EFI - Enzyme Similarity Tool

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RadicalSAM.org, our resource for investigating sequence-function space in the radical SAM superfamily, has been updated with sequences from the UniProt Release 2024_01 and InterPro Release 98 databases (January 24, 2024) !!

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Pfam Clans

These data are sourced from the UniProt and EMBL-EBI InterPro databases.

Download as tab-separated text file.
Clan ID Clan Short Name Clan Size UniRef90 Size UniRef50 Size
CL0001 EGF 391,193 170,266 62,218
CL0003 SAM 218,479 84,479 19,196
CL0004 Concanavalin 686,513 373,410 130,284
CL0005 Kazal 55,145 22,695 8,594
CL0007 KH 346,345 141,227 24,237
CL0010 SH3 1,928,328 872,906 229,573
CL0012 Histone 199,772 68,505 23,406
CL0013 Beta-lactamase 583,344 333,810 86,498
CL0014 Glutaminase_I 752,951 386,685 58,865
CL0015 MFS 2,230,474 1,109,060 263,880
CL0016 PKinase 2,603,834 1,339,015 470,896
CL0018 bZIP 113,299 48,303 17,303
CL0020 TPR 3,151,472 1,696,541 671,640
CL0021 OB 2,273,665 1,000,588 176,897
CL0022 LRR 709,211 372,845 166,042
CL0023 P-loop_NTPase 12,364,126 6,077,765 1,357,726
CL0025 His_Kinase_A 1,863,953 1,125,344 407,366
CL0026 CU_oxidase 325,997 145,423 34,984
CL0027 RdRP 991,218 489,134 232,372
CL0028 AB_hydrolase 2,251,041 1,330,402 362,873
CL0029 Cupin 1,634,725 890,280 222,753
CL0030 Ion_channel 487,840 238,440 71,230
CL0031 Phosphatase 669,707 343,809 82,263
CL0032 Dim_A_B_barrel 538,261 273,744 49,623
CL0033 POZ 331,434 136,529 54,453
CL0036 TIM_barrel 7,371,945 3,774,739 676,585
CL0037 Lysozyme 406,088 219,309 59,105
CL0039 HUP 1,805,315 950,905 165,356
CL0040 tRNA_synt_II 697,258 337,467 46,439
CL0041 Death 91,714 42,475 15,877
CL0042 Flavoprotein 292,828 150,316 25,851
CL0043 Chelatase 265,578 143,511 30,544
CL0044 Ferritin 349,707 171,053 30,251
CL0045 Rubredoxin 75,173 41,414 5,216
CL0046 Thiolase 545,362 267,279 51,001
CL0047 CuAO_N2_N3 14,730 6,836 1,224
CL0048 LolA_LolB 130,840 78,713 27,569
CL0050 HotDog 553,415 296,832 61,704
CL0051 NTF2 408,430 240,114 68,474
CL0052 NTN 529,583 257,985 51,833
CL0053 4H_Cytokine 32,943 12,022 3,420
CL0054 Knottin_1 9,391 5,035 2,103
CL0055 Nucleoplasmin 216,755 33,251 10,405
CL0056 C_Lectin 229,680 145,219 60,850
CL0057 Met_repress 213,415 121,715 35,076
CL0059 6_Hairpin 483,952 273,150 73,559
CL0060 DNA_clamp 72,948 33,031 9,132
CL0061 PLP_aminotran 1,644,391 826,196 120,324
CL0062 APC 1,130,469 497,912 98,522
CL0063 NADP_Rossmann 12,290,845 6,558,317 1,275,965
CL0064 CPA_AT 438,286 216,596 44,313
CL0065 Cyclin 132,144 59,991 21,265
CL0066 Trefoil 152,734 74,148 22,498
CL0067 SIS 331,617 145,002 23,199
CL0068 RIIa 15,968 7,351 2,913
CL0069 GFP 5,762 2,825 595
CL0070 ACT 341,079 146,883 19,901
CL0071 His_phosphatase 271,962 144,115 38,337
CL0072 Ubiquitin 965,080 458,823 127,789
CL0073 P53-like 74,580 27,193 7,999
CL0074 Matrix 67,118 11,518 1,661
CL0075 Defensin 8,337 3,884 1,190
CL0077 FAD_PCMH 332,199 185,627 32,717
CL0079 Cystine-knot 90,429 28,237 8,926
CL0080 Beta-tent 159,520 87,542 14,640
CL0081 MBD-like 160,471 77,552 24,491
CL0082 MIF 45,065 23,071 4,723
CL0083 Omega_toxin 30,857 15,205 4,410
CL0084 ADP-ribosyl 118,781 67,201 25,028
CL0087 Acyl-CoA_dh 466,245 205,128 23,680
CL0088 Alk_phosphatase 516,092 314,587 79,313
CL0089 GlnB-like 160,935 77,409 14,296
CL0090 Globin 130,266 64,248 13,896
CL0091 NAD_Ferredoxin 239,629 117,251 21,695
CL0092 ADF 67,173 26,333 6,568
CL0093 Peptidase_CD 168,111 117,001 62,322
CL0094 Peptidase_ME 290,757 150,384 31,547
CL0095 Peptidase_ML 23,963 14,191 4,119
CL0096 Pept_Inhib_IE 202 128 68
CL0097 TypeIII_Chap 35,379 17,165 5,621
CL0098 SPOUT 326,657 174,242 31,642
CL0099 ALDH-like 549,489 248,467 31,787
CL0100 C1q_TNF 50,266 21,805 7,723
CL0101 PELOTA 124,448 54,587 11,141
CL0103 Gal_mutarotase 388,373 214,489 51,384
CL0104 Glyoxalase 513,483 292,941 43,706
CL0105 Hybrid 3,363,059 1,679,820 348,629
CL0106 6PGD_C 621,869 308,613 43,257
CL0108 Actin_ATPase 1,144,543 557,962 126,165
CL0109 CDA 321,904 175,094 31,138
CL0110 GT-A 1,528,718 896,381 272,396
CL0111 GT-C 282,934 182,604 83,388
CL0112 Yip1 44,864 23,194 8,434
CL0113 GT-B 1,326,011 839,754 286,433
CL0114 HMG-box 115,343 49,463 18,835
CL0115 Steroid_dh 104,174 63,922 18,449
CL0116 Calycin 166,947 92,534 30,661
CL0117 uPAR_Ly6_toxin 36,505 16,176 6,092
CL0118 Ribokinase 368,723 198,751 41,764
CL0122 UTRA 98,578 43,822 9,790
CL0123 HTH 10,735,976 5,445,099 1,410,764
CL0124 Peptidase_PA 483,569 250,636 89,547
CL0125 Peptidase_CA 833,707 435,800 160,616
CL0126 Peptidase_MA 1,177,932 672,779 199,357
CL0127 ClpP_crotonase 815,369 393,164 69,608
CL0128 vWA-like 448,474 241,914 74,118
CL0129 Peptidase_AA 563,390 257,309 98,777
CL0130 Peptidase_AD 68,781 40,368 13,427
CL0131 DoxD-like 135,645 82,152 18,444
CL0132 AbrB 94,453 53,364 13,961
CL0133 AT14A-like 12,815 6,493 2,186
CL0135 Arrestin_N-like 54,259 24,431 8,864
CL0136 Plasmid-antitox 226,240 146,449 36,598
CL0137 HAD 1,219,178 636,165 146,122
CL0139 GADPH_aa-bio_dh 485,135 221,324 27,105
CL0140 Viral_NABP 2,104 356 114
CL0141 MtN3-like 69,872 36,898 10,609
CL0142 Membrane_trans 714,900 338,343 54,197
CL0143 B_Fructosidase 140,712 81,177 17,028
CL0144 Periplas_BP 730,935 353,653 85,690
CL0145 Golgi-transport 150,569 53,232 11,382
CL0146 Herpes_glyco 559 109 52
CL0147 Traffic 21,349 9,325 2,847
CL0148 Viral_Gag 106,927 26,024 8,132
CL0149 CoA-acyltrans 317,754 186,010 62,859
CL0153 dUTPase 50,632 26,190 3,970
CL0154 C2 396,099 169,881 45,351
CL0155 CBM_14_19 31,672 19,961 11,231
CL0156 Nucleocapsid 36,927 1,101 496
CL0157 Kleisin 42,044 23,320 4,766
CL0158 GH_CE 259,152 155,314 46,250
CL0159 E-set 2,988,543 1,659,139 696,012
CL0161 GAF 624,660 355,747 117,146
CL0163 Calcineurin 598,490 333,863 91,105
CL0164 CUB 84,947 37,130 14,914
CL0165 Cache 220,275 116,883 43,827
CL0166 PRD 32,050 13,158 4,802
CL0167 Zn_Beta_Ribbon 1,402,182 663,286 178,418
CL0168 PAN 64,790 36,659 17,753
CL0169 Rep 88,043 34,842 13,941
CL0170 Peptidase_MD 73,728 43,479 13,453
CL0171 Phospoesterase 158,561 79,883 14,265
CL0172 Thioredoxin 1,622,388 885,244 205,242
CL0173 STIR 109,539 67,817 33,458
CL0174 TetR_C 432,835 239,168 53,435
CL0175 TRASH 158,561 89,412 31,886
CL0176 Chemosens_recp 37,549 27,860 16,016
CL0177 PBP 2,448,681 1,188,228 251,845
CL0178 PUA 299,964 150,037 29,345
CL0179 ATP-grasp 824,529 412,718 75,679
CL0181 ABC-2 502,405 275,929 69,789
CL0182 IT 396,017 193,567 35,551
CL0183 PAS_Fold 830,829 518,079 219,222
CL0184 DMT 733,414 383,335 90,923
CL0186 Beta_propeller 2,672,981 1,383,142 518,922
CL0187 LysM 206,590 123,778 46,218
CL0188 CH 167,112 69,270 17,312
CL0190 HSP20 160,433 86,943 25,685
CL0191 POTRA 101,343 59,102 20,661
CL0192 GPCR_A 1,007,185 457,639 154,658
CL0193 MBB 1,214,806 688,255 228,895
CL0194 DNA_pol_B-like 49,971 24,227 8,542
CL0195 DBL 16,126 9,895 2,153
CL0196 DSRM 159,386 68,053 15,317
CL0197 GME 69,772 34,337 6,733
CL0198 HHH 773,018 397,277 77,090
CL0199 DPBB 459,889 251,343 56,047
CL0200 Prefoldin 34,533 17,542 5,395
CL0201 Peptidase_SH 20,654 11,194 4,426
CL0202 GBD 587,377 319,625 103,547
CL0203 CBD 39,842 25,737 9,676
CL0204 Adhesin 65,346 23,724 9,461
CL0205 Di-copper 33,240 16,980 6,297
CL0207 Rhomboid-like 118,250 68,068 19,801
CL0208 UBC 167,811 69,234 21,257
CL0209 Bet_v_1_like 413,446 224,902 53,232
CL0210 HNOX-like 38,185 20,086 6,377
CL0212 SNARE 6,579 2,819 855
CL0213 ShK-like 15,435 10,497 6,213
CL0214 UBA 203,998 89,679 22,748
CL0217 Rotavirus_VP7 19,299 850 99
CL0219 RNase_H 1,828,556 1,078,205 431,149
CL0220 EF_hand 608,837 274,951 99,530
CL0221 RRM 697,176 298,589 94,563
CL0222 MviN_MATE 328,616 190,538 65,589
CL0223 MACRO 113,515 61,973 13,674
CL0224 DHQS 209,562 104,265 15,869
CL0225 FtsL 55,047 30,878 10,428
CL0226 M6PR 19,291 9,794 3,646
CL0227 Enolase_N 177,278 77,734 9,166
CL0228 Acyltransferase 283,762 152,253 38,611
CL0229 RING 1,242,997 560,589 191,163
CL0230 HO 56,684 29,434 6,265
CL0231 MazG 109,271 58,279 8,509
CL0232 NifU 108,299 52,887 6,556
CL0233 SufE_NifU 134,646 70,721 11,198
CL0234 CTPT 58,787 32,115 8,653
CL0235 PspA 67,592 28,479 6,823
CL0236 PDDEXK 898,727 499,909 161,155
CL0237 HD_PDEase 539,557 302,938 79,611
CL0238 PP2C 261,812 147,771 49,020
CL0239 Insulin 8,028 3,564 1,465
CL0240 PFK 218,272 109,950 21,872
CL0241 ABC_membrane 489,716 250,677 53,402
CL0242 DNA_primase_lrg 7,864 4,237 1,496
CL0243 AEP 33,629 19,490 3,538
CL0244 PGBD 125,538 74,624 25,720
CL0245 EDD 105,407 51,234 10,545
CL0247 2H 62,002 39,568 14,525
CL0248 ParBc 133,077 78,864 24,430
CL0249 Phage_tail_L 5,752 1,811 634
CL0250 GAD 47,460 20,463 1,923
CL0251 MORN 64,203 38,656 19,966
CL0254 THDP-binding 667,628 324,798 37,980
CL0255 ATP_synthase 183,240 89,094 24,240
CL0257 Acetyltrans 1,356,369 798,938 216,075
CL0258 DALR 335,171 169,448 20,359
CL0259 OstA 53,250 31,578 11,200
CL0260 NTP_transf 561,673 319,456 89,037
CL0261 NUDIX 488,478 275,125 61,695
CL0262 Trigger_C 97,751 56,176 18,521
CL0263 His-Me_finger 247,210 143,264 57,943
CL0264 SGNH_hydrolase 310,268 192,550 66,875
CL0265 HIT 148,765 81,056 14,336
CL0266 PH 857,345 349,098 86,178
CL0267 S11_L18p 156,100 58,428 9,857
CL0268 Pec_lyase-like 390,530 247,376 112,166
CL0269 Maf 115,610 65,770 10,902
CL0270 Iso_DH 257,562 113,334 11,767
CL0271 F-box 315,683 179,438 88,600
CL0272 RGS 64,046 23,545 6,523
CL0273 CYTH 56,539 33,120 9,921
CL0274 WRKY-GCM1 84,325 48,705 22,646
CL0276 Nucleot_cyclase 733,408 444,426 181,573
CL0277 FAD-oxidase_C 180,462 97,325 17,464
CL0278 AIG2 46,275 26,282 8,140
CL0279 GatB_YqeY 80,170 40,405 5,328
CL0280 PIN 427,065 261,250 71,780
CL0281 CCT 23,055 10,256 3,383
CL0282 Serum_albumin 2,809 1,005 219
CL0283 LigB 52,080 30,058 6,303
CL0284 Allatostatin 216 122 68
CL0285 YycI_YycH 5,312 2,874 1,136
CL0286 GCS 259,575 106,901 15,987
CL0287 Transthyretin 556,051 348,426 128,169
CL0288 DAP_epimerase 110,840 60,450 9,102
CL0289 FBD 148,991 79,396 13,211
CL0290 EPT_RTPC 114,874 55,986 8,692
CL0291 KNTase_C 145,952 96,245 34,517
CL0292 LysE 610,114 320,204 61,734
CL0293 CDC 44,203 20,949 7,007
CL0296 GroES 611,932 298,436 42,117
CL0297 PhoU 78,877 39,278 8,225
CL0298 tRNA_bind_arm 132,065 61,476 5,587
CL0299 Peptidase_SF 184,098 100,574 27,327
CL0300 TAT 29,913 15,430 5,305
CL0301 PA14 31,984 21,225 9,398
CL0302 Arginase 155,383 79,671 15,592
CL0303 H2TH 128,565 59,778 8,963
CL0304 CheY 1,995,534 1,076,010 292,469
CL0305 PTH2 17,882 9,602 2,167
CL0306 HeH 121,290 53,783 15,761
CL0307 FUSC 83,400 40,361 11,064
CL0308 DMSO_reductase 35,596 18,597 3,140
CL0310 DinB 166,566 112,775 24,094
CL0311 SCP2 72,410 39,949 9,291
CL0312 HemS_ChuX 6,743 3,153 651
CL0314 PP-binding 313,146 184,867 72,851
CL0315 Gx_transp 145,834 79,789 19,521
CL0316 Acyl_transf_3 189,330 118,278 49,019
CL0317 Multiheme_cytos 92,401 62,310 21,156
CL0318 Cytochrome-c 363,420 234,253 58,711
CL0319 SHS2 128,760 67,477 16,788
CL0320 PepSY 101,645 55,454 20,183
CL0321 PLAT 32,711 15,352 5,221
CL0322 RND_permease 420,993 219,754 47,260
CL0323 Patatin 265,245 155,495 46,047
CL0324 Homing_endonuc 39,058 23,801 10,423
CL0326 Reo_sigma 2,758 390 121
CL0327 Pilus 80,960 52,396 18,458
CL0328 2heme_cytochrom 582,574 189,906 38,402
CL0329 S5 881,412 397,578 61,770
CL0330 AVL9 47,855 20,165 4,600
CL0331 EpsM 57,573 35,336 14,850
CL0333 gCrystallin 28,055 12,849 4,086
CL0334 THBO-biosyn 162,270 79,844 10,707
CL0335 FumRed-TM 55,516 25,480 4,619
CL0336 FMN-binding 307,299 182,150 33,479
CL0337 RF 125,446 58,409 6,155
CL0339 PFL-like 134,537 58,430 9,689
CL0340 PTase-anion_tr 92,478 40,290 9,602
CL0341 LDH_C 96,851 35,270 4,464
CL0342 TolB_N 100,221 55,946 17,255
CL0343 MHC 140,184 31,845 5,136
CL0344 4Fe-4S 1,041,767 539,811 91,835
CL0345 Aerolisin_ETX 3,074 1,788 942
CL0346 Ribo_L29 51,371 22,376 4,259
CL0347 Tetraspannin 76,560 34,873 12,457
CL0348 Phage_tail 27,626 13,372 5,958
CL0349 SLOG 144,719 81,045 17,677
CL0350 PRC-barrel 125,422 66,852 13,900
CL0351 CHCH 36,316 18,143 5,400
CL0352 EsxAB 58,214 32,281 11,171
CL0353 TIMP-like 23,558 8,935 2,576
CL0354 bBprotInhib 2,933 1,385 380
CL0355 CheC-like 35,749 18,731 4,875
CL0356 AMP_N-like 113,372 58,238 10,913
CL0357 SMAD-FHA 212,048 117,828 43,882
CL0359 Intron-mat_II 150,396 21,276 4,662
CL0360 MTH1187-YkoF 16,451 8,744 1,227
CL0361 C2H2-zf 932,619 468,373 213,526
CL0362 RAMPS-Cas5-like 52,077 39,114 15,189
CL0363 H-int 44,197 29,829 14,492
CL0364 Leu-IlvD 467,698 232,753 36,778
CL0365 MurF-HprK_N 33,503 15,340 2,130
CL0366 JAB 115,634 55,119 15,150
CL0367 CI-2 9,981 5,557 1,947
CL0368 PhosC-NucP1 51,512 31,731 10,699
CL0369 GHD 391,635 208,940 43,180
CL0370 Uteroglobin 1,791 1,023 376
CL0371 Inovirus-Coat 803 568 335
CL0373 Phage-coat 64,218 30,743 9,499
CL0374 PEP-carboxyk 64,537 29,136 3,656
CL0375 Transporter 108,280 40,532 11,924
CL0376 Oxa1 124,575 56,163 10,761
CL0377 FAH 138,574 72,986 8,663
CL0378 ANL 750,322 420,630 105,224
CL0379 PgaPase 13,325 7,141 1,978
CL0380 IDO-like 24,034 12,250 2,177
CL0381 Metallo-HOrase 595,011 346,866 71,839
CL0382 DNA-mend 401,100 230,572 78,413
CL0383 PheT-TilS 80,912 45,804 11,370
CL0385 Hydrophilin 8,397 3,661 956
CL0387 DHFred 141,198 85,485 13,589
CL0388 FadR-C 230,886 111,397 24,701
CL0389 TRAF 19,218 7,148 2,986
CL0391 CAP_C-like 13,839 6,435 2,280
CL0392 Chaperone-J 297,379 149,253 44,810
CL0394 DsrEFH-like 49,353 27,142 5,110
CL0395 Tubby_C 40,281 20,417 6,875
CL0396 Marvel-like 44,832 21,020 5,877
CL0397 TusA-like 48,259 27,033 4,846
CL0398 RMMBL_DRMBL 76,063 37,886 6,532
CL0399 Asp-glut_race 88,539 48,368 8,357
CL0400 GG-leader 2,536 1,279 662
CL0401 AsmA-like 83,177 50,009 22,934
CL0402 Cdc48_2-like 28,457 11,301 2,473
CL0403 ADC-like 18,090 11,161 2,568
CL0404 BPD_transp_1 1,869,498 881,394 135,598
CL0405 DNA_b-psBarrel 40,537 20,433 8,553
CL0406 YjbJ-CsbD-like 34,268 15,371 2,591
CL0407 TBP-like 64,045 30,645 7,586
CL0408 PUP 214,224 113,029 23,094
CL0409 GAP 164,391 65,815 16,724
CL0410 LEF-8-like 99,924 27,841 4,283
CL0411 Vir 19,917 12,371 4,193
CL0412 Frag1-like 25,156 15,174 5,444
CL0413 Toprim-like 331,457 151,366 29,035
CL0414 TerB 37,237 20,042 5,071
CL0416 Anoctamin-like 55,314 24,877 7,399
CL0417 BIR-like 19,745 10,164 4,504
CL0418 GIY-YIG 124,470 77,652 21,357
CL0419 T3SS-Chaperone 15,363 8,281 3,354
CL0420 GlpM-like 3,199 1,098 287
CL0421 LppaM 12,792 6,671 4,031
CL0422 Fibrinogen_C 58,971 27,816 10,276
CL0423 AhpD-like 123,166 64,671 9,549
CL0424 T3SS-hook 51,745 33,342 15,784
CL0425 ComplexI-N 564,071 181,310 24,363
CL0426 HRDC-like 77,786 38,248 7,996
CL0428 TolA-TonB-Cterm 99,432 65,163 31,290
CL0429 UcrQ-like 3,486 1,787 514
CL0430 CopD_like 75,309 42,227 9,544
CL0431 PF 175,732 66,458 16,974
CL0433 SPFH 178,346 83,936 13,577
CL0435 NPR 7,152 3,184 1,114
CL0436 FliG 62,849 31,310 6,535
CL0437 EF-G_C 243,010 89,624 9,312
CL0439 NusG-like 62,346 26,803 5,289
CL0441 AlbA 48,974 29,684 10,010
CL0442 Tubulin_C 110,382 37,792 6,137
CL0445 SNARE-fusion 54,081 22,779 6,843
CL0446 Bacteriocin_TLN 2,412 1,384 505
CL0447 Hypoth_1 11,583 6,025 1,218
CL0448 Cargo_bd_muHD 35,588 11,570 2,883
CL0449 G-PATCH 49,285 24,134 8,589
CL0451 FnI-like 42,677 17,134 5,079
CL0452 Tropomyosin-lke 22,208 8,118 1,816
CL0453 Apoptosis-Inhib 51,267 22,524 4,425
CL0456 Golgi_traff 8,237 3,409 1,275
CL0457 4HB_MCP 83,493 43,959 14,209
CL0458 IIaaRS-ABD 219,701 102,573 11,825
CL0459 BRCT-like 112,475 58,840 16,042
CL0461 Metallothionein 5,825 2,511 697
CL0462 TPA-repeat 5,840 2,156 556
CL0464 5_3_exonuc_C 83,199 43,637 9,051
CL0465 Ank 645,165 353,061 167,944
CL0466 PDZ-like 518,225 264,412 66,967
CL0469 l-integrase_N 187,097 105,638 30,462
CL0470 ThrE 28,234 12,936 3,432
CL0471 DUF362 37,116 27,122 7,236
CL0472 Peptidase_U 134,908 86,957 37,917
CL0474 SICA_like 976 633 471
CL0475 Cyclophil-like 214,559 112,524 23,508
CL0476 tRNA-IECD_N 8,671 4,913 1,403
CL0477 TRD 63,096 53,510 29,185
CL0478 ATPase_I_AtpR 14,818 7,896 3,108
CL0479 PLD 222,083 120,257 30,065
CL0481 HUH 65,547 43,193 14,934
CL0482 Prolamin 42,922 20,208 7,440
CL0484 Peroxisome 33,114 14,895 4,185
CL0486 Fer2 383,181 196,280 25,766
CL0487 FKBP 356,116 184,913 48,393
CL0488 FixH-like 17,680 11,537 4,261
CL0489 SAF 218,342 119,067 40,872
CL0490 PepSY_TM-like 41,048 23,771 5,568
CL0491 LYR-like 31,412 16,289 5,100
CL0492 S4 270,938 119,014 15,882
CL0493 PTS_EIIC 90,268 30,419 4,406
CL0494 DnaA_N 80,196 39,324 7,512
CL0496 Tad-like 61,006 43,061 17,539
CL0497 GST_C 254,013 127,046 22,751
CL0498 Nribosyltransf 22,464 12,777 3,912
CL0499 O-anti_assembly 87,667 62,781 36,156
CL0500 Glycine-zipper 84,281 41,466 10,566
CL0502 STAS 195,601 112,244 32,968
CL0504 Phage_barrel 128,939 59,545 19,376
CL0505 Pentapeptide 92,546 59,475 28,486
CL0506 Succ_CoA_synth 135,367 55,911 7,861
CL0507 Fungal_trans 251,022 144,074 56,199
CL0508 YkuD 131,116 75,025 18,337
CL0509 RBP11-like 81,775 25,527 4,259
CL0511 Retroviral_zf 196,093 99,829 52,332
CL0512 CRAL_TRIO 83,627 39,573 12,862
CL0513 LCCL-domain 12,122 4,937 1,611
CL0515 LTXXQ-like 22,471 14,163 7,271
CL0516 ISP-domain 201,510 105,757 19,866
CL0517 MBOAT-like 63,057 34,494 9,796
CL0520 Keratin_assoc 6,108 3,797 1,565
CL0521 GOLD-like 29,300 12,729 3,585
CL0522 YbjQ-like 22,291 11,102 1,779
CL0523 GAG-polyprotein 185,038 145,149 82,501
CL0524 MPT63-MPB63 9,931 6,236 3,358
CL0525 pap2 182,687 103,301 33,802
CL0526 SUKH 39,247 22,413 9,228
CL0528 DUF1214 17,704 11,545 2,798
CL0529 FMN-dep-NRtase 161,727 93,004 18,183
CL0530 DNase_I-like 259,336 154,377 57,596
CL0531 AMP-binding_C 479,476 266,750 56,870
CL0532 LIG 19,897 12,012 4,925
CL0533 PRTase-like 369,757 167,114 24,943
CL0534 YjgF-like 156,171 80,096 11,007
CL0535 CBM 14,981 7,575 2,235
CL0536 HEXAPEP 298,964 157,835 27,848
CL0537 CCCH_zf 103,302 45,895 16,981
CL0539 RNase_III 70,310 38,028 8,598
CL0540 GCP 22,158 10,258 3,988
CL0541 SH2-like 141,312 47,579 11,891
CL0542 RAS_GEF_N 42,963 16,611 4,325
CL0543 Viral_gly_cn_dm 52,938 4,453 1,540
CL0544 AcylCoA_ox_dh_N 423,313 184,521 20,050
CL0545 APCOP-app_sub 38,203 17,936 4,702
CL0546 Hexosaminidase 49,481 29,094 8,126
CL0547 GF_recep_C-rich 37,262 13,973 2,929
CL0548 IHF-likeDNA-bdg 116,040 44,903 8,770
CL0550 SRCR 40,413 22,930 9,427
CL0551 BCLiA 18,086 7,423 2,583
CL0552 Hect 78,980 35,780 10,556
CL0559 CBD9-like 39,837 27,068 11,660
CL0560 Chalcone-like 12,179 7,429 2,488
CL0561 LisH 31,719 11,315 3,285
CL0562 Holin-V 1,910 1,172 319
CL0563 Holin-II 3,710 948 396
CL0564 Holin-III 5,299 1,455 543
CL0567 Phage_TACs 20,477 10,118 3,289
CL0568 Man_lectin 16,557 9,535 4,228
CL0570 PPP-I 77,963 41,762 11,709
CL0571 30K_movement 8,428 2,346 1,064
CL0572 TIKI 43,577 27,733 9,437
CL0573 KA1-like 38,283 15,321 4,120
CL0576 STARBD 14,519 7,521 2,855
CL0577 Paramyxovirin_C 648 71 37
CL0578 AbiEI 7,541 5,072 1,968
CL0580 YqgF 73,499 36,374 5,565
CL0582 TrkA_C 131,760 64,814 12,039
CL0584 FF 14,155 5,646 1,652
CL0586 CTC1 1,748 770 350
CL0587 STAND_N 7,102 5,614 3,313
CL0588 Ribos_L15p_L18e 62,909 27,751 3,542
CL0589 KIX_like 9,969 5,517 1,974
CL0590 OML_zippers 5,487 1,501 703
CL0591 TKC_like 237,804 112,896 10,079
CL0592 beta_Roll 67,581 54,629 37,635
CL0593 G5 18,384 11,302 4,399
CL0595 Fusion_gly 26,669 2,787 1,258
CL0596 VPS23_C 16,042 6,773 2,097
CL0597 Post-HMGL 40,079 15,174 1,150
CL0598 B_GA 9,127 5,423 3,691
CL0599 GH57_38_middle 35,262 20,019 5,089
CL0600 S15_NS1 140,274 23,575 2,320
CL0601 Cob_adeno_trans 33,325 17,171 2,426
CL0602 Kringle 34,042 13,375 4,023
CL0603 AA_dh_N 255,374 118,233 13,863
CL0604 post-AAA 138,981 71,716 13,103
CL0605 ssDNA_NP_VP 16,756 3,840 1,135
CL0606 Phage_fibre 4,767 1,578 626
CL0607 TNF_receptor 49,073 21,736 6,153
CL0608 Reductase_C 226,751 104,080 12,766
CL0609 sPC4_like 29,206 12,625 3,433
CL0611 Hexon 13,003 1,784 497
CL0612 PHM_PNGase_F 13,979 8,116 3,492
CL0613 Terp_synthase 331,952 186,054 40,940
CL0614 L27 29,387 10,131 1,784
CL0615 ALDC 30,239 15,853 4,597
CL0616 SPOC 41,009 19,517 4,763
CL0617 Peroxidase 100,456 52,411 13,115
CL0618 MCR 5,617 967 149
CL0619 Mog1p_PsbP 23,289 12,157 4,238
CL0620 Antihemostatic 3,349 1,590 888
CL0621 Colipase 4,692 1,933 528
CL0622 Acylphosphatase 83,607 48,102 11,085
CL0623 SRP9_14 7,062 3,321 930
CL0625 eIF4e 18,726 8,680 2,869
CL0626 Levi_coat 398 95 39
CL0627 Antibiotic_NAT 11,176 6,591 1,649
CL0628 EspA_CesA 924 182 74
CL0629 PLA2 22,398 10,858 4,131
CL0630 PSI 58,388 23,178 5,060
CL0631 YgaC_TfoX-N 82,053 54,501 9,543
CL0632 FERM_M 113,149 45,418 9,488
CL0633 NusB 73,031 39,445 7,759
CL0634 CheY-binding 8,103 4,071 799
CL0635 DmpA_ArgJ 180,627 101,693 18,196
CL0636 Leukocidin 4,145 1,700 393
CL0637 KaiA_RbsU 2,437 1,383 332
CL0639 Rof 8,961 4,555 1,374
CL0640 Colicin_D_E5 532 431 358
CL0642 SOCS_box 33,867 10,610 2,954
CL0643 YqbG 11,592 5,936 2,476
CL0644 Fz 45,217 16,614 4,965
CL0645 Anti-sigma_N 53,977 36,814 17,139
CL0646 T3SS 4,461 1,508 481
CL0647 FG_rpt 9,162 4,713 1,868
CL0648 Aha1_BPI 41,082 20,418 7,380
CL0649 PseudoU_synth 358,791 195,792 38,055
CL0650 AOC_barrel 25,744 15,004 4,491
CL0651 Mad2 20,770 9,301 3,235
CL0652 S24e_L23_L15e 65,321 23,897 2,635
CL0653 VCCI 908 146 71
CL0654 WYL 82,967 47,901 11,968
CL0655 PilP 17,490 11,273 4,528
CL0656 VSA 5,034 3,734 569
CL0658 OB_enterotoxin 2,695 831 325
CL0659 CAP 81,812 53,074 24,619
CL0660 SHOCT 55,020 32,674 10,415
CL0661 Gain 83,833 37,986 11,183
CL0662 Triple_barrel 35,207 18,569 6,692
CL0663 CNF1_YfiH 47,051 28,732 6,820
CL0664 UB2H 91,197 40,265 5,078
CL0665 BET 16,355 6,962 2,119
CL0666 Vault 1,966 820 263
CL0667 Fer2_BFD 104,835 50,280 7,009
CL0668 Pre-PUA 19,422 8,701 1,970
CL0669 NOG1_N 10,277 5,014 1,676
CL0670 4PPT 70,120 41,672 13,736
CL0671 AAA_lid 796,487 351,577 52,058
CL0672 p35 121,918 70,627 21,699
CL0673 GYF 26,542 15,388 6,498
CL0674 Triple_B_spiral 1,668 245 128
CL0676 SLATT 8,464 5,700 2,793
CL0677 GHMP_C 119,396 65,132 12,934
CL0678 CLIP 5,347 3,543 1,747
CL0679 TACC 7,009 2,710 936
CL0680 WW 91,586 42,383 12,640
CL0681 HAMP 487,861 270,370 89,769
CL0682 MBG 7,191 6,319 4,997
CL0683 MICOS 2,496 1,285 432
CL0684 NFACT_RNA-bind 26,628 15,195 4,030
CL0685 AmpE_CobD-like 25,560 13,579 2,247
CL0686 aG_PT 1,771 1,177 479
CL0687 Zn_chelatase 11,259 8,955 4,864
CL0688 BECR 5,156 3,504 2,111
CL0689 TSP3 41,686 27,715 16,405
CL0690 TrbC_VirB2 32,954 17,437 8,386
CL0691 Phage_tail_2 18,245 9,137 3,645
CL0692 TSP1 90,602 38,997 13,007
CL0693 Cas9_lobe 2,150 1,589 734
CL0694 Choline_binding 17,971 8,702 4,969
CL0695 EndoU 13,153 8,849 2,025
CL0696 Vmethyltransf 9,854 1,921 928
CL0697 SDH_beta 83,959 38,888 6,194
CL0698 TrbL 17,259 6,682 2,357
CL0700 ArdcN 20,155 9,936 3,660
CL0701 NAD_kinase_C 131,144 67,878 15,142
CL0702 UIM 14,221 5,317 1,644
CL0703 YtcA 8,544 2,757 599
CL0704 HMA 174,563 96,602 21,090
CL0705 VBS-like 34,423 11,868 3,095
CL0706 EMC6 8,576 3,999 1,207
CL0707 Saposin_like 12,950 6,179 2,245
CL0708 Polo-box 8,544 3,265 1,140
CL0709 STING 2,001 1,054 432
CL0710 YeeE 41,888 26,173 3,570
CL0713 Acyl-CoA_desat 185,646 97,707 18,977
CL0714 COX1-like 1,813,921 176,147 29,344
CL0715 Nckap1_CYFIP1-2 12,333 3,880 1,492
CL0716 Aquaporin-like 111,667 51,199 10,797
CL0717 YbaB 41,958 20,355 3,598
CL0718 Perilipin_sf 7,271 3,340 1,040
CL0719 Moesin_tail 9,539 1,789 386
CL0720 Lag3_N 1,788 918 299
CL0721 LAMP 8,000 3,575 1,040
CL0722 SDH_alpha 70,541 33,613 6,096
CL0723 TRADD-N 4,302 1,680 588
CL0724 Kinetochore 13,329 6,788 2,484
CL0725 Apolipoprotein 7,348 3,575 1,167
CL0726 Resistin 1,336 610 170
CL0727 Nucleosidase 47,669 25,642 6,161
CL0728 Cas2 33,756 21,477 4,484
CL0729 Kre28-like_sf 1,910 973 322
CL0730 IL8 24,536 12,392 3,907
CL0731 SPOCS 6,012 3,528 1,402
CL0732 RMP1-like 3,127 1,843 838
CL0733 Ribosomal_L25 86,106 45,107 7,231
CL0734 Rpp14-Pop5-like 8,117 4,718 1,772
CL0735 GatC-like 37,955 19,809 3,697
CL0736 Get5_C_sf 808 349 146
CL0737 Mtd 4,456 2,276 1,056
CL0738 Arg_repressor_C 33,691 14,968 2,106
CL0740 GCV_T_C 199,188 80,319 9,780
CL0741 RGM 32,871 18,849 7,992
CL0742 PTS_IIA-like 5,162 2,528 669
CL0743 Spectrin 62,675 29,251 6,592
CL0745 MIT 30,800 11,880 3,071
CL0746 AFF4_CHD 5,040 2,027 492
CL0747 THUMP 51,033 23,355 4,772
CL0748 DNA_prim_N 46,856 25,960 6,457
CL0749 GH127_M 38,464 24,401 5,711
CL0750 ADAM_CR_sf 56,133 23,782 5,223
CL0751 Secretin_N0 90,175 52,570 21,452
CL0752 PsbQ-like 5,432 2,836 776
CL0753 ATPD-E_C 33,303 9,394 1,266
CL0754 PGM_I-III 143,520 69,257 10,146
CL0755 SASP 12,301 5,312 1,180
CL0756 GMC 2,764 895 201
CL0757 TRAP 4,039 1,760 579
CL0758 L31 48,228 18,201 2,166
CL0759 Nop_N_sf 9,061 3,715 685
CL0760 RBG 32,463 17,801 6,509
CL0761 ABC_sf 181 28 24
CL0763 GpW_gp25-like 51,607 22,831 5,145
CL0764 PHP14-like 36,267 15,939 2,115
CL0765 PAC 6,441 3,566 1,321
CL0766 NCPF 8,869 5,219 1,290
CL0767 MXAN_049 4,715 3,236 1,533
CL0768 DUF960 2,197 1,081 404
CL0769 SsdA_imm 3,159 2,261 509
CL0770 GH84_C 1,731 921 228
CL0771 YaaA-like 23,088 11,829 2,159

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