EFI - Genome Neighborhood Tool

This web resource is supported by a Research Resource from the National Institute of General Medical Sciences (R24GM141196-01).
The tools are available without charge or license to both academic and commercial users.
Important Notice

The UniProtKB database used by the EFI tools is undergoing major reorganization starting with the 2025_04 release (https://www.uniprot.org/release-notes/forthcoming-changes). When the reorganization is fully implemented (2026_02 release, Spring 2026), the number of proteins in UniProtKB is expected to decrease from ~253M accessions in the current 2025_03 release to ~141M accessions in the 2026_02 release.

In response to these changes, we are planning to provide the current 2025_03 release until the 2026_02 release is available.

More information about the changes is located here.

Release Notes

June 19, 2019

The genome network diagram (GND) explorer has been updated. InterPro families can now be added as genome filters, and SwissProt annotations can be highlighted. The ability to zoom in and out by scale (rather than genome window) is also present.

April 6, 2019

The GNT user interface has been updated. The results page contains a tab-style interface that logically groups results on the page and allows download of SSN and GNNs without having to scroll the page past the submission information.

December 10, 2018

Users now have the ability to regenerate GNNs from an existing GNT job (only applicable to GNT jobs started after 12/10/2018). This allows the user to use a different neighborhood size or cooccurrence to generate a GNN from an existing job, saving computation time.

The genomic neighborhood diagram viewer has the capability to graphically filter diagrams by Pfam. The users can press the Ctrl button on the keyboard and click on an arrow and all arrows with that particular family will be highlighted. Users can now submit GNT jobs directly from the EST download page.

Previous Updates

To improve usability of the GNT, the various tools have been separated into separate tabs.

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