EFI - Enzyme Similarity Tool

This web resource is supported by a Research Resource from the National Institute of General Medical Sciences (R24GM141196-01).
The tools are available without charge or license to both academic and commercial users.
Important Notice

The UniProtKB database used by the EFI tools is undergoing major reorganization starting with the 2025_04 release (https://www.uniprot.org/release-notes/forthcoming-changes). When the reorganization is fully implemented (2026_02 release, Spring 2026), the number of proteins in UniProtKB is expected to decrease from ~253M accessions in the current 2025_03 release to ~141M accessions in the 2026_02 release.

In response to these changes, we are planning to provide the current 2025_03 release until the 2026_02 release is available.

More information about the changes is located here.


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Click here to contact us for help, reporting issues, or suggestions.

Carl R. Woese Institute for Genomic Biology
University of Illinois at Urbana-Champaign
1206 W. Gregory Drive Urbana, IL 61801
efi@enzymefunction.org