EFI - Computationally-Guided Functional Profiling

This site uses the CGFP-ShortBRED programs (https://bitbucket.org/biobakery/cgfp/src and http://huttenhower.sph.harvard.edu/shortbred).

For more information on CGFP-ShortBRED, see

Levin, B. J., Huang, Y. Y., Peck, S. C., Wei, Y., Martínez-del Campo, A., Marks, J. A., Franzosa, E. A., Huttenhower, C., Balskus, E. P. A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline. Science 355, eaai8386 (2017). (DOI: 10.1126/science.aai8386)

For more information on ShortBRED, see

Kaminski J., Gibson M. K., Franzosa E. A., Segata N., Dantas G., Huttenhower C. High-specificity targeted functional profiling in microbial communities with ShortBRED. PLoS Comput Biol. 2015 Dec 18;11(12):e1004557. DOI: 10.1371/journal.pcbi.1004557

These programs use data computed by MicrobeCensus.

Nayfach, S. and Pollard, K.S. Average genome size estimation improves comparative metagenomics and sheds light on the functional ecology of the human microbiome. Genome Biology 2015;16(1):51.

Portions of the metagenome data used on this site come from the Human Microbiome Project.

The Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 486, 207-214 (14 June 2012). DOI: 10.1038/nature11234
The Human Microbiome Project Consortium. A framework for human microbiome research. Nature 486, 215-221 (14 June 2012). DOI: 10.1038/nature11209

If you use the EFI web tools, please cite us.

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