EFI - Enzyme Similarity Tool

This web resource is supported by a Research Resource from the National Institute of General Medical Sciences (R24GM141196-01).

The tools are available without charge or license to both academic and commercial users.

Please cite your use of the EFI tools:

Rémi Zallot, Nils Oberg, and John A. Gerlt, The EFI Web Resource for Genomic Enzymology Tools: Leveraging Protein, Genome, and Metagenome Databases to Discover Novel Enzymes and Metabolic Pathways. Biochemistry 2019 58 (41), 4169-4182. https://doi.org/10.1021/acs.biochem.9b00735

Nils Oberg, Rémi Zallot, and John A. Gerlt, EFI-EST, EFI-GNT, and EFI-CGFP: Enzyme Function Initiative (EFI) Web Resource for Genomic Enzymology Tools. J Mol Biol 2023. https://doi.org/10.1016/j.jmb.2023.168018

Family Information

Family ID	Short Name	UniProt	UniRef90	UniRef50
PF00001	7tm_1	372,992	164,720	55,727
PF00002	7tm_2	76,230	35,074	11,433
PF00003	7tm_3	48,744	22,798	6,547
PF00004	AAA	381,952	177,055	36,427
PF00005	ABC_tran	1,681,846	959,709	115,660
PF00006	ATP-synt_ab	101,782	33,902	2,770
PF00007	Cys_knot	11,387	4,275	1,154
PF00008	EGF	105,117	51,511	18,791
PF00009	GTP_EFTU	236,279	80,018	9,938
PF00010	HLH	197,915	84,646	26,233
PF00011	HSP20	75,489	44,030	12,139
PF00012	HSP70	112,227	49,616	14,858
PF00013	KH_1	103,333	39,641	9,673
PF00014	Kunitz_BPTI	31,464	18,327	8,221
PF00015	MCPsignal	146,152	104,758	32,350
PF00016	RuBisCO_large	21,918	5,985	782
PF00017	SH2	132,520	46,751	11,294
PF00018	SH3_1	194,642	80,001	18,797
PF00019	TGF_beta	35,236	12,759	3,414
PF00020	TNFR_c6	18,343	9,555	3,432
PF00021	UPAR_LY6	9,300	5,216	1,987
PF00022	Actin	74,089	24,378	7,634
PF00023	Ank	207,852	121,547	60,075
PF00024	PAN_1	23,642	15,822	9,061
PF00025	Arf	67,886	23,319	7,026
PF00026	Asp	52,364	34,045	13,058
PF00027	cNMP_binding	185,907	107,400	27,285
PF00028	Cadherin	112,334	51,639	15,325
PF00029	Connexin	19,864	6,014	931
PF00030	Crystall	21,147	7,556	1,659
PF00031	Cystatin	13,676	7,675	2,886
PF00032	Cytochrom_B_C	54,505	9,575	816
PF00033	Cytochrome_B	68,085	10,690	1,214
PF00034	Cytochrom_C	73,533	50,984	9,779
PF00035	dsrm	58,958	28,312	7,365
PF00036	EF-hand_1	26,747	11,351	4,828
PF00037	Fer4	41,448	22,093	4,345
PF00038	Filament	55,046	20,681	4,385
PF00039	fn1	3,906	1,418	166
PF00040	fn2	15,514	6,264	1,394
PF00041	fn3	265,078	120,828	37,191
PF00042	Globin	34,835	18,117	4,349
PF00043	GST_C	79,812	46,681	8,549
PF00044	Gp_dh_N	47,270	17,034	1,258
PF00045	Hemopexin	23,154	9,072	2,167
PF00046	Homeodomain	260,278	100,803	33,708
PF00047	ig	46,556	20,541	9,080
PF00048	IL8	24,728	12,840	3,902
PF00049	Insulin	7,967	3,610	1,371
PF00050	Kazal_1	12,878	7,019	3,177
PF00051	Kringle	18,856	8,078	2,765
PF00052	Laminin_B	11,581	6,344	1,606
PF00053	EGF_laminin	48,456	22,922	6,222
PF00054	Laminin_G_1	17,020	8,363	2,287
PF00055	Laminin_N	21,659	10,514	2,057
PF00056	Ldh_1_N	44,659	16,723	2,181
PF00057	Ldl_recept_a	73,101	36,568	14,996
PF00058	Ldl_recept_b	28,104	12,146	3,588
PF00059	Lectin_C	111,563	71,989	33,482
PF00060	Lig_chan	56,550	26,516	9,099
PF00061	Lipocalin	23,510	10,264	2,927
PF00062	Lys	5,176	3,004	1,078
PF00063	Myosin_head	97,395	45,407	10,058
PF00064	Neur	4,794	316	55
PF00066	Notch	7,599	3,710	1,067
PF00067	p450	505,627	314,466	93,522
PF00068	Phospholip_A2_1	8,825	5,004	1,611
PF00069	Pkinase	1,366,665	700,432	225,773
PF00070	Pyr_redox	736	523	310
PF00071	Ras	280,759	97,778	29,167
PF00072	Response_reg	927,396	557,047	120,228
PF00073	Rhv	14,460	1,740	438
PF00074	RnaseA	3,895	2,343	771
PF00075	RNase_H	50,936	34,374	14,387
PF00076	RRM_1	547,921	244,190	76,391
PF00077	RVP	31,431	13,009	3,707
PF00078	RVT_1	338,604	245,744	130,441
PF00079	Serpin	49,265	25,547	9,437
PF00080	Sod_Cu	21,231	12,789	3,171
PF00081	Sod_Fe_N	30,041	12,398	1,273
PF00082	Peptidase_S8	151,638	103,451	31,969
PF00083	Sugar_tr	281,470	149,277	36,777
PF00084	Sushi	71,284	35,957	14,529
PF00085	Thioredoxin	163,228	87,162	20,969
PF00086	Thyroglobulin_1	21,248	9,036	2,678
PF00087	Toxin_TOLIP	6,254	3,441	1,197
PF00088	Trefoil	9,600	5,684	1,912
PF00089	Trypsin	186,795	116,008	46,749
PF00090	TSP_1	71,784	32,477	10,554
PF00091	Tubulin	83,049	27,271	5,437
PF00092	VWA	99,373	55,182	18,226
PF00093	VWC	27,741	9,657	2,380
PF00094	VWD	30,092	18,961	8,339
PF00095	WAP	14,844	8,178	3,960
PF00096	zf-C2H2	563,375	290,545	132,787
PF00097	zf-C3HC4	74,368	39,109	16,825
PF00098	zf-CCHC	123,490	79,384	44,512
PF00100	Zona_pellucida	28,182	14,420	5,038
PF00101	RuBisCO_small	4,668	1,985	259
PF00102	Y_phosphatase	88,059	40,275	12,325