967 283,759 70,861
CL0182 IT 409,440 200,347 35,905
CL0183 PAS_Fold 871,245 542,205 225,017
CL0184 DMT 756,949 395,505 93,023
CL0186 Beta_propeller 2,922,427 1,528,236 557,413
CL0187 LysM 212,533 127,763 46,970
CL0188 CH 176,814 70,959 18,306
CL0190 HSP20 169,963 92,390 27,154
CL0191 POTRA 102,954 59,701 20,751
CL0192 GPCR_A 1,050,770 490,537 163,954
CL0193 MBB 1,261,168 720,736 240,160
CL0194 DNA_pol_B-like 52,423 25,745 9,019
CL0195 DBL 16,154 9,915 2,087
CL0196 DSRM 215,803 110,969 40,060
CL0197 GME 71,360 35,150 6,768
CL0198 HHH 811,078 417,008 80,389
CL0199 DPBB 493,319 267,397 59,232
CL0200 Prefoldin 36,961 18,935 5,682
CL0201 Peptidase_SH 21,381 11,334 4,427
CL0202 GBD 713,130 388,670 125,185
CL0203 CBD 46,616 28,331 10,093
CL0204 Adhesin 69,092 25,158 10,089
CL0205 Di-copper 35,429 18,399 6,628
CL0207 Rhomboid-like 122,447 70,212 20,192
CL0208 UBC 183,358 76,804 23,037
CL0209 Bet_v_1_like 432,575 235,868 55,298
CL0210 HNOX-like 39,473 20,719 6,533
CL0212 SNARE 6,963 3,067 905
CL0213 ShK-like 16,619 11,464 6,688
CL0214 UBA 256,565 112,666 27,698
CL0217 Rotavirus_VP7 19,300 769 88
CL0219 RNase_H 1,958,179 1,162,835 469,961
CL0220 EF_hand 677,114 305,984 105,173
CL0221 RRM 761,919 334,470 102,933
CL0222 MviN_MATE 327,875 189,860 63,167
CL0223 MACRO 116,447 59,064 14,098
CL0224 DHQS 207,115 102,032 13,702
CL0225 FtsL 55,508 31,048 10,476
CL0226 M6PR 23,721 11,788 4,082
CL0227 Enolase_N 180,557 80,594 9,198
CL0228 Acyltransferase 290,738 155,543 39,020
CL0229 RING 1,342,725 620,780 210,853
CL0230 HO 58,496 30,607 6,402
CL0231 MazG 111,107 59,049 8,483
CL0232 NifU 109,875 53,734 6,632
CL0233 SufE_NifU 137,874 72,772 11,591
CL0234 CTPT 59,537 32,667 8,638
CL0235 PspA 71,540 30,188 7,163
CL0236 PDDEXK 920,423 514,347 165,830
CL0237 HD_PDEase 551,748 311,111 81,444
CL0238 PP2C 276,653 155,246 49,954
CL0239 Insulin 8,400 3,844 1,553
CL0240 PFK 224,247 112,861 22,213
CL0241 ABC_membrane 503,679 258,421 54,622
CL0242 DNA_primase_lrg 8,180 4,447 1,565
CL0243 AEP 39,103 23,366 5,130
CL0244 PGBD 128,751 76,871 26,137
CL0245 EDD 107,160 51,815 10,506
CL0247 2H 65,557 41,587 15,181
CL0248 ParBc 134,325 79,798 24,794
CL0249 Phage_tail_L 6,076 1,840 655
CL0250 GAD 47,767 20,642 1,910
CL0251 MORN 68,197 40,823 20,655
CL0254 THDP-binding 678,554 329,191 37,898
CL0255 ATP_synthase 185,920 90,581 24,605
CL0257 Acetyltrans 1,408,750 828,635 222,990
CL0258 DALR 339,302 172,097 20,457
CL0259 OstA 53,563 31,686 11,245
CL0260 NTP_transf 596,538 339,458 96,536
CL0261 NUDIX 502,768 282,403 62,822
CL0262 Trigger_C 98,049 56,604 18,517
CL0263 His-Me_finger 254,928 148,124 59,441
CL0264 SGNH_hydrolase 333,153 204,476 69,945
CL0265 HIT 152,468 83,500 14,980
CL0266 PH 1,049,742 435,999 104,346
CL0267 S11_L18p 159,530 59,791 10,048
CL0268 Pec_lyase-like 426,087 268,007 118,480
CL0269 Maf 116,980 66,410 10,976
CL0270 Iso_DH 260,338 115,054 11,714
CL0271 F-box 346,575 198,967 96,719
CL0272 RGS 67,530 26,010 7,148
CL0273 CYTH 61,450 36,182 11,177
CL0274 WRKY-GCM1 96,460 56,224 26,069
CL0276 Nucleot_cyclase 754,436 455,955 184,577
CL0277 FAD-oxidase_C 187,093 101,632 17,967
CL0278 AIG2 55,511 31,395 8,798
CL0279 GatB_YqeY 80,915 41,010 5,337
CL0280 PIN 439,685 268,813 73,710
CL0281 CCT 26,331 11,887 3,769
CL0282 Serum_albumin 2,837 1,059 223
CL0283 LigB 53,203 30,612 6,401
CL0284 Allatostatin 239 135 75
CL0285 YycI_YycH 5,366 2,885 1,139
CL0286 GCS 262,729 110,025 15,693
CL0287 Transthyretin 594,676 367,275 133,916
CL0288 DAP_epimerase 113,219 61,537 9,219
CL0289 FBD 150,591 80,613 13,244
CL0290 EPT_RTPC 116,082 57,320 8,603
CL0291 KNTase_C 150,759 99,277 35,671
CL0292 LysE 613,599 320,938 61,563
CL0293 CDC 31,556 14,137 5,047
CL0296 GroES 630,937 307,972 42,940
CL0297 PhoU 79,210 39,360 8,238
CL0298 tRNA_bind_arm 138,545 64,829 6,145
CL0299 Peptidase_SF 187,136 102,014 27,573
CL0300 TAT 30,474 15,666 5,338
CL0301 PA14 32,608 21,801 9,610
CL0302 Arginase 159,011 81,532 15,745
CL0303 H2TH 136,887 62,378 9,237
CL0304 CheY 2,025,108 1,091,493 293,704
CL0305 PTH2 18,760 10,121 2,359
CL0306 HeH 141,540 64,253 19,310
CL0307 FUSC 87,112 41,966 11,376
CL0308 DMSO_reductase 35,896 18,833 3,137
CL0310 DinB 171,574 115,971 24,257
CL0311 SCP2 82,526 44,376 9,685
CL0312 HemS_ChuX 7,835 3,837 845
CL0314 PP-binding 321,693 190,057 74,538
CL0315 Gx_transp 146,386 80,137 19,596
CL0316 Acyl_transf_3 196,248 122,524 50,474
CL0317 Multiheme_cytos 90,021 61,388 20,767
CL0318 Cytochrome-c 369,607 238,019 59,157
CL0319 SHS2 131,544 69,205 17,026
CL0320 PepSY 105,016 57,332 20,700
CL0321 PLAT 35,600 16,921 5,660
CL0322 RND_permease 424,367 222,319 47,003
CL0323 Patatin 272,430 160,659 47,200
CL0324 Homing_endonuc 39,490 24,058 10,521
CL0326 Reo_sigma 3,067 577 224
CL0327 Pilus 84,546 54,677 19,345
CL0328 2heme_cytochrom 591,480 194,437 38,855
CL0329 S5 913,160 413,778 64,207
CL0330 AVL9 50,396 21,761 4,887
CL0331 EpsM 59,668 35,866 14,995
CL0333 gCrystallin 29,470 13,609 4,234
CL0334 THBO-biosyn 164,167 80,708 10,715
CL0335 FumRed-TM 56,651 25,878 4,681
CL0336 FMN-binding 424,066 252,715 62,053
CL0337 RF 127,261 59,314 6,298
CL0339 PFL-like 136,602 59,046 9,715
CL0340 PTase-anion_tr 95,249 41,272 9,715
CL0341 LDH_C 99,469 36,324 4,583
CL0342 TolB_N 101,105 56,363 17,293
CL0343 MHC 140,403 32,067 5,273
CL0344 4Fe-4S 1,075,507 556,498 92,994
CL0345 Aerolisin_ETX 3,286 1,944 1,006
CL0346 Ribo_L29 52,239 22,768 4,316
CL0347 TSPAN_4TM-like 81,752 37,868 13,513
CL0348 Phage_tail 28,575 13,697 6,044
CL0349 SLOG 148,208 82,573 17,840
CL0350 PRC-barrel 131,995 70,972 14,917
CL0351 CHCH 38,847 19,695 5,833
CL0352 EsxAB 60,345 33,987 11,587
CL0353 TIMP-like 24,651 9,688 2,727
CL0354 bBprotInhib 2,979 1,399 390
CL0355 CheC-like 35,840 18,794 4,863
CL0356 AMP_N-like 116,760 60,117 11,191
CL0357 SMAD-FHA 219,785 122,750 44,947
CL0359 Intron-mat_II 151,918 21,236 4,886
CL0360 MTH1187-YkoF 16,776 8,904 1,256
CL0361 C2H2-zf 1,040,178 533,890 237,599
CL0362 RAMPS-Cas5-like 52,440 39,395 15,224
CL0363 H-int 45,602 30,732 14,691
CL0364 Leu-IlvD 563,479 269,184 39,902
CL0365 MurF-HprK_N 218,889 119,097 17,934
CL0366 JAB 119,533 56,604 15,558
CL0367 CI-2 10,761 5,922 2,051
CL0368 PhosC-NucP1 52,547 32,277 10,760
CL0369 GHD 418,900 223,474 45,625
CL0370 Uteroglobin 1,805 1,033 384
CL0371 Inovirus-Coat 836 579 345
CL0373 Phage-coat 73,863 35,940 11,350
CL0374 PEP-carboxyk 65,161 29,490 3,653
CL0375 Transporter 113,850 43,639 12,670
CL0376 Oxa1 126,705 58,268 10,854
CL0377 FAH 141,636 74,342 8,714
CL0378 ANL 769,102 429,629 106,054
CL0379 PgaPase 13,829 7,370 2,032
CL0380 IDO-like 24,760 12,680 2,221
CL0381 Metallo-HOrase 608,423 354,185 72,760
CL0382 DNA-mend 408,050 234,331 79,856
CL0383 PheT-TilS 81,866 46,223 11,370
CL0385 Hydrophilin 8,658 3,795 987
CL0387 DHFred 144,314 87,130 13,901
CL0388 FadR-C 236,468 113,357 24,899
CL0389 TRAF 58,412 26,859 10,253
CL0391 CAP_C-like 14,672 6,930 2,377
CL0392 Chaperone-J 310,860 156,895 46,556
CL0394 DsrEFH-like 50,044 27,300 5,175
CL0395 Tubby_C 47,287 23,659 7,855
CL0396 Marvel-like 48,769 23,153 6,371
CL0397 TusA-like 48,630 27,277 4,872
CL0398 RMMBL_DRMBL 77,663 38,837 6,649
CL0399 Asp-glut_race 89,992 49,078 8,437
CL0400 GG-leader 2,705 1,345 691
CL0402 Cdc48_2-like 32,031 12,793 2,639
CL0403 ADC-like 18,467 11,408 2,626
CL0404 BPD_transp_1 1,899,435 892,115 136,321
CL0405 DNA_b-psBarrel 46,542 23,541 9,717
CL0406 YjbJ-CsbD-like 35,103 15,722 2,688
CL0407 TBP-like 182,225 87,057 13,741
CL0408 PUP 221,083 117,038 23,982
CL0409 GAP 173,456 71,910 17,753
CL0410 LEF-8-like 101,588 28,554 4,215
CL0411 Vir 19,918 12,377 4,186
CL0412 Frag1-like 26,199 15,960 5,658
CL0413 Toprim-like 341,161 155,829 29,524
CL0414 TerB 37,573 20,158 5,099
CL0416 Anoctamin-like 58,857 27,268 7,823
CL0417 BIR-like 20,951 10,979 4,828
CL0418 GIY-YIG 129,095 80,458 22,526
CL0419 T3SS-Chaperone 15,498 8,351 3,343
CL0420 GlpM-like 3,292 1,113 268
CL0421 LppaM 11,065 5,414 3,354
CL0422 Fibrinogen_C 62,524 30,631 11,104
CL0423 AhpD-like 126,549 66,386 9,731
CL0424 T3SS-hook 52,124 33,768 15,876
CL0425 ComplexI-N 569,171 186,194 24,517
CL0426 HRDC-like 79,920 39,396 8,221
CL0428 TolA-TonB-Cterm 100,112 65,530 31,462
CL0429 UcrQ-like 3,722 1,936 567
CL0430 CopD_like 76,979 43,299 9,728
CL0431 PF 187,509 71,334 17,666
CL0433 SPFH 203,607 97,994 17,163
CL0435 NPR 7,484 3,408 1,173
CL0436 FliG 63,123 31,840 6,548
CL0437 EF-G_C 248,225 91,767 9,483
CL0439 NusG-like 63,059 27,221 5,429
CL0441 AlbA 50,064 30,427 10,249
CL0442 Tubulin_C 114,442 39,398 6,150
CL0445 SNARE-fusion 96,398 41,554 12,095
CL0446 Bacteriocin_TLN 2,460 1,412 530
CL0447 Hypoth_1 11,854 6,088 1,220
CL0448 Cargo_bd_muHD 42,567 15,005 3,622
CL0449 G-PATCH 52,396 26,353 9,188
CL0451 FnI-like 52,505 21,874 6,836
CL0452 Tropomyosin-lke 23,266 8,663 1,882
CL0453 Apoptosis-Inhib 52,784 23,196 4,484
CL0456 Golgi_traff 8,703 3,702 1,324
CL0457 4HB_MCP 85,823 44,691 14,393
CL0458 IIaaRS-ABD 225,654 106,657 12,467
CL0459 BRCT-like 117,166 61,865 16,792
CL0461 Metallothionein 6,108 2,667 744
CL0462 TPA-repeat 6,221 2,315 585
CL0464 5_3_exonuc_C 85,462 44,832 9,332
CL0465 Ank 684,528 379,566 177,750
CL0466 PDZ-like 537,929 276,803 68,913
CL0469 l-integrase_N 226,395 125,021 35,797
CL0470 ThrE 28,665 13,145 3,453
CL0471 DUF362 36,932 27,111 7,209
CL0472 Peptidase_U 136,967 88,127 38,240
CL0474 SICA_like 976 633 469
CL0475 Cyclophil-like 221,362 116,009 23,934
CL0476 tRNA-IECD_N 9,058 5,219 1,479
CL0477 TRD 63,600 54,126 29,570
CL0478 ATPase_I_AtpR 16,140 8,590 3,285
CL0479 PLD 229,606 125,015 30,576
CL0481 HUH 66,051 43,392 15,081
CL0482 Prolamin 49,043 23,395 8,489
CL0484 Peroxisome 41,043 17,997 5,008
CL0486 Fer2 389,719 199,638 25,997
CL0487 FKBP 367,753 190,953 49,545
CL0488 FixH-like 17,678 11,629 4,265
CL0489 SAF 228,170 125,528 42,655
CL0490 PepSY_TM-like 41,869 24,189 5,562
CL0491 LYR-like 33,897 17,936 5,442
CL0492 S4 302,985 134,019 16,911
CL0493 PTS_EIIC 93,555 31,329 4,514
CL0494 DnaA_N 83,406 41,187 8,060
CL0496 Tad-like 61,884 43,943 17,684
CL0497 GST_C 274,520 138,788 25,350
CL0498 Nribosyltransf 26,148 14,544 4,464
CL0499 O-anti_assembly 88,165 63,411 36,307
CL0500 Glycine-zipper 85,829 42,213 10,674
CL0502 STAS 202,494 116,557 34,295
CL0504 Phage_barrel 159,494 66,824 23,646
CL0505 Pentapeptide 96,654 60,810 28,735
CL0506 Succ_CoA_synth 138,251 57,083 7,833
CL0507 Fungal_trans 258,473 151,657 58,265
CL0508 YkuD 133,137 76,129 18,424
CL0509 RBP11-like 83,318 26,043 4,318
CL0511 Retroviral_zf 209,903 110,018 56,325
CL0512 CRAL_TRIO 90,525 43,488 13,692
CL0513 LCCL-domain 12,635 5,263 1,656
CL0515 LTXXQ-like 22,732 14,247 7,313
CL0516 ISP-domain 206,860 108,594 20,183
CL0517 MBOAT-like 64,993 36,064 10,079
CL0520 Keratin_assoc 6,166 3,892 1,640
CL0521 GOLD-like 45,480 19,822 5,241
CL0522 YbjQ-like 26,609 13,309 2,316
CL0523 GAG-polyprotein 216,699 167,361 93,999
CL0524 MPT63-MPB63 10,120 6,350 3,417
CL0525 pap2 190,670 108,239 34,645
CL0526 SUKH 41,231 23,663 9,561
CL0528 DUF1214 17,954 11,748 2,834
CL0529 FMN-dep-NRtase 163,407 94,243 18,400
CL0530 DNase_I-like 313,724 182,903 67,090
CL0531 AMP-binding_C 569,676 314,521 65,659
CL0532 LIG 21,123 12,948 5,229
CL0533 PRTase-like 376,668 171,105 25,846
CL0534 YjgF-like 158,844 81,506 11,242
CL0535 CBM 15,486 7,810 2,261
CL0536 HEXAPEP 349,428 180,388 30,415
CL0537 CCCH_zf 117,723 53,878 19,591
CL0539 RNase_III 73,535 39,947 9,237
CL0540 GCP 23,452 11,056 4,198
CL0541 SH2-like 154,609 54,133 12,728
CL0542 RAS_GEF_N 45,118 18,277 4,565
CL0543 Viral_gly_cn_dm 53,006 4,574 1,579
CL0544 AcylCoA_ox_dh_N 433,333 189,010 20,210
CL0545 APCOP-app_sub 39,868 18,664 4,777
CL0546 Hexosaminidase 51,824 30,165 8,284
CL0547 GF_recep_C-rich 38,928 14,967 3,077
CL0548 IHF-likeDNA-bdg 117,047 45,291 8,834
CL0550 SRCR 42,384 24,311 9,906
CL0551 BCLiA 18,927 7,910 2,734
CL0552 Hect 83,620 38,798 11,079
CL0559 CBD9-like 41,232 28,053 11,951
CL0560 Chalcone-like 12,726 7,748 2,555
CL0561 LisH 39,489 15,201 4,121
CL0562 Holin-V 1,882 1,173 323
CL0563 Holin-II 3,982 977 396
CL0564 Holin-III 5,496 1,479 555
CL0567 Phage_TACs 25,120 11,775 4,168
CL0568 Man_lectin 17,793 10,294 4,527
CL0570 PPP-I 97,303 53,684 16,336
CL0571 30K_movement 9,212 2,979 1,276
CL0572 TIKI 44,554 28,268 9,471
CL0573 KA1-like 41,943 16,969 4,465
CL0576 STARBD 14,924 7,856 2,914
CL0577 Paramyxovirin_C 646 69 34
CL0578 AbiEI 7,594 5,101 1,964
CL0580 YqgF 74,552 36,720 5,635
CL0582 TrkA_C 133,941 65,937 12,083
CL0584 FF 15,198 6,272 1,790
CL0586 CTC1 1,859 840 372
CL0587 STAND_N 7,514 6,017 3,542
CL0588 Ribos_L15p_L18e 62,730 27,469 3,346
CL0589 KIX_like 10,780 6,033 2,197
CL0590 OML_zippers 5,592 1,529 723
CL0591 TKC_like 308,080 141,078 11,805
CL0592 beta_Roll 68,508 55,254 37,960
CL0593 G5 18,442 11,433 4,424
CL0595 Fusion_gly 27,062 3,066 1,407
CL0596 VPS23_C 17,060 7,281 2,208
CL0597 Post-HMGL 109,391 45,719 3,324
CL0598 B_GA 8,598 5,109 3,573
CL0599 GH57_38_middle 36,687 20,842 5,189
CL0600 S15_NS1 141,739 24,328 2,445
CL0601 Cob_adeno_trans 33,754 17,266 2,387
CL0602 Kringle 35,377 14,126 4,185
CL0603 AA_dh_N 260,042 120,790 13,985
CL0604 post-AAA 145,627 74,685 13,494
CL0605 ssDNA_NP_VP 17,128 4,052 1,191
CL0606 Phage_fibre 19,570 8,713 2,806
CL0607 TNF_receptor 52,825 24,203 7,162
CL0608 Reductase_C 233,488 108,894 13,173
CL0609 sPC4_like 33,798 14,998 4,469
CL0611 Hexon 13,061 1,822 503
CL0612 PHM_PNGase_F 20,712 12,297 4,864
CL0613 Terp_synthase 341,911 191,652 42,176
CL0614 L27 31,173 10,932 1,875
CL0615 ALDC 32,625 17,006 4,773
CL0616 SPOC 47,161 22,780 6,070
CL0617 Peroxidase 110,020 57,099 14,130
CL0618 MCR 5,635 961 142
CL0619 Mog1p_PsbP 25,692 13,691 4,788
CL0620 Antihemostatic 3,507 1,721 952
CL0621 Colipase 16,054 9,173 4,769
CL0622 Acylphosphatase 86,468 49,835 11,618
CL0623 SRP9_14 7,528 3,598 979
CL0625 eIF4e 19,855 9,277 3,047
CL0626 Levi_coat 412 96 40
CL0627 Antibiotic_NAT 11,381 6,731 1,649
CL0628 EspA_CesA 933 185 74
CL0629 PLA2 23,465 11,627 4,575
CL0630 PSI 61,585 25,153 5,368
CL0631 YgaC_TfoX-N 87,086 57,721 10,505
CL0632 FERM_M 119,313 49,470 9,933
CL0633 NusB 73,652 39,839 7,790
CL0634 CheY-binding 8,217 4,115 811
CL0635 DmpA_ArgJ 183,559 103,624 18,217
CL0636 Leukocidin 4,184 1,740 397
CL0637 KaiA_RbsU 2,454 1,392 331
CL0639 Rof 9,286 4,738 1,446
CL0640 Colicin_D_E5 551 451 377
CL0642 SOCS_box 35,621 11,810 3,213
CL0643 YqbG 12,837 6,386 2,650
CL0644 Fz 49,201 18,462 5,366
CL0645 Anti-sigma_N 57,082 38,637 17,490
CL0646 T3SS 4,577 1,541 473
CL0647 FG_rpt 9,621 5,131 1,985
CL0648 Aha1_BPI 49,371 25,239 8,937
CL0649 PseudoU_synth 363,702 198,303 38,455
CL0650 AOC_barrel 28,596 16,494 4,850
CL0651 Mad2 22,145 10,101 3,423
CL0652 S24e_L23_L15e 66,702 24,276 2,729
CL0653 VCCI 927 146 71
CL0654 WYL 84,650 48,594 12,054
CL0655 PilP 18,979 11,941 4,831
CL0656 VSA 5,032 3,734 588
CL0658 OB_enterotoxin 2,749 864 324
CL0659 CAP 89,062 57,110 26,104
CL0660 SHOCT 61,777 36,929 11,737
CL0661 Gain 88,829 41,001 11,951
CL0662 Triple_barrel 37,473 20,049 7,111
CL0663 CNF1_YfiH 47,464 28,985 6,807
CL0664 UB2H 91,782 40,353 5,041
CL0665 BET 17,780 7,685 2,246
CL0666 Vault 2,076 865 271
CL0667 Fer2_BFD 106,834 51,090 6,991
CL0668 Pre-PUA 25,307 11,578 2,636
CL0669 NOG1_N 10,727 5,193 1,682
CL0670 4PPT 72,372 43,145 14,147
CL0671 AAA_lid 979,942 447,530 69,147
CL0672 p35 119,276 67,987 19,032
CL0673 GYF 28,025 16,137 6,698
CL0674 Triple_B_spiral 1,676 254 135
CL0676 SLATT 8,970 5,941 2,842
CL0677 GHMP_C 121,882 66,310 13,061
CL0678 CLIP 5,970 3,997 1,953
CL0679 TACC 7,304 2,914 1,010
CL0680 WW 98,358 46,686 13,431
CL0681 HAMP 495,269 274,062 90,048
CL0682 MBG 7,172 6,316 5,016
CL0683 MICOS 2,650 1,397 457
CL0684 NFACT_RNA-bind 27,034 15,537 4,075
CL0685 AmpE_CobD-like 25,873 13,664 2,241
CL0686 aG_PT 1,871 1,202 485
CL0687 Zn_chelatase 11,920 9,436 5,023
CL0688 BECR 4,858 3,303 2,063
CL0689 TSP3 42,098 28,005 16,382
CL0690 TrbC_VirB2 33,007 17,495 8,373
CL0691 Tail_Terminator 26,223 12,097 5,057
CL0692 TSP1 94,801 42,090 13,739
CL0693 Cas9_lobe 2,153 1,597 725
CL0694 Choline_binding 17,661 8,633 4,903
CL0695 EndoU 13,596 4,578 2,139
CL0696 Vmethyltransf 9,907 1,956 949
CL0697 SDH_beta 85,274 39,998 6,225
CL0698 TrbL 17,278 6,948 2,391
CL0700 ArdcN 20,671 10,275 3,749
CL0701 NAD_kinase_C 134,653 69,588 15,357
CL0702 UIM 19,122 7,267 2,004
CL0703 YtcA 8,787 2,813 609
CL0704 HMA 183,590 100,427 21,723
CL0705 VBS-like 40,469 14,607 3,812
CL0706 EMC6 9,083 4,301 1,287
CL0707 Saposin_like 13,904 6,783 2,413
CL0708 Polo-box 9,020 3,590 1,221
CL0709 STING 1,793 992 445
CL0710 YeeE 42,259 26,392 3,643
CL0713 Acyl-CoA_desat 191,680 101,332 19,470
CL0714 COX1-like 1,820,367 168,011 28,308
CL0715 Nckap1_CYFIP1-2 12,960 4,185 1,562
CL0716 Aquaporin-like 116,821 53,503 11,295
CL0717 YbaB 42,375 20,559 3,704
CL0718 Perilipin_sf 7,550 3,689 1,068
CL0719 Moesin_tail 10,075 2,105 413
CL0720 Lag3_N 1,905 1,018 317
CL0721 LAMP 8,335 3,853 1,106
CL0722 SDH_alpha 71,497 34,558 6,098
CL0723 TRADD-N 4,554 1,835 606
CL0724 Kinetochore 14,776 7,668 2,749
CL0725 Apolipoprotein 7,703 3,723 1,223
CL0726 Resistin 1,399 668 174
CL0727 Nucleosidase 49,093 26,400 6,304
CL0728 Cas2 34,289 21,690 4,549
CL0729 Kre28-like_sf 1,985 1,047 337
CL0730 IL8 25,373 12,963 4,049
CL0731 SPOCS 6,896 4,052 1,587
CL0732 RMP1-like 3,334 2,007 897
CL0733 Ribosomal_L25 87,216 45,750 7,214
CL0734 Rpp14-Pop5-like 8,463 4,996 1,851
CL0735 GatC-like 38,187 20,004 3,744
CL0736 Get5_C_sf 850 371 123
CL0737 Mtd 4,775 2,423 1,071
CL0738 Arg_repressor_C 34,152 15,195 2,122
CL0740 GCV_T_C 299,834 112,012 14,853
CL0741 RGM 34,515 20,234 8,642
CL0742 PTS_IIA-like 5,247 2,549 672
CL0743 Spectrin 85,355 35,262 9,115
CL0745 MIT 33,979 13,489 3,341
CL0746 AFF4_CHD 6,922 2,917 809
CL0747 THUMP 54,446 25,359 5,272
CL0748 DNA_prim_N 53,810 29,657 7,560
CL0749 GH127_M 39,333 24,926 5,772
CL0750 ADAM_CR_sf 58,907 25,659 5,702
CL0751 Secretin_N0 91,994 53,526 21,811
CL0752 PsbQ-like 27,417 14,379 3,530
CL0753 ATPD-E_C 33,773 9,512 1,282
CL0754 PGM_I-III 145,452 70,776 10,091
CL0755 SASP 12,715 5,460 1,180
CL0756 GMC 2,866 949 208
CL0757 TRAP 4,146 1,862 590
CL0758 L31 48,893 18,510 1,554
CL0759 Nop_N_sf 9,687 4,002 698
CL0760 RBG 116,257 66,693 28,275
CL0761 ABC_sf 181 28 24
CL0762 GlyR 56,197 28,443 5,608
CL0763 GpW_gp25-like 53,246 23,247 5,194
CL0764 PHP14-like 36,471 16,108 2,134
CL0765 PAC 6,803 3,808 1,399
CL0766 NCPF 9,029 5,309 1,336
CL0767 MXAN_049 4,771 3,254 1,521
CL0768 DUF960 2,170 1,083 403
CL0769 SsdA_imm 4,665 3,146 820
CL0770 GH84_C 3,407 1,820 565
CL0771 UDG-like 133,120 77,485 12,059
CL0772 YqiB 5,517 2,355 712
CL0773 STD 2,402 1,432 531
CL0774 MTHFR_C-like 6,463 2,598 507
CL0775 MlaD-like 90,904 48,470 9,970
CL0776 PBP_NTD 106,156 55,398 10,888
CL0777 XRCC4_N 7,906 4,264 1,691
CL0778 BON 54,232 31,397 9,931
CL0779 Head_shaft 21,745 13,108 4,825
CL0780 LppM-like 2,430 1,427 579
CL0781 NadN_C 58,642 30,705 7,977
CL0782 BBOX 107,180 51,331 15,753
CL0783 WWE 28,344 13,107 4,739
CL0785 VPS9 22,614 10,738 3,173
CL0786 H-NS_histone_C 17,125 6,823 1,605
CL0787 NADAR-like 14,933 9,350 3,488
CL0788 CorA-like 83,851 43,466 12,651
CL0789 SUD_C-like 4,561 229 12
CL0790 Cas9_WED-like 391 214 60
CL0791 Ago_N 24,065 10,395 2,939
CL0792 MLKL_N-like 15,016 7,004 2,079
CL0793 GspE_N-like 57,911 34,549 6,898
CL0794 Mur_ligase_C_sf 239,783 135,078 23,226
CL0795 NSUN_ferredox 45,264 24,133 4,986
CL0796 Mu-transpos_C 30,379 17,621 5,838
CL0797 RXXXE-like 3,161 2,686 1,855
CL0798 INSIG-like 14,787 8,611 2,326
CL0799 PRMT_C 27,754 11,151 3,044
CL0800 LiaI-LiaF-TM 13,955 9,708 4,178
CL0801 OST_core 10,080 4,588 1,315
CL0802 MinC_N 11,804 5,395 1,001
CL0803 PBP_GOBP 13,691 9,223 4,586
CL0804 PurM_N-like 161,552 84,384 9,651
CL0805 PWI-like 44,467 18,830 3,452
CL0806 SNaCT 3,137 1,277 336
CL0807 WY-like 5,079 2,850 1,841
CL0808 Sufu_N 14,273 7,394 2,644
CL0809 CXC 45,815 21,778 6,785
CL0810 GRIP-like 11,996 5,534 2,085
CL0812 YKT-like_S 29,313 17,515 7,102
CL0813 COMMD_HN 8,786 3,853 1,133
CL0814 Brichos_S 9,619 3,709 1,094
CL0815 BACOVA_03322_C 1,573 860 276
CL0816 TBC-like 112,619 48,248 13,888
CL0817 SPMIP5_TBD 2,639 1,493 497
CL0818 GT-D-like 1,568 1,028 601
CL0819 TIL 21,610 14,214 6,984
CL0820 RBAF-like 3,057 1,652 535
CL0821 C4-like 65,138 34,501 8,350
CL0822 WIV 710 97 47
CL0823 XPD_ARCH 9,143 4,282 1,237
CL0824 HHD 4,980 1,792 406
CL0825 CTLH 25,407 10,716 3,087
CL0826 NuiA-like 1,770 1,254 496
CL0827 bHLH 231,222 96,957 29,732
CL0828 PABC-like 18,282 7,312 1,854
CL0829 PAH 16,590 8,438 3,080
CL0831 SAND 12,515 4,832 1,540
CL0832 CobW_C 51,409 24,382 4,260
CL0833 Nup120_hel_sf 3,320 1,443 382
CL0834 BAAB_hairpin 5,687 3,200 1,223
CL0835 MYCPN_LP 133 43 25
CL0836 TMEM126 1,687 873 339
CL0838 Phage_portal 63,507 31,388 12,111
CL0839 Tbcl_zf 547,828 226,931 53,858
CL0840 H_lectin 9,535 5,559 2,921
CL0841 Wzc_PBSD 12,112 5,098 1,062
CL0842 UPA-like 13,425 4,600 1,305
CL0843 MFPT-like 5,972 4,287 2,015
CL0844 Matrix_Mononaga 3,435 303 88
CL0845 Beta_tulip 7,150 3,511 1,403
CL0846 HVO_1158-like 1,038 696 297
CL0847 Ice_binding 10,290 8,107 4,393
CL0848 YphA 3,282 2,162 709
CL0849 3b-a_propeller 5,816 4,070 2,480
CL0850 INO80_complex 5,177 2,598 979
CL0851 YhhM-like 3,351 1,474 448
CL0852 DH-like 141,810 63,397 15,859
CL0853 TMD0-like 15,429 7,751 1,730
CL0854 DGR_Avd-like 38,135 29,829 6,590
CL0855 TMMD-like 13,420 8,771 4,224
CL0856 Imm33 2,885 1,698 596
CL0857 APA-like 883 622 179
CL0858 ColE3imm-like 1,006 685 280
CL0859 DMP12-like 3,322 2,122 1,011
CL0860 LMG18311-like 1,471 659 263
CL0861 MavL-like_sf 870 611 278
CL0862 LTE-like 25,352 14,886 4,613
CL0864 NACHT_N 11,671 9,422 5,322
CL0865 ZnExoPePases 761,459 421,757 89,666
CL0866 ALR_C-like 939,622 357,687 50,754
CL0867 NqrA_FMN-like 79,201 40,442 4,213
CL0868 p22phox-like 2,211 1,098 230
CL0869 AraA_N-like 13,400 5,609 578
CL0870 EXR-like 23,989 17,863 11,128
CL0871 YefM-like 57,333 36,021 8,852
CL0872 PfC-like 24,165 13,657 4,310
CL0873 RBM_T3SS-Flag 31,491 16,686 4,687
CL0874 PMD-like 40,089 30,719 13,935
CL0875 MscS_C_sf 85,414 48,422 12,489
CL0876 SLD5_C-like 13,993 6,170 1,763
CL0877 RHS_sf 52,550 37,458 21,530
CL0878 CamS-like 2,565 1,076 242
CL0879 R3H-like 46,658 24,173 5,856
CL0880 SLC44-like 40,050 19,130 5,620
CL0881 SUEL-RBL_sf 27,147 12,929 3,829
CL0882 Agd3_CE_sf 6,528 1,957 503
CL0883 CBM87 6,227 1,821 433
CL0884 MmeI_HD-like 45,027 27,184 3,858
CL0885 L9_N_sp 58,387 30,905 7,474
CL0886 ADH_DHQS_C-like 132,311 65,594 10,116
CL0887 MliC_ACP-like 8,103 4,038 1,694
CL0888 CoiA_N-like 5,571 2,977 1,646
CL0889 DmsR_N-like 9,607 5,707 1,764
CL0890 Haemocyanin_C 3,781 2,131 741
CL0891 Cry1_MapZ 1,934 814 397
CL0892 SNYG 4,441 2,765 1,187
CL0893 AD 18,269 7,938 1,397
CL0894 BPTI 34,989 20,160 9,254
CL0895 DnaJ_CRD 75,051 31,770 4,106

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