EFI - Taxonomy Tool

This web resource is supported by a Research Resource from the National Institute of General Medical Sciences (R24GM141196-01).

The tools are available without charge or license to both academic and commercial users.

Important Notice

The UniProtKB database used by the EFI tools is undergoing major reorganization starting with the just-released version 2025_04 (https://www.uniprot.org/help/refprot_only_changes). When the reorganization is fully implemented (2026_02 release, Spring 2026), the number of proteins in UniProtKB will decrease from ~253M accessions in the previous 2025_03 release to ~141M accessions in the 2026_02 release.

In response to these changes, we will provide the previous 2025_03 release until the 2026_02 release is available.

The current 2025_04 release removed 82M UniProt IDs; the UniProt pages providing functional annotation for these IDs are no longer active. A new Metadata Tool provides access to the node attribute metadata for all UniProt IDs in the 2025_03 release that the tools continue to use during the UniProtKB reorganization. The Tool is available using the tab at the top of each page.

More information about the reorganization is located here.

Dataset Completed

The parameters for generating the initial dataset are summarized in the table.

Job Number	26116
Time Started -- Finished	11/6 06:25 PM -- 11/6 06:55 PM
Database Version	UniProt: 2022-04 / InterPro: 91
Input Option	Families (Option B)
Job Name	IP91_IPR004184_All
E-Value for SSN Edge Calculation
Pfam / InterPro Family	IPR004184
Number of IDs in Pfam / InterPro Family	25,513
Exclude Fragments	No
Total Number of Sequences in Dataset	25,513

The taxonomy distribution for the UniProt IDs identified as members of the input list of families is displayed.

The UniRef90 and UniRef50 clusters containing the UniProt IDs in the sunburst are identified using the lookup table provided by UniProt/UniRef. These UniRef90 and UniRef50 clusters may contain UniProt IDs from other families; in addition, the UniRef90 and UniRef50 clusters at a selected taxonomy category may contain UniProt IDs from other categories. This results from conflation of UniProt IDs in UniRef90 and UniRef50 clusters that share ≥90% and ≥50% sequence identity, respectively.

The numbers of UniProt IDs, UniRef90 cluster IDs, and UniRef50 cluster IDs for the selected category are displayed.

The sunburst is interactive, providing the ability to zoom to a selected taxonomy category by clicking on that category; clicking on the center circle will return the display to the next highest rank.

Number of sequences at each length - UniProt

Number of sequences at each length - UniRef90

Number of sequences at each length - UniRef50

Portions of these data are derived from the Universal Protein Resource (UniProt) databases.

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