This web resource is supported by a Research Resource from the National Institute of General Medical Sciences (R24GM141196-01).
The tools are available without charge or license to both academic and commercial users.
Reorganization of UniProtKB
With the current 2026_02 release, the UniProtKB database is reorganized to include an
expanded number of Reference Proteomes to better capture biodiversity.
This includes the removal of proteins from taxonomically unclassified organisms,
i.e., those without a binomial species name (genus and species). The total number of
accessions in UniProtKB has been reduced from 253,635,358 in the “legacy” 2025_03
release to 149,810,139 in the current 2026_02 release.
We are providing the option to select either the “legacy” 2025_03 database or the
current UniProtKB database (now 2026_02) when generating SSNs. You can select the
database in the “Database” accordion on the pages for the EFI-EST options, the EFI-GNT
tool, and the Taxonomy Tool. We suggest that you compare the SSNs, GNNs, and GNDs
generated from both databases as you explore the information you are seeking.
Update of EFI Tools
The EFI Tools are being upgraded on 9/23/26. While the updated site is functionally
identical to the old site, jobs run prior to that date will only be available
through the results link in the finalization email (not the Previous Jobs tab).
User accounts created on the old site will no longer be available, and users
are encouraged to create new accounts when the upgraded site becomes available.
Markers that uniquely define clusters in the submitted SSN have been identified.
Files detailing the identities of the markers and which sequences they represent are available for download.
SSN With Marker Identification Results
The SSN submitted has been edited to include the marker ID and type
and the number of markers that were identified.
File
Size
SSN with identify results (ZIP)
CGFP Family and Marker Data
The CD-HIT ShortBRED families by cluster file contains mappings of ShortBRED
families to SSN cluster number as well as a color that is assigned
to each unique ShortBRED family. The ShortBRED marker data file
lists the markers that were identified.
File
Size
CD-HIT ShortBRED families by cluster
ShortBRED marker data
Submission is currently disabled due to site maintenance.
Submission is currently disabled due to site maintenance.
